Full Dataset Research Articles

Mars Global Surveyor’s Mars Orbiter Camera (MOC) Wide‐Angle Images (1999–2006): 1. Data Processing

AbstractEarth‐based telescopes and Mars‐orbiting spacecraft have revealed Mars to be a dynamic body with periodic changes spanning hours to years, and other changes that present no discernible pattern. Understanding these surface and atmospheric variations requires observing and tracking them, and that requires global, consistent image data that spans several years. In support of that goal, the Mars Orbiter Camera Wide Angle “daily global map” images, in both red and blue, have undergone a modern processing with photometric corrections. They have been projected and blended into equirectangular and polar stereographic monochromatic and synthetic three‐color mosaics in intervals of 1 day and ΔLs = 2°, 5°, 10° (approximately 4 days, 10 days, and 2.5 weeks, respectively). The full data set presents three dimensions of Mars—location, time, and color—while ranges or values within each dimension can be combined in different ways, presenting a highly complex interplay for exploration. In this work, the methods to generate the data are presented along with an overview of the data set. In the companion paper (Robbins, 2023a, https://doi.org/10.1029/2022JE007621), several new observations are made along with replication of known, previously described phenomena.

Nuclear neutron radius and weak mixing angle measurements from latest COHERENT CsI and atomic parity violation Cs data

The COHERENT collaboration observed coherent elastic neutrino nucleus scattering using a 14.6 kg cesium-iodide (CsI) detector in 2017 and recently published the updated results before decommissioning the detector. Here, we present the legacy determination of the weak mixing angle and of the average neutron rms radius of ^{133}{textrm{Cs}} and ^{127}{textrm{I}} obtained with the full CsI dataset, also exploiting the combination with the atomic parity violation (APV) experimental result, that allows us to achieve a precision as low as sim 4.5% and to disentangle the contributions of the ^{133}{textrm{Cs}} and ^{127}{textrm{I}} nuclei. Interestingly, we show that the COHERENT CsI data show a 6sigma evidence of the nuclear structure suppression of the full coherence. Moreover, we derive a data-driven APV+COHERENT measurement of the low-energy weak mixing angle with a percent uncertainty, independent of the value of the average neutron rms radius of ^{133}{textrm{Cs}} and ^{127}{textrm{I}}, that is allowed to vary freely in the fit. Additionally, we extensively discuss the impact of using two different determinations of the theoretical parity non-conserving amplitude in the APV fit. Our findings show that the particular choice can make a significant difference, up to 6.5% on R_n(Cs) and 11% on the weak mixing angle. Finally, in light of the recent announcement of a future deployment of a 10 kg and a sim 700 kg cryogenic CsI detectors, we provide future prospects for these measurements, comparing them with other competitive experiments that are foreseen in the near future.

The QTc-Bazett Interval in Former Very Preterm Infants in Adolescence and Young Adulthood is Not Different from Term-Born Controls.

Although relevant for precision pharmacovigilance, there are conflicting data on whether former preterm birth is associated with QTc-Bazett prolongation in later life. To explore QTc-Bazett interval differences between former preterm and/or extremely low birth weight (ELBW) cases and term-born controls in adolescence and young adulthood, we analyzed pooled individual data after a structured search on published cohorts. To test the absence of a QTc-Bazett difference, a non-inferiority approach was applied (one-sided, upper limit of the 95% confidence interval [CI] mean QTc-Bazett difference, 5 and 10 ms). We also investigated the impact of characteristics, either perinatal or at assessment, on QTc-Bazett in the full dataset (cases and controls). Data were reported as median and range. The pooled dataset contained 164 former preterm and/or ELBW (cases) and 140 controls born full-term from three studies. The median QTc-Bazett intervals were 409 (335-490) and 410 (318-480) ms in cases and controls. The mean QTc-Bazett difference was 1 ms, with an upper 95% CI of 6 ms (p>0.05 and p<0.01 for 5 and 10 ms, respectively). In the full dataset, females had a significantly longer QTc-Bazett than males (415 vs. 401 ms; p<0.0001). QTc-Bazett intervals are not significantly different between former preterm and/or ELBW cases and term-born controls, and we rejected a potential prolongation > 10 ms in cases. When prescribing QTc-prolonging drugs, pharmacovigilance practices in this subpopulation should be similar to the general public (NCT05243537).

