Frequent Pauses Research Articles

Efficient Screening in Obstructive Sleep Apnea Using Sequential Machine Learning Models, Questionnaires, and Pulse Oximetry Signals: Mixed Methods Study.

Obstructive sleep apnea (OSA) is a prevalent sleep disorder characterized by frequent pauses or shallow breathing during sleep. Polysomnography, the gold standard for OSA assessment, is time consuming and labor intensive, thus limiting diagnostic efficiency. This study aims to develop 2 sequential machine learning models to efficiently screen and differentiate OSA. We used 2 datasets comprising 8444 cases from the Sleep Heart Health Study (SHHS) and 1229 cases from Taipei Veterans General Hospital (TVGH). The Questionnaire Model (Model-Questionnaire) was designed to distinguish OSA from primary insomnia using demographic information and Pittsburgh Sleep Quality Index questionnaires, while the Saturation Model (Model-Saturation) categorized OSA severity based on multiple blood oxygen saturation parameters. The performance of the sequential machine learning models in screening and assessing the severity of OSA was evaluated using an independent test set derived from TVGH. The Model-Questionnaire achieved an F1-score of 0.86, incorporating demographic data and the Pittsburgh Sleep Quality Index. Model-Saturation training by the SHHS dataset displayed an F1-score of 0.82 when using the power spectrum of blood oxygen saturation signals and reached the highest F1-score of 0.85 when considering all saturation-related parameters. Model-saturation training by the TVGH dataset displayed an F1-score of 0.82. The independent test set showed stable results for Model-Questionnaire and Model-Saturation training by the TVGH dataset, but with a slightly decreased F1-score (0.78) in Model-Saturation training by the SHHS dataset. Despite reduced model accuracy across different datasets, precision remained at 0.89 for screening moderate to severe OSA. Although a composite model using multiple saturation parameters exhibits higher accuracy, optimizing this model by identifying key factors is essential. Both models demonstrated adequate at-home screening capabilities for sleep disorders, particularly for patients unsuitable for in-laboratory sleep studies.

Prosodic changes with age: a longitudinal study with three public figures in European Portuguese

Purpose The analysis of acoustic parameters contributes to the characterisation of human communication development throughout the lifetime. The present paper intends to analyse suprasegmental features of European Portuguese in longitudinal conversational speech samples of three male public figures in uncontrolled environments across different ages, approximately 30 years apart. Participants and methods Twenty prosodic features concerning intonation, intensity, rhythm, and pause measures were extracted semi-automatically from 360 speech intervals (3-4 interviews from each speaker x 30 speech intervals x 3 speakers) lasting between 3 to 6 s. Results Twelve prosodic parameters presented significant age effects at least in one speaker. Group mean comparisons revealed significant differences between the youngest (i.e. 50 years) and the oldest age groups (i.e. 80 years) in seven parameters. The results from the analysis point to a lower and less variable fo, higher fo minimum, wider fo peaks, more vocal effort and more variable global intensity, slower speech and articulation rate, and also more frequent and longer pauses in older ages. Conclusion This longitudinal study has the potential to contribute to the characterization of the normal aging process, proving to be significant in the domains of human-machine communication, speech recognition systems, applied linguistics, or the implementation of strategies in communicative contexts with older adults

Morphological complexity as a predictor of cognitive effort in neural machine translation post-editing

Abstract This study examines how morphological complexity affects cognitive effort in neural machine translation (NMT) post-editing across six languages. Analysis of the DivEMT dataset shows that morphologically richer target languages like Ukrainian and Turkish require more editing time, keystrokes, and frequent pauses, indicating higher cognitive demands. Vietnamese, despite simpler morphology, also showed high cognitive effort, suggesting other factors like syntax influence processing load. Mean Size of Paradigm (MSP) analysis confirmed Ukrainian and Turkish’s high morphological complexity compared to isolating languages like Vietnamese. Higher error rates in morphologically rich languages demonstrate increased editing needs. While user perceptions varied, the data reveals that greater linguistic distance correlates with higher cognitive effort in NMT post-editing, showing typological divergence impacts beyond morphology alone.

