Function In Young Children Research Articles

High-gamma frequency flash stimulation as a possible cognitive facilitator in rat pups.

High-gamma frequency flashes can enhance cognition by synchronizing neural oscillations in mammals. Early flash treatment promotes the development of improved cognitive functions in young children. However, it is unclear whether exposure to high-gamma frequency flashes in preschool-aged individuals affects cognition in preadolescents by regulating neural oscillations in the brain. Here, we aimed to investigate the effects of gamma-frequency flashes on cognitive ability. In this study, the effect of high-frequency flicker on cognitive performance was verified by behavioural experiments such as the open-field test and the water maze, but also proteomics. We found that external 40 Hz and 70 Hz frequency flashes synchronized neural oscillations at the corresponding frequencies in the primary visual cortex (V1) of rats. Rats that underwent 70 Hz flash intervention had better cognitive behavioural performance in the early stages of training. The 70 Hz flash frequency upregulated proteins associated with neuronal growth and differentiation, such as Snapin, FoxO3, Hspa12a, and Penk, and activated the MAPK signalling pathway, signalling pathway regulating stem cell pluripotency, and the neuroactive ligand-receptor interaction pathway. These proteins and pathways play important roles in cognitive functions. Our study revealed that 70 Hz flashes received by young children early in their development substantially promote the growth of cognitive capabilities in the brain. Exposure to 70 Hz flashes may be a new intervention method and a new strategy for improving cognition.

Impact of obesity on pulmonary function of preschool children: an impulse oscillometry study.

The increasing global prevalence of obesity poses significant public health problems, as obesity exerts adverse effects on many systems and lung function. However, research on the lung function of preschool children with obesity is limited and inconclusive. In addition, studies specific to obesity indices that influence lung function in young children with obesity are limited. This study aimed to evaluate lung function of obese versus normal-weight preschool children using impulse oscillometry (IOS) and identify obesity indices predictive of altered lung function. We enrolled obese children aged 3-7 years as well as age- and sex-matched normal-weight controls. The participants underwent IOS assessments that measured the resistance at 5 Hz (R5) and 20 Hz (R20), the difference in resistance between these frequencies (R5-R20), reactance at 5 Hz (X5), resonance frequency, and reactance area (AX). We compared these parameters between groups and analyzed the correlations between obesity indices and IOS measures within the obese group using multiple linear regression. The study included 68 participants (n=34 each group). In the obese group, significantly higher values were observed for R5 (adjusted for height, p = 0.02; % predicted, p = 0.01; z-score, p < 0.001), R5-R20 (absolute value, p = 0.002; adjusted for height, p = 0.001), and AX (z-score, p = 0.01). AX adjusted for height showed a greater trend (p = 0.07). The waist-to-height ratio was the most robust independent predictor of total and peripheral airway resistance, with increases in R5 (b = 1.65, p = 0.02) and R5-R20 (b = 1.39, p = 0.03) and a near-significant correlation with AX (b = 12.12, p = 0.06). Preschool children with obesity exhibit impaired lung function, characterized by elevated total and peripheral airway resistance. Waist-to-height ratio was the strongest predictor of these changes.

Initiatives to improve lung and sleep health in children: Delphi consensus from the pediatrics, pulmonary, and sleep conference.

The lung and sleep health of adults is heavily influenced by early factors, both genetic and environmental; therefore, optimizing respiratory health begins in childhood. Multiple barriers impede improvements in lung and sleep health for children. First, the traditional siloing between general pediatric care in the community, pediatric pulmonary and sleep subspecialty care, and the research community limits the translation of knowledge into practice. Additionally, identifying and addressing health disparities remains a challenge. The 2021 NHLBI-sponsored workshop "Defining and Promoting Pediatric Pulmonary Health (DAP3H)" was a first step in defining critical gaps in our current healthcare system in identifying and optimizing lung and sleep health in children. The workshop identified key opportunities including measuring pulmonary function in young children, sleep-focused outcomes, developing biomarkers, and longitudinal research cohorts. To expand on the work of DAP3H and continue initiatives to improve childhood lung and sleep health, the Pediatrics & Pulmonary Network: Improving Health Together conference was held in 2023. A modified Delphi process was applied to form consensus surrounding gaps, barriers, and action items, with the goal of identifying the most urgent opportnities for improving childhood lung and sleep health. Cross-cutting foundational principles were identified as: (1) Authentic Stakeholder Collaboration & Engagement, (2) Reach & Implementation in Real World Settings, (3) Understanding Current Landscape & Resources and (4) Purposeful Diversity, Equity, & Inclusion Initiatives. To improve lung and sleep health in children, these principles should be the foundation for research design, development, and implementation.

