Function Of Stimulus Duration Research Articles

How to define thresholds for level and interaural-level-difference discrimination: Insights from scedasticities and distributions

Sensitivity to changes in the stimulus level at one or at both ears and to changes in the interaural level difference (ILD) between the two ears has been studied widely. Several different definitions of threshold and, for one of them, two different ways of averaging single-listener thresholds have been used (i.e., arithmetically and geometrically), but it is unclear which definition and which way of averaging is most suitable. Here, we addressed this issue by examining which of the differently defined thresholds yielded the highest degree of homoscedasticity (homogeneity of the variance). We also examined how closely the differently defined thresholds followed the normal distribution. We measured thresholds from a large number of human listeners as a function of stimulus duration in six experimental conditions, using an adaptive two-alternative forced-choice paradigm. Thresholds defined as the logarithm of the ratio of the intensities or amplitudes of the target and the reference stimulus (i.e., as the difference in their levels or ILDs; the most commonly used definition) were clearly heteroscedastic. Log-transformation of these latter thresholds, as sometimes performed, did not result in homoscedasticity. Thresholds defined as the logarithm of the Weber fraction for stimulus intensity and thresholds defined as the logarithm of the Weber fraction for stimulus amplitude (the most rarely used definition) were consistent with homoscedasticity, but the latter were closer to the ideal case. Thresholds defined as the logarithm of the Weber fraction for stimulus amplitude also followed the normal distribution most closely. The discrimination thresholds should therefore be expressed as the logarithm of the Weber fraction for stimulus amplitude and be averaged arithmetically across listeners. Other implications are discussed, and the obtained differences between the thresholds in different conditions are compared to the literature.

Cross-dimensional magnitude interactions reflect statistical correlations among physical dimensions: Evidence from space-time interaction

Magnitudes of different physical dimensions have been assumed to be processed by a common metric in order to account for interactions between different dimensions (e.g., space, time). This paper tested a different hypothesis, that these cross-dimensional interactions reflect people's experience of statistical correlations among physical dimensions. In the experiment, we manipulated the correlation between space (length) and time (duration). A stimulus consisting of two vertical bars that demarcated a variable stimulus length was presented for a variable stimulus duration; participants were to reproduce either the stimulus length or the stimulus duration. Critically, to reproduce a stimulus length, participants held down the spacebar to grow or shrink (in a blocked design) a length to the stimulus length such that space (i.e. reproduced length) positively or negatively co-varied with time. Reproduced lengths did not vary as a function of stimulus duration under positive space-time correlation but decreased as a function of stimulus duration under negative space-time correlation; reproduced durations increased as a function of stimulus length under positive space-time correlation but this space-on-time effect appeared to be attenuated under negative space-time correlation. These findings are consistent with a Bayesian inference account whereby cross-dimensional interactions reflect people's prior belief/knowledge of cross-dimensional statistical correlation, which itself tunes to recent input.

The Design Principles of Biochemical Timers: Circuits that Discriminate between Transient and Sustained Stimulation.

Many cellular responses for which timing is critical display temporal filtering-the ability to suppress response until stimulated for longer than a given minimal time. To identify biochemical circuits capable of kinetic filtering, we comprehensively searched the space of three-node enzymatic networks. We define a metric of "temporal ultrasensitivity," the steepness of activation as a function of stimulus duration. We identified five classes of core network motifs capable of temporal filtering, each with distinct functional properties such as rejecting high-frequency noise, committing to response (bistability), and distinguishing between long stimuli. Combinations of the two most robust motifs, double inhibition (DI) and positive feedback with AND logic (PFAND), underlie several natural timer circuits involved in processes such as cell cycle transitions, Tcell activation, and departure from the pluripotent state. The biochemical network motifs described in this study form a basis for understanding common ways cells make dynamic decisions.

Visual expectations change subjective experience without changing performance.