Adaptive Template Reconstruction for Effective Pattern Classification.

A novel instance-based algorithm for pattern classification is presented and evaluated in this paper. This new method is motivated by the challenge of pattern classifications where only limited and/or noisy training data are available. For every classification, the proposed system transforms the query data and the training templates based on their distributions in the feature space. One of the major novelties of the proposed method is the concept of template reconstruction enabling improved performance with limited training data. The technique is compared with similar algorithms and evaluated using both the image and time-series modalities to demonstrate its effectiveness and versatility. Two public image databases, FASHION-MNIST and CIFAR-10, were used to test its effectiveness for the classification of images using small amounts of training samples. An average classification improvement of 2~3% was observed while using a small subset of the training database, compared to the performances achieved by state-of-the-art techniques using the full datasets. To further explore its capability in solving more challenging classification problems such as non-stationary time-series electroencephalography (EEG) signals, a clinical grade 64-electrode EEG database, as well as a low-quality (high-noise level) EEG database, obtained using a low-cost system equipped with a single dry sensor, have also been used to test the algorithm. Adaptive reconstruction of the feature instances has been seen to have substantially improved class separation and matching performance for both still images and time-series signals. In particular, the method is found to be effective for the classification of noisy non-stationary data with limited training data volumes, indicating its potential suitability for a wide range of applications.

Stop filtering: Multi-view attribute-enhanced dialogue learning

There is a growing interest in improving the conversational ability of models by filtering dialogue corpora. Previous filtering strategies rely on a scoring method to assess and discard samples from one perspective, enabling the model to enhance the corresponding dialogue attributes (e.g., consistency). However, the discarded samples may achieve high scores in other perspectives and can also provide regularization effects on the model learning. In this work, we propose a multi-view attribute-enhanced dialogue learning framework that can capture the attribute-related features steadily and comprehensively. Instead of filtering the raw dataset, our framework introduces adapters to learn knowledge from the attribute-related sub-sets after pre-training the model on the full dataset. Considering the variety of dialogue attributes, we further design a multi-view enhancement mechanism, including multi-view selection and inter-view fusion. It groups the high-quality samples from multiple perspectives, respectively, and enhances different attributes of responses with the corresponding sub-sets and adapters, keeping knowledge independent and allowing flexible integration. Empirical results and analysis show that our framework outperforms the state-of-the-art data filtering methods significantly in terms of enhancing dialogue attributes and fusing view-specific knowledge.

Characterization of patterns and variability in the dynamics of outdoor aquatic mesocosms: exploring the capabilities and challenges in data supporting aquatic system models

Aquatic mesocosms are complex test systems used within regulatory risk assessment of plant protection products. These model ecosystems allow researchers to capture interactions of multiple species under realistic environmental conditions. They enable assessment of direct and indirect effects of stressors at all trophic levels (i.e., from primary producers to secondary consumers) and impacts on ecosystem functions. Due to the limited ability to test the multitude of potential exposure scenarios, cross-linking aquatic mesocosm studies with virtual mesocosms, i.e., aquatic system models (ASMs), can serve to meet the demand for more environmental realism and ecological relevance in risk assessment. In this study, full control data sets from seven aquatic mesocosm studies conducted at a single test facility under GLP were analysed graphically and using descriptive statistics. Thereby, not only a comprehensive data base but also an insight into the species present, their dynamics over time, and variability in unchallenged mesocosms was observed. While consistency in dynamics could be discerned for physical and chemical parameters, variability was evident for several biological endpoints. This variability points to amplification of small differences over time as well as to stochastic processes. The outline of existing gaps and uncertainties in data leads to the estimation of what can be expected to be captured and predicted by ASMs.

