Future Development Research Articles

Overview of the Balanced Suspension Patents

Background: The suspension has the role of transmitting and carrying the forces and moments between the wheels and the frame and controlling the wheel runout, thus providing the car with good comfort and operational stability. Objective: Through the analysis of the current situation of suspension research, we summarize the research line and specific technical solutions of suspension, and finally, we provide an outlook on the future development direction of suspension, which in turn can provide some reference value for readers. Methods: The existing suspensions are classified into passive suspensions, semi-active suspensions, and active suspensions, and their improvement methods are described to compare the advantages and disadvantages of different improvement methods. Results: By comparing the results of suspension studies, semi-active suspension can effectively improve the smoothness and handling stability of the vehicle. Semi-active suspension has the advantages of low energy consumption, simple control, lower cost, easy implementation, and high reliability, while the effect of vibration control can be close to active suspension to some extent and far better than passive suspension. Conclusion: This paper introduces passive suspension, semi-active suspension, and active suspension in three categories and describes the working principle, functions, problem-solving advantages, and shortcomings of the three suspensions, respectively. Semi-active suspension is more suitable for the future development trend of suspension.

Research Progress on Pole-Climbing Robots: A Review

Background: Pole-climbing robots are a type of application robot commonly used for quality inspection, cleaning, and maintenance of utility poles, high voltage lines, bridge cables, transmission pipelines, and other important facilities with a certain height. The working conditions are often harsh and dangerous, making manual participation unsafe. The pole-climbing robot can provide a platform for maintenance and cleaning work. Remote control operation of the pole-climbing robot is achieved through communication and control technology. It has been created to improve efficiency and reduce personnel accidents greatly. At the same time, the continuous development of science and technology has led to the expansion of robot design concepts. It has also brought about great changes and growth in the development of pole-climbing robots. Objective: The purpose of this paper is to report the latest progress in the research of pole-climbing robots from bionic and non-bionic perspectives and to provide a research reference for researchers in this field. Method: By analyzing academic theses and published patents, this paper presents a new classification of pole-climbing robots from the perspective of bionic and non-bionic. By summarizing the literature, the structural characteristics of various pole-climbing robots and their differences and applications are summarized. Results: The performance of the pole-climbing robots is analyzed from the viewpoint of structural characteristics and action execution methods. In turn, the characteristics of various types of pole-climbing robots are summarized. Finally, based on the above discussion, the future problems and development directions of pole-climbing robots are predicted. Conclusion: The pole-climbing robots can be divided into two categories, bionic and non-bionic, based on the analysis of design features. Both bionic and non-bionic pole-climbing robots have good development and applications in their respective directions. Also, bionic and non-bionic pole-climbing robots have different detailed classifications based on material, structure, and other perspectives. They have different advantages and disadvantages in terms of the performance of pole-climbing action execution. It provides a research reference for future researchers in this field.

A Review on Biomimetic Cilia Microrobots: Driving Methods, Application and Research Prospects

Abstract: With the development of science and technology, microrobots have been used in medicine, biology, rescue, and many other fields. However, the microrobots have problems such as energy and motion due to miniaturization. In order to solve the problem of the energy supply of microrobots, researchers have provided more drive schemes for microrobots. Inspired by the biological cilia, the biomimetic cilia have been developed and applied to microrobots to achieve propulsion, liquid pumping, liquid mixing, and particle manipulation. This review summarizes the different driving modes of microrobots, focusing on the application of magnetic drive and optical drive in the field of micro-robots. The structure and function of biological cilia and biomimetic cilia are introduced. The application of biomimetic cilia microrobots in various fields is discussed, and the current challenges and future development trends of biomimetic cilia microrobots are summarized. This review hopes to provide useful help for researchers of biomimetic cilia microrobots

Cancer Stem Cells and Treatment of Cancer: An Update and Future Perspectives.

