Aperiodic Research Articles

Long-term outcome of transanal irrigation for individuals with spina bifida: a 12-year experience study.

Transanal irrigation (TAI) effectively addresses fecal incontinence and improves quality of life in individuals with spina bifida. Given the scarcity of follow-up studies lasting > 5years and reports of numerous TAI discontinuations, we assessed the enduring effectiveness and impact of TAI > 10years after its initiation on the quality of life in individuals with spina bifida. We recruited individuals with spina bifida enrolled in a bowel management program who initiated TAI in 2010 and participated in 4-month and 3-year follow-up studies at a spina bifida clinic. Raw data on bowel-related characteristics at baseline and after 4months and 3years of TAI were collected, and new survey-based demographic information, bowel-related characteristics, and the Fecal Incontinence Quality of Life scale scores were analyzed alongside extant datasets. Among 34 participants (age, mean [standard deviation] 17.7 [3.2] years), the mean follow-up was 11.8 (0.3) years; 21 participants persistently used TAI (persistent users), 12 discontinued TAI (discontinued users), and 1 used TAI and antegrade continence enema at the time of analysis. The fecal incontinence rate among persistent users decreased from 76.2% at baseline to 14.3% at the time of analysis; 11 (91.7%) discontinued users had fecal incontinence before TAI initiation, and the majority of discontinued users (66.7%) discontinued TAI because of improved bowel function. The fecal incontinence rate and quality of life did not differ significantly between discontinued users and persistent users. TAI effectively alleviated fecal incontinence among persistent users. One-third of users discontinued TAI but had improved fecal continence. We recommend periodic bowel function evaluation in TAI users and to reevaluate the necessity for TAI maintenance.

Convolution of periodic multiplicative functions and the divisor problem

Convolution of periodic multiplicative functions and the divisor problem

Atomic H over crystal surface: effective potential dependence on sample properties

Abstract We considered the behavior of the lowest electronic level of atomic H in a semi-infinite space bounded by a flat surface. 
We impose a third kind boundary condition on the electronic wave functions, where the boundary condition parameter models the adsorbent properties of the surface.
For the crystal surface, the double periodic function as the boundary parameter seems reasonable; therefore, this case is considered.
It is shown that there are two modes of atom adsorption on the sample surface depending on the parameters of the boundary condition. 
In the first case the effective atomic potential, considered as a function of the distance between H and the boundary plane, exhibits a well pronounced minimum at some finite distance and a relatively small effective range of interaction distances between the atoms and samples.
The second case occurs under the condition of a large positive affinity of the atomic electron to the sample boundary and low initial H-concentration inside the sample. 
In such a situation, the minimum of the effective potential is close to the sample surface, and a significant amount of energy can be emitted throughout the adsorption process.

Solving Partial Differential Equations Using Fourier Series

This research paper aims to study the methods of solving partial differential equations using Fourier series. Partial differential equations are a powerful and practical tool in mathematics and physics to describe many phenomena and processes that involve continuous change at the level of equations and functions. The basic concepts related to the Fourier series and how to represent functions using it in the field of mathematics will be reviewed. Application examples of partial differential equations, such as waves, heat and diffusion, and how to use the Fourier series to solve them will also be presented. The steps of solving the partial differential equation using the Fourier series will be explained. The importance of Fourier series in the theory of partial differential equations is that periodic functions f(x) defined on (-∞,∞) or functions defined on a finite interval can be represented by an infinite interval of sines and cosines. In this research, the solution of the partial differential equation using the Fourier series was studied with the solution of an example.

Shape Preserving Approximation of Periodic Functions: Conclusion

AbstractWe give here the final results about the validity of Jackson-type estimates in comonotone approximation of $$2\pi $$ 2 π -periodic functions by trigonometric polynomials ($$q=1$$ q = 1 ). For coconvex ($$q=2$$ q = 2 ) and the so called co-q-monotone, $$q>2$$ q > 2 , approximations, everything is known by now. Thus, this paper concludes the research on Jackson type estimates of Shape Preserving Approximation of periodic functions by trigonometric polynomials. It is interesting to point out that the results for comonotone approximation of a periodic function are substantially different than the analogous results for comonotone approximation of a continuous function on a finite interval, by algebraic polynomials.