QUOTAS: A New Research Platform for the Data-driven Discovery of Black Holes

We present QUOTAS, a novel research platform for the data-driven investigation of supermassive black hole (SMBH) populations. While SMBH data—observations and simulations—have grown in complexity and abundance, our computational environments and tools have not matured commensurately to exhaust opportunities for discovery. To explore the BH, host galaxy, and parent dark matter halo connection—in this pilot version—we assemble and colocate the high-redshift, z > 3 quasar population alongside simulated data at the same cosmic epochs. As a first demonstration of the utility of QUOTAS, we investigate correlations between observed Sloan Digital Sky Survey (SDSS) quasars and their hosts with those derived from simulations. Leveraging machine-learning algorithms (ML), to expand simulation volumes, we show that halo properties extracted from smaller dark-matter-only simulation boxes successfully replicate halo populations in larger boxes. Next, using the Illustris-TNG300 simulation that includes baryonic physics as the training set, we populate the larger LEGACY Expanse dark-matter-only box with quasars, and show that observed SDSS quasar occupation statistics are accurately replicated. First science results from QUOTAS comparing colocated observational and ML-trained simulated data at z3 are presented. QUOTAS demonstrates the power of ML, in analyzing and exploring large data sets, while also offering a unique opportunity to interrogate theoretical assumptions that underpin accretion and feedback models. QUOTAS and all related materials are publicly available at the Google Kaggle platform. (The full data set—observational data and simulation data—are available at: https://www.kaggle.com/ and the codes are available at:https://www.kaggle.com/datasets/quotasplatform/quotas)

Response of Wheat, Maize, and Rice to Changes in Temperature, Precipitation, CO2 Concentration, and Uncertainty Based on Crop Simulation Approaches.

The influence of global climate change on agricultural productivity is an essential issue of ongoing concern. The growth and development of wheat, maize, and rice are influenced by elevated atmospheric CO2 concentrations, increased temperatures, and seasonal rainfall patterns. However, due to differences in research methodologies (e.g., crop models, climate models, and climate scenarios), there is uncertainty in the existing studies regarding the magnitude and direction of future climate change impacts on crop yields. In order to completely assess the possible consequences of climate change and adaptation measures on crop production and to analyze the associated uncertainties, a database of future crop yield changes was developed using 68 published studies (including 1842 samples). A local polynomial approach was used with the full dataset to investigate the response of crop yield changes to variations in maximum and minimum temperatures, mean temperature, precipitation, and CO2 concentrations. Then, a linear mixed-effects regression model was utilized with the limited dataset to explore the quantitative relationships between them. It was found that maximum temperature, precipitation, adaptation measure, study area, and climate model had significant effects on changes in crop yield. Crop yield will decline by 4.21% for each 1 °C rise in maximum temperature and increase by 0.43% for each 1% rise in precipitation. While higher CO2 concentrations and suitable management strategies could mitigate the negative effects of warming temperatures, crop yield with adaptation measures increased by 64.09% compared to crop yield without adaptation measures. Moreover, the uncertainty of simulations can be decreased by using numerous climate models. The results may be utilized to guide policy regarding the influence of climate change and to promote the creation of adaptation plans that will increase crop systems' resilience in the future.

Non-destructive recognition of copy paper based on advanced spectral fusion and feature optimization

In order to provide more clues for ongoing investigations and case handling, as well as achieve fast, non-destructive, and accurate identification of copy paper found at crime scenes, this study aims to utilize advanced spectral fusion technology to characterize and identify the three-dimensional features of the “origin-manufacturer-brand” of copy paper. Confocal Raman Microscopic and Fourier transform infrared spectroscopy were employed to collect spectral data from 200 samples from four regions (Shandong, Henan, Shaanxi, Jiangsu). The effects of different preprocessing methods, such as Hilbert transformation and deconvolution, on the model's ability to distinguish were compared. Feature variables were extracted using principal component analysis, and Bayesian discriminant classification models were constructed based on single infrared spectroscopy, Raman spectroscopy, and three types of spectral fusion datasets. By comparing the classification accuracy of different models, the primary fusion based on the full spectrum dataset was selected as the optimal model for the three-dimensional feature classification of copy paper. The accuracy achieved for origin (96%), manufacturer (100%), and brand (100%) was satisfactory, and the classification results were highly accurate. This study provides valuable insights and serves as a reference for its application in forensic science research.

