A cheap and ecologically friendly pre-sowing method that increases germination rates and seedling vigor, which in turn enhances growth and productivity, is considered seed priming. A field experiment was conducted in 2022 in farmer’s field to evaluate the effective priming method suitable for the balanced germination, growth, and yield of maize. An experiment consists of a single-factor randomized complete block design with 3 replications and 8 treatments. The analysis of the data was conducted with R Studio software at the p <0.05 level of significance, and a mean comparison was done using DMRT (Duncan's Multiple Range Test). According to this study, seed priming increased the germination, growth, and yield of crop growth parameters such as germination percentage, germination index, days to 100% germination, stem diameter at 35 days, days to 100% tasseling, days to 100% silking, plant population/ha, number of cobs per plant, ear length, ear girth, kernels per cob, 1000 kernel weight, fresh grain yield, adjusted grain yield, fresh Stover yield, and fresh biomass yield. The highest germination percentage (98.61%) and index (11.89 days), the earliest days to 100% germination (12.00 days), early tassel emergence (63.00 days), early silking emergence (66.00 days), the highest number of kernels per cob (529.37), 1000 kernel weight (337.10 g), harvest index (0.62), ear length (22.38 mm), and ear girth (49.72mm) were recorded on the treatment primed with cow urine for 18 hours. However, the highest fresh Stover yield (2954.07 kg/ha) and fresh biomass yield (6336.29 kg/ha) are recorded on stoves primed with DAP for 18 hours. Cow-urine priming for 18 hours improved the germination and economic yield of maize. Efficient cow-urine priming is a cost-effective, eco-friendly, and finest alternative approach to increasing the maize yield.