Cancer stem cells (CSCs) play an essential role in tumour progression and metastasis. Stem cell ability of self-renewal enables it to persist over time, thereby contributing to cancer relapse or recurrence and also resistance to current therapies. Therefore, targeting CSCs emerged as a promising strategy of cancer treatment. CSCs exhibit differentiation, self-renewal, and plasticity, they contribute to formation of malignant tumours, also favors, metastasis, heterogeneity, multidrug resistance, and radiation resistance. Coventional cancer treatments predominantly target cancer cells that are not CSCs, CSCs frequently survive, eventually leading to relapse. This article focuses on the development of novel therapeutic strategies that combine conventional treatments and CSC inhibitors to eradicate cancer cells and CSCs, for the better and permanent treatment. However, the diversity of CSCs is a significant obstacle in the development of CSC-targeted therapies, necessitating extensive research for a better understanding and exploration of therapeutic approaches. Future development of CSC-targeted therapies will rely heavily on overcoming this obstacle.

Review of Surface Treatment Technology for Improving Wear Resistance of Magnesium Alloys

Background: As the lightest metal structural material in engineering, magnesium alloy has excellent mechanical properties, such as high specific strength, high specific stiffness, good damping performance, and good machinability. It is widely used in the fields of precision parts, automobiles, aerospace, and military. However, poor friction and wear performance are significant magnesium defects of the alloys, which make its use limited in some areas with high working conditions, so it is essential to improve the wear resistance of the magnesium alloy surface. Objective: The aim of this study was to summarize the technology of improving the wear resistance of magnesium alloy in recent year. The influence of different surface treatment technology for enhancing friction and wear properties was also analyzed, which could provide a reference for related scholars and researchers. Method: In this paper, the literature related to friction and wear properties of magnesium alloys in recent years were reviewed, the principles of various surface treatment technology of magnesium alloys were explained, and the advantages and disadvantages of each technology were analyzed. Results: Based on the literature analyses related to the wear resistance of magnesium alloys, the problems existing in the surface treatment technology for improving the wear resistance of magnesium alloys are summarized, and future development directions are put forward. Conclusion: Among the technologies to improve the wear resistance of magnesium alloys, the combination of various techniques can better meet the working demands. The environmentally friendly and efficient manner has a good prospect for development.

Research on Developing Cyclone Coupling Techniques for Heterogeneous Separators with Design Optimization of Hydrocyclone Separators

Abstract: Hydrocyclone separator is a widely used equipment in the field of liquid-solid separation due to its simple structure, convenient operation, and high separation efficiency. This paper provides a comprehensive review of the working principles, application areas, design optimization, and performance evaluation of hydrocyclone separators, while discussing their future development trends. In addition, particular attention has been given to the aspects related to patents in this study.The focus is on analyzing the structural parameters and flow field characteristics of hydrocyclone separators, as well as the different effects on separation efficiency caused by various hydrocyclone structures and adjustments in hydrocyclone size. The research analysis is conducted on the inlet, cylindrical section, overflow pipe section, cone section, hydrocyclone materials, and other parts, taking into account detailed analysis of operational conditions such as inlet flow rate, pressure drop, separation efficiency, and fluid properties. The future development trend of hydraulic hydrocyclone separators lies in refinement, intelligence, multifunctionality, integration, and energy-saving and environmental protection. In the field of liquid-solid separation, the integration of hydrocyclone separation technology and intelligent devices is becoming increasingly important, and future research will focus on developing new hydrocyclone coupling separation techniques to further improve production efficiency and convenience in daily life. The application prospects are broad, and it is expected to bring significant economic and social benefits to society. It also possesses the potential for patent protection.

Commentary Innovations in Tissue Regeneration and Wound Healing: A Comparative Study of Nigeria and South Africa

Tissue regeneration and wound healing represent critical areas in medical science, with significant advance-ments in recent years. These fields involve restoring damaged tissues and promoting recovery, which are essential for improv-ing patient outcomes and quality of life. Innovations such as biomaterials, stem cell therapy, advanced wound dressings, and regenerative medicine have significantly impacted these areas. This study provides a comparative analysis of innovations in tissue regeneration and wound healing in Nigeria and South Africa. The focus includes technological advancements, research contributions, and statistical data to highlight progress and challenges in both countries. Data from various healthcare institu-tions, research publications, and government reports form the basis of this analysis.Additionally, surgical innovations that minimize wound occurrence and improve wound healing, such as mini-mally invasive surgery, negative pressure wound therapy (NPWT), and the use of advanced suture materials, are transforming clinical outcomes in both Nigeria and South Africa. Minimally invasive techniques reduce tissue damage, leading to smaller wounds and faster recovery. NPWT has proven effective in managing chronic wounds and reducing infection rates, while an-timicrobial and absorbable sutures have lowered complications related to wound closure. Cold plasma therapy and stem cell applications are also emerging as promising approaches for chronic wound care and tissue regeneration. These innovations, coupled with the efforts in regenerative medicine and biomaterials, are providing both nations with effective tools to manage wound healing more efficiently. This comparative study aims to shed light on the current state of tissue regeneration and wound healing in these nations, offering insights into the advancements made, the effectiveness of various approaches, and the potential future devel-opments in this vital medical field.