It is widely believed that visual expectations can change the subjective experiences of humans. We investigated how visual expectations in a recognition task affected objective performance and subjective perception. Using a 2-alternative-forced-choice task based on digit recognition of briefly presented and visually masked digits, we found over two experiments that expectations changed the quality of the experiences without changing the performance capabilities associated with the quality of experience. Expectations were manipulated by providing a cue indicating the set of possible digits that might appear on each trial. The results also inform the debate about whether subjective experiences can be categorized in a dichotomous manner or in a graded manner. We found that subjective experiences were graded near the objective threshold and more dichotomous away from the threshold. Furthermore, distinct expectations resulted in a more dichotomous distribution of subjective experience. We also provide evidence of an interesting relationship between stimulus duration, objective performance and subjective ratings. Only experiences that were rated as evoking some degree of perception showed systematic improvements in objective performance as a function of stimulus duration. These findings suggest that subjective experience cannot be understood without considering the broader cognitive context, namely that the quality of subjective experiences is dependent on a multitude of factors such as attention, task requirements and cognitive expectations.

Lightness/pitch and elevation/pitch crossmodal correspondences are low-level sensory effects.

We tested the sensory versus decisional origins of two established audiovisual crossmodal correspondences (CMCs; lightness/pitch and elevation/pitch), applying a signal discrimination paradigm to low-level stimulus features and controlling for attentional cueing. An audiovisual stimulus randomly varied along two visual dimensions (lightness: black/white; elevation: high/low) and one auditory dimension (pitch: high/low), and participants discriminated either only lightness, only elevation, or both lightness and elevation. The discrimination task and the stimulus duration varied between subjects. To investigate the influence of crossmodal congruency, we considered the effect of each CMC (lightness/pitch and elevation/pitch) on the sensitivity and criterion of each discrimination as a function of stimulus duration. There were three main findings. First, discrimination sensitivity was significantly higher for visual targets paired congruently (compared with incongruently) with tones while criterion was unaffected. Second, the sensitivity increase occurred for all stimulus durations, ruling out attentional cueing effects. Third, the sensitivity increase was feature specific such that only the CMC that related to the feature being discriminated influenced sensitivity (i.e. lightness congruency only influenced lightness discrimination and elevation congruency only influenced elevation discrimination in the single and dual task conditions). We suggest that these congruency effects reflect low-level sensory processes.

Stereoscopic Slant Contrast and the Perception of Inducer Slant at Brief Stimulus Presentations.

Slant contrast refers to a stereoscopic phenomenon in which the perceived slant of a test object is affected by the disparity of a surrounding inducer object. Slant contrast has been proposed to involve cue conflict, but it is unclear whether this idea is useful in explaining slant contrast at short stimulus presentations (<1 s). We measured both slant contrast and perceived inducer slant while varying the presentation duration (100-800 ms) of stereograms with several spatial configurations. In three psychophysical experiments, we found that (a) both slant contrast and perceived inducer slant increased as a function of stimulus duration, and (b) slant contrast was relatively stable across different test and inducer shapes at each short stimulus duration, whereas perceived inducer slant increased when cue conflict was reduced. These results suggest that at brief, not long stimulus presentations, the cue conflict between disparity and perspective plays a smaller role in slant contrast than other depth cues.

Elemental, configural, and occasion setting mechanisms in biconditional and patterning discriminations

Three experiments explored the utility of considering mechanisms of occasion setting for understanding patterning and biconditional discriminations – two more complex conditional discriminations in which the stimulus-outcome relations of occasion setting are embedded. In Experiment 1, rats were trained in an appetitive conditioning task with either a biconditional or a patterning discrimination using relatively brief CSs (10s) and differential outcomes as USs. In this study, rats learned the positive patterning task before they had learned negative patterning, and the biconditional task was the most difficult. However, a detailed examination of the results suggested that rats trained in the biconditional task responded to the stimulus compounds mainly on the basis of individual stimulus-outcome associations. Different conditioned response (CR) topographies as a function of reinforcer type complicated interpretation of these results. Experiment 2 confirmed that the biconditional task, with the parameters used here, was not learned, regardless of whether training involved differential or non-differential outcomes. In Experiment 3 the CS duration was increased to 30s and two different USs were used that each supported similar CR topographies. Under these conditions, we observed that whereas the positive patterning task was learned most rapidly, the biconditional discrimination was learned faster than the negative patterning task. Considered in relation to other findings on patterning and biconditional discriminations, the results suggest that elemental, configural, and/or modulatory occasion setting mechanisms may play different roles in these complex conditional discrimination tasks especially as a function of stimulus duration and differential outcome training.

The effects of payoff manipulations on temporal bisection performance

There is growing evidence that alterations in reward rates modify timing behavior demonstrating the role of motivational factors in interval timing behavior. This study aimed to investigate the effects of manipulations of rewards and penalties on temporal bisection performance in humans. Participants were trained to classify experienced time intervals as short or long based on the reference durations. Two groups of participants were tested under three different bias conditions in which either the relative reward magnitude or penalty associated with correct or incorrect categorizations of short and long reference durations was manipulated. Participants adapted their choice behavior (i.e., psychometric functions shifted) based on these payoff manipulations in directions predicted by reward maximization. The signal detection theory-based analysis of the data revealed that payoff contingencies affected the response bias parameter (B″) without altering participants' sensitivity (A′) to temporal distances. Finally, the response time (RT) analysis showed that short categorization RTs increased, whereas long categorization RTs decreased as a function of stimulus durations. However, overall RTs did not exhibit any modulation in response to payoff manipulations. Taken together, this study provides additional support for the effects of motivational variables on temporal decision-making.

SMA Selectively Codes the Active Accumulation of Temporal, Not Spatial, Magnitude.

Estimating duration depends on the sequential integration (accumulation) of temporal information in working memory. Using fMRI, we directly compared the accumulation of information in temporal versus spatial domains. Participants estimated either the duration or distance of the dynamic trajectory of a moving dot or, in a control condition, a static line stimulus. Comparing the duration versus distance of static lines activated an extensive cortico-striatal network. By contrast, comparing the duration versus distance of dynamic trajectories, both of which required sequential integration of information, activated SMA alone. Indeed, activity in SMA, as well as right inferior occipital cortex, increased parametrically as a function of stimulus duration and also correlated with individual differences in the propensity to overestimate stimulus duration. By contrast, activity in primary visual cortex increased parametrically as a function of stimulus distance. Crucially, a direct comparison of the parametric responses to duration versus distance revealed that activity in SMA increased incrementally as a function of stimulus duration but not as a function of stimulus distance. Collectively, our results indicate that SMA responds to the active accumulation of information selectively in the temporal domain.

Action Planning and the Timescale of Evidence Accumulation.

Perceptual decisions are based on the temporal integration of sensory evidence for different states of the outside world. The timescale of this integration process varies widely across behavioral contexts and individuals, and it is diagnostic for the underlying neural mechanisms. In many situations, the decision-maker knows the required mapping between perceptual evidence and motor response (henceforth termed “sensory-motor contingency”) before decision formation. Here, the integrated evidence can be directly translated into a motor plan and, indeed, neural signatures of the integration process are evident as build-up activity in premotor brain regions. In other situations, however, the sensory-motor contingencies are unknown at the time of decision formation. We used behavioral psychophysics and computational modeling to test if knowledge about sensory-motor contingencies affects the timescale of perceptual evidence integration. We asked human observers to perform the same motion discrimination task, with or without trial-to-trial variations of the mapping between perceptual choice and motor response. When the mapping varied, it was either instructed before or after the stimulus presentation. We quantified the timescale of evidence integration under these different sensory-motor mapping conditions by means of two approaches. First, we analyzed subjects’ discrimination threshold as a function of stimulus duration. Second, we fitted a dynamical decision-making model to subjects’ choice behavior. The results from both approaches indicated that observers (i) integrated motion information for several hundred ms, (ii) used a shorter than optimal integration timescale, and (iii) used the same integration timescale under all sensory-motor mappings. We conclude that the mechanisms limiting the timescale of perceptual decisions are largely independent from long-term learning (under fixed mapping) or rapid acquisition (under variable mapping) of sensory-motor contingencies. This conclusion has implications for neurophysiological and neuroimaging studies of perceptual decision-making.

Submillisecond unmasked subliminal visual stimuli evoke electrical brain responses.

Subliminal perception is strongly associated to the processing of meaningful or emotional information and has mostly been studied using visual masking. In this study, we used high density 256-channel EEG coupled with an liquid crystal display (LCD) tachistoscope to characterize the spatio-temporal dynamics of the brain response to visual checkerboard stimuli (Experiment 1) or blank stimuli (Experiment 2) presented without a mask for 1 ms (visible), 500 µs (partially visible), and 250 µs (subliminal) by applying time-wise, assumption-free nonparametric randomization statistics on the strength and on the topography of high-density scalp-recorded electric field. Stimulus visibility was assessed in a third separate behavioral experiment. Results revealed that unmasked checkerboards presented subliminally for 250 µs evoked weak but detectable visual evoked potential (VEP) responses. When the checkerboards were replaced by blank stimuli, there was no evidence for the presence of an evoked response anymore. Furthermore, the checkerboard VEPs were modulated topographically between 243 and 296 ms post-stimulus onset as a function of stimulus duration, indicative of the engagement of distinct configuration of active brain networks. A distributed electrical source analysis localized this modulation within the right superior parietal lobule near the precuneus. These results show the presence of a brain response to submillisecond unmasked subliminal visual stimuli independently of their emotional saliency or meaningfulness and opens an avenue for new investigations of subliminal stimulation without using visual masking.

Decision processes in temporal discrimination

The processing dynamics underlying temporal decisions and the response times they generate have received little attention in the study of interval timing. In contrast, models of other simple forms of decision making have been extensively investigated using response times, leading to a substantial disconnect between temporal and non-temporal decision theories. An overarching decision-theoretic framework that encompasses existing, non-temporal decision models may, however, account both for interval timing itself and for time-based decision-making. We sought evidence for this framework in the temporal discrimination performance of humans tested on the temporal bisection task. In this task, participants retrospectively categorized experienced stimulus durations as short or long based on their perceived similarity to two, remembered reference durations and were rewarded only for correct categorization of these references. Our analysis of choice proportions and response times suggests that a two-stage, sequential diffusion process, parameterized to maximize earned rewards, can account for salient patterns of bisection performance. The first diffusion stage times intervals by accumulating an endogenously noisy clock signal; the second stage makes decisions about the first-stage temporal representation by accumulating first-stage evidence corrupted by endogenous noise. Reward-maximization requires that the second-stage accumulation rate and starting point be based on the state of the first-stage timer at the end of the stimulus duration, and that estimates of non-decision-related delays should decrease as a function of stimulus duration. Results are in accord with these predictions and thus support an extension of the drift–diffusion model of static decision making to the domain of interval timing and temporal decisions.

Efficient Cue-Combination Even at the Temporal Limits of Perception

Attempts to measure cue combination at very brief stimulus durations are rare. Previous studies with static (2 s duration) stimuli have demonstrated efficient (maximum likelihood estimate—MLE) cue combination between shading and binocular disparity (SVG 2011, JOV 2012). Here, we present a novel methodology and additional experimental data, which enables us to visualise the depth discrimination performance of observers as a 2D surface defined by the axes duration and physical depth. By separately mapping this surface for shade, binocular disparity, and for both cues in combination, we can trace how channel variances change as a function of presentation time. The variances of the shade and stereo-disparity channels fall as a function of duration. For the shade cue, variance is initially lower, but the variance of the binocular disparity channel falls more quickly with duration. MLE is then used to infer cue weightings as a function of stimulus duration and predicts that observers will initially rely upon shade information for approximately the first 16 ms while longer presentations >60 ms see a switch towards disparity. This prediction is consistent with what we find in our cue-conflict experimental study with similarly brief presentations.

