Full Replacement Research Articles

Time-domain computation of the reliability of standby systems with and without priority under general repair

In this paper, we consider a two-unit, non-identical cold standby system under general repair with or without priority. In the prioritized case, one unit in the system is designated to serve as standby only, that is, the standby unit is only utilized when the main unit has failed and is being repaired, whereas in the non-prioritized case, both units serve alternately as standby with each unit being put to standby mode when its repair is complete. The effect of each repair is modelled by a degree θ, 0≤θ≤1, where θ=0 means full repair (or full replacement) and θ=1 means minimal repair. For these cases, and for arbitrary distributions of the lifetimes and repair times of the units in the system, we obtain the reliability function in the time domain as opposed to the Laplace domain. Our functions utilize results from classical and generalized renewal theory results. We validated our formulas on various in-house standby configurations, as well as standby configurations occurring in coolant systems of nuclear power plants.

Design of saccharide based organic binder for low-grade iron ore pelletization using atomistic simulations and machine learning methods

Inorganic binders like bentonite, used for pelletization of low-grade iron ore, generate iron ore slimes with comparatively high silica and alumina content necessitating extra steps for their removal during iron making process. This demands the usage of organic binders as full or partial replacement of bentonite for iron ore pelletization. In this work, adsorption of organic binders with saccharides skeleton and –H, –OH, –CH2OH and –CH2CH2OH as polar substituents, on goethite surface was studied using density functional theory, molecular dynamics and machine learning. It was observed that adsorption energy of binders on goethite surface had weak dependence on number of hydrogen bonds between them. With this favorable interaction in mind, a library containing 64 organic binders was constructed and adsorption energy of 30 of these binders was computed using molecular dynamics, followed by training of a linear regression model, which was then used to predict the adsorption energy of rest of the binders in the library. It was found that the introduction of –CH2CH2OH at R2 position resulted in statistically significant higher adsorption energy. Binder34 and Binder44 were identified as viable candidates for both goethite and hematite ore pelletization and adsorption of their n-mers on goethite and hematite surfaces was also quantified.

Digital light 4D printing of bioresorbable shape memory elastomers for personalized biomedical implantation

Four-dimensional (4D) printing unlocks new potentials for personalized biomedical implantation, but still with hurdles of lacking suitable materials. Herein, we demonstrate a bioresorbable shape memory elastomer (SME) with high elasticity at both below and above its phase transition temperature (Ttrans). This SME can be digital light 3D printed by co-polymerizing glycerol dodecanoate acrylate prepolymer (pre-PGDA) with acrylic acid monomer to form crosslinked Poly(glycerol dodecanoate acrylate) (PGDA)-Polyacrylic acid (PAA), or PGDA-PAA network. The printed complex, free-standing 3D structures with high-resolution features exhibit shape programming properties at a physiological temperature. By tuning the pre-PGDA weight ratios between 55 wt% and 70 wt%, Ttrans varies between 39.2 and 47.2 ℃ while Young's moduli (E) range 40–170 MPa below Ttrans with fractural strain (εf) of 170 %-200 %. Above Ttrans, E drops to 1–1.82 MPa which is close to those of soft tissue. Strikingly, εf of 130–180 % is still maintained. In vitro biocompatibility test on the material shows > 90 % cell proliferation and great cell attachment. In vivo vascular grafting trials underline the geometrical and mechanical adaptability of these 4D printed constructs in regenerating the aorta tissue. Biodegradation of the implants shows the possibility of their full replacement by natural tissue over time. To highlight its potential for personalized medicine, a patient-specific left atrial appendage (LAA) occluder was printed and implanted endovascularly into an in vitro heart model. Statement of significance4D printed shape-memory elastomer (SME) implants particularly designed and manufactured for a patient are greatly sought-after in minimally invasive surgery (MIS). Traditional shape-memory polymers used in these implants often suffer from issues like unsuitable transition temperatures, poor biocompatibility, limited 3D design complexity, and low toughness, making them unsuitable for MIS. Our new SME, with an adjustable transition temperature and enhanced toughness, is both biocompatible and naturally degradable, particularly in cardiovascular contexts. This allows implants, like biomedical scaffolds, to be programmed at room temperature and then adapt to the body's physiological conditions post-implantation. Our studies, including in vivo vascular grafts and in vitro device implantation, highlight the SME's effectiveness in aortic tissue regeneration and its promising applications in MIS.

