Background The future of smart factories and pharmaceutical industries has evolved significantly since the 19th century. Computers have been used in the pharmaceutical field since the 1980s with the emergence of Artificial Intelligence (AI). In addition, automation and robotics are used in the pharmaceutical industry to improve the efficiency of pharmaceutical development and production. Purpose The present review article covers the future roles of AI, automation and robotics in pharmaceutical industries. Methodology The current review article employed a comprehensive search strategy across relevant databases, including PubMed, Scopus and Web of Science, utilizing keywords such as AI, Automation, Robotics and Pharmaceutical Industries. The articles considered a focus on recent advancements and emerging trends in the intersection of AI, automation and robotics within pharmaceutical sectors. Results AI, incorporating predictive machine learning and reasoning techniques, aids in the preclinical identification of molecules and forecasting potential lead compounds before conducting clinical trials. automation offers significant benefits in monitoring and predictive maintenance of production lines, power distribution and control machines. Robotic process automation improves efficiency by connecting computer terminals to handle various manufacturing process elements. Conclusion Artificial intelligence, automation and Robotics have sparked innovations in the healthcare business, benefiting the global ecosystem and healthcare delivery. Incorporating these advanced tools in pharmaceutical industries from raw material selection to final product development could improve the quality and safety of the pharmaceutical products and reduce the time and cost.