Dynamic Changes of Growth and Thyroid Function in Young Children With Chronic Hepatitis B Treated With Peginterferon Monotherapy.

Peginterferon (PegIFN) has shown promising results in the treatment of chronic hepatitis B (CHB). This study aimed to evaluate the effects of PegIFN α-2b on growth and thyroid function in young children with CHB. A retrospective study was performed by extracting clinical data from children with CHB who received PegIFN α-2b monotherapy at the Public Health Clinical Center of Chengdu between June 2017 and December 2020. Mean, SD, independent samples t test and 1-way repeated analysis of variance were used to evaluate relevant data. A total of 62 children were included in this study. Overall, significant differences were observed in the weight-for-age z score (WAZ), height-for-age z score (HAZ) and body mass index-for-age z score (BAZ) at different time points ( P < 0.001). WAZ, HAZ and BAZ were not affected by PegIFN α-2b at 24 weeks of treatment (all P > 0.05). WAZ, HAZ and BAZ at the end of treatment and 48 weeks after treatment; WAZ at 96 weeks after treatment were lower than baseline levels (all P < 0.05). No statistical differences were found in HAZ and BAZ at 96 weeks after treatment compared with baseline. Thyroid dysfunction developed in 17.7% of children during the treatment. Thyroid dysfunction was transient and had no effect on growth. PegIFN α-2b has inhibitory effects on growth and can increase the incidence of thyroid dysfunction in young children with CHB. These effects are generally reversible with the cessation of therapy, although WAZ had not returned to baseline after 96 weeks of observation.

Effects of I AM TAP Program on Executive Function of Children 3-5 years in Bangkok Metropolitan Region Residential Care Homes: A Quasi-experimental Study

Executive function is important to the success of an individual. Children who have a history of being abused mentally and physically before entering a residential care home may have executive function deficits. They often face fear, stress, and a lack of interpersonal interaction, which affects their executive function. This quasi-experimental study aimed to increase children’s executive function through the I AM TAP Program. This program integrates sensory and physical activities, including working memory, inhibitory control, and cognitive flexibility. Two residential care homes of young children aged 3-5 years in the Bangkok Metropolitan Region were randomly assigned to experimental and control groups. Then, 36 children from each setting and 11 caregivers were selected according to the inclusion criteria. The experimental group received I AM TAP Program training twice weekly for 9 weeks, 20-30 minutes each session. The control group attended the routine activities provided in a residential care home. Executive function was assessed with the Mahidol University Executive Function-101 instrument. The data were analyzed using independent t-tests, paired t-tests, and covariance analysis. The results of this study, a testament to the effectiveness of the I AM TAP Program, revealed a significant increase in the mean scores of executive functions on 3 subscales in the experimental group. These scores not only improved from the pre-program levels but also surpassed those of the control group, as measured one week after program completion. This promising outcome suggests that the I AM TAP Program has the potential to enhance executive function in young children. Nurses can potentially apply this program to promote executive function, and caregivers can be equipped with information on how to support the children in the residential care home. However, it is crucial to conduct further testing with various groups of children in different settings before considering widespread implementation

Testing the Hard to Test: A Pilot Study Examining the Role of Questionnaires in Eliciting Visual Behaviours in Children with Autistic Spectrum Disorder.