Partial and Complete Fluid Replacement Maintains Exercise Performance in a Warm Environment Following Prolonged Cold-Water Immersion.

Wheelock, CE, Stooks, J, Schwob, J, Hess, HW, Pryor, RR, and Hostler, D. Partial and complete fluid replacement maintains exercise performance in a warm environment following prolonged cold-water immersion. J Strength Cond Res 38(2): 290-296, 2024-Special warfare operators may be exposed to prolonged immersion before beginning a land-based mission. This immersion will result in substantial hypohydration because of diuresis. This study tested the hypothesis that both partial and full postimmersion rehydration would maintain performance during exercise in the heat. Seven men (23 ± 2 years; V̇o2max: 50.8 ± 5.3 ml·kg-1·min-1) completed a control trial (CON) without prior immersion and 3 immersion (18.0°C) trials without rehydration (NO) or with partial (HALF) or full (FULL) rehydration. After immersion, subjects completed a 60-minute weighted ruck march (20.4 kg; 5.6 kph) and a 15-minute intermittent exercise protocol (iEPT) in a warm environment (30.0°C and 50.0% relative humidity). The primary outcome was distance (km) covered during the iEPT. A priori statistical significance was set to p ≤ 0.05. Immersion resulted in 2.3 ± 0.4% loss of body mass in all immersion trials (p < 0.01). Distance covered during the first 13-minute interval run portion of iEPT was reduced in the NO rehydration trial (1.59 ± 0.18 km) compared with all other conditions (CON: 1.88 ± 0.18 km, p = 0.03; HALF: 1.80 ± 0.18 km, p < 0.01; FULL: 1.86 ± 0.28 km, p = 0.01). During the final 2 minutes of the iEPT, distance in the NO rehydration trial (0.31 ± 0.07 km) was reduced compared with the FULL rehydration trial (0.37 ± 0.07 km; p < 0.01) but not compared with CON (0.35 ± 0.07 km; p = 0.09) or HALF (0.35 ± 0.07 km; p = 0.08). Both partial and full postimmersion fluid replacement maintained intermittent exercise performance and should be applied as rehydration strategies.

Explicature in Translating Arabic Modern Fiction into English: Protraction and Interjection

This study aims at investigating ‘explicature’ as a quadruple norm in translating Arabic modern fiction into English on the basis of the translator’s visibility. It is to show how explicature focuses on the author’s background knowledge and appreciates the reader’s language peculiarities by means of language catalysts in parentheses (i.e. interpolations). Four levels of explicature were found out: literal, formal, usable and liberal. Protracting and interjecting the potential reader’s flow of attention, the translator’s interpolations were obligatorily filling-out or specifying, optionally text-building or aesthetic, pragmatically local or global and technically inherent or revelatory. They could be modified by either full insertion, direct replacement, reverse replacement or full deletion. As the two medial types (formal and usable) are the most notable, this quadruple model of explicature is intended to be a distinct norm in translating texts of fiction across such two completely different linguistic systems and cultural backgrounds as Arabic and English.