Novel pneumonia score based on a machine learning model for predicting mortality in pneumonia patients on admission to the intensive care unit

BackgroundScores for predicting the long-term mortality of severe pneumonia are lacking. The purpose of this study is to use machine learning methods to develop new pneumonia scores to predict the 1-year mortality and hospital mortality of pneumonia patients on admission to the intensive care unit (ICU). MethodsThe study population was screened from the MIMIC-IV and eICU databases. The main outcomes evaluated were 1-year mortality and hospital mortality in the MIMIC-IV database and hospital mortality in the eICU database. From the full data set, we separated patients diagnosed with community-acquired pneumonia (CAP) and ventilator-associated pneumonia (VAP) for subgroup analysis. We used common shallow machine learning algorithms, including logistic regression, decision tree, random forest, multilayer perceptron and XGBoost. ResultsThe full data set of the MIMIC-IV database contained 4697 patients, while that of the eICU database contained 13760 patients. We defined a new pneumonia score, the "Integrated CCI-APS", using a multivariate logistic regression model including six variables: metastatic solid tumor, Charlson Comorbidity Index, readmission, congestive heart failure, age, and Acute Physiology Score III. The area under the curve (AUC) and accuracy of the integrated CCI-APS were assessed in three data sets (full, CAP, and VAP) using both the test set derived from the MIMIC-IV database and the external validation set derived from the eICU database. The AUC value ranges in predicting 1-year and hospital mortality were 0.784–0.797 and 0.691–0.780, respectively, and the corresponding accuracy ranges were 0.723–0.725 and 0.641–0.718, respectively. ConclusionsThe main contribution of this study was a benchmark for using machine learning models to build pneumonia scores. Based on the idea of integrated learning, we propose a new integrated CCI-APS score for severe pneumonia. In the prediction of 1-year mortality and hospital mortality, our new pneumonia score outperformed the existing score.

Minimal shift of eastern wild turkey nesting phenology associated with projected climate change

Climate change may induce mismatches between wildlife reproductive phenology and temporal occurrence of resources necessary for reproductive success. Verifying and elucidating the causal mechanisms behind potential mismatches requires large-scale, longer-duration data. We used eastern wild turkey (Meleagris gallopavo silvestris) nesting data collected across the southeastern U.S. over eight years to investigate potential climatic drivers of variation in nest initiation dates. We investigated climactic relationships with two datasets, one inclusive of successful and unsuccessful nests (full dataset) and another of just successful nests (successfully hatched dataset), to determine whether successfully hatched nests responded differently to weather changes than all nests did. In the full dataset, each 10 cm increase in January precipitation was associated with nesting occurring 0.46–0.66 days earlier, and each 10 cm increase in precipitation during the 30 days preceding nesting was associated with nesting occurring 0.17–0.21 days later. In the successfully hatched dataset, a 10 cm increase in March precipitation was associated with nesting occurring 0.67–0.74 days earlier, and an increase of one unit of variation in February maximum temperature was associated with nesting occurring 0.02 days later. We combined the results of these modeled relationships with multiple climate scenarios to understand potential implications of future climate change on wild turkey nesting phenology; results indicated that mean nest initiation date is projected to change by <0.1 day by 2040–2060. Wild turkey nesting phenology did not track changes in spring green-up timing, which could result in phenological mismatch between the timing of nesting and the availability of resources critical for successful reproduction.

Statistical analysis of hypersonic glide vehicle radar cross section

AbstractThe capability to design, manufacture and test Hypersonic Glide Vehicles (HGVs) has been demonstrated by a number of nations, and they are increasingly forming part of military inventories, potentially offering capabilities highly unique to this technology. This article reports the simulated Monostatic Radar Cross Section of a generic HGV in five frequency ranges, HF, VHF, UHF, L, and S‐bands associated with different radar types. Full spherical datasets of complex co‐ and cross‐polar data are synthesised so that backscatter resulting from illumination by r.f./microwave energy of linear or circular polarisation can subsequently be computed from the raw dataset. Circular polarisation is commonly employed by ground‐based Ballistic Missile Early Warning Systems and Space Object Surveillance and Identification radars to avoid polarisation mis‐match losses resulting from ionospheric Faraday rotation effects. The data was generated using Ansys' Finite Element Solver at 10, 150 and 430 MHz, with the Geometric Optics/Physical Optics based SBR+ solver employed for 1.3 and 3 GHz data. All data was produced at below the Nyquist sampling interval relevant to the target's electrical size. These datasets were then imported into a Matlab routine which extracted data over limited angular ranges associated with the likely radar line‐of‐sight in particular scenarios, typically having a standard deviation of ±10° about the direction of flight, applying either a Gaussian or Uniform sampling distribution as part of a Monte Carlo analysis. These extracted data were then used to form histograms giving the probability of sampling particular RCS values. Probability density functions and cumulative distribution functions were then fitted, to aid in the representation of statistical target fluctuations for each band and angular sampling range. The HGV exists in either the ‘Rayleigh’, ‘resonance’ or ‘optical’ scattering regimes, depending on its relative electrical size. The results suggest that for this target shape at HF and VHF cases a simple Swerling 0 (fluctuation invariant) approximation is adequate in most instances, whilst a Gamma distribution may be applied for UHF band cases. At L and S‐band a Beta distribution was found to provide a good fit to the available data.

