Fusospirochetal Infections Research Articles

Burning mouth sensation associated with fusospirochetal infection in edentulous patients

Six middle-aged and elderly edentulous, systemically ill patients complaining of burning mouth sensation had a fusospirochetal infection of the oral mucosa. Metronidazole was successful in the treatment of three of these patients.

In vitro susceptibility of oral spirochetes to metronidazole.

In vitro susceptibility of Borrelia buccalis, Borrelia vincentii, Treponema microdentium, Treponema pallidum, and Treponema reiterii to metronidazole, was ascertained by a tube susceptibility technique. The data obtained confirm and extend the conclusion of previous investigators that under in vitro conditions metronidazole will immobilize spirochetes. It appears that metronidazole will probably be an efficacious agent for the treatment of fusospirochetal infections.

Experimental intracutaneous fusobacterial and fusospirochetal infections.

Experimental intracutaneous fusobacterial and fusospirochetal infections.

Studies on synergistic infections. I. Experimental infections with anaerobic streptococci.

from a variety of suppurative and gangrenous conditions. Meleney (1931) was able to produce experimental spreading infections in rabbits and dogs by the subcutaneous injection of mixtures of a microaerophilic streptococcus and a hemolytic staphylococcus which he had recovered from a human case of postoperative synergistic gangrene. Even if double the inoculum of each organism was injected alone, however, only localized lesions developed. To the contrary, Macdonald et al (1954, 1956) concluded that oral anaerobic streptococci, isolated from the exudate of human suppurative periodontitis, were not a necessary component of experimental fusospirochetal infections initiated by such exudates. As to the pathogenic capabilities of anaerobic streptococci alone, the reports in the literature vary widely. Prevot (1925) recorded that all of the recognized species were capable of producing suppurative and gangrenous lesions. On the other hand, Colebrook and Hare (1933) tested seven strains derived from the human vagina

The production of fusospirochetal infections in guinea pigs with recombined pure cultures.

Journal Article The Production of Fusospirochetal Infections in Guinea Pigs with Recombined Pure Cultures Get access J. B. MacDonald, J. B. MacDonald From the Division of Dental Research, Faculty of Dentistry, University of Toronto, Toronto 2-B, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar R. M. Sutton, R. M. Sutton From the Division of Dental Research, Faculty of Dentistry, University of Toronto, Toronto 2-B, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar M. L. Knoll M. L. Knoll From the Division of Dental Research, Faculty of Dentistry, University of Toronto, Toronto 2-B, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 95, Issue 3, November 1954, Pages 275–284, https://doi.org/10.1093/infdis/95.3.275 Published: 01 November 1954 Article history Received: 08 February 1954 Published: 01 November 1954

In vitro sensitivity of Fusobacteria to various antibiotics.

TN THE recent past, antibiotics have been utilized in the treatment of Vincent's infection or ulcerative gingivitis. Penicillin, topically applied in the form of pastes, lozenges, or mouthwashes, was first used in the treating of infections with remarkable efficacy according to the reports by Atkinson,' Stewart, Webster and Frey,'2 Glickman,4 and Wihr. Aureomycin and streptomycin have also been used as medicament by Goldman and Bloom' and Rosenthal and Winters (1950).10 Previous workers (Lemierre, Reilly, Morin, and Rathery 7 Prevot and Ferly,8 and Lahelle6) have shown that the fusiform bacilli are sensitive, in vitro, to penicillin. The most complete work was that of Lahelle who titrated the drug against 17 strains of Fusobacteria in glucose broth, incubated anaerobically, and found all strains to be sensitive to penicillin, in vitro. The inhibitory concentrations ranged from 0.00125 to 0.005 units per milliliter of medium. Rivett and Peterson9 found the growth of fusiform bacilli, at pH 7.2, in a medium containing 0.75 per cent peptone and 0.25 per cent yeast extract, to be inhibited by streptolin, streptothrycin, and streptomycin in the coneentrations of 0.1, 0.06 and 10.0 units per milliliter, respectively. The purpose of this work is to present findings on the in vitro sensitivity of the Fusobacteria, known to be prevalent in the lesions of ulcerative gingivitis, to various antibiotics now available and being used in the therapy of fusospirochetal infections.

Studies of fusospirochetal infection. I. Pathogenicity for guinea pigs of individual and combined cultures of spirochetes and other anaerobic bacteria derived from the human mouth.

Studies of fusospirochetal infection. I. Pathogenicity for guinea pigs of individual and combined cultures of spirochetes and other anaerobic bacteria derived from the human mouth.

Studies of fusospirochetal infection. III. Further studies of a guinea pig passage strain of fusospirochetal infection, including the infectivity of sterile exudate filtrates, of mixed cultures through ten transfers, and of recombined pure cultures.