Correlation of early contrast-enhanced ultrasound parameters with postoperative graft function and at six months after kidney transplantation

Abstract Purpose We analyzed which contrast-enhanced ultrasound (CEUS) parameters are associated with reduced kidney function in the early postoperative period and are prognostic for kidney function six months after transplantation. Materials and Methods This prospective observational study included 74 patients in whom quantitative CEUS analysis and Doppler ultrasound were performed early after kidney transplantation (10±6 days). For each region of interest (ROI) the time-to-peak intensity (TTP) and the respective delta between ROIs within interlobar artery, cortex, and medulla were compared. Results were correlated with kidney function at the time of imaging and six months later. Results Patients with an eGFR<30 ml/min at the time of investigation had significantly slower cortical enhancement with a longer cortical TTP (cTTP: 16.1±0.9 vs. 11.7±0.7 sec, p<0.001), as well as a significant delay between the arterial and cortical phases (c–a), as shown in longer ∆TTP (c–a): 8.2±0.9 vs. 4.2 ± 0.5 sec, p<0.001. There was a significant negative correlation between cTTP and eGFR with a correlation coefficient of −0.37 (p<0.001), as well as between ∆TTP (c–a) and eGFR with a correlation coefficient of −0.40 (p<0.001). Reduced kidney function after 6 months correlated significantly with the findings of the initial CEUS examination (p=0.005, correlation coefficient −0.39). Conclusion CEUS revealed significant differences in temporal enhancement dynamics in patients with reduced kidney function after transplantation. Quantitative CEUS might therefore be able to depict graft function regarding microvascular damage and be of prognostic value regarding long-term renal outcomes.

The acute effects of the PAP treatment on nasal mucosa in patients with OSAS

Abstract BACKGROUND. Obstructive sleep apnea syndrome (OSAS) is a common disease in developed countries. PAP (Positive Airway Pressure) therapy is the most commonly used treatment modality, particularly in moderate to severe OSAS patients. However, several side effects make PAP treatment challenging to tolerate. This study examined the acute effects of PAP treatment on nasal functions. MATERIAL AND METHODS. This study included 32 patients who were diagnosed with severe OSAS following a PSG test and started PAP treatment. Symptom analysis was carried out with the SNOT-20 questionnaire; nasal physiological analysis was carried out with rhinomanometry and acoustic rhinometry tests performed before and after PAP treatment for one night and for one month. A saccharin test was carried out to assess the nasal mucociliary clearance before and after the treatment. RESULTS. A statistically significant difference between nasal symptom scores (p=0.003) and sleep quality (p=0.006) was observed in SNOT-20 questionnaire results. Total nasal resistance was significantly increased after one night’s sleep with PAP and after a one-month treatment with PAP. It was found that there was a statistically significant relation between the total nasal resistance value and PAP pressure. CONCLUSION. This study shows that PAP treatment increases nasal congestion after one night of treatment and after one month of treatment with a cumulative effect. PAP therapy positively affects sleeping quality and life quality, while negatively affecting nasal functions in the acute period.

The discussion of the relationship between cardiopulmonary bypass and postoperative thyroid function changes in pediatric congenital heart disease, and the analysis of oral thyroid hormone therapy and cardiac prognosis.