Recent Patents for Optical Component Polishing Technology

Background: Fluid jet polishing, Airbag polishing, Magnetorheological polishing, and Ion beam polishing are all emerging polishing technologies commonly used for processing optical components, which can be used to manufacture various high-precision and high-quality optical components. Their processing mechanisms are to remove materials by high-speed jet impacting the surface of the workpiece; using a spherical flexible airbag as a polishing tool to obtain a super-smooth surface by adding polishing fluid containing fine abrasives; controlling the magnetic field to form a flexible polishing belt of Magnetorheological fluid, which undergoes relative motion to achieve material removal; using a neutral ion beam to bombard the surface of the workpiece to remove workpiece surface atoms and obtain a super-smooth surface through energy and momentum transfer between ions and workpiece atoms. The characteristics and removal mechanisms of various polishing methods are briefly described, and the advantages and key issues that need to be addressed for each polishing technology are pointed out, and suggestions and prospects for future research, application, and development are also given. Objective: In order to meet the growing demand for high-precision optical components and mass-manufactured optical components, this paper aims to study the various polishing technologies that are continuously improved and suggestions are made for future research and development directions. Method: This paper reviews the current patents related to various polishing technologies, such as Fluid jet polishing, Airbag polishing, Magnetorheological polishing and Ion beam polishing and other representative polishing technologies. Results: Various types of polishing technologies have been studied, and the main problem at the current stage is the lack of accuracy. The problem of the polishing device, such as fluid jet polishing, only considers the change of fluid velocity and pressure to construct the removal function model for analysis and summary, and suggestions for the latest research progress of various polishing technologies are given. Conclusion: The improvement and optimization of polishing technology are beneficial to improving the polishing accuracy and quality of optical components and have great help for the future development of related patents.

CircRNAs as a novel class of potential diagnostic biomarkers in bipolar disorders.

Bipolar disorder (BD) is a severe mood disorder with uncertain causes and debilitating signs and symptoms. Gene expression is crucial to the pathophysiology of BD and could be influenced by genetic or epigenetic factors, by either direct modification of mRNA templates or by regulation of post-transcriptional translation. Recent evidence has shown that several critical processes in psychiatric diseases, such as neuronal activity or plasticity, synaptic transmission, and neuronal depolarization, have all been linked to circular RNAs (circRNAs). The circRNA profile of neuronal cells, which may be easily ascertained by a liquid biopsy, may shed light on the molecular pathophysiology of psychiatric disorders, including BD. This approach could aid in future development in diagnosis and treatment. In this review, we provide an in-depth understanding of the roles of circRNAs in the pathophysiology of BD and offer new insight into their potential as emerging diagnostic tools and therapeutic targets.

Alkaloids as Additional Weapons in the Fight against Breast Cancer: A Review.

Breast carcinoma is among the most frequent cancerous tumour in females around the globe. The major modalities now employed in the therapeutic management of breast cancer include surgeries, chemotherapy, and specialized medicines. Despite their potential to help individuals' problems, they are also associated with many negative impacts. As a result, natural products are increasingly regarded to be a preferable alternative. Alkaloids are essential biochemical substances that can be used to develop new drugs. Numerous alkaloids that originate from natural plants have been shown in vitro and in vivo to have anti-proliferation and anti-metastasis actions on different kinds of carcinoma. According to the data collected in this study, the utilization of alkaloids as anti-tumor medicines appears to be extremely potent; nevertheless, extensive studies and clinical trials are required before utilizing individual alkaloids. In this overview, we provide a detailed and vital exploration of pre-existing alkaloids possessing anti-tumor activities due to bioactive compounds. This study also includes an overview of synthesized analogues and pharmacological characteristics that will be beneficial to scientists working on alkaloids for medicinal purposes. In a recent survey of the literature, alkaloids are an important component of plantderived antitumor medicines that hold great potential for the future development of cancer therapy and preventive therapies. We have also discussed structural analysis relationship (SAR) studies. Moreover, it covers clinical trial medications and FDA-approved medicines from the last five years that will be useful in further research.