Studies of fusospirochetal infection. III. Further studies of a guinea pig passage strain of fusospirochetal infection, including the infectivity of sterile exudate filtrates, of mixed cultures through ten transfers, and of recombined pure cultures.

Infectivity of Fuso-Spirochetal Exudates for Guinea Pigs, Hamsters, Mice and Chick Embryos By Several Routes of Inoculation

PREVIOUS investigators have reported the production of characteristic experimental lesions by inoculation of exudates from Vincent's and other fusospirochetal diseases in healthy animals of several species, including rabbits,'guinea pigs,5-8 mice, 5 9 hedgehogs,'0 monkeys, and a chimpanzee.'2 Hamsters and chick embryos do not seem to have been tested, and no previous attempt is known to have been made to determine the infectivity of these exudates by titration. The present investigation, part of a more extensive study of the bacteriology of fusospirochetal infections, includes roughly quantitative data on infectivity along with the results of efforts to determine which of the animals species tested is most satisfactory for titration and for maintenance of the infection by passage.

Induced Fuso-Spirochetal Infection in Dogs

Induced Fuso-Spirochetal Infection in Dogs

Treatment of fusospirochetal and streptococcal infections by topical application of penicillin

Treatment of fusospirochetal and streptococcal infections by topical application of penicillin

VINCENT'S DISEASE OF THE SKIN

This is a report of the case of a patient suffering from Vincent's disease, with lesions affecting the feet, the corners of the mouth, the gums, the tongue and the tonsillar and pharyngeal regions. Vincent's infection of the gums in its chronic form is regarded as fairly common. Acute forms affecting the gums and the tonsillar and pharyngeal tissues and even extending to the bronchi and lungs have been recorded. Cutaneous lesions due to fusospirochetal infection have been encountered but in only a comparatively few instances. An interesting series of cases of acute fusospirochetal angina is that of Goldman and Kully,¹who reported 7 cases of its occurrence in Negroes with lesions of the buccal and pharyngeal mucous membrane, all of which were fatal. Two of the patients had positive serologic reactions, while 3 had cutaneous lesions, ranging from erythematous patches to bullae

FOUR CASES OF FUSOSPIROCHETAL INFECTIONS INVESTIGATED WITH RESPECT TO PRODUCTION OF ANTIBODIES

Acta Pathologica Microbiologica ScandinavicaVolume 22, Issue 1 p. 34-43 FOUR CASES OF FUSOSPIROCHETAL INFECTIONS INVESTIGATED WITH RESPECT TO PRODUCTION OF ANTIBODIES O. Lahelle, O. Lahelle Kapt. W. Wilhelmsen Og Frues Bakteriologiske Institutt (Chief: Professor Th. Thjøtta, M. D.) The Dermatological Department (Chief: Professor N. Danbolt, M. D.) Rikshospitalet, OsloSearch for more papers by this author O. Lahelle, O. Lahelle Kapt. W. Wilhelmsen Og Frues Bakteriologiske Institutt (Chief: Professor Th. Thjøtta, M. D.) The Dermatological Department (Chief: Professor N. Danbolt, M. D.) Rikshospitalet, OsloSearch for more papers by this author First published: March 1945 https://doi.org/10.1111/j.1699-0463.1945.tb04052.xCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume22, Issue1March 1945Pages 34-43 RelatedInformation

The Relation of Medication to the Treatment of Fusospirochetal Infections of the Mouth

The Relation of Medication to the Treatment of Fusospirochetal Infections of the Mouth J. H. Klock, (DC), U.S.N.R. J. H. Klock, (DC), U.S.N.R. Main Dispensary, Naval Air Station, Jacksonville, Florida Search for other works by this author on: Oxford Academic Google Scholar The Military Surgeon, Volume 95, Issue 1, July 1944, Pages 42–43, https://doi.org/10.1093/milmed/95.1.42 Published: 01 July 1944

The Treatment of Fuso-Spirochetal Infections of the Mouth and Throat with Sulfathiazole

The Treatment of Fuso-Spirochetal Infections of the Mouth and Throat with Sulfathiazole