The Analysis of English Teacher Talk Modification in Classroom Interaction of 2nd Grade Students at MTsN 6 Kubang Putiah

This research was due to some problems that were found in MTsN 6 Kubang Putih. First, teacher gave less pauses during her talk in the classroom. Teacher talk should be give more pauses for students’ comprehension. Second, the teacher did not do self-repeat frequently. She only does it sometimes. Self-repeat in teacher talk also need to be done frequently. Self-repeat is when the teacher repeat her sentence or word for the students to get a better understanding. This research was descriptive qualitative. , the subject of the research is the teacher and students of English class of the second grade in MTsN 6 Kubang Putih in academic year 2021. There is six class and one class consist of 30 students. The researcher focused on teacher’s talk in the classroom interaction in English class. The researcher used purposive sampling to choose the student to be interviewed or participant. The data of the present study are collected through observation in the classroom and conducting interview. The researcher found that the modifications seen in teacher talk in language classrooms, including a slower rate of speech, longer and more frequent pauses, exaggerated and simplified pronunciation, more basic vocabulary, less subordination, more declaratives and statements versus questions, and more self-repetition, were all present. This supports the findings from Chaudron and Dodu's study of modification of teacher talk in language classrooms. The findings of this research highlighted the importance of teacher modifications in language teaching. It is essential for teachers to vary their speech rate, use pauses, and stress particular words in order to emphasize the messages they are trying to communicate within the classroom. Self-repeat can aid learners in understanding the instructional content better. Additionally, teachers should incorporate simple vocabulary within their discussions, and use more declarative senteces. Modifying the teacher talk is an effective strategy in helping learners better comprehend the material being presented.

Language bursts and text quality in digital writing by young EFL learners

This study investigates the relationship between pausing and revision behaviors, as captured by pause bursts (P-bursts) and revision bursts (R-bursts), and text quality in digital L2 writing contexts among young English as a Foreign Language (EFL) learners. The study involved 22 elementary school students aged 10–11 years, with English proficiency levels ranging from A1 to A2 (CEFRL). Participants completed a picture description writing task, and their writing processes were recorded using keystroke logging software. The results revealed that frequent pauses (P-bursts) were negatively correlated with text quality, suggesting cognitive overload or difficulties in language processing. In contrast, revision bursts (R-bursts) exhibited a positive correlation with text quality, indicating that the revision process played a crucial role in refining and improving the written output. Regression analysis further demonstrated that R-bursts significantly predicted text quality, underscoring the importance of revision behavior among young L2 writers. These findings contribute to our understanding of the cognitive processes underlying L2 writing in digital contexts and highlight the central role of revisions in enhancing text quality among young EFL learners. Educational implications emphasize the need for instructional practices that encourage and support the revision process in writing instruction for this population.

A Preliminary Study on Characterizing Syntactic Processing and Pause Patterns in Bilingual English-Bahasa Indonesia Specific Language Impairment

A 12-year-old boy received a diagnosis of an unspecified "language disorder," suggesting the possibility of Specific Language Impairment (SLI) along with atypical pausing behavior. Interested to find out the possibility of incorporating pausing behavior into SLI diagnosis, this research sought to explore the distinctions in pause patterns between the spoken Bahasa Indonesia (BI) and English of Indonesian children, utilizing data from the child with suspected SLI (sSLI) and a control group for comparative analysis. Employing a quantitative approach and analyses related to phonology, syntax, and bilingual language production, the study revealed that the child with sSLI tended to display longer and more frequent pauses than the control group, particularly during communication in BI. Despite multiple influencing factors, pause patterns had the potential to serve as an indicative tool and a means to integrate bilingualism into the diagnosis of SLI.

Discursive characteristics of negative manipulative communicative demonstrativeness