This study aims to investigate the relationship between CPB factors and changes in TH levels in postoperative patients and the effect of oral levothyroxine sodium tablets on outcomes in patients with postoperative TF abnormalities. Select patients who underwent CHD surgery between September 2017 and September 2023 and were aged 13 years or younger. The relationship between CPB and postoperative TF changes and the influencing factors were analyzed. In addition, patients with different diseases and ages were divided into the medication group and the non-medication group. The primary outcome was postoperative ejection fraction (EF), and the secondary outcomes were PICU hospitalization days and total hospital cost. Seven hundred 53 patients were included. The longer the CPB time and ACC time, the lower the postoperative triiodothyronine (T3) and thyroxin (T4) levels (p < 0.001 and p < 0.001). The longer the CPB time, the more pronounced the postoperative T3 level abnormality (p < 0.001). The longer the CPB time, ACC time, and DHCA time, the more pronounced the postoperative T4 level abnormalities (p < 0.001 and p < 0.001 and p = 0.046). The postoperative EF of patients in the medication group was slightly higher than that of the non-medication group, and the EF before discharge was significantly higher than that of the non-medication group (p = 0.021, p = 0.015, and p = 0.024). Postoperative PICU days in the medication group [3.0 (2.0,7.0) versus4.0 (2.0,10.0), p = 0.020] were shorter than the non-medication group, and the proportion of ≤ 5days was more [154 (66.1%) versus304 (58.5%), p = 0.047]. The total hospitalization cost was slightly lower in the medication group (p < 0.05). The duration of CPB, ACC, and DHCA in the open surgery process for CHD affects patients' thyroid function in the postoperative period. In our study, we found that oral levothyroxine sodium tablets are beneficial to the children's postoperative recovery.

Some Results of Conformable Fourier Transforms

Based on a new definition of $\alpha$-periodical functions with $0 &lt; \alpha \leq 1$ introduced by Khalil et al. (2014), we introduce a new definition of conformable Fourier transform for such a class of functions. Further, we establish some operational formulas, and we set the relation between the newly defined conformable Fourier transform and the classical Fourier transform. Finally, some classical results of periodical functions are obtained, and some illustrative examples are constructed.

Coexistence of hidden attractors in memristive chaotic system

In this paper, a charge controlled memristor model is introduced into the Sprott-A system equation to construct a new memristor chaotic system and the calculation of this new system satisfies the characteristics of no equilibrium points. The periodic function is added to the new constructed memristor chaotic system, and the coexistence of attractors in memristor chaotic system without equilibrium points is obtained by adjusting the control parameters. Through different analytical methods to explore the characteristics of the new system. The dynamic behaviors of the system before and after the periodic transformation are compared and analyzed. In the end, DSP simulation is used to verify the feasibility of the theoretical model. The coexistence of attractors in memristor chaotic systems can improve the flexibility and security of chaotic encryption systems. Further research on this kind of phenomena can meet the needs of higher encryption.

Quality and postharvest conservation of sour passion fruit genotypes

The postharvest phase is a limiting factor for climacteric fruits such as passion fruit due to rapid deterioration causing wilting and favoring the occurrence of pathogenic microorganisms. From this perspective, this study aimed to evaluate the postharvest quality of passion fruit genotypes cultivated in Mâncio Lima, Acre, as a function of the storage period after harvest. The experiment was set up and conducted at the Plant Science Laboratory of the Federal University of Acre, Campus Floresta. The experimental design was in randomized blocks, in a 10 x 5 factorial arrangement referring to 10 sour passion fruit genotypes and five postharvest evaluation periods, with three replications of six fruits. The fruits were evaluated for physical and chemical quality. Analysis of variance and polynomial regression were performed at 5% significance. The genotypes showed oscillations regarding the physical and chemical characteristics of the fruits depending on the storage time. All evaluated genotypes are recommended for cultivation. However, when harvested directly from the ground after detached from the plant, fruits must be stored for up to 10 days at room temperature.

On Autonomous Superposition Operators in Spaces of μ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\mu $$\\end{document}–Almost Periodic Functions and Applications to Linear Differential Equations

In this article we focus mainly on the class of almost periodic functions in view of the Lebesgue measure (briefly: μ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\mu $$\\end{document}-a.p. functions) and on some if its subclasses. We are going to deal with autonomous superposition operators acting in the space of μ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\mu $$\\end{document}-a.p. functions. We will indicate necessary and sufficient conditions under which the autonomous superposition operator maps the space under consideration into itself as well as conditions under which it is continuous. As a corollary from these results we indicate when the autonomous superposition operator defined on that space is a bijection. Next, we will analyse in detail the situation when the composition of μ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\mu $$\\end{document}-a.p. function with a continuous function or with a homeomorphism gives a Stepanov almost periodic function. As an application of our results we indicate a subclass of μ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\mu $$\\end{document}-a.p. functions for which linear differential equations with a non-homogeneous term belonging to this subclass may not have μ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\mu $$\\end{document}-a.p. solutions.