Machine Learning and Bagging to Predict Midterm Electricity Consumption in Saudi Arabia

Electricity is widely regarded as the most adaptable form of energy and a major secondary energy source. However, electricity is not economically storable; therefore, the power system requires a continuous balance of electricity production and consumption to be stable. The accurate and reliable assessment of electrical energy consumption enables planning prospective power-producing systems to satisfy the expanding demand for electrical energy. Since Saudi Arabia is one of the top electricity consumers worldwide, this paper proposed an electricity consumption prediction model in Saudia Arabia. In this work, the authors obtained a never-before-seen dataset of Saudi Arabia’s electricity consumption for a span of ten years. The dataset was acquired solely by the authors from the Saudi Electrical Company (SEC), and it has further research potential that far exceeds this work. The research closely examined the performance of ensemble models and the K* model as novel models to predict the monthly electricity consumption for eighteen service offices from the Saudi Electrical Company dataset, providing experiments on a new electricity consumption dataset. The global blend parameters for the K* algorithm were tuned to achieve the best performance for predicting electricity consumption. The K* model achieved a high accuracy, and the results of the correlation coefficient (CC), mean absolute percentage error (MAPE), root mean squared percentage error (RMSPE), mean absolute error (MAE), and root mean squared error (RMSE) were 0.9373, 0.1569, 0.5636, 0.016, and 0.0488, respectively. The obtained results showed that the bagging ensemble model outperformed the standalone K* model. It used the original full dataset with K* as the base classifier, which produced a 0.9383 CC, 0.1511 MAPE, 0.5333 RMSPE, 0.0158 MAE, and 0.0484 RMSE. The outcomes of this work were compared with a previous study on the same dataset using an artificial neural network (ANN), and the comparison showed that the K* model used in this study performed better than the ANN model when compared with the standalone models and the bagging ensemble.

Making plant–pollinator data collection cheaper for restoration and monitoring

Abstract Wildflower plantings are a key tool for wild bee conservation, and plant–bee interaction data are frequently used in seed mix design to ensure that plantings provide sufficient resources for a diversity of bees. Plant–bee interaction data are also used in monitoring programmes to measure the success of bee‐supporting habitat. However, collecting plant–bee interaction data can be expensive and these data are not used by many seed mix design practitioners and monitoring programmes. Therefore, a crucial question is how does the conservation value of seed mixes vary as a function of the intensity of the data collection effort underpinning their design? We leverage a plant–bee interaction data set to ask how bee richness is expected to change when informed by different scenarios of reduced data collection effort and cost. From the original, large data set, we created subsets of data by randomly reducing (1) the number of specimens sampled, (2) the number of sites sampled, (3) the number of sampling days per site and (4) using data from a single, representative taxon (bumble bees). We ask whether seed mixes designed from these reduced data sets support comparable bee richness to the full data set, and for any reduction in cost. Reductions in the number of specimens sampled and the number of sampling days per site yield seed mixes that support comparable bee richness to the full data set. Reductions in the number of sites yielded seed mixes that support lower bee richness than the full data set. Using bumble bee interaction data only yields seed mixes that support lower bee richness than the full data set, especially when few plants are included in the mixes. Synthesis and applications. We recommend prioritizing broad spatial, temporal and taxonomic coverage of plant–bee interaction data to guide cost‐effective seed mix design. Our results also provide guidance for practitioners designing programmes to monitor bee richness in restored habitat because plant–bee interaction data may be made cheaper by collecting fewer specimens per sampling event or collecting on fewer dates per site (as long as coverage of the full bee flight season is maintained).

Estimation of PM2.5 Hourly Concentration in Sichuan Province Based on GTWR-XGBoost Model

Aerosol optical depths of satellites and meteorological factors have been widely used to estimate concentrations of surface particulate matter with an aerodynamic diameter ≤ 2.5 μm. Research on a high time resolution and high-precision PM2.5 concentration estimation method is of great significance for timely and accurate air quality prediction and air pollution prevention and mitigation. Himawari-8 AOD hour product and ERA5 meteorological reanalysis data were used as estimation variables, and a GTWR-XGBoost combined model was proposed to estimate hourly PM2.5 concentration in Sichuan Province. The results showed that:① the performance of the proposed combination model was better than that of the KNN, RF, AdaBoost, GTWR, GTWR-KNN, GTWR-RF, and GTWR-AdaBoost models in the full dataset; the fitting accuracy indexes R2, MAE, and RMSE were 0.96, 3.43 μg·m-3, and 5.52 μg·m-3, respectively; and the verification accuracy indexes R2, MAE, and RMSE were 0.9, 4.98 μg·m-3, and 7.92 μg·m-3, respectively. ② The model had a high goodness of fit (R2 of the whole dataset was 0.96, and R2 of different times ranged from 0.91 to 0.98) when applied to the estimation of PM2.5 concentration hour. It showed that the model had good time stability for hourly estimation and could provide accurate estimation information for regional air quality assessment. ③ In terms of time, the annual average PM2.5hourly concentration estimation showed an inverted U-shaped trend. It began to increase gradually at 09:00 am to a peak of 44.56 μg·m-3 at 11:00 and then gradually decreased. Moreover, the seasonal variation was very obvious, with winter>spring>autumn>summer. ④ In terms of spatial distribution, it showed the characteristics of high in the east and low in the west and a high degree of local pollution.

Using a Graph Engine to Visualize the Reconnaissance Tactic of the MITRE ATT&amp;CK Framework from UWF-ZeekData22

There has been a great deal of research in the area of using graph engines and graph databases to model network traffic and network attacks, but the novelty of this research lies in visually or graphically representing the Reconnaissance Tactic (TA0043) of the MITRE ATT&amp;CK framework. Using the newly created dataset, UWF-Zeekdata22, based on the MITRE ATT&amp;CK framework, patterns involving network connectivity, connection duration, and data volume were found and loaded into a graph environment. Patterns were also found in the graphed data that matched the Reconnaissance as well as other tactics captured by UWF-Zeekdata22. The star motif was particularly useful in mapping the Reconnaissance Tactic. The results of this paper show that graph databases/graph engines can be essential tools for understanding network traffic and trying to detect network intrusions before they happen. Finally, an analysis of the runtime performance of the reduced dataset used to create the graph databases showed that the reduced datasets performed better than the full dataset.

The first full body diffusible iodine-based contrast-enhanced computed tomography dataset and teaching materials for a member of the Testudines.

Diffusible iodine-based contrast-enhanced Computed Tomography (diceCT) is now a widely used technique for imaging metazoan soft anatomy. Turtles present a particular challenge for anatomists; gross dissection is inherently destructive and irreversible, whereas their near complete shell of bony plates, covered with keratinous scutes, presents a barrier for iodine diffusion and significantly increases contrast-enhanced CT preparation time. Consequently, a complete dataset visualizing the internal soft anatomy of turtles at high resolution and in three dimensions has not yet been successfully achieved. Here we outline a novel method that augments traditional diceCT preparation with an iodine injection technique to acquire the first full body contrast-enhanced dataset for the Testudines. We show this approach to be an effective method of staining the soft tissues inside the shell. The resulting datasets were processed to produce anatomical 3D models that can be used in teaching and research. As diceCT becomes a widely employed method for nondestructively documenting the internal soft anatomy of alcohol preserved museum specimens, we hope that methods applicable to the more challenging of these, such as turtles, will contribute toward the growing stock of digital anatomy in online repositories.