Temporal Autoregressive Matrix Factorization for High-Dimensional Time Series Prediction of OSS.

Open-source software (OSS) plays an increasingly significant role in modern software development tendency, so accurate prediction of the future development of OSS has become an essential topic. The behavioral data of different open-source software are closely related to their development prospects. However, most of these behavioral data are typical high-dimensional time series data streams with noise and missing values. Hence, accurate prediction on such cluttered data requires the model to be highly scalable, which is not a property of traditional time series prediction models. To this end, we propose a temporal autoregressive matrix factorization (TAMF) framework that supports data-driven temporal learning and prediction. Specifically, we first construct a trend and period autoregressive model to extract trend and period features from OSS behavioral data, and then combine the regression model with a graph-based matrix factorization (MF) to complete the missing values by exploiting the correlations among the time series data. Finally, use the trained regression model to make predictions on the target data. This scheme ensures that TAMF can be applied to different types of high-dimensional time series data and thus has high versatility. We selected ten real developer behavior data from GitHub for case analysis. The experimental results show that TAMF has good scalability and prediction accuracy.

Mapping the Landscape of Obesity Effects on Male Reproductive Function: A Bibliometric Study.

Due to changes in lifestyle and dietary habits, the global population with obesity is increasing gradually, resulting in a significant rise in the number of individuals having obesity. Obesity is caused by an imbalance between energy intake and consumption, leading to excessive fat accumulation, which interferes with normal human metabolism. It is also associated with cardiovascular disease, metabolic syndrome, male reproductive endocrine regulation disorders, systemic and local inflammatory reactions, excessive oxidative stress, and apoptosis. All these factors can damage the internal environment for sperm generation and maturation, resulting in male sexual dysfunction, a decline in sperm quality, and lower fertility. This study analyzes the trends and priorities of the effects of obesity on male reproductive disorders from a bibliometric perspective. This study uses the Web of Science as the statistical source, covering all time spans. Tools like Web of Science, VOSviewer, and CiteSpace are used to analyze countries, institutions, authors, journals, and keywords in the field. Total publications, total citations, and average number of citations are selected for statistics. The results show that the research on the impact of obesity on male reproductive function can be roughly divided into three stages: the initial stage, the slow development stage, and the rapid development stage. Our statistical scope includes 463 highly relevant articles that we have screened. We found that the journal with the most publications in this field is Andrologia, and the institution with the highest total citations is the University of Utah. The most influential countries, institutions, and authors in this field are the United States, the University of Utah, and Carrell, Douglas. Currently, research related to the impact of obesity on male reproduction focuses mainly on three aspects: biochemistry, molecular biology, and reproductive biology. The keyword explosion results indicate that sperm, obesity, and male reproduction are at the forefront and trends of future research in this field. There has been a shift from basic biochemical and molecular research to research on molecular mechanisms relying on omics technologies. However, we have observed that the number of papers published in 2022 is lower than in 2021, indicating a growth interruption during this period. Considering that this deviation may be due to the impact of the COVID-19 pandemic, it may hinder the progress of certain experiments in 2022. In recent years, China has rapidly developed research in this field. However, the average citation rate is relatively low, indicating the need for Chinese scholars to improve the quality of their articles further. Based on our research and in the context of global obesity, men are at risk of increased infertility. Addressing this issue relies on our continued research into the mechanisms of obesity-related male reproductive disorders. Over the past forty-three years, with the contributions of scientists worldwide, research in this field has flourished. The impact of obesity on male reproductive disorders has been extensively studied. Currently, research in this field primarily focuses on male sperm function, sperm quality, and the effects or mechanisms of cells on male reproduction. Future trends in this field should concentrate on the relationship between male fertility and energy metabolism, as well as the endocrine function of adipose tissue. This study comprehensively analyzes the current research status and global trends in obesity and male reproductive disorders. We also discuss the future developments in this field, making it easier for researchers to understand its developmental history, current status, and trends, providing valuable reference for effective exploration in this area.

