Frequency Of Squamous Cell Carcinoma Research Articles

FREQUENCY OF SQUAMOUS CELL CARCINOMA IN POST BURN PATIENTS

Burn injuries, particularly those leading to chronic scars, can predispose individuals to the development of squamous cell carcinoma (SCC). The risk of malignant transformation increases with burn severity and long-term scarring. Understanding the prevalence of SCC in post-burn patients is crucial for implementing preventive and management strategies. Objective: To assess the frequency of squamous cell carcinoma (SCC) in patients with post-burn scars and evaluate associations between demographic and burn-related factors with the development of SCC. Methods: A prospective descriptive study was conducted on 70 patients with a history of burn injuries and resulting scars. The study was carried out over a defined period at a tertiary care hospital. Patient demographic variables such as age, gender, socioeconomic background, and education level were collected. The severity of burns was categorized as partial-thickness or full-thickness, and the aetiology of burns was classified as thermal, chemical, or electrical. Burn locations were also documented. Histopathological examination of biopsy specimens from suspicious scars confirmed SCC diagnosis. Statistical analysis using chi-square tests was employed to identify associations between categorical variables and SCC occurrence. Results: Of the 70 patients included, 53 were males (75.7%) and 17 females (24.3%), with a mean age of 53.97 ± 4.91 years. Full-thickness burns were observed in 57.1% of the patients, while 42.9% had partial-thickness burns. The most common burn cause was thermal (45.7%), with the lower extremities being the most affected region (57.1%). SCC developed in 8.6% (6 out of 70) of the patients. The latency period for SCC ranged between 28 and 37 years, with an average of 31.5 years. Full-thickness burns were more commonly associated with SCC development compared to partial-thickness burns. Conclusion: The study reported a frequency of 8.6% for squamous cell carcinoma in patients with post-burn scars. Full-thickness burns were associated with a higher risk of SCC development. Long-term surveillance and proactive management of burn scars are critical in preventing malignant transformations.

Trends of skin cancer incidence in Turkey: A hospital-based study

Abstract Background: The incidence of skin cancers is increasing every year. The purpose of the study was to determine the change in the incidence of skin cancers and their subtypes over the years. Materials and Methods: A total of 1507 patients who applied to the Dermatology Clinic between January 1, 2010, and January 1, 2020, and were diagnosed with Squamous Cell Carcinoma (SCC), Basal Cell Carcinoma (BCC), and melanoma were included in the study. Sociodemographic characteristics of the patients, comorbidities, tumor type, tumor number, lesion size, lymph node or organ metastasis, number of recurrences, and number of previous surgeries were recorded. Results: A total of 1056 (52.4%) patients had BCC, 733 (36.4%) SCC, and 225 (11.2%) had melanoma. The mean age was 69.8 (±14.61) in females and 67.65 (±13.33) in males (P < 0.001) at the time of diagnosis. The highest rate of recurrence was detected in 39 patients (7.1%) and the earliest recurrence time (15.77 months (±14.24) was detected in SCC (P < 0.01, P = 0.01, respectively). The mean age of skin cancer was found to be significantly lower in those who had undergone organ transplantation and those who had autoimmune diseases (P = 0.004, P = 0.008, respectively). Also, organ metastases were more common (P = 0.005), and the mean tumor size was lower in patients with autoimmune diseases (P = 0.008). Conclusion: It was found that the frequency of SCC has increased and approached BCC over the years, and the frequency of malignant melanoma has been similar. Results support that more emphasis should be placed on skin cancer screening and prevention in high-risk groups.

The Frequency of Squamous Cell Carcinoma Among Patients with Long Standing Burn Scars

The Frequency of Squamous Cell Carcinoma Among Patients with Long Standing Burn Scars

Evaluation of oral pathologic lesions in elderly patients in Isfahan, Iran, 1989-2018 years

Objective: One of the most important alterations in elderly is the destruction and loss of teeth and oral mucosal lesions. The aim of this study was to determine the frequency of biopsed pathologic lesions in elderly registered in the pathology department of Isfahan University of Medical Sciences during 1989 to 2018 years. Material and Methods: This crosssectional descriptive-analytic study was performed on pathologic lesions in elderly archived in Faculty of Dentistry, Isfahan University of Medical Sciences. In this study, all archived information of elderly over 65 years including gender, age, location of lesion, clinical diagnosis, pathology diagnosis, and diagnosis year were evaluated in last three decades, and were analyzed statistically. Results: The age range of elderly patients was 65 to 90 years with a mean of 72.8 ± 4.9. The highest frequency for location of lesions was related to mandibular vestibule (21.1%). The most clinical diagnosed lesions were squamous cell carcinoma (24.5%) and Epulis Fissuratum (13.4%). The highest pathologic diagnosed lesions were related to reactive lesions group (35.6%). The squamous cell carcinoma malignancies and other malignancies were increased significantly in elderly patients with high age. Conclusion: According to the considerable frequency of oral lesions in elderly and increased frequency of squamous cell carcinoma and other malignancies, attention to oral lesions in elderly and periodic examinations are important to early diagnosis and treatment. KEYWORDS Pathology; Biopsy; Elderly; Oral lesions; Isfahan.

Comparative proteomic analysis in serum of former uranium miners with and without radon induced squamous lung cancer

SummaryFormer uranium miners of the Wismut Company, East Germany, have been exposed to ionizing radiation from radon decay products and therefore were at high risk for lung cancer. Since histological types of cancer in the so called Wismut cohort revealed an association of high radon exposure with a higher relative frequency of squamous cell carcinoma (SqCC), we used comparative proteomic analysis to identify differentially expressed proteins in serum exposed uranium miners with SqCC.MethodePooled sera of exposed former uranium miners without lung disease and pooled sera of former uranium miners with SqCC were analysed by 2-D gel electrophoresis. MALDI-TOF-MS was performed from reproducable, significantly, at least 5-fold up-regulated protein spots. Proteins were identified by MASCOT peptide mass fingerprint search. Additionally a receiver operating characteristic curve for CYFRA 21-1 was created.ResultsThe protein spots were identified as Keratin 10 (K10), Keratin 1 (K1), complement factor H (CFH) and a haptoglobin (Hpt) fragment. The sensitivity for CYFRA 21-1 reveals 60% at a specifity of 95 and 80% at a specifity of 80%. Plotting the sensitivity against specifity reveals an AUC of 0.88.ConclusionIn SqCC Keratin 10 and 1 were strongly induced. This was associated with CYFRA 21-1, confirming the cytokeratin fragment as a tumormarker.

Epidermal Growth Factor Receptor Mutation Frequency in Squamous Cell Carcinoma and Its Diagnostic Performance in Cytological Samples: A Molecular and Immunohistochemical Study.

BackgroundEpidermal growth factor receptor (EGFR) mutation is the most frequent mutation tested in lung cancer for targeted therapy in the era of personalized medicine. Knowledge about EGFR mutation is constantly expanding regarding its frequency, clinicopathological association, advancements in testing methodology and sample requirement. We investigated EGFR mutation frequency in non-small cell lung cancer (NSCLC) in North Indian patients and evaluated its diagnostic performance in cytological samples.MethodsMolecular EGFR testing was done in 250 cases of NSCLC by both real-time polymerase chain reaction (PCR) (Therascreen) and mutation-specific EGFR immunohistochemistry (IHC). Thirty cases had both cytology samples and biopsy including 20 pleural effusions and 10 fine-needle aspirates. EGFR mutation concordance between pleural effusion and biopsy was studied.ResultsEGFR mutation was overall 31.6% in NSCLC with 36.5% in adenocarcinoma and 15% in squamous cell carcinoma. L858R mutation accounted for 50.7% and DEL19 for 39.3% of total EGFR mutations. Complex mutations were seen in 2% of cases. Sensitivity of mutation-specific EGFR IHC was 48.3% and specificity was 92.3%. L858R showed higher sensitivity (55% vs. 33.3%) but similar specificity (93.2% vs. 91.3%) compared to DEL19. EGFR mutation was successful in 95% of pleural effusion and showed 83.3% concordance with tissue biopsy.ConclusionsEGFR mutation frequency in North Indian patients was comparable to that of Asia-Pacific region and showed a similar pattern of histological distribution. EGFR mutation in squamous cell carcinomas is increasingly recognized which was 15% in our study. Mutation-specific EGFR IHC shows variable but generally low sensitivity and considering its significant pre- and post-analytical variables, it should be highly discouraged in patient management. Cytological samples may not only serve as suitable alternative but may be complementary to tissue biopsies.

Impaired functional vitamin B6 status is associated with increased risk of lung cancer.

Circulating vitamin B6 levels have been found to be inversely associated with lung cancer. Most studies have focused on the B6 form pyridoxal 5'-phosphate (PLP), a direct biomarker influenced by inflammation and other factors. Using a functional B6 marker allows further investigation of the potential role of vitamin B6 status in the pathogenesis of lung cancer. We prospectively evaluated the association of the functional marker of vitamin B6 status, the 3-hydroxykynurenine:xanthurenic acid (HK:XA) ratio, with risk of lung cancer in a nested case-control study consisting of 5,364 matched case-control pairs from the Lung Cancer Cohort Consortium (LC3). We used conditional logistic regression to evaluate the association between HK:XA and lung cancer, and random effect models to combine results from different cohorts and regions. High levels of HK:XA, indicating impaired functional B6 status, were associated with an increased risk of lung cancer, the odds ratio comparing the fourth and the first quartiles (OR4thvs.1st ) was 1.25 (95% confidence interval, 1.10-1.41). Stratified analyses indicated that this association was primarily driven by cases diagnosed with squamous cell carcinoma. Notably, the risk associated with HK:XA was approximately 50% higher in groups with a high relative frequency of squamous cell carcinoma, i.e., men, former and current smokers. This risk of squamous cell carcinoma was present in both men and women regardless of smoking status.

A clinicopathological study of surgically resected lung cancer in patients with usual interstitial pneumonia

BackgroundThe clinicopathological characteristics of lung cancer with concomitant usual interstitial pneumonia (UIP) are insufficiently understood. This study aimed to elucidate a characteristic pathological feature of lung cancer that develops in patients with UIP, with a focus on the location of its onset. MethodsWe reviewed surgically obtained specimens, including 547 tumors from 526 patients who underwent lobectomy for lung cancer. Surveyed patients were classified into three groups: patients with UIP (UIP group), patients with lung pathology other than UIP (non-UIP group), and patients without any associated lung pathology (normal group). The histology as well as the lobe and location of the onset of lung cancer were compared among these groups. The peripheral location was subdivided into subpleural, inner and tumor involved centrally secondary to extension. ResultsThe UIP group comprised 82 patients (male, 71 [87%]; mean age, 71 years; smoking rate, 94%), the non-UIP group comprised 334 patients (male, 267 [80%]; mean age, 69 years; smoking rate, 81%), and the normal group comprised 110 patients (male, 33 [30%]; mean age, 63; smoking rate, 29%). No statistical differences were noted in sex, mean age, or smoking index between the UIP and non-UIP groups. Compared with the non-UIP group, the frequency of squamous cell carcinoma (63% vs. 32%), lower lobe origin (76% vs. 32%), and subpleural location (24% vs. 5%) were significantly higher in the UIP group. ConclusionsLung cancers in patients with UIP show a predilection for the subpleural region, where UIP is also thought to originate.

Frequency of Head and Neck Squamous Cell Carcinomas and Related Variables in Southern Iran (Ahvaz City): 10-Year Retrospective Study

Objective:Squamous cell carcinoma (SCC) is a life threatening lesion but there has been only limited research about its frequency in Iran. The aim of this study was to evaluate the frequency of squamous cell carcinoma of the head and neck in the records of the pathology department of Imam Khomeini hospital in Ahvaz between 2005 and 2015.Methods:The retrospective and cross-sectional study was conducted using 55,708 medical records of cancer throughout the body, accumulated in the pathology department of Imam Khomeini in Ahvaz in the designated period. Information about age, gender, site of involvement, histological characteristics, status of lymph node metastasis, smoking habit, family history, job and education level was extracted and data were analyzed with the Chi-square test with SPSS version 22.Result:Of the total of 55,708 records, 582 patients (1.04%) had head and neck squamous cell carcinomas. The male to female ratio was 2.85. The frequencies in the head, mouth and neck were 28.7%, 22% and 49.3% respectively. Significant relationships between being male and location (neck) (p = 0.002), age (60 to 80 years old) and being a farmer (p = 0.001) was observed. The most important correlated risk factors were: smoking, sunlight exposure, rural residence, job and education level.Conclusion:Head and neck squamous cell carcinomas were found to account for 1.04% of all cancers in Ahvaz, one of the southern provinces of Iran.

Evolution of the Histo-Epidemiological Profile of Urological Cancers in Togo

Background:Urological cancers are an important public health issue and pose problems with diagnosis and adequate management in developing countries. Our aim was to determine and report epidemiological and histological features of urological cancers in Togo.Materials and methods:A retrospective descriptive study was conducted of cases of urological cancers observed in the laboratory of pathological anatomy of the CHU Tokoin over the last 4 years (2012-2016). The parameters studied were frequency, age, sex, sites of development and histological type.Results:Epidemiological data were collected for 182 cases, representing 16.4% of all cancers (1108 cases). The annual frequency was 45.5±1.1 cases on average. The male: female sex ratio was 8.6 with a mean age of 60.2 years. Regarding location, in decreasing order of frequency, the tumors were found in the prostate (n=121 cases; 66.5%), bladder (n=28; 15.4%), kidney (n=19; 10.4%), testis (n=10; 5%), penis (n=3; 1.7%) and scrotum (n=1; 0.5%). Histologically, prostate cancers were predominantly adenocarcinomas (n=116 cases; 95.8%) with a Gleason score of 6 (n=46; 39.7%) predominant. Bladder cancers were mainly squamous cell carcinomas (n=11; 39.3%) followed by transitional carcinomas (n=9 cases; 32.1%) and adenocarcinomas (n=7; 25%). Kidney cancers were predominantly nephroblastomas (n=10, 52.6%) in children and clear cell carcinomas (n=8 cases; 42.1%) in adults. Testicular cancers were Burkitt lymphomas in 5 cases. The cases of penis and scrotum cancers were all squamous cell carcinomas.Conclusion:Urological cancers are experiencing an upsurge in frequency in Togo, dominated by prostate cancer, with a high frequency of squamous cell carcinoma of the bladder due to endemic bilharziasis.

Lung Cancer in HIV Positive Patients, in the Era of Highly Active Antiretroviral Therapy

SESSION TITLE: Lung Cancer Posters SESSION TYPE: Original Investigation Poster PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM PURPOSE: With the introduction of antiretroviral therapies (HAART) the causes of mortality in HIV patients (pts) have changed considerably. The incidence of lung cancer has risen dramatically in these pts, with lung cancer being a major contributor to mortality in HIV-positive pts. Our objective was to determine the characteristics of non-small cell lung cancer (NSCLC) in HIV-positive pts and compare them with HIV-negative NSCLC pts. METHODS: We reviewed the charts of 1440 HIV-positive pts that followed at our institution's infectious disease clinic from 2000 to 2010. Demographics, CD4 counts and NSCLC characteristics were studied. RESULTS: A total of 19 (1.34%) pts with NSCLC were identified; there were more females than males (68%vs 32%). Regarding HIV infection: median (M) age of HIV diagnosis was 43 years (22-66), the most common modes of infection were heterosexual contact (53%) and IV drug use (31%). M CD4 at diagnosis was 71 (12-800). 89.5% of pts had been in HAART therapy, but only 47% were compliant with the regimen. About co-infections: 47% had hepatitis C and 21% hepatitis B. 95% were current or former smokers. In regards to NSCLC, M age at diagnosis was 50 years (43-69), M CD4 count at cancer diagnosis was 252 (13-818), 79% of the pts were stage IV at diagnosis, 84% of the pts were symptomatic at diagnosis with almost half of these pts (47%) having a prior lung infection. Adenocarcinoma was the most prevalent histologic subtype followed by squamous cell. Following cancer diagnosis, only 32% of the pts received a combination of chemotherapy and HAART therapy. Compared with HIV-positive pts, the HIV-negative pts were older at diagnosis (M age 70 years), contained fewer smokers (55%), and had a greater frequency of squamous cell carcinomas (38% vs. 16%), with only 61%of the of pts presenting with stage IV NSCLC. CONCLUSIONS: We observed a higher incidence of NSCLC in HIV-positive young females. Most of the pts presented with advanced disease and almost half of these pts had a prior lung infection. Our HIV-positive pts were 20 years younger at the time of diagnosis compared with the national median age of NSCLC diagnosis (70 years). CLINICAL IMPLICATIONS: NSCLC HIV-positive pts tend to have a worse prognosis than the general population, management can be difficult as many pts present with advanced disease and co-infections. The risk of NSCLC based on gender differences, especially among HIV-positive females requires further investigation at this could impact cancer screening in the HIV-positive population. DISCLOSURE: The following authors have nothing to disclose: Narjust Duma, Jaimie Mittal, Sobia Nizami, Mohleen Kang, David Cennimo No Product/Research Disclosure Information

The pattern of lip cancer occurrence over the 1990-2011 period in public hospitals in Madrid, Spain.

Some regions of Spain along with Canada and Australia have the highest rates of lip cancer in the world. The objective of this study was to examine the trends in the pattern of occurrence of lip cancer in Madrid, Spain. Data were extracted from the Central Tumour Registry of Madrid, between 1990 and 2011. Variables examined were age, sex, topographic and morphological location and tumour histology. Two consecutive periods, 1990-2001 and 2002-2011, were studied by descriptive and analytical methods, and the data from the two periods were statistically compared. A total of 881 cases were registered during the period 1990-2011. Comparing data between the two periods (1990-2001 and 2002-2011), subtle variations in age, histology and location were noted. Gender ratios remained constant. The mean age increased from 66.3 to 69.7 years (P < 0.05). In the second period, the histological distribution showed an increase in frequency of basal cell carcinoma, from 2.1% to 4.7%, while the frequency of squamous cell carcinomas remained constant. Basal cell carcinoma no longer predominantly occurred in women, decreasing from 80% to 21.1% (P < 0.001). The distribution by gender of squamous cell carcinoma had become more equal due an increase in its frequency in women (P < 0.001). Frequency of tumours on lip mucosa and commissure had increased between the two periods (P < 0.004). The pattern of lip cancer reported to Public Hospitals of Madrid is changing: declining rates are noted since 2001-02. However, it is necessary to monitor these data to confirm the observed trends in future years.

Frequency of squamous cell carcinoma (SCC) invasion in transected SCC in situ referred for Mohs surgery: the Dartmouth-Hitchcock experience.

Squamous cell carcinoma (SCC) in situ may be transected in a superficial biopsy, which makes it difficult to distinguish between in situ and invasive carcinoma. This study investigated the frequency of invasive SCC in transected SCC in situ referred for Mohs surgery. A retrospective chart review was performed to identify subjects with biopsy-proven, transected SCC in situ referred for Mohs surgery. The incidence of invasion, histologic variables, preoperative and intraoperative correlations, and clinical factors were determined and recorded. Of 51 cases identified, five (9.8%) were found to harbor invasive SCC, 15 (29.4%) showed SCC in situ, and 28 (54.9%) showed evidence of scarring, inflammation, or actinic keratosis at the prior biopsy site. Invasive lesions required significantly more stages of Mohs surgery to obtain tumor clearance but were similar with regard to patient age, symptoms, and family and personal histories of skin cancer. Preoperative lesion size and duration were greater in invasive cases, but these differences did not reach statistical significance. A small number of transected SCCs in situ, to which the caveat "invasion cannot be ruled out" can be applied, have an invasive component that is identified during Mohs surgery. Definitive treatment choices should depend on the physician's impression, the clinical characteristics of the lesion, tumor location, patient comorbidities, and patient desires.

Molecular variants of human papilloma virus 16 E2, E4, E5, E6 and E7 genes associated with cervical neoplasia in Romanian patients.

The aim of this study was to identify and associate the sequence variations of human Papillomavirus 16 (HPV16) genes from women who live in two different areas of Romania and associate them with malignant progression. One hundred twenty-four HPV16-positive cervical isolates were collected, and the E2, E4, E5, E6 and E7 viral genes were sequenced. Two new missense mutations in the E6 gene (C279G and A305C) were found (together or alone, in association with other mutations) in 44 of 124 cases. The most frequently simultaneously mutated genes were E4/E2 hinge, E5 and E6 (p = 0.0004) in squamous cell carcinoma (SCC) samples. Also, for SCC patients, the best-correlated mutation patterns were obtained for E4/E2 hinge-E5 (r = 0.7984; p < 0.0001). No sample was found to have all of the investigated viral genes concurrently mutated. Phylogenetic analysis was performed to characterize the viral variants. Similar results were found for SCC and cervical intraepithelial neoplasia III (CINIII) cases. After all of the target gene sequences were assembled, all patients were found to be infected with viruses of the HPV16- European-German (EG) lineage, and two clusters were identified, the first (55/96 variants) from Moldavia and the second (41/96 variants) from Bucharest. The distinct cluster derived from EG in Moldavia could partially explain the increased frequency of SCC in this area. This study has generated a comprehensive set of sequence variation data on HPV16 circulating in Romania to join the existing data and highlight the important role of HPV16 variants during cervical carcinogenesis.

Current treatment options for the management of esophageal cancer

In recent years, esophageal cancer characteristics and management options have evolved significantly. There has been a sharp increase in the frequency of esophageal adenocarcinoma and a decline in the frequency of squamous cell carcinoma. A more comprehensive understanding of prognostic factors influencing outcome has also been developed. This has led to more management options for esophageal cancer at all stages than ever before. A multidisciplinary, team approach to management in a high volume center is the preferred approach. Each patient should be individually assessed based on type of cancer, local or regional involvement, and his or her own functional status to determine an appropriate treatment regimen. This review will discuss management of esophageal cancer relative to disease progression and patient functional status.

Fatores de risco associados à ocorrência de carcinoma de células escamosas em ruminantes e equinos no semiárido da Paraíba

Neste trabalho descreve-se a frequência de carcinomas de células escamosas diagnosticados pelo Laboratório de Patologia Animal (LPA) do Hospital Veterinário da Universidade Federal de Campina Grande (UFCG) em bovinos, ovinos, caprinos e equinos no semiárido da Paraíba, durante o período de 1983 a 2010, analisando dados epidemiológicos e fatores de risco. Foi realizada a análise dos fatores de risco, mediante o teste de qui-quadrado de aderência, considerando como variáveis espécie, raça, sexo, idade e localização da massa tumoral. Durante o período foram registrados 3.153 diagnósticos provenientes de biópsias e necropsias. Destes, 81 casos (2,7%) foram de carcinomas de células escamosas. A frequência por espécie foi de 4% (42/1052) em bovinos, 2,5% (15/603) em equinos, 1,7% (12/709) em ovinos e 1,5% (12/789) em caprinos, sendo significativamente maior em bovinos (p&lt;0,001). Todos os casos apresentavam características histológicas de CCE, variando apenas o grau de diferenciação celular. Em bovinos e caprinos, a frequência do tumor foi significativamente maior em animais adultos (p&lt;0,001 e p&lt;0,005, respectivamente). Nos bovinos a localização preferencial foi em olhos e região periocular (p&lt;0,001) e nos ovinos na pele (p=0,018), principalmente na cabeça, enquanto que nas outras espécies não foram encontradas diferenças significantes na localização do tumor. Sugere-se que a maior frequência de CCE em bovinos deve-se à constituição do rebanho, formado predominantemente por fêmeas da raