AbstractMaximum sea surface salinity (SSS) anomalies are found in the central Pacific during the eastern Pacific El Niño (EPEN) and located further westward during the central Pacific El Niño (CPEN), but whether these differences affect event strengths is unclear. By performing ocean general circulation model experiments via modifying freshwater flux anomalies, we find salinity effects on surface warming during both types are highly sensitive to zonal locations of SSS anomalies, with the strongest warming induced by the SSS anomalies near the international dateline. Further analysis reveals that vertical mixing and entrainment dominate this temperature sensitivity, with the strongest response to SSS anomalies occurring in the central Pacific. The central‐Pacific SSS anomalies increase EPEN warming by 0.15°C while the westward‐located SSS anomalies make little contribution to CPEN warming. Therefore, the distinct zonal structures of SSS anomalies facilitate stronger EPEN than the CPEN, increasing their difference in intensity by about 10%.