SummaryIn this article, a compact quad element coplanar waveguide (CPW) fed ultra‐wideband (UWB) multiple input multiple output (MIMO) antenna for future generation wireless communication system using a machine learning (ML) optimization approach is presented. The proposed antenna is used for 5G new radio (n46/n77/n47/n78/n48/n79), Wi‐Fi 5, Wi‐Fi 6, and dedicated short range communications (DSRC) services, vehicle to infrastructure (V2I), vehicle to vehicle (V2V), and vehicle to network (V2N) in the entire operating frequency band. It is operating from 3.2 to 11.85 GHz. The bandwidth is 8.65 GHz, and the percentage of impedance bandwidth is 115%. The comparative analysis between dual and quad elements are presented. It is optimized through the various ML model K‐nearest neighbor (KNN), extreme gradient boosting (XGB), artificial neural network (ANN), and random forest (RF). The KNN ML model achieved a higher accuracy of 93%, and it accurately predicted the S parameters of the suggested UWB antenna. The MIMO parameters are calculated and found within the acceptable limits. There is a strong correlation between the simulated and measured results. Hence, the suggested antenna is a suitable candidate for future wireless communication systems.