Myocardial contractile function in the post-traumatic period of cardiac contusion in rats with different stress resistance: A preclinical experimental randomized trial

Background. Pathogenesis of cardiac contusion involves primary traumatic and secondary hypoxic mechanisms of myocardial contractile function depression as well as body reactions aimed at adapting to altered environment. A significant part of these reactions is realized in the context of stress. The intensity of the stress component in myocardial dysfunction is largely determined by the individual stress reactivity of the body. Objectives. To assess the contractile function and functional reserves of the myocardium of rats with a high and low level of stress resistance in the post-traumatic period of cardiac contusion. Methods. A preclinical experimental randomized trial involved 134 white mature nonlinear male rats weighing about 270 g. The animals were divided by sequentially performed Open Field and Porsolt Forced Swim tests into 2 groups: group 1 — animals with low stress resistance, group 2 — animals with high stress resistance. Within each group, the animals were randomized into control and experimental subgroups. In the experimental subgroups, 6, 12 and 24 hours after simulating cardiac contusion, the force and rate indicators of myocardial contractility were evaluated using the Fallen isolated heart model. The summary measures of the study included assessing the contractile force and rate of isolated hearts of rats with low and high stress resistance, particularly under conditions of high-frequency rhythm load (ranging from 4.0 to 8.3 Hz) during the post-traumatic period of cardiac contusion. Data analysis was performed using software packages MS Office 2013 (Microsoft Corporation, USA) and Statistica, v. 10 (StatSoft, USA). The differences were considered to be statistically significant at p &lt; 0.05. Results. 6, 12 and 24 hours after simulating a cardiac contusion, contractile force and rate of isolated hearts decreased in group 1 and group 2. In low stress-resistant animals, immediately following the stabilization period and during high-frequency rhythm test, the contractility force and rate in isolated hearts were statistically significantly lower (p = 0.0008) compared to those recorded in highly stress-resistant individuals. During the stimulation of a high-frequency rhythm, isolated hearts in the experimental group revealed diastolic dysfunction at all time points. In highly stress-resistant animals, diastolic dysfunction occurred at a heart rate of 300 min-1 and above, whereas in low stress-resistant animals, it manifested at a heart rate of 240 min-1 and above. At the same heart rate, diastolic dysfunction in low stress-resistant animals was statistically significantly greater (p = 0.0008) compared to that of highly resistant animals. Conclusion. The post-traumatic period following experimental myocardial contusion is characterized by a reduction in the force and rate of myocardial contractility, as well as a decrease in functional reserves of the myocardium, regardless of stress resistance. High stress resistance is associated with better preservation of cardiac contractile function and contractility reserves, whereas low stress resistance correlates with a more pronounced degree of myocardial dysfunction and a significant reduction in functional reserves of the contused heart. Differences in the severity of contractile dysfunction under conditions of high and low body resistance to stress can be attributed to varying degrees of secondary myocardial damage in the contused area, resulting from the misbalance between stress-activating and stress-limiting mechanisms involved in the development of secondary damage.

Unraveling the thrombin–Alzheimer’s connection: Oral anticoagulants as potential neuroprotective therapeutics