Roentgen Manifestations of Acute Infectious Mononucleosis in the Abdomen

Acute mononucleosis or acute glandular fever is an infectious disease characterized by fever, lymphadenopathy, a mononucleosis, and an increased titer for sheep cell agglutinins. Pfeiffer in 1889 described an epidemic disease of children which he called “Drusenfieber,” characterized by fever and enlargement and tenderness of the cervical lymph nodes. In 1922 Longcope described a syndrome closely related to the one described by Pfeiffer and, because of the associated mononucleosis, recommended the term “infectious mononucleosis,” which Sprunt and Evans had previously suggested. Acute mononucleosis occurs mainly in children and young adults, and is believed to be contagious, but no causative agent bas been definitely isolated. Some believe it to be a fusospirochetal infection. Sectioned lymph nodes show hyperplasia of the lymphoid tissue. The spleen may become palpable and tender. The unusual features of the disease are the mononuclear leukocytosis with an absolute reduction in the number of polynuclear granular cells to from 2,000 to 4,000 per cu. mm., and the specific agglutination test (heterophile test) which is practically pathognomonic in high titers, especially if no serum has previously been administered to the patient. The term “heterophile” was applied by Landsteiner to reactions of antibodies with antigens which are not related in their origin, and was based on the Forssman principle, i.e., the existence of serological relationships between substances in the cells of animals widely separated in the zoological system. Abdominal symptoms in acute mononucleosis are not unusual, and an occasional case has been reported in which they have been predominant. The following case, in which we think lymphadenopathy was demonstrated roentgenographically, was of purely abdominal type. Case Report A male nurse, twenty years of age, presented himself for treatment on Aug. 17, 1939, with a history of diarrhea and diffuse pains in the upper abdomen for three days. Physical examination showed a soft, flat abdomen with slight deep tenderness in the upper quadrants. A blood count showed a total of 5,900 white cells per cu. mm., with a normal differential count, in which the mononuclear cells amounted to 1 per cent. Under routine treatment the diarrhea ceased, but the pain persisted. Gastro-intestinal roentgen studies, on Sept. 5, showed no intrinsic lesion of the stomach or duodenum. There was a slight “ironing out” of the rugae along the inner concave border of the descending duodenum with slight displacement of this part of the duodenum toward the right and posteriorly, suggestive of a space-occupying mass in the region of the pancreatic head. Extrinsic pressure defects were evident on the inferior aspect of the left half of the transverse colon, due to a lobulated mass.

Venereal Fuso-Spirochetosis

Summary and Conclusions 1. Among 622 cases of pudendal lesions examined at the Venereal Laboratory at Charity Hospital, New Orleans, La., 37 cases of primary fusospirochetal infections were encountered. 2. The colored race, the male sex and the age groups between 20 and 30 years were most frequently represented in our series of patients suffering from the infection. 3. Intense local pain and penetrating foul discharge were the principal clinical manifestations. In twelve cases constitutional symptoms were present. One case was fatal. 4. Superficial erosions, well circumscribed ulcerations and progressive destruction of the genitalia and perineum represented the most frequently encountered lesions. 5. As causal organisms the symbiotic group of Vincent's organisms could be demonstrated in all lesions while other etiological factors could be excluded. Treponema Vincenti appears to be the most important member of this group in the pathogenesis of the ulcerative lesions.

On the Identity of the Goldberger and Underhill Types of Canine Blacktongue. Secondary Fuso-Spirochetal Infection in Each: One Figure

On the Identity of the Goldberger and Underhill Types of Canine Blacktongue. Secondary Fuso-Spirochetal Infection in Each: One Figure

CONJUNCTIVITIS DUE TO FUSOSPIROCHETAL INFECTION

The literature contains few references to fusospirochetal infections of the eyes, for in general they do not seem to be a favorable site for the development of such lesions. The earliest recorded occurrence of fusiform bacilli in the eye was in a case of metastatic ophthalmitis reported by Bertozzi1in 1907. The presence of these organisms in cases of dacryocystitis has been noted by Wakisaka,2and by Lohlein.3Gifford4cultivated them from an ulcer surrounding the canaliculus and also from a chalazion. Fusiform bacilli have produced orbital cellulitis secondary to sinusitis, as has been noted by Kompanejetz5and by Seecof.6Scholtz7found them in a case of gangrene of the conjunctiva secondary to an old injury with a retained foreign body. There are five previously reported cases of conjunctivitis due to fusiform bacilli and spirochetes. In all but one instance the conjunctivitis was

PYOTHORAX DUE TO FUSOSPIROCHETAL INFECTION

Fusiform bacilli and Vincent's spirilla are frequently credited with causing severe infections in the mouth and pharynx. During the last few years a number of cases have been reported in which fusospirochetal infection was considered responsible for severe pulmonary infection. Since the first descriptions of the fusospirochetal organisms by Plaut 1 in 1894 and Vincent 2 in 1899, the organisms have been known to exist in the upper respiratory tract in the absence of any evidence of acute infection. Controversy still exists as regards the pathogenicity of these organisms. Smith 3 has experimented at length and has reported that so-called fusospirochetal pulmonary infections are probably due to a symbiosis of a spirochete, a fusiform bacillus, a vibrio and a coccus. Lichtenberg, Werner and Leuck, 4 who recently reviewed the literature in regard to authentic proof of the pathogenicity of these organisms and reported experimental data of their own, concluded that