There is a higher prevalence of visual problems in children with Autistic Spectrum Disorder (ASD) compared with the neuro-typical population. Issues relating to visual perception can be evident as atypical visual behaviours (ViBes). The aim of the study was to compare findings of parents and eye health professionals using questionnaires to describe visual function in young children with ASD. Parents/Caregivers of patients diagnosed with ASD attending routine hospital eye clinics were invited to participate. A questionnaire to draw out presence of ViBes was completed by the parent prior to attending clinic. The clinician independently completed the same questionnaire and undertook a clinical ocular assessment. 32 children were recruited (mean age 7 years, range 4-11). Most caregivers indicated they had noted at least one atypical ViBe (97%, median 5, range 0-8). Parental-reported ViBe8 scores were higher than clinician-reported scores (p = 0.04). The most commonly reported ViBes by both groups related to use of vision at the same time as other senses, and atypical fixation (e.g. looking away during speech or side viewing). There was weak correlation between visual acuity and parental ViBe8 score (rho = 0.364) and no correlation between refractive error and parental ViBe8 score (rho = 0.047). Clinicians were likely to under-report atypical visual function compared with parent. Refraction and visual acuity alone do not detect all visual problems in children with ASD. A Visual Behaviour (ViBe) questionnaire offers a structured approach and shared language to allow documentation of functional visual assessment for both parents, carers, and educational professionals. Use of the ViBe questionnaire may promote understanding between caregiver and professional and provide a baseline for visual behaviours.

Nutritional status, dietary habits, and their relation to cognitive functions: A cross-sectional study among the school aged (8-14 years) children of Bangladesh.

Limited research addressed links between nutritional status, dietary habits, and cognitive functions in young children. This study assessed the status of cognitive functions and their association with nutritional status and dietary habits of school age children of Bangladesh. This cross-sectional multi-centre study was conducted on 776 participants in 11 conveniently selected educational institutions. A printed questionnaire with three sections (Section 1: background information, section 2: PedsQL™ Cognitive Functioning Scale, and section 3: semi-quantitative food-frequency questionnaire) was utilized for the data collection purpose. Sections 1 and 3 were self-reported by parents, and trained volunteers completed section 2 in-person along with the anthropometric measurements. Statistical analyses were done in Stata (v.16). Mean with standard deviation and frequencies with percentages were used to summarize quantitative and qualitative variables, respectively. Pearson's chi-square test and Spearman's rank correlation coefficient were used to explore bivariate relationships. The mean age of the participants was 12.02±1.88 years, and the majority (67%) were females. The prevalence of poor cognitive function was 46.52%, and among them, 66.02% were females. In terms of body mass index (BMI), 22.44% possessed normal weight, 17.51% were overweight, and 5.19% were obese. This study found a statistically significant relationship between BMI and cognitive functions. Furthermore, different dietary components (e.g., protein, carbohydrate, fat, fiber, iron, magnesium) showed a significant (p<0.05 for all) weak positive correlation with cognitive function. BMI and dietary habits were associated with the cognitive function of young children in Bangladesh. Although the cross-sectional design of the study precludes causal relationships from being determined, the study finding deserves further examination via longitudinal research.

Establishing Reference Values for a New Computerized Cognitive Function Test Program for Children.

To establish reference values for the computerized cognitive test and evaluate cognitive function improvements across different age groups, we introduce the computerized Cognitive Function Test program (eCFT), specifically designed for children. We aimed to establish eCFT reference values and assess cognitive function improvements across different age groups. We included children aged 3-6 years with confirmed normal cognition based on the Korean Developmental Screening Test for Infants and Children and Kaufman Assessment Battery for Children-II. The eCFT consists of 8 subtests for visual perception, attention, memory, and executive function. A total of 66 participants (36 males and 30 females) with an average age of 4.4 years participated. The age 6 group consistently outperformed both age group 3 and 4 in terms of correct responses. With regard to the completed stage, the "selective auditory stimulus" test findings were 2.0 and 3.9 for the age 3 and age 6 groups, respectively (p<0.05). The "trail-making" test findings were 1.7, 2.1, 2.6, and 2.8, respectively (between ages 3 and 6, p<0.01; between ages 4 and 6, p<0.05); moreover, the age 5 group surpassed the age 3 group (2.6 and 1.7, respectively, p<0.05). The eCFT is an easily accessible tool to evaluate cognitive function in young children. We introduce reference values with a cutoff range for preschool-aged children, enabling early intervention for those with cognitive impairment. Given its accessibility and relatively short evaluation time, the eCFT has potential for clinical use.