The article is devoted to the concept definition of negative manipulative communicative demonstrativeness and the identification its implementation means in speech. In the course of the work, the interdisciplinary approach and the method of psycholinguistic analysis of the communicants’ speech output were used. The material for the analysis was the characters’ statements from Russian literature of the XIX century. It is established that the negative manipulative communicative demonstrativeness is a tonality of communication characterized by exaggerated negative self-presentation in the process of self-explanation, accentuation of the dominant destructive emotion, implemented to benefit from the recipient expressed by means of semiotic polymodality. The study shows that the negative manipulative communicative demonstrativeness performs attractive, expressive, influencing, entertaining, pragmatic and conative functions, implements communicative strategies of self-pity, outrage, foolishness, buffoonery, self-abasement and self-flagellation. Linguistic means of expressing this tonality are revealed: metaphorical litota, synecdoche with negative connotation, increasing negative gradation, intensifying particles-phraseological units of religious content, negative adjectives in a diminutive form, emotive interjections with the component «God», prayerful ritual utterances, rhetorical questions, antithesis (self-pity); paradox with negative connotative meaning, enhanced antithesis (shocking); negative hyperbolic tropes, reiteration, exclamation sentences (foolishness); hyperbolic comparison (buffoonery); negative epithets and prosodic units, including a quiet voice, speech with pressure, an elevated tone and frequent pausing (self-abasement); negative nouns, imperative sentences and cliched phrases with negative connotation (self-flagellation). The paralinguistic means of actualizing this tonality are indicated: phonational and kinetic demonstratives. The scientific novelty of the research is determined by the unexplored nature of the phenomenon under consideration.

A Corpus Study of Dyslexic University Students’ L2 Writing Processes

Second/foreign language (L2) writing is a critical skill for university students, and one that has attracted a great deal of attention in the literature on academic writing. Yet, one aspect that has received relatively less attention so far is the writing processes of language learners with dyslexia in this context. This study investigates the L2 writing processes of high-functioning dyslexic university students compared to their non-dyslexic counterparts, focusing on pausing and revision behaviours. The data come from a learner corpus representing the writing processes in addition to the written products. The participants are French-speaking learners of English who wrote two texts in English while keystroke logging technology captured their writing processes in real time. The analysis of the data reveals that dyslexic learners exhibit longer overall pausing time and more frequent pauses within words than the control group, indicating potential challenges with word-level processing in L2. They also exhibit longer overall revision time as well as longer mean revision duration than non‑dyslexic learners. Qualitative analysis reveals differences in editing approaches. While dyslexic learners engage in a non-linear editing process, non‑dyslexic learners follow a more linear process. These findings may be indicative of the heavy cognitive load that dyslexic students arguably experience when managing writing processes in L2 contexts.

Male and Female’s Speaking Abilities Differences in Debating Context

This study analyzed the differences in male and female speaking skills such as organization, opinion, rebuttal, sentence structure, and fluency in debate activities. This study used descriptive-qualitative methods and collected the data by using observations, audiovisual recordings, and interviews. As a result, male students were better than female students in constructing speeches, presenting their arguments, responding to opponents, organizing sentences, lexical hedges, and intensifiers in their sentences, and speaking their own words fluently. They could understand the main points, rephrase sentences, use reinforcing words, and sometimes produce pauses. On the contrary, female students were unsuccessful in delivering the main points, using unfinished sentences, repeating the sentences, using lexical hedges and intensifiers, and producing frequent pauses in debate activities. Thus, teachers should use different methods in teaching, assessing, and measuring the speaking ability of male and female students in debate activities, particularly in Speaking classes.

Advancements in Home-Based Devices for Detecting Obstructive Sleep Apnea: A Comprehensive Study

Obstructive Sleep Apnea (OSA) is a respiratory disorder characterized by frequent breathing pauses during sleep. The apnea–hypopnea index is a measure used to assess the severity of sleep apnea and the hourly rate of respiratory events. Despite numerous commercial devices available for apnea diagnosis and early detection, accessibility remains challenging for the general population, leading to lengthy wait times in sleep clinics. Consequently, research on monitoring and predicting OSA has surged. This comprehensive paper reviews devices, emphasizing distinctions among representative apnea devices and technologies for home detection of OSA. The collected articles are analyzed to present a clear discussion. Each article is evaluated according to diagnostic elements, the implemented automation level, and the derived level of evidence and quality rating. The findings indicate that the critical variables for monitoring sleep behavior include oxygen saturation (oximetry), body position, respiratory effort, and respiratory flow. Also, the prevalent trend is the development of level IV devices, measuring one or two signals and supported by prediction software. Noteworthy methods showcasing optimal results involve neural networks, deep learning, and regression modeling, achieving an accuracy of approximately 99%.

The kinesin-5 tail and bipolar minifilament domains are the origin of its microtubule crosslinking and sliding activity.

Kinesin-5 crosslinks and slides apart microtubules to assemble, elongate, and maintain the mitotic spindle. Kinesin-5 is a tetramer, where two N-terminal motor domains are positioned at each end of the motor, and the coiled-coil stalk domains are organized into a tetrameric bundle through the bipolar assembly (BASS) domain. To dissect the function of the individual structural elements of the motor, we constructed a minimal kinesin-5 tetramer (mini-tetramer). We determined the x-ray structure of the extended, 34-nm BASS domain. Guided by these structural studies, we generated active bipolar kinesin-5 mini-tetramer motors from Drosophila melanogastor and human orthologues which are half the length of native kinesin-5. We then used these kinesin-5 mini-tetramers to examine the role of two unique structural adaptations of kinesin-5: 1) the length and flexibility of the tetramer, and 2) the C-terminal tails which interact with the motor domains to coordinate their ATPase activity. The C-terminal domain causes frequent pausing and clustering of kinesin-5. By comparing microtubule crosslinking and sliding by mini-tetramer and full-length kinesin-5, we find that both the length and flexibility of kinesin-5 and the C-terminal tails govern its ability to crosslink microtubules. Once crosslinked, stiffer mini-tetramers slide antiparallel microtubules more efficiently than full-length motors.

Mouse tracking and consumer experience: exploring the associations between mouse movements, consumer emotions, brand awareness and purchase intent

ABSTRACT Consumer emotions and brand awareness are closely linked to the online advertising experience. Interactivity can enhance consumers’ engagement with social media sites and brands. However, there is a lack of research on evaluating consumers’ experience in social media interactive campaigns. To address this gap, the study proposes using mouse tracking as an unobtrusive method to collect consumers’ behavioural responses while interacting with gamified campaigns. The study involved 21 users who completed two experimental tasks, during which mouse data and explicit self-reported responses about their emotional states, brand awareness, and purchase intent were collected. Thirteen mouse features were calculated, including time between clicks, time between movements, speed, acceleration, total number of clicks, total number of movements, and total number of pauses. The study found that fast movements and a low number of actions were associated with a positive user experience in terms of brand awareness and intention to buy or recommend the product, while slow movements and long or frequent pauses were associated with negative emotions such as stress, frustration, and confusion. The findings indicate that mouse tracking can be a valuable tool for assessing brand engagement and the emotional dimensions of users’ interactions with gamified marketing campaigns.

Pausing and fluency in speech of patients with relapsing-remitting multiple sclerosis

ABSTRACT Multiple Sclerosis (MS) causes a variety of symptoms in speech production, such as more frequent pauses and an increase in the duration of pauses in the speech. However, there is almost no data on whether the disease affects speech fluency in other ways, such as changes in the frequency of disfluencies in speech. The main question of this study is the following: if we examine speech fluency in speech tasks requiring different cognitive load, will there be a difference between patients and controls? Twenty people with relapsing-remitting MS (3 men and 17 women) and 20 age- and education-matched control speakers (4 men and 16 women) participated in the study. Speech samples were recorded with each participant in three speech tasks: 1) spontaneous narratives about their own lives, 2) narratives about their previous day, and 3) narrative recalls based on a heard text. In the speech samples, pauses and disfluencies were annotated and the duration of pauses was measured. Then, the frequency of pauses and disfluencies were calculated and the types of disfluencies were examined. The results show that there are differences in the frequency and duration of pauses between people with MS and controls. However, there were no significant differences in the frequency of disfluencies between the groups. The same types of disfluencies occurred in the same frequency in both groups. The results help to better understand the speech production processes in MS.

Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes

Gain-of-function mutations in the LRRK2 gene cause Parkinson's disease (PD), increasing phosphorylation of RAB GTPases through hyperactive kinase activity. We find that LRRK2-hyperphosphorylated RABs disrupt the axonal transport of autophagosomes by perturbing the coordinated regulation of cytoplasmic dynein and kinesin. In iPSC-derived human neurons, knockin of the strongly hyperactive LRRK2-p.R1441H mutation causes striking impairments in autophagosome transport, inducing frequent directional reversals and pauses. Knockout of the opposing protein phosphatase 1H (PPM1H) phenocopies the effect of hyperactive LRRK2. Overexpression of ADP-ribosylation factor 6 (ARF6), a GTPase that acts as a switch for selective activation of dynein or kinesin, attenuates transport defects in both p.R1441H knockin and PPM1H knockout neurons. Together, these findings support a model where a regulatory imbalance between LRRK2-hyperphosphorylated RABs and ARF6 induces an unproductive "tug-of-war" between dynein and kinesin, disrupting processive autophagosome transport. This disruption may contribute to PD pathogenesis by impairing the essential homeostatic functions of axonal autophagy.

GENETICS OF STUTTERING

Stuttering is characterized by frequent repetition or lengthening of sounds, syllables or words, or by frequent hesitations or pauses that disrupt the rhythmic flow of speech. It may be accompanied by movements of the face and/or other parts of the body that coincide in time with the repetitions, prolongations, or pauses in speech flow. The prevalence of stuttering ranges from 0.3% to 5.6%. Usually for 80%-90% of patients stuttering starts gradually when children are 2-7 years old. Longitudinal research shows that 65% -85% of stuttering children recover. The rate of heritability of stuttering is about 70%, indicating that almost one third of the disorder is caused by environmental factors. Currently four stuttering genes have been identified that are involved in intracellular metabolism: GNPTAB, GNPTG, NAGPA and AP4E1. The disorder is caused by single nucleotide synonymous or missense mutations in the exons of these genes. Different people affected by stuttering can carry different sets of mutant variants ‒ from one to several. The effect of the identified genes on neurobiological processes in the human brain and on the development of stuttering remains unknown. So far it has only been discovered that stuttering occurs due to lysosomal dysfunction, which adversely affects the organization of neurofilaments of speech neural networks. The contribution of identified genes to stuttering cumulatively is only 20%. There were identified also 9 candidate stuttering genes (FADS2, PLXNA4, CTNNA3, ARNT2, EYA2, PCSK5, SLC24A3, FMN1 and ADARB2) and 7 regions of 6 chromosomes (2p, 3p, 3q, 12q, 14q, 15q and 16q) reliably linked to this disorder.
 Further successful genetic studies of stuttering are needed to improve our understanding and treatment of this long-enigmatic disorder.

Adaptative and non-adaptive phonetic variation: Clear speech and second-language speech

Two independent lines of research have revealed a somewhat surprising convergence between clear speech and second-language (L2) speech. Specifically, relative to conversational L1 speech, both clear speech and L2 speech typically exhibit slower speaking rates (fewer syllables per second), longer and more frequent inter-word pauses, and less segment- and syllable-level reduction. These phonetic features result in a general pattern of lower information density (more phonetic material produced for a given linguistic message or text) compounded by longer utterance durations to yield substantially lower information transmission rates for both clear speech and L2 speech relative to conversational L1 speech. However, clear speech and L2 speech diverge in terms of intelligibility. While clear speech is a highly effective strategy for enhancing overall intelligibility, L2 speech is typically characterized by greater likelihood of listener errors in word recognition accuracy. This pattern of convergent phonetics and divergent intelligibility highlights the complicated relationship between phonetic form and communicative efficiency. While clear speech is a listener-oriented talker adaptation to listener limitations, L2 speech reflects talker-oriented talker-listener misalignment. The phonetic similarities between these adaptative (clear speech) and non-adaptive (L2 speech) sources of variation underscore the dynamics of human speech communication with the talker-listener relation as the fulcrum.

Paclitaxel effects on axonal localization and vesicular trafficking of NaV1.8.

Patients treated with paclitaxel (PTX) or other antineoplastic agents can experience chemotherapy-induced peripheral neuropathy (CIPN), a debilitating side effect characterized by numbness and pain. PTX interferes with microtubule-based transport, which inhibits tumor growth via cell cycle arrest but can also affect other cellular functions including trafficking of ion channels critical to transduction of stimuli by sensory neurons of the dorsal root ganglia (DRG). We examined the effects of PTX on voltage-gated sodium channel NaV1.8, which is preferentially expressed in DRG neurons, using a microfluidic chamber culture system and chemigenetic labeling to observe anterograde channel transport to the endings of DRG axons in real time. PTX treatment increased the numbers of NaV1.8-containing vesicles traversing the axons. Vesicles in PTX-treated cells exhibited greater average velocity, along with shorter and less frequent pauses along their trajectories. These events were paralleled by greater surface accumulation of NaV1.8 channels at the distal ends of DRG axons. These results were consistent with observations that NaV1.8 is trafficked in the same vesicles containing NaV1.7 channels, which are also involved in pain syndromes in humans and are similarly affected by PTX treatment. However, unlike Nav1.7, we did not detect increased NaV1.8 current density measured at the neuronal soma, suggesting a differential effect of PTX on trafficking of NaV1.8 in soma versus axonal compartments. Therapeutic targeting of axonal vesicular traffic would affect both Nav1.7 and Nav1.8 channels and increase the possibilities of alleviating pain associated with CIPN.