Tinnitus suppression by electric stimulation of the auditory nerve

Electric stimulation of the auditory nerve via a cochlear implant (CI) has been observed to suppress tinnitus, but parameters of an effective electric stimulus remain unexplored. Here we used CI research processors to systematically vary pulse rate, electrode place, and current amplitude of electric stimuli, and measure their effects on tinnitus loudness and stimulus loudness as a function of stimulus duration. Thirteen tinnitus subjects who used CIs were tested, with nine (70%) being “Responders” who achieved greater than 30% tinnitus loudness reduction in response to at least one stimulation condition and the remaining four (30%) being “Non-Responders” who had less than 30% tinnitus loudness reduction in response to any stimulus condition tested. Despite large individual variability, several interesting observations were made between stimulation parameters, tinnitus characteristics, and tinnitus suppression. If a subject's tinnitus was suppressed by one stimulus, then it was more likely to be suppressed by another stimulus. If the tinnitus contained a “pulsating” component, then it would be more likely suppressed by a given combination of stimulus parameters than tinnitus without these components. There was also a disassociation between the subjects' clinical speech processor and our research processor in terms of their effectiveness in tinnitus suppression. Finally, an interesting dichotomy was observed between loudness adaptation to electric stimuli and their effects on tinnitus loudness, with the Responders exhibiting higher degrees of loudness adaptation than the Non-Responders. Although the mechanisms underlying these observations remain to be resolved, their clinical implications are clear. When using a CI to manage tinnitus, the clinical processor that is optimized for speech perception needs to be customized for optimal tinnitus suppression.

Duration tuning in the inferior colliculus of the mustached bat

We studied duration tuning in neurons of the inferior colliculus (IC) of the mustached bat. Duration-tuned neurons in the IC of the mustached bat fall into three main types: short (16 of 136), band (34 of 136), and long (29 of 136) pass. The remaining 51 neurons showed no selectivity for the duration of sounds. The distribution of best durations was double peaked with maxima around 3 and 17 ms, which correlate with the duration of the short frequency-modulated (FM) and the long constant-frequency (CF) signals emitted by Pteronotus parnellii. Since there are no individual neurons with a double-peaked duration response profile, both types of temporal processing seem to be well segregated in the IC. Most short- and band-pass units with best frequency in the CF2 range responded to best durations > 9 ms (66%, 18 of 27 units). However, there is no evidence for a bias toward longer durations as there is for neurons tuned to the frequency range of the FM component of the third harmonic, where 83% (10 of 12 neurons) showed best durations longer than 9 ms. In most duration-tuned neurons, response areas as a function of stimulus duration and intensity showed either V or U shape, with duration tuning retained across the range of sound levels tested. Duration tuning was affected by changes in sound pressure level in only six neurons. In all duration-tuned neurons, latencies measured at the best duration were longer than best durations, suggesting that behavioral decisions based on analysis of the duration of the pulses would not be expected to be complete until well after the stimulus has occurred.

Revealing boundary-contour based surface representation through the time course of binocular rivalry

We varied the surface boundary-contour properties of binocular rivalry (BR) stimuli to measure the rivalry percept as a function of stimulus duration. Experiment 1 compared perception from BR stimuli with monocular boundary contour (MBC) and binocular boundary contour (BBC). We found global dominance is achieved with stimulus duration as short as 30ms for the MBC rivalry stimuli, whereas it takes more than 150ms for the BBC rivalry stimuli. This shows that global dominance can occur rapidly in the absence of a corresponding boundary contour in one half-image. Experiment 2 measured the detection of a monocular Gabor probe located centrally on a 1.5° versus 3.0° MBC rivalry stimulus. We found reliable binocular suppression is observed earlier with the 1.5° MBC stimulus, presumably because of the probe being spatially located nearer to the boundary contour. These findings, in conjunction with those in Su et al. (2011), support the notion that the representation of the dominant surface begins at the MBC and spreads toward the center of the image.