SBI++: Flexible, Ultra-fast Likelihood-free Inference Customized for Astronomical Applications

Flagship near-future surveys targeting 108–109 galaxies across cosmic time will soon reveal the processes of galaxy assembly in unprecedented resolution. This creates an immediate computational challenge on effective analyses of the full data set. With simulation-based inference (SBI), it is possible to attain complex posterior distributions with the accuracy of traditional methods but with a >104 increase in speed. However, it comes with a major limitation. Standard SBI requires the simulated data to have characteristics identical to those of the observed data, which is often violated in astronomical surveys due to inhomogeneous coverage and/or fluctuating sky and telescope conditions. In this work, we present a complete SBI-based methodology, SBI ++ , for treating out-of-distribution measurement errors and missing data. We show that out-of-distribution errors can be approximated by using standard SBI evaluations and that missing data can be marginalized over using SBI evaluations over nearby data realizations in the training set. In addition to the validation set, we apply SBI ++ to galaxies identified in extragalactic images acquired by the James Webb Space Telescope, and show that SBI ++ can infer photometric redshifts at least as accurately as traditional sampling methods—and crucially, better than the original SBI algorithm using training data with a wide range of observational errors. SBI ++ retains the fast inference speed of ∼1 s for objects in the observational training set distribution, and additionally permits parameter inference outside of the trained noise and data at ∼1 minute per object. This expanded regime has broad implications for future applications to astronomical surveys. (Code and a Jupyter tutorial are made publicly available at https://github.com/wangbingjie/sbi_pp.)

Characterizing temporal variability and repeatability of dose-dependent functional genomics approach for evaluating triclosan toxification

Dose-dependent functional genomics approach has shown great advantage in identifying the molecular initiating event (MIE) of chemical toxification and yielding point of departure (POD) at genome-wide scale. However, POD variability and repeatability derived from experimental design (settings of dose, replicate number, and exposure time) has not been fully determined. In this work, we evaluated POD profiles perturbed by triclosan (TCS) using dose-dependent functional genomics approach in Saccharomyces cerevisiae at multiple time points (9 h, 24 h and 48 h). The full dataset (total 9 concentrations with 6 replicates per treatment) at 9 h was subsampled 484 times to generate subsets of 4 dose groups (Dose A - Dose D with varied concentration range and spacing) and 5 replicate numbers (2 reps - 6 reps). Firstly, given the accuracy of POD and the experimental cost, the POD profiles from 484 subsampled datasets demonstrated that the Dose C group (space narrow at high concentrations and wide dose range) with three replicates was best choice at both gene and pathway levels. Secondly, the variability of POD was found to be relatively robustness and stability across different experimental designs, but POD was more dependent on the dose range and interval than the number of replicates. Thirdly, MIE of TCS toxification was identified to be the glycerophospholipid metabolism pathway at all-time points, supporting the ability of our approach to accurately recognize MIE of chemical toxification at both short- and long-term exposure. Finally, we identified and validated 13 key mutant strains involved in MIE of TCS toxification, which could serve as biomarkers for TCS exposure. Taken together, our work evaluated the repeatability of dose-dependent functional genomics approach and the variability of POD and MIE of TCS toxification, which will benefit the experimental design for future dose-dependent functional genomics study.

A SPectroscopic Survey of Biased Halos in the Reionization Era (ASPIRE): JWST Reveals a Filamentary Structure around a z = 6.61 Quasar

We present the first results from the JWST program A SPectroscopic survey of biased halos In the Reionization Era (ASPIRE). This program represents an imaging and spectroscopic survey of 25 reionization-era quasars and their environments by utilizing the unprecedented capabilities of NIRCam Wide Field Slitless Spectroscopy (WFSS) mode. ASPIRE will deliver the largest () galaxy redshift survey at 3–4 μm among JWST Cycle 1 programs and provide extensive legacy values for studying the formation of the earliest supermassive black holes, the assembly of galaxies, early metal enrichment, and cosmic reionization. In this first ASPIRE paper, we report the discovery of a filamentary structure traced by the luminous quasar J0305–3150 and 10 [O iii] emitters at z = 6.6. This structure has a 3D galaxy overdensity of δ gal = 12.6 over 637 cMpc3, one of the most overdense structures known in the early universe, and could eventually evolve into a massive galaxy cluster. Together with existing VLT/MUSE and ALMA observations of this field, our JWST observations reveal that J0305–3150 traces a complex environment where both UV-bright and dusty galaxies are present and indicate that the early evolution of galaxies around the quasar is not simultaneous. In addition, we discovered 31 [O iii] emitters in this field at other redshifts, 5.3 < z < 6.7, with half of them situated at z ∼ 5.4 and 6.2. This indicates that star-forming galaxies, such as [O iii] emitters, are generally clustered at high redshifts. These discoveries demonstrate the unparalleled redshift survey capabilities of NIRCam WFSS and the potential of the full ASPIRE survey data set.