Regulation of the phage lambda viral packaging motor's grip and DNA end-clamp mechanism

Many viruses utilize ATP-powered motors to package DNA into viral capsids. Here we use single DNA manipulation with optical tweezers and rapid solution exchange to interrogate the dynamics of DNA gripping by the phage lambda motor. Binding of poorly hydrolyzed ATP analogs results in persistent gripping and when slips occasionally occur, the release velocity is very slow, indicating significant friction between the motor and DNA. ADP induces more frequent transitions between gripping and faster slipping. Independent of nucleotides, an “end clamp” mechanism arrests slipping when the end of the DNA is about to exit the capsid. These features are qualitatively similar to those exhibited by the phage T4 motor, although there are some notable differences. Specifically, there are quantitative differences in the DNA grip/release kinetics and their dependence on nucleotides and applied force. But the most striking difference is that there are frequent long pauses during DNA exit from the capsid even in the absence of nucleotides. This pausing occurs at low capsid filling and does not increase with length of DNA packaged, indicating that it is not caused by jamming/knotting of the packaged DNA, but is attributable to fluctuation of apo-state motor subunits into a DNA gripping conformation. This finding supports our previous hypothesis that pauses which are frequently observed during packaging are caused by fluctuation of motor subunits into such a conformation. Overall, compared with T4, the lambda motor exhibits stronger interactions with DNA, which may be attributable to the small terminase subunit in the lambda packaging motor complex.

Analizing The English Teacher Talk In Efl Classroom Interaction

The study used qualitative research design. The purpose of this study was to identify and explore information about teachers' conversation in classroom interaction at SMAN 1 Banuhampu. The key informant of this research is the 11th grade English teacher at SMAN 1 Banuhampu. Furthermore, the supporting informants are the 11th grade students of SMAN 1 Banuhampu. To collect data, observation and interview were used. Based on the findings, the research questions are answered. First, what are the formal features of teachers' speech? The formal features of teachers' speech in class 11 of SMAN 1 Banuhampu are that teachers have slow speaking speed, long pauses, frequent pauses, exaggerated pronunciation, simplified pronunciation, basic vocabulary, slow level of subordination, declarative statements that are often repeated, and often independent. Furthermore, the functional features of teacher speaking in class 11 of SMAN 1 Banuhampu are that the teacher speaks the most in class I, the teacher uses teacher speech in asking questions, and the teacher also uses teacher speech in giving feedback.

KNOWLEDGE REGARDING ERGONOMICS TO PREVENT HEALTH HAZARDS OF EXTENDED COMPUTERS USAGE AMONG ADMINISTRATIVE STAFF

Introduction: The science of creating a job to fit the worker is known as ergonomics. Ineffectiveness and suffering at work stem results from disregarding ergonomic principles. Poor seating, a lack of frequent short pauses while working, and poor viewing distance all contribute to symptoms like pain, numbness, tingling, etc. in various body parts like the wrists, shoulders, back, and legs as well as eye strains. Numerous health risks can be avoided with correct workplace organisation, seat height, working posture, armrest and backrest use, wrist and elbow alignment that is straight, and keyboard positioning.
 Methodology: A self-structured knowledge questionnaire was used to collect data from 150 study participants who were chosen through the purposive sample method. To collect information about personal profile variables, a self-structured knowledge questionnaire is used. The study's results showed that the majority of participants, 60.7%, had average knowledge, 20.7% had poor knowledge, and 18.7% had good knowledge regarding ergonomics to prevent the health risks associated with prolonged computer use. Except for the length of computer stay, which was found to be statistically significant at the 0.05 level of significance, the majority of the demographic variables were not significantly associated with the level of administrative staff knowledge regarding ergonomic to prevent health hazards of extended computer usage.
 Conclusion: Study concluded that administrative staff have average knowledge (60.7%) regarding ergonomic to prevent health hazard of extended computers usage and only 18.7 % of study participants have good knowledge regarding ergonomic to prevent health hazard of extended computers usage.