Production mode selection for automakers considering product substitution under the dual-credit policy

Purpose This paper aims to compare and analyze the effect of the dual-credit policy and product substitution rate on the automakers’ operational strategies under different production modes (e.g. centralized and independent), and further illustrate which production mode is more conducive to improving new energy vehicle (NEV) development.Design/methodology/approach The decision-making models for a centralized production mode where an integrated automaker produces both NEVs and fuel vehicles (FVs) and for independent production mode where an NEV automaker faces competition from a traditional FV automaker were formulated. The equilibrium solutions of each production mode were obtained by extreme value and game theory methods. The conclusions of the theoretical analysis were further verified with numerical analyses using IBM-MATLAB R2019a. Some management insights could be obtained by comparison analysis.Findings Under the dual-credit policy, an increase in the NEV credit trading price will always raise production quantity of NEVs, but only in an independent production mode where a higher trading price will also bring higher total profits to NEV automakers. In addition, only when the NEV credit trading price is high enough, a rising product substitution rate will be more favorable to NEV production and restrain FV production. Furthermore, an independent production mode is more favorable for the initial production of NEVs, but as each of the two vehicle types captures a certain amount of market share, a centralized production mode will be more conducive to the full replacement of FVs by NEVs.Originality/value The main contributions of this study include the formulation of decision-making models for FVs and NEVs in not only a centralized production mode but also an independent production mode. Moreover, this paper comprehensively analyzes how the dual-credit policy and product substitution relationship affect automakers’ production and pricing decisions. Then, the specific conditions under which each production mode is more conducive to NEV production and sales are summarized. The results proposed in this study provide scientific managerial insights for automakers and policy makers.

Preliminary Investigation on the Mechanical Properties of Carboxylated Nitrile Butadiene Rubber (XNBR) Blended with Different Loadings of Butyl Reclaimed Rubber (BRR)

Reclaimed rubber (RR) from butyl tubes was evaluated as a partial and full replacement of a virgin rubber which is carboxylated nitrile butadiene (XNBR). This study involves the blending of carboxylated nitrile butadiene rubber with butyl reclaimed rubber (XNBR/BRR) in various loadings andcured with sulfur by using a two-roll mill. The objective is to investigate the effect of RR loading on crosslink density and mechanical properties of XNBR/BRR blends. The mechanical properties such as hardness, rebound resilience, tear strength, tensile strength, elongation at break, and modulus were evaluated. In this study, the amount of reclaimed rubber varied from 0 phr to 161 phr. The results showed that the rebound resilience, tear strength, and tensile strength had a reduction of 43%, 27%, and 67%, respectively. Also, the hardness and modulus increased by 17% and 60% each. As for the elongation at break, it had a decrease of 69% and then an increment of about 77%. These results appeared due to the low molecular 1 weight of the BRR800 and the presence of processing oil and carbon black in the reclaimed rubber itself. This study could prove that reclaimed rubber can be fully utilized by putting it to good use in producing good quality rubber-based products.

Emulsified sausages with yeast protein as an animal fat replacer: Effects on nutritional composition, spatial structure, gel performance, and sensory quality

This paper investigated the effect of yeast protein (YP)-fat replacement on the nutritional composition, spatial structure, gel performance, and sensory quality of emulsified sausages. YP is enriched with essential amino acids (36.49 g/100 g), which improved the nutritional quality of sausages whereas reducing its fat content. Moreover, YP could absorb water and fat, thus the YP-added sausages exhibiting an amount-dependent increase in emulsion stability and water migration. The microstructure illustrated that YP acted as a filler to improve structural homogeneity and compactness of the pork gel network. And YP-fat replacement could significantly enhance the hardness, gel strength and elasticity of sausages whereas decreasing the viscosity. Additionally, at partial or full YP-fat replacement (25–100%), the YP-added sausages scored higher in odor and texture, as well as better antioxidant stability than controls. Overall, YP can be employed as a new fat substitute for the preparation of healthy and nutritional sausages, while maintaining the sensory quality.