Bidirectional relationships between emotion understanding and executive functions in young children: A latent change score modeling study

An overarching framework in the field of developmental psychology highlights the close linkage of cognition with emotion; however, the extent to which this framework supports the relationship between executive functions and emotion understanding in young children remains unclear. Hence, we employ a longitudinal tracking study to investigate the bidirectional relationship between emotion understanding and executive functions. A total of 112 children (M = 48.01 months, 68 boys) were recruited to perform tests at three time points within 2 years. Results from our cross-lagged model analysis indicated that early executive functions significantly predicted the development of emotion understanding at Time 2 and Time 3, while emotion understanding at Time 2 significantly predicted the subsequent development of executive functions in Time 3, controlling for age, gender, and family socioeconomic status (SES). Moreover, the latent change score model analysis further revealed the developmental trends and interrelations of executive functions and emotion understanding over time. Specifically, children with higher initial level of executive functions exhibited faster growth in emotion understanding over time, and then this improved emotion understanding predicted the changes in later executive functions. Overall, these findings elucidate significant developmental progressions for how emotion understanding and executive functions interact with each other during early childhood.

Enhancing young children's executive function through physical activities: A three-level meta-analysis

Background and aimsThe cultivation of executive functions during early childhood establishes the fundamental underpinning for advanced cognitive development in adulthood. Presently, there remains a degree of controversy surrounding the empirical findings pertaining to the impact of physical activity on the executive functions of young children. This study aimed at elucidating the potential moderating factors influencing the relationship between physical activity and the executive functions of young children. MethodsIn this study, we have conducted a meta-analysis encompassing twenty-four experimental studies with a total of 1426 participants. The meta-analysis was conducted using Stata version 17.0 and R version 4.3.2 software, with Hedges'g serving as the chosen effect size metric. ResultsThe outcomes of our investigation underscore the salient point that physical activity possesses the capacity to enhance the executive functions of young children. Furthermore, it is noteworthy that the developmental impact of physical activity on the executive functions of young children is notably contingent upon the duration of the intervention. The implementation of game-based pedagogical approaches within the realm of sports activities emerges as a particularly potent means to foster the development of executive functions in young children. ConclusionsThis meta-analysis serves to proffer quantitative evidence affirming the positive influence of physical activities on the executive functions of young children during their early developmental years. It carries substantial implications for practical application.

Factors associated with nasal airway resistance in young children

AimThis study investigated the association between nasal obstruction and its associated factors in young children by quantitatively measuring the nasal airway resistance (NAR). MethodsA total of 82 children aged 3–6 years (31 boys and 51 girls) were included in the study. Questionnaires were used to collect information about allergies, nasal diseases, stuffy nose, oral habits, and feeding behavior problems from the parents. Furthermore, measurements of the height, body weight, calf circumference, grip strength, tongue pressure, occlusal force, lip-closure strength, mouth rinsing function test, and NAR were taken. ResultsThe NAR was negatively correlated with the height and age of the children. Additionally, NAR was associated with feeding behavior problems, as reported by the parents of the children. ConclusionThe findings of this study suggest that interviewing parents about their children's feeding behavior problems may prove valuable in diagnosing nasal disorders in young children. Early improvements in nasal obstruction may address feeding behavior problems and contribute to the normal growth and development of oral functions in young children.

Neurite density of the hippocampus is associated with trace eyeblink conditioning latency in 4- to 6-year-olds.

Limited options exist to evaluate the development of hippocampal function in young children. Research has established that trace eyeblink conditioning (EBC) relies on a functional hippocampus. Hence, we set out to investigate whether trace EBC is linked to hippocampal structure, potentially serving as a valuable indicator of hippocampal development. Our study explored potential associations between individual differences in hippocampal volume and neurite density with trace EBC performance in young children. We used onset latency of conditioned responses (CR) and percentage of conditioned responses (% CR) as measures of hippocampal-dependent associative learning. Using a sample of typically developing children aged 4 to 6years (N = 30; 14 girls; M = 5.70years), participants underwent T1- and diffusion-weighted MRI scans and completed a 15-min trace eyeblink conditioning task conducted outside the MRI. % CR and CR onset latency were calculated based on all trials involving tone-puff presentations and tone-alone trials. Findings revealed a connection between greater left hippocampal neurite density and delayed CR onset latency. Children with higher neurite density in the left hippocampus tended to blink closer to the onset of the unconditioned stimulus, indicating that structural variations in the hippocampus were associated with more precise timing of conditioned responses. No other relationships were observed between hippocampal volume, cerebellum volume or neurite density, hippocampal white matter connectivity and any EBC measures. Preliminary results suggest that trace EBC may serve as a straightforward yet innovative approach for studying hippocampal development in young children and populations with atypical development.

Socioeconomic Status and its Impact on Receptive Vocabulary and Executive Function in Young Children

This article examines the impact of Socioeconomic Status (SES) on the development of receptive vocabulary and executive function in young children. Integrating current research, the paper highlights the challenges faced by children from low SES backgrounds in terms of language comprehension and executive functioning. Studies indicate a close relationship between SES and a child's receptive language abilities and executive functions, which are crucial for overall learning and development. The article also explores how SES influences cognitive development in children through various pathways, such as home language environment, stress levels, and access to resources. Additionally, the paper discusses early intervention measures and policy recommendations for children from low SES backgrounds to bridge the developmental gap associated with SES.

The 10-Word Auditory Verbal Learning Test and Vocabulary Performance in 4- and 5-Year-Old Children.

Understanding the different factors that determine vocabulary development in young children is essential for the diagnosis and rehabilitation of language disorders in children. Language development is closely related to other cognitive processes such as auditory verbal learning and memory. This research focuses on the development of a novel auditory verbal learning test (AVLT) for 4- and 5-year-old children within the Dutch population. This new test is an adaptation of the common AVLT for both older children and adults, usually including a list of 15 words. Considering the lower attention span and limited executive functioning in young children, the word list of this new instrument is reduced to 10 words. Besides, a second recognition form has been developed to improve the ability to distinguish between possible underlying learning and memory deficits. Ninety-five preschool children (ages 4;0-5;12 [years;months]) were tested with this new AVLT 10-word test for kids (10WT-K), yielding different measures of verbal auditory memory. Forty-eight of 95 children received a recognition task with semantically unrelated items, and 47 of 95 received a recognition task with semantically related items. Three additional language skills were assessed to establish test validation: receptive and expressive vocabulary performance and nonword repetition. Outcome of the 10WT-K was related to scores on the language measures. Positive correlations were found between the total score of the 10WT-K and all three aforementioned language skills. We found no correlations between frequency of error types (intrusions and repetitions) and language measures. Furthermore, children who were administered the recognition list with semantically related items showed fewer correct answers and more false-positive and false-negative responses than children who received a recognition list with semantically unrelated items. The 10WT-K for young children can be used to (a) measure different aspects of auditory verbal learning and memory, (b) clarify the nature of possible verbal learning difficulties, and (c) identify a possible nature of language disorders. The word recognition task tested with semantically related items provides a more accurate measurement of individual differences, namely, in distinguishing retrieval and storage abilities. The significant relation found between auditory verbal short-term memory capacity and vocabulary performance in preschool children is a first step toward establishing test validity.

Longitudinal Examination of Potential Bilingual Advantage Effects for Selective Attention and Cognitive Functioning in Young Children

ABSTRACT A good deal of research purports that bilingualism has a positive effect on some aspects of cognitive functioning. However, this effect is not consistent, and little research examines trajectories of cognitive skill development in bilingual children. Moreover, it remains unclear whether different types of bilingualism impact how cognitive abilities unfold. The reported study investigates children’s data from three linguistic groups (179 sequential bilingual, 96 simultaneous bilingual and 57 monolingual German-speaking children) and examines differences (1) regarding cognitive outcome measures pertaining to selective attention, visuospatial thinking and abstract thinking and (2) searches for substantial developmental trajectory differences regarding said measures. Children were tested at 3 points in time; at age 4;10, 6;2 and 7;4. Results indicate no significant linguistic group differences in selective attention, visuospatial thinking and abstract thinking when controlling for gender, language comprehension of the child, and families’ socioeconomic status. Moreover, the three linguistic groups did not differ in developmental trajectories. Theoretical and practical implications are discussed.

“Attentive Kindergarten”: A Small Group Intervention Boosting Attention among Kindergarten Children

(1) Background: The purpose of this study was to investigate the effectiveness of a small group intervention program named “Attentive Kindergarten” (AK), aimed at enhancing attention functioning among typically developing preschool-aged children. The program focuses on improving sustained attention, selective spatial attention, and response inhibition based on cognitive training principles. (2) Methods: The study’s sample included 51 children, 15 of whom received the AK intervention and 36 of whom served as a control group. Computerized cognitive tests were used for pre- and postintervention evaluations to assess sustained attention, response inhibition, and selective spatial attention. Quantitative analyses were conducted to examine the differences between the two groups as a result of the intervention program. (3) Results: The AK group demonstrated improvements in all attention functions that were measured. These improvements were larger than those obtained in the control group. (4) Conclusions: The results suggest that cognitive training programs, such as Attentive Kindergarten, can enhance attention functioning in young children. The present findings have important implications for early intervention programs aimed at improving young children’s cognitive skills, which, in turn, can decrease the likelihood of future attention problems and other related difficulties.

Understanding the use and benefits of assistive devices among young children with cerebral palsy and their families in Norway: a cross-sectional population-based registry study

Purpose Assistive technology intervention has become an important strategy in enhancing function in young children with cerebral palsy. This study aimed to provide an in-depth knowledge of the use of assistive devices by describing their purposes, the environments in which they are used, frequency of use and perceived benefits from the caregiver’s perspective. Material and methods This is a cross-sectional population-based study using data from national cerebral palsy registers in Norway. Of a total of 202 children, 130 participated (mean age 49.9 months, SD 14.0 months). Results The 130 children and their families used a median of 2.5 assistive devices (range 0–12) to support positioning, mobility, self-care and training, stimulation and play. Devices most commonly had one or two main purposes and were used both at home and in kindergarten/school. The usage rate varied from less than twice a week to several times a day. The majority of parents reported significant benefits for caregiving and/or the child’s functioning. Total use increased in accordance with the level of the child’s gross motor limitations and was associated with restrictions imposed by housing concerns. Conclusions The frequent use of a wide range of devices, and the intended and perceived benefits, demonstrates that early provision of assistive devices can be an effective function-enhancing strategy in young children with cerebral palsy. However, the findings also indicate that factors others than the child’s motor abilities must be considered when integrating the use of devices into the child’s daily routines and activities. Implications for Rehabilitation Early provision of assistive devices can be a powerful strategy to support everyday functioning and facilitate care in young children with cerebral palsy. Assistive devices seems to be most effective when they are well integrated into the child’s daily routines and activities across environments. The clinical classifications of motor abilities (Gross Motor Function Classification System and Manual Ability Classification System) can be used to estimate the need for assistive devices, however, factors others than the child’s motor function seem to be critical for optimum effectiveness, such as type of equipment, its physical and social environment and the intended benefits of use.

Dietary fiber and growth, iron status and bowel function in children 0-5 years old: a systematic review.