Fos expression in the prefrontal cortex and nucleus accumbens following exposure to retrospective timing tasks.

The dorsal striatum and prefrontal cortex have been implicated in interval timing. We examined whether performance of temporal discrimination tasks is associated with increased neuronal activation in these areas, as revealed by Fos expression, a marker for neuronal activation. In Experiment 1, rats were trained on a discrete-trials temporal discrimination task in which a light (22 cd/m²) was presented for a variable time, t (2.5-47.5 s), after which levers A and B were presented. A response on lever A was reinforced if t < 25 s, and a response on lever B was reinforced if t > 25 s. A second group was trained on a light-intensity discrimination procedure, in which a light of variable intensity, i (3.6-128.5 cd/m²) was presented for 25 s. A response on lever A was reinforced if i < 22 cd/m², and a response on lever B was reinforced if i > 22 cd/m². In Experiment 2, bisection procedures were used to assess temporal (200-800 ms, 22 cd/m²) and light-intensity (3.6-128.5 cd/m², 400 ms) discrimination. The increase in proportional choice of lever B as a function of stimulus duration or intensity conformed to a two-parameter logistic equation. Fos expression in the prefrontal cortex and nucleus accumbens was higher in rats performing temporal discrimination tasks than in those performing light-intensity discrimination tasks, indicating greater neuronal activation in these areas during temporal discrimination tasks. Fos expression in the dorsal striatum did not differ between rats performing temporal and light-intensity discrimination tasks. These results suggest that the prefrontal cortex and nucleus accumbens are involved in temporal discrimination.

Apparent contrast peaks, rather than plateaus, as a function of stimulus duration

Apparent contrast peaks, rather than plateaus, as a function of stimulus duration

Discriminating the biological motion of animals

Research into biological motion perception has revealed that the human visual system is sensitive to the movement patterns created by both humans and non-human animals when locomoting. In order to further assess the ability of the human visual system to detect the biological motion of animals with different locomotory patterns, observers were required to discriminate between point light displays depicting an animal in motion and point light displays containing dots moving in ways constrained by the properties present in the biological motion displays, but containing no biological motion themselves. Initial results indicated that naA¯ ve subjects could accurately discriminate between the displays containing biological motion and those containing motion of a non-biological nature. In order to assess this effect further, a second experiment was carried out to investigate the ability of naA¯ve observers to discriminate between biological and non-biological point light displays as a) a function of random punctate visual interference density and b) a function of stimulus duration. To allow further investigation into how biological motion information concerning animals might be utilised by the visual system in naturalistic situations, subjects were tested for simple animal phobias in order to assess whether those subjects with a high fear of certain target animals (snakes and spiders, chosen for the sake of general prevalence of fear) would be able to distinguish the target animal from non-biological trials in the presence of a) greater density of noise and b) shorter stimulus duration. Results indicated that noise density had a significant effect on discrimination performance for both groups even at the lowest level.

Iterated rippled noise discrimination at long durations

Iterated rippled noise (IRN) was used to study discrimination of IRN stimuli with a lower number of iterations from IRN stimuli with a higher number of iterations as a function of stimulus duration (100-2000 ms). Such IRN stimuli differ in the strength of the repetition pitch. In some cases, the gain used to generate IRN stimuli was adjusted so that both IRN stimuli in the discrimination task had the same height of the first peak in the autocorrelation function or autocorrelogram. In previous work involving short-duration IRN stimuli (<500 ms), listeners were not able to discriminate between IRN stimuli that had different numbers of iterations but the same height of the first peak in the autocorrelation function. In the current study, IRN discrimination performance improved with increases in duration, even in cases when the height of the first peak in the autocorrelation was the same for the two IRN stimuli. Thus, future studies involving discrimination of IRN stimuli may need to use longer durations (1 s or greater) than those that have been used in the past.