Impact of Incorporating Rice Husk Ash (RHA) into Recycled Concrete Aggregates (RCA) on the Compressive and Flexural Strength of Concrete

This study aimed to assess the strength characteristics of concrete using Recycled Concrete Aggregates (RCA) as full replacement to coarse aggregates and Rice Husk Ash (RHA) as an admixture. The concrete samples were subjected to curing for 7, 14, and 28 days. Specifically, the study evaluated the workability of freshly mixed concrete and compared the compressive and flexural strength with RCA and RHA to normal concrete. Four different treatment mixtures were used with three replicates with varying ratio of RHA to cement: Treatment 1 (1 cement: ¾ RHA), Treatment 2 (1 cement: ½ RHA), Treatment 3 (1 cement: ¼ RHA). In all cases, RCA completely replaced natural coarse aggregates. The results indicated that the slump which measures the workability of the RCA concrete met the desired standard specifications. Additionally, the RCA concrete with the highest RHA content obtained the highest compressive and flexural strength on the 28th day test but did not exceed the control. Furthermore, the study revealed that the concrete specimens could handle maximum loads for flexure rather than compression load.

Maximizing the use of recycled aggregates from combined thermal/mechanical and accelerated carbonation treatment

The global emphasis on using recycled concrete aggregates (RCA) to reduce the depletion of natural resources has grown significantly. However, the presence of adhered mortar limits their usage in concrete to the coarse fraction and at low replacement rates, as complete replacement remains a challenge. This study aims to improve concrete with low-quality recycled aggregates through thermal/mechanical treatment combined with accelerated carbonation. Physical, chemical and mechanical properties of concretes with 100% coarse and fine RCA were evaluated. Results revealed that after the combined treatment the water absorption of coarse and fine RCA decreased by 18% and 6%, respectively. SEM images showed the precipitation of calcite with better crystallinity, resulting in a denser cement matrix, although water absorption and porosity were slightly improved. Furthermore, compressive and flexural strength of treated concrete achieved 91% and 96% of the control series, considering full RCA replacement and a higher w/c ratio.

Reoperations after Ross procedure: a retrospective study

Aim. To analyze the immediate outcomes of reinterventions after Ross procedure.Material and methods. From April 2009 to December 2022, 224 Ross operations in adults were performed at the Federal Center for Cardiovascular Surgery. The retrospective study included 17 patients who required repeated interventions (14 men/3 women). The mean age of the patients was 38±11 years, with a minimum age of 21 and a maximum of 54 years. A history of infective endocarditis was revealed in 4 (23,5%) patients, hypertension — in 3 (17,6%) patients. Of the 17 included patients, 15 patients underwent the classic Ross operation ("full root replacement"), while 2 — a modified technique (1 — wrapping with aorta, 1 — wrapping with a Dacron graft). Annulus enhancement was previously performed in 3 patients.Results. Interventions on the pulmonary autograft and homograft were performed in 16 and 4 cases, respectively. The main indication for pulmonary autograft intervention was aortic regurgitation in 15 cases, and neoaortic aneurysm in 14 cases. In 3 patients, there was pulmonary homograft stenosis, while in 1 case — thrombosis. Two patients required interventions on other valves: 1 — mitral valve stenosis, 1 — severe tricuspid regurgitation. Mean reoperation, cardiopulmonary bypass and myocardial ischemia time were 289±62, 126±35 and 98±22 min, respectively. Combined interventions were performed in 6 cases. David valve-sparing procedure was performed in 9 patients, Bentall-de Bono technique — in 3, aortic valve repair — in 2, mechanical aortic valve replacement — in 2, supracoronary ascending aorta replacement — in 2, pulmonary homograft replacement — in 2, pulmonary homograft thrombectomy — in 1, pulmonary homograft repair — in 1 patient, mitral valve replacement — in 1 patient, tricuspid valve repair — in 1 patient. One patient required resternotomy for bleeding. There were no postoperative complications (perioperative myocardial infarction, acute kidney injury, stroke, sternal infection, cardiac tamponade) and deaths. The median length of stay in intensive care unit was 21 [16-23] hours.Conclusion. Reoperations after the Ross procedure may be required for different pathologies, but all can be performed surgically with a high safety in experienced operator.

Bond responses and anchorage length of GFRP bar in precast recycled aggregate concrete

Precast recycled aggregate concrete (PRAC) employs precast reject-derived recycled aggregates (PRAs) and exhibits mechanical properties on par with or superior to those of natural aggregate concrete (NAC). Nevertheless, the durability of PRAC is hampered by aged mortar. To address this issue, integrating high durability glass fiber reinforced polymer (GFRP) bars into PRAC emerges as a potential solution for constructing enduring structures. Building upon this context, the study focuses on the bond responses between PRAC and GFRP bars, an area with limited existing research. Three main tasks were conducted: Firstly, a comprehensive test program involving 108 pullout samples was conducted to investigate the key variables' effects on bond failure mode and stress-slip relationship. Subsequently, an equation was developed to determine the peak bond strength of recycled aggregate concrete (RAC) based on available test data. Additionally, reliability analyses were performed to discuss the anchorage length of GFRP bar embedded in RAC. The findings are as follows: (a) The PRAC's bond capacity initially increased then decreased with rising PRA content. At full replacement, PRAC's bond strength was 28.3% lower than NAC. However, a two stage mixing approach restored PRAC's bond capacity to NAC levels. (b) Helical wrapping of the GFRP bar consistently exhibited the highest bond capacity, with an average bond strength 51% greater than a sand coated GFRP bar and 21% higher than a GFRP bar treated with both helical wrapping and sand coating. (c) Current codes specifying the critical anchorage length for FRP bar in NAC were often unsafe for RAC. Hence, a new expression, factoring in RA content, type and RAC mixing method, was proposed to determine the suitable anchorage length.

ONOMOTOPEIA AS A MEANS OF EXPRESSIVENESS IN A GRAPHIC NOVEL: SOME NUANCES OF TRANSLATION

The article is devoted to onomatopoeia as a means of expressiveness in a graphic novel, to be precise, to the peculiarities of the translation of onomatopoeic words from French into Ukrainian. The purpose of the study is to find out the characteristic traits of onomatopoeia in a graphic novel and analyze its translation strategies, compiling a mini-dictionary of onomatopoeias (language pair French — Ukrainian). In the course of the research, it was found that the graphic novel relies on a purely visual and textual component. It is the visual accompaniment of colors, text and drawing style that helps to understand how to perceive onomatopoeia in context. Such an artistic tool as a speech bubble is also responsible for conveying the meaning of onomatopoeia, so the shape, size, and style of letters must be taken into account during interpretation. When working on the translation of onomatopoeia in graphic novels, it is necessary to rely on general linguistic knowledge, analyzing the type of onomatopoeia by origin (human sounds, animal sounds, nature sounds, sounds of objects) and the meaning of formative onomatopes for a more effective selection of analogues. At the same time, the process of translation is primarily a creative process, so it is impossible to offer a specific model of work on the text. Having studied the ways of translating onomatopoeia in a number of comics about Tintin (Hergé) and in “Persepolis” (Marjan Satrapi), we came to the conclusion that the translators used the following strategies: transcription / transliteration; partial adaptation (replacement of one or two letters); complete replacement of the onomatopoeic word with a word specific to the Ukrainian language; full replacement of the word with partial replacement of the meaning; replacing the onomatopoeia with the root of the corresponding verb. Common in translation practice is the addition and removal of certain elements (onomatopoeia included), which is generally not approved, but is not a drawback provided that the author’s intention is followed. Often the translator has to combine strategies to achieve an accurate and expressive result.

Nutrient intake, digestibility, and utilization in goats fed graded levels of hempseed cake finisher diets

Globally, the price of soybean meal, the most common proteinaceous ingredient in livestock diets, has become highly expensive prompting a search for alternative ingredients. Hemp seed cake is a promising alternative but could be limited by its high neutral detergent fiber and ether extract contents which impede nutrient intake and digestibility. However, some ruminant species such as goats have superior ability to digest high fiber and ether extract diets. Thus, the current research evaluated nutrient intake and digestibility, rumen fermentation, and microbial protein synthesis of goats fed hempseed cake as a substitute for soybean meal in finisher diets. A total of 25 Kalahari Red castrates (27 ± 3 kg, 4–5 months old) were assigned to five dietary treatments (5 goats/ diet) in a completely randomized design. A maize-lucerne-based finishing diet was formulated with hempseed cake substituting soybean meal as the primary protein ingredient at 0, 25, 50, 75, or 100 g/kg dry matter. Ether extract intake exhibited a positive linear trend (P ≤ 0.05) while crude protein intake and microbial nitrogen supply exhibited a negative linear trend (P ≤ 0.05) with dietary inclusion of hempseed cake. However, feeding hempseed cake did not influence (P > 0.05) apparent nutrient digestibility, rumen fermentation parameters and nitrogen use efficiency. In conclusion, the substitution of soybean meal for hempseed cake decreased crude protein intake and microbial nitrogen supply in goat finisher diets without compromising nutrient digestibility and nitrogen use efficiency. The study recommends partial or full replacement of soybean meal with hempseed cake in goat finisher diets.

The Black Soldier Fly (Hermetia illucens) Larvae Meal Can Cost-Effectively Replace Fish Meal in Practical Nursery Diets for Post-Larval Penaeus vannamei under High-Density Culture

The black soldier larvae meal (BSFLM) has been the most extensively studied insect protein source in shrimp nutrition. However, both the availability and prices of BSFLM are still a constraint for its widespread use as an ingredient in animal feeds. The present study investigated the growth and economic performance of post-larval (PL) P. vannamei fed nursery diets with a progressive replacement of fish meal (FML) for BSFLM at 0, 25, 50, 75, and 100%. These replacements corresponded to a dietary inclusion (% of the diet, as-is) of FML and BSFLM of 16.50 and 6.33%, 11.00 and 13.04%, 5.50 and 19.74%, and 0 and 26.46%, respectively. A total of 102,647 shrimp at the age of PL15 with 2.7 ± 0.2 mg body weight (BW) were stocked in fifty 1.5 m3 tanks under 1369 PLs/m3 (2053 ± 33 PLs/tank) and reared for 42 days. Final shrimp survival (90.5 ± 7.6%), daily weight gain (14.7 ± 1.1 mg/day), and apparent feed intake (0.67 ± 0.03 g of feed per stocked shrimp) were unaffected by dietary treatment. The highest gained yield (791 ± 52 and 776 ± 38 g/m3) and final BW (621 ± 7.2 and 632 ± 7.2 mg) were attained when FML was replaced for BSFLM at 50 and 75% with the lowest at 0% (726 ± 34 g/m3 and 598 ± 8.1 mg, respectively). Shrimp fed diets with 0 and 100% replacement of FML exhibited the highest feed conversion ratio (1.25 ± 0.04 and 1.24 ± 0.08) compared to those fed a diet with 50% (1.16 ± 0.06). At a price of USD 2.00/kg, BSFLM demonstrated a favorable ROI (return of investment) when compared to FML, irrespective of the replacement level. With 25 and 50% replacement, BSFLM remained cost-competitive up to 3.50 USD/kg. At 75% FML replacement, there were no significant differences in ROI with a price range of 2.00 up to 3.04 USD/kg. At full replacement, ROI dropped significantly at a BSFLM price of 2.50 USD/kg and beyond. It can be concluded that FML can be fully replaced for BSFLM in well-balanced nursery diets for P. vannamei. Although the full replacement of FML for BSFLM was successfully accomplished, the competitive ROI was sustained only when the price of BSFLM did not exceed 3.04 USD/kg at its dietary highest inclusion of 19.74%. Further research may be necessary to fine-tune cost-effective inclusion levels of BSFLM to optimize the economic outcomes while considering the fluctuating prices of FML.

Strength and durability study on alccofine based geo-polymer concrete

Geopolymer concrete (GPC) emerging as the most innovative construction material, which not only reduces the requirement of Ordinary Portland cement (OPC) but also enhances the properties of the concrete as well, and decreases the ejection of harmful gases into the atmosphere like Carbon dioxide (CO2), Nitrogen, and Sulphur, Which is a prime concern for the environment. The need for concrete is raising uncharacteristically and so does for the OPC, to minimize the demand for OPC cementitious materials like Fly ash, Ground Granulated Blast Furnace Slag (GGBS), Silica Fume, Alccofine, Metakaolin, namely mineral admixtures used as partial or full replacements to the OPC. This present paper reports the properties of GPC made with Flyash, GGBS, and Alccofine for Mix M40- grade concrete the outcomes were contrasted with Nominal concrete which is made using 100 percent cement, Fly ash content of 50% was kept constant throughout the investigation whereas GGBS and Alccofine content varied with an interval of 5%. The concrete was tested for workability, strength, and durability aspects, an increment in the slump, and in the strength was noted, and great resistance was observed under the acid attack test for a GPC mixes, a combination of 50% Fly ash, 35% GGBS, and 15% Alccofine GPC mix was shown optimum results.

ASSESSMENT OF THE QUALITY AND SUITABILITY OF DAIRY PRODUCTS FOR PRODUCTION OF HARD CHEESE

Some aspects of feeding dairy cows and factors affecting the production of high-quality milk suitable for the production of cheeses are considered, in particular, the study of the possibility of full or partial replacement of corn silage with silage from one-year forage crops in the rations. The study was conducted on cows of the Ukrainian black and spotted dairy breed using the method of periods. In the first period (duration 36 days), in addition to the main diet, the animals were fed 25 kg of corn silage, in the second (29 days) - 17 kg of hay from one-year forage crops, and in the third (35 days) - 12 kg of corn silage + 10 kg hay one-year forage crops. The main ration consisted of cereal and legume hay, winter wheat straw, fodder beets, a mixture of grain concentrates and premix. Density, content of dry matter, fat, total protein and casein and its fractional composition, lactose, degree of bacterial contamination, coagulation time of milk under the action of rennet enzyme were determined in milk.&#x0D; At the end of each period, batches of cheese were produced, the acidity, content of dry matter, fat, protein, degree of maturity were determined in the samples, and their expert evaluation was carried out. Since for the production of high-quality cheeses, milk must meet certain organoleptic parameters, chemical composition, bacterial contamination, the article provides requirements for its quality, as well as recommended rations and composition of premixes. It has been established that for feeding cows in cheese-making areas during the stall period, it is possible to recommend partial or complete replacement of corn silage (as it contains little calcium, which causes slow rennet coagulation of milk) with hay from one-year forage crops, which will lead to improvement of the technological properties of milk (reduction of time coagulation with rennet enzyme for 4-5 minutes, increasing the yield of mature cheese by 7-8%) and will contribute to increasing the casein content in cheese (by 0.12-0.15%), k-fraction of casein (by 1.6-2.1%) and calcium, which are he main indicators of milk suitability for cheese production.

Review on new approach methods to gain insight into the feto-maternal interface physiology

Non-human animals represent a large and important feature in the history of biomedical research. The validity of their use, in terms of reproducible outcomes and translational confidence to the human situation, as well as ethical concerns surrounding that use, have been and remain controversial topics. Over the last 10 years, the communities developing microphysiological systems (MPS) have produced new approach method (NAMs) such as organoids and organs-on-a-chip. These alternative methodologies have shown indications of greater reliability and translatability than animal use in some areas, represent more humane substitutions for animals in these settings, and – with continued scientific effort – may change the conduct of basic research, clinical studies, safety testing, and drug development. Here, we present an introduction to these more human-relevant methodologies and suggest how a suite of pregnancy associated feto-maternal interface system-oriented NAMs may be integrated as reliable partial-/full animal replacements for investigators, significantly aid animal-/environmental welfare, and improve healthcare outcomes.

ХАРАКТЕРИСТИКА РАСПРОСТРАНЕННОСТИ ЗАБОЛЕВАНИЙ СЛИЗИСТОЙ ОБОЛОЧКИ РТА У ДЕТЕЙ ДОШКОЛЬНОГО ВОЗРАСТА В ЗАВИСИМОСТИ ОТ ТИПА СЕМЬИ И МОРФОФУНКЦИОНАЛЬНОГО РАЗВИТИЯ РЕБЕНКА

Introduction. The article is devoted to the study of the prevalence of oral mucosa diseases in preschool children living in the Republic of Tatarstan, taking into account family type and morphofunctional development. The subject of the study is diseases of the oral mucosa in preschool children.&#x0D; The goal is to study the effect of family type on the occurrence of oral mucosal diseases in preschool children depending on their morphofunctional development.&#x0D; Methodology. The study was carried out on the basis of the UniDent dental clinics chain, as well as in the «Fairy Tale» preschool commercial institution and municipal preschool institutions of the Republic of Tatarstan. The voluntary study involved 2,556 children of both sexes from 2,429 families. The children examined were divided into groups depending on the type of family. The study identified 5 types of families: full families, single-parent families, extended families, restored families, and replacement families.&#x0D; Results and discussion. The most vulnerable were children from the replacement families, the prevalence of which reached 100%, the least prone children from full families – 40.7%. Some of the most common diseases of the oral mucosa were acute herpes stomatitis and traumatic injuries of oral mucosa. Analysis showed that the group of 4.6–6 years recorded the highest prevalence of diseases. No significant difference was found in the study of the effect of sex on the occurrence of oral mucosa diseases.&#x0D; Conclusions. The results of the study indicate a high prevalence of oral mucosal diseases, however, the disparate prevalence of these diseases in children depending on the type of family. There were no significant gender differences in the prevalence of oral mucosal disease. The data obtained on the high prevalence of oral diseases among preschool children indicate a steady increase in dental morbidity, as well as the influence of the child's family type.

What can be done with today’s budget and demand? Scenarios of rural public transport automation in Mühlwald (South Tyrol)

Rural public transport is typically limited in its coverage, frequency and service period. This is often linked to a low and dispersed demand, which makes the provision of competitive transport services often financially unsustainable. Autonomous vehicles (AVs) might change this condition, allowing for an upgrade of public transport in rural areas. Nevertheless, current studies are mostly focused on urban areas, while the potential for rural applications remains underexplored. This paper contributes to this research line by developing a set of so-called AV scenarios for a potential upgrade of public transport in the rural study area of Mühlwald (South Tyrol, Italy). These scenarios are designed following three core principles. First, line-based and on-demand applications of AVs are not only individually tested, but even combined over space and time in different manners to exploit their synergy. Second, the performances of the scenarios are quantified by assuming the today´s agency cost budget, public-transport demand and peak-hour system capacity to be fixed parameters to comply with. Third, the uncertainties regarding the impacts of AVs on the agency costs are taken into account by defining optimistic, neutral and pessimistic variants of each scenario. Results indicate that the full replacement of current bus lines with a system of on-demand shared taxis might provide the highest performance improvements with the same budget as today, but only with a much bigger fleet. At the same time, the combination of bus lines and on-demand services over time (and space) might provide similarly competitive results while keeping the needed fleet size, service distance and service time relatively low. With this study, policy makers may get insights into the potential improvements of rural public transport that might be initially obtained with different uses of AVs, given a fixed agency cost budget and demand.