While dietary fiber intake is low in many children, the current trend to plant-based diets is associated with higher fiber intake in children raised on these diets. As older reports indicate that diets providing high fiber intake in children 0-5 years may affect growth, iron status and bowel function, we summarized the available evidence in this systematic review. To identify, critically appraise, and synthesize evidence on the effect of high fiber intake on growth, iron and bowel function in children 0-5 years, with relevance to the Nordic and Baltic countries. Following a pre-registered protocol, we searched MEDLINE, EMBASE, Cochrane Central of Controlled Trials, and Scopus for clinical trials and prospective cohort studies published until November 2021. Two reviewers independently screened retrieved literature, extracted relevant data, and performed risk of bias assessment. Outcomes were growth, iron metabolism and bowel function in children 0-5 years. We narratively described findings from studies that met inclusion criteria. From 5,644 identified records, five articles met the inclusion criteria. Two RCTs had an overall moderate risk of bias, while the three observational studies had serious risk. Overall, we found no robust association between high intake of dietary fiber and growth. In the RCTs, higher intake of fiber had a positive effect on bowel movements and constipation. No studies on fiber intake and iron status were identified.The certainty of the overall evidence was inconclusive for growth and bowel function, while no assessment was made for iron status. We found no clear association between high intake of dietary fiber and growth or bowel function in young children living in affluent countries, albeit with only a limited number of studies. There is a lack of studies investigating health effects of high fiber intake in small children.

Revisiting the relationship between maternal parenting behaviors and executive functions in young children: Effect of measurement methods.

The past decade of studies showed that parenting behaviors (e.g., warmth, autonomy, and control) were associated with children's executive functions (EF) in the early years. However, different measurement methods had been used across studies, making it hard to compare the effects of parenting on EF across studies. Therefore, the present study aimed to examine the effect of the measurement methods on the relationship between maternal parenting behaviors and children's EF among a group of Chinese preschoolers. One hundred and twenty-six children (62 boys; Mage = 48.65 months) were assessed with direct measures on children's EF (inhibition and working memory tasks), and parenting behaviors of their mothers during interaction with children were observed and coded. Mothers also reported their parenting practices and children's difficulties in executive functions. The results of structural equation modeling showed that the latent performance-based EF was uniquely predicted by maternal positive control and negative control in mother-child interaction, while children's EF difficulties reported by mothers were predicted by mother-reported warmth and support, and autonomy granting. Overall, the results suggest that the relationship between maternal parenting and children's EF depends on the measurement methods of parenting and executive functions.

Associations between prenatal and early-life air pollution exposure and lung function in young children: Exploring influential windows of exposure on lung development

BackgroundEvidence in the literature suggests that air pollution exposures experienced prenatally and early in life can be detrimental to normal lung development, however the specific timing of critical windows during development is not fully understood. ObjectivesWe evaluated air pollution exposures during the prenatal and early-life period in association with lung function at ages 6–9, in an effort to identify potentially influential windows of exposure for lung development. MethodsOur study population consisted of 222 children aged 6–9 from the Fresno-Clovis metro area in California with spirometry data collected between May 2015 and May 2017. We used distributed-lag non-linear models to flexibly model the exposure-lag-response for monthly average exposure to fine particulate matter (PM2.5) and ozone (O3) during the prenatal months and first three years of life in association with forced vital capacity (FVC), and forced expiratory volume in the first second (FEV1), adjusted for covariates. ResultsPM2.5 exposure during the prenatal period and the first 3-years of life was associated with lower FVC and FEV1 assessed at ages 6–9. Specifically, an increase from the 5th percentile of the observed monthly average exposure (7.55 μg/m3) to the median observed exposure (12.69 μg/m3) for the duration of the window was associated with 0.42 L lower FVC (95% confidence interval (CI): −0.82, −0.03) and 0.38 L lower FEV1 (95% CI: −0.75, −0.02). The shape of the lag-response indicated that the second half of pregnancy may be a particularly influential window of exposure. Associations for ozone were not as strong and typically CIs included the null. ConclusionsOur findings indicate that prenatal and early-life exposures to PM2.5 are associated with decreased lung function later in childhood. Exposures during the latter months of pregnancy may be especially influential.