Present Situation and Future Prospects of Motor Cooling System

Background: The motor cooling system is mainly used in aerospace, automotive, and marine fields, where the motor system is cooled to extend the service life and safety of the motor. The running power of motors rises too fast, which leads to the failure of heat dissipation as expected and shortens the service life of motors. Therefore, it is necessary to choose an appropriate cooling mode for motors to improve their cooling structure, reduce their temperature rise, and improve their reliability and service life. The internal motor cooling system can perform fixed-point heat dissipation, but the overall heat dissipation is poor. The external motor cooling system can perform overall heat dissipation but has high requirements on the structure. Over the years, the application and development of motor cooling systems have gained more and more attention. Objective: This paper discusses the structural characteristics, advantages, and development trends of the motor cooling system in order to reduce the temperature rise of the motor and improve its reliability and service life. This paper aims to provide an overview and systematic guidance for future designs of the motor cooling system. Methods: According to the structural characteristics of the motor cooling system and the requirements of the motor application field, the most typical internal cooling system and external cooling system in the motor cooling system are summarized. Results: By analyzing the causes and hazards of motor heating, the limited requirements of the motor system in use are summarized. The motor system is classified and compared based on the structure, heat dissipation principle, and use of the motor heat dissipation system. The characteristics of small volume and strong heat dissipation ability are also summarized. Based on the analysis of the internal and external cooling system, the problems of complex structure and poor cooling effect are summarized, and the future development trend and direction of the motor cooling system are discussed in detail. Conclusion: This paper divides the motor cooling system into an internal cooling system and an external cooling system according to the specifications and operating environment. This paper expounds on internal and external cooling systems' different principles, advantages, and disadvantages. This paper summarizes the cooling systems in recent years in order to facilitate their subsequent development and use. The main components of additional patents for future inventions are motor cooling systems, innovation in structure simplification, and cost performance optimization.

Overview of Path Planning Algorithms

Background: Path-planning algorithms are widely used in robotics, vehicles, UAVs, carrier-based aircraft towing vehicles, etc. Using these algorithms, an optimal path with safe obstacle avoidance and high efficiency can be planned. In recent years, path-planning algorithms have received more and more attention from scholars at home and abroad. Objective: In order to promote the application and development of path-planning algorithms, an in-depth analysis of the current development status of path-planning algorithms was presented. The most widely used and representative algorithms in several representative results were extracted, and the characteristics and advantages and disadvantages of each algorithm were analyzed and elaborated in detail for the readers' reference. Methods: The existing path-planning algorithms were classified, and a brief overview of each traditional algorithm was given, followed by an in-depth study of the improved algorithms to summarize the advantages and disadvantages of each type of algorithm. Finally, based on these research results, the future development trend of path-planning algorithms was projected. Results: Through the research and analysis of the path-planning algorithm, it was found that the path- planning algorithm before the improvement had the problems of an unsmooth path, low computational efficiency, a slow response time, the inability to safely avoid obstacles, etc. After the improvement and optimization of the path-planning algorithm, the performance was greatly improved. Conclusion: After research and analysis, it was found that multi-algorithm fusion had great potential for development in path-planning compared to the application and optimization of a single algorithm. In addition, further research is needed in the areas of algorithm adaptability, fusion, intelligent algorithms, and extending the range of algorithmic applications.

Review of emerging trends and projection of future developments in large language models research in ophthalmology

BackgroundLarge language models (LLMs) are fast emerging as potent tools in healthcare, including ophthalmology. This systematic review offers a twofold contribution: it summarises current trends in ophthalmology-related LLM research and...

Progress of Cancer Stem Cells in Retinoblastoma.

The theory of cancer stem cells is a breakthrough discovery that offers exciting possibilities for comprehending the biological behavior of tumors. More and more evidence suggests that retinoblastoma cancer stem cells promote tumor growth and are likely to be the origin of tumor formation, drug resistance, recurrence, and metastasis. At present, some progress has been made in the verification, biological behavior, and drug resistance mechanism of retinoblastoma cancer stem cells. This article aims to review the relevant research and explore future development direction.

Advances in the Synthesis and Bioactivity of Polysaccharide Selenium Nanoparticles: A Review.

Selenium, an essential trace element of the human body, is pivotal in human health and disease prevention. Nevertheless, the narrow therapeutic index of selenium, where the toxic and therapeutic doses are close, limits its clinical utility. Significantly, nanoscale selenium synthesized by different methods using polysaccharides as stabilizers has low toxicity properties and exhibits excellent bioactivity. Its biological activities, such as anti-tumor, anti-inflammatory, antioxidant, antibacterial, and immune function enhancement, are improved compared with traditional organic and inorganic selenium compounds, conferring greater potential for application in biomedicine. Therefore, this review evaluates the advancements in various synthesis methodologies for polysaccharide selenium nanoparticles (Se NPs) and their biological activities. It aims to provide a comprehensive theoretical basis and research directions for the future development of highly efficient, minimally toxic, and biocompatible polysaccharide-Se NPs and the application of polysaccharide-Se NPs in biomedicine.

Recent Advances in the Nanotechnology-Based Applications of Essential Oils

Abstract: Essential oils (EOs), which are volatile aromatic substances extracted from plants, exhibit antibacterial, antitumor, antiviral, antioxidant, anti-inflammatory, and other effects. Eos are widely used in different fields because of their various biological activities. EOs are volatile and insoluble in water, so their effective utilization rate is greatly reduced. In this regard, researchers propose to use nanotechnology to construct an EOs nanosystem to solve the application problems and improve the utilization rate of EOs. This review summarizes the latest research progress and application status of EOs nanocapsules, EOs nanoemulsion, EOs nanofiber membrane, EOs nanoparticles and EOs nanoliposome, including the methodologies, characteristics and applications.Analyzes the advantages and disadvantages of existing EOs nanotechnology and provides an outlook for future development.

Enhanced Solubility and Increased Bioavailability with Engineered Nanocrystals

Abstract: The exploration of nanocrystal technology is currently receiving significant attention in various fields, including therapeutic formulation, clinical formulation, in-vivo and in-vitro correlation research, and related investigations. The domain of nanocrystals in pharmaceutical delivery has received significant interest as a potential solution for the difficulties associated with medications that have low solubility. The nanocrystals demonstrate promise in improving solubility and bioavailability, presenting a potential resolution to significant challenges. Significantly, nanocrystals have exhibited efficacy in the context of oral administration, showcasing prompt absorption due to their quick breakdown, hence fitting with the requirements of medications that necessitate fast commencement of action. In addition, the adaptability of drug nanocrystals encompasses several methods of administration, including oral, parenteral, ophthalmic, cutaneous, pulmonary, and targeted delivery modalities. The observed consistency can be ascribed to the increased solubility of nanocrystals of the medicine, which effectively counteracts the influence of food on the absorption of the drug. Surface modification tactics have a significant influence on insoluble medicines by enhancing hydrophilicity and reducing plasma protein adsorption on the crystal surface. The surface properties of nanocrystals are modified through the utilization of specific surfactants and polymers, which are subsequently incorporated into polymer solutions via high-pressure homogenization procedures. This article encompasses an examination of the drug distribution mechanism, the nanocrystal formulation technology, the therapeutic applications, the potential future developments, and the challenges associated with the solubility and bioavailability of tailored nanocrystals, as discussed in this article. Consequently, it possesses the capacity to provide guidance for future investigations pertaining to nanocrystal technology.

A Futuristic Development in 3D Printing Technique Using Nanomaterials with a Step Toward 4D Printing.

3D bioprinting has shown great promise in tissue engineering and regenerative medicine for creating patient-specific tissue scaffolds and medicinal devices. The quickness, accurate imaging, and design targeting of this emerging technology have excited biomedical engineers and translational medicine researchers. Recently, scaffolds made from 3D bioprinted tissue have become more clinically effective due to nanomaterials and nanotechnology. Because of quantum confinement effects and high surface area/volume ratios, nanomaterials and nanotechnological techniques have unique physical, chemical, and biological features. The use of nanomaterials and 3D bioprinting has led to scaffolds with improved physicochemical and biological properties. Nanotechnology and nanomaterials affect 3D bioprinted tissue engineered scaffolds for regenerative medicine and tissue engineering. Biomaterials and cells that respond to stimuli change the structural shape in 4D bioprinting. With such dynamic designs, tissue architecture can change morphologically. New 4D bioprinting techniques will aid in bioactuation, biorobotics, and biosensing. The potential of 4D bioprinting in biomedical technologies is also discussed in this article.