Fungal Foot Infection Research Articles

A study of fungal infections of diabetic foot in tertiary care hospital of U.P

A study of fungal infections of diabetic foot in tertiary care hospital of U.P

Fusarium falciforme Infection of Foot in a Patient with Type 2 Diabetes Mellitus: A Case Report and Review of the Literature

Fungal infections of foot in patients with diabetes are not uncommon; however, foot infection due to Fusarium species has been rarely reported. We report here a case of a 50-year-old male with type 2 diabetes who developed multiple spontaneous nodular lesions on right foot without any systemic symptoms and signs for 6months. The lesions were unresponsive to broad-spectrum antibacterial treatment. Fine needle aspiration cytology of nodular lesions revealed the presence of fungal hyphae, and Fusarium species was isolated from the same sample which was identified as Fusarium solani species complex: Fusarium falciforme. Radiological investigations and blood culture ruled out any dissemination of the disease. The lesions healed after voriconazole therapy for 3months. No relapse was noted at the end of the next 6-month follow-up. All reported cases of Fusarium infection of foot in patients with diabetes in English and non-English literature since 1970 have been reviewed.

Is fungal foot infection the initiating and maintaining cause of knee osteoarthritis?

So far fungal foot infection (FFI) has been considered as troubling, however, not dangerous, by the general public as well as doctors. Nevertheless, new immunology information and anatomy dispositions led us to the distinct suspicions. We propose a FFI-induced knee joint osteoarthritis (OA) model. We suppose repeated recurrences of fungal foot disease to be the initiating immunology impulse. The aim of the work is to introduce a new model and to determine antigen epitopes initiating and maintaining the knee OA using computer simulation. Freely accessible immunological databases and servers were used in this search. Presentable antigen epitopes in Trichophyton rubrum dermatophyte products were identified for molecules of the six most abundant alleles of DRB1 locus of human major histocompatibility complex. Subsequently, similar sequences in human joint peptides (collagens, aggrecan and others) were matched to these antigen epitopes by a comparative program. A number of pairs with very similar fungal and joint peptide sequences, supposed to initiate and maintain the knee OA antigen epitopes, were found. A FFI-induced knee joint OA model is shown to the medical community which can initiate further discussion, research and practical verification.

Review: Oral antifungal drugs promote cure of fungal foot infections

Source Citation Bell-Syer SE, Hart R, Crawford F, et al. Oral treatments for fungal infections of the skin of the foot. Cochrane Database Syst Rev. 2002;(2):CD003584 (latest version 5 Dec 2001). 12...