Rat Ovary Function Research Articles

The Effect of Electromagnetic Fields of Extremely Low Frequency 30 Hz on Rat Ovaries.

We studied the effects of extremely low-frequency electromagnetic field on the ovaries in rats. The female rats were exposed to a 30 Hz sinusoidal magnetic field of 4 kA/m for 2 h per day for a period of 10 weeks, including the period of embryonic development. After the exposure, the duration of the estrous cycle and serum levels of luteinizing hormone, follicle stimulating hormone, progesterone, and estradiol E2 were measured in different phases of the estrous cycle and morphological changes in the ovaries were evaluated. Lower levels of follicle stimulating hormone in the proestrus and progesterone in the estrus phase were found; in the ovaries, the content of primordial follicles was lower than in the control. The exposure to electromagnetic field in the selected mode caused no significant defects in the structure and function of rat ovaries.

Effects of Cuminum cyminum Essence on Rat Ovary Function following Administration of Dopaminergic Agonist and Antagonist

Effects of Cuminum cyminum Essence on Rat Ovary Function following Administration of Dopaminergic Agonist and Antagonist

Effect of paclitaxel on morphology and function of rat ovaries

The morphology and function of the ovaries at the early and late terms after single intravenous injection of paclitaxel in the maximum tolerated dose (MTD) were studied in female Wistar rats. Evaluation of the structural and functional elements of the female gonads showed that the targets for the drug were primordial, bi-and multilayer follicles. The number of graafian follicles and corpora lutea did not decrease. A more pronounced (copared to the control) depletion of the ovarian reserve potentialities was detected during the remote period. The drug did not decrease mating capacity and efficiency. On the other hand, high fetal mortality was observed in females treated with paclitaxel, which decreased with lengthening of the period between the cytostatic treatment and mating.

Interaction of Human Growth Hormone and Gonadotrophins on the Function of Rat Ovaries

Hypophysectomized and normal female rats were used for studying the interaction of human growth hormone and gonadotrophins in stimulating the rat ovary. Groups of rats were injected with increasing doses of gonadotrophins (Pergonal or Metrodin) in addition to human growth hormone (Norditropin) or placebo. In the test for follicle stimulating hormone activity the weight of the ovaries was recorded. In the hypophysectomized rats Norditropin and Pergonal or Metrodin had a synergistic stimulating effect on the ovary, resulting in a greater number and a larger follicle size. Norditropin had a slight stimulatory effect of its own. In the ovarian ascorbic acid depletion test for luteinising hormone activity Norditropin had a significant effect of its own. In combination with Pergonal an additive effect was seen. The effect of Norditropin was observed in hypophysectomized rats only.