In Alzheimer&amp;rsquo;s disease (AD), toxic amyloids formed by amyloid-&amp;beta; (A&amp;beta;) proteins and tau are implicated in the development of inflammatory, vascular, and neurodegenerative brain disorders. Thrombin has also been recognized as a proteopathic factor involved in A&amp;beta;-induced neurovascular dysfunction. Vascular A&amp;beta; activates the contact system in the blood, stimulating the production of inflammatory bradykinin and procoagulant thrombin. Thrombin, in turn, triggers inflammation, platelet activation, and the formation of fibrinolysis-resistant, A&amp;beta;-containing fibrin clots, leading to A&amp;szlig;-type cerebral amyloid angiopathy and associated neuropathology. Targeting thrombin with oral anticoagulants can normalize proinflammatory and prothrombotic states, counteracting the neurovascular consequences of AD. Pre-clinical studies have shown that such interventions preserve vascular and blood&amp;ndash;brain barrier integrity, improve cerebral blood flow and brain perfusion, and reduce parenchymal accumulations of toxic A&amp;beta;, tau, fibrin(ogen), and thrombin. These effects mitigate neuroinflammatory and neurodegenerative processes, ultimately preserving cognitive functions for a longer period. Recent observational clinical studies in patients with atrial fibrillation (AF) demonstrated that treatment with direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs) reduced the risk of dementia by up to 48% compared to non-users. The anti-dementia effects were most prominent in elderly patients but were also observed in individuals with low AF risk or newly diagnosed AF. In addition, DOACs reduced the risk of intracranial hemorrhage by approximately 50% compared to VKAs. The current review highlights the potential neuroprotective role of DOACs in AD. By preventing excessive thrombin generation caused by A&amp;beta; pathology, DOACs could protect vascular and neuronal functions, thereby slowing cognitive decline. DOACs, such as dabigatran, apixaban, and rivaroxaban, warrant further clinical investigation for their potential repurposing as disease-modifying therapeutics in AD.

Exploring the Diversity of Kink Solitons in (3+1)-Dimensional Wazwaz–Benjamin–Bona–Mahony Equation

The Wazwaz–Benjamin–Bona–Mahony (WBBM) equation is a well-known regularized long-wave model that examines the propagation kinematics of water waves. The current work employs an effective approach, called the Riccati Modified Extended Simple Equation Method (RMESEM), to effectively and precisely derive the propagating soliton solutions to the (3+1)-dimensional WBBM equation. By using this upgraded approach, we are able to find a greater diversity of families of propagating soliton solutions for the WBBM model in the form of exponential, rational, hyperbolic, periodic, and rational hyperbolic functions. To further graphically represent the propagating behavior of acquired solitons, we additionally provide 3D, 2D, and contour graphics which clearly demonstrate the presence of kink solitons, including solitary kink, anti-kink, twinning kink, bright kink, bifurcated kink, lump-like kink, and other multiple kinks in the realm of WBBM. Furthermore, by producing new and precise propagating soliton solutions, our RMESEM demonstrates its significance in revealing important details about the model behavior and provides indications regarding possible applications in the field of water waves.

The energy-frequency diagram of the (1+1)-dimensional Φ4 oscillon

Two different methods are used to study the existence and stability of the (1+1)-dimensional Φ4 oscillon. The variational technique approximates it by a periodic function with a set of adiabatically changing parameters. An alternative approach treats oscillons as standing waves in a finite-size box; these are sought as solutions of a boundary-value problem on a two-dimensional domain. The numerical analysis reveals that the standing wave’s energy-frequency diagram is fragmented into disjoint segments with ωn+1< ω < ωn, where ωn = ω0/(n + 1), n = 0, 1, 2, ., and ω0 is the endpoint of the continuous spectrum (mass threshold of the model). The variational approximation involving the first, zeroth and second harmonic components provides an accurate description of the oscillon with the frequency in (ω1, ω0), but breaks down as ω falls out of that interval.

Assessing the impact of virtual reality on the restoration of motor function in the acute period of ischemic stroke

Aim: to evaluate the effectiveness of using virtual reality to restore motor function in patients in the acute period of ischemic stroke.Material and methods. We studied 207 patients in the acute period of ischemic stroke, who were divided into two groups by randomization: study group – 105 patients, comparison group – 102 patients. All patients received all necessary standardized therapy. Patients in the study group additionally received classes using the ReviVR device. Efficacy was assessed using the NIHSS, FMA-LE, and BBS scales.Results. On all scales studied, patients in the study group demonstrated better results in relation to the comparison group, both in terms of the final result and in terms of the level of change in indicators during the rehabilitation process. The use of virtual reality made it possible to reduce disability on the NIHSS scale to 7.0 (4.0; 9.0) points, which is better than the results of the comparison group – 9.0 (5.0; 13.0) points with a high level of significance p &lt; 0.001. The increase in motor function according to FMA-LE in the study group was higher and amounted to 21.0 (15.0; 24.0) points versus 18.0 (7.0; 22.0) points in the comparison group with a significance level of p = 0.002. The study group also showed better results on the BBS scale – 26.0 (17.0; 34.0) versus 18.0 (5.0; 29.0) points with a significance level of p &lt; 0.001.Conclusion. The use of virtual reality together with standardized therapy in the acute period of ischemic stroke is effective in restoring motor function of the affected lower limb, improving balance and reducing general disability in general.

Optical dromions for M-fractional Kuralay equation via complete discrimination system approach along with sensitivity analysis and quasi-periodic behavior

This paper investigates new analytical wave solutions for the fractional Kuralay-IIB equations (FK-IIBE), including a new definition of the fractional derivative. This model works in disciplines such as ferromagnetic materials, optical fibers, wave mixing, and nonlinear optics. The integrable motion of space curves can be determined by our governing model. This research holds great importance in the area of optical fibers, exact and analytical solitons solution. The polynomial method’s complete discrimination system (CDSPM) is used to identify a variety of exact and analytical soliton solutions such as periodic, hyperbolic, rational, Jacobian elliptic (JE), and trigonometric functions. Additionally, we also convert the JE function into a solitary wave (SW) solution. To provide a comprehensive understanding of the dynamic aspects of the system, we also address bifurcation points, quasi-periodic behavior, sensitivity analysis, Poincarè maps, time series profile, and critical solution conditions. The research offers straightforward, efficient algorithms that can consistently and effectively address FK-IIBE. Machine learning technologies are also utilized to satisfy the criteria defined by dynamic analysis. Python regression learner tools are used for reverse engineering to analyze the mathematical model’s equilibrium based on parameter intervals and thresholds determined by dynamical analysis.

The Effect of Gum Chewing on Gastrointestinal System Functions in Patients Undergoing Colorectal Surgery: A Systematic Review

In the postoperative period, gas and secretions in the stomach and small and large intestines due to delayed motility of the gastrointestinal system cause abdominal bloating, nausea, vomiting and pain, and this situation negatively affects the comfort level of patients. Chewing gum is among the methods used to prevent ileus after surgery. Chewing gum activates the cephalic vagal reflex and stimulates bowel function in the postoperative period. In this article, the effect of chewing gum in preventing ileus after colorectal surgery and the factors affecting the success rate are reviewed in the light of current literature.

Modified infra-promontorium trans-channel approach to the petrous apex. Case report

This article describes the approach to the petrous pyramid developed at National Medical Research Center of Otorhinolaryngology, namely an endoscopy – microscopy-guided modified trans-channel infra-promontorium approach with internal carotid artery retraction maneuver in patients with lesions of the petrous pyramid but with preserved hearing. A clinical report describing the apical cholesteatoma of the petrous pyramid and the use of this approach are presented. Anatomical and functional features after the surgery are also described. The purpose of this paper is advancing of the surgical approach to the petrous pyramid with the possibility of hearing preservation. The results of surgical treatment in lesions of the petrous pyramid were evaluated in the immediate and distant periods. The functions of facial mimic muscles were evaluated immediately after the surgery, in 6 months, and in one year. The functions of facial mimic muscles remained at the baseline level during the whole follow-up period. The pure tone audiogram demonstrated the preserved hearing function in the postoperative period. Complete elimination of the pathological process was achieved in all cases (n=15); according to the MRI of the temporal bones, no relapses occurred in a year. The surgical approach proposed for patients with the lesions of the petrous pyramid enables complete removal of the pathological process from the petrous pyramid with the preservation of hearing and facial functions, based on the subjective examinations (audiometry, facial function diagnosis) and radiology (CT and MRI of temporal bones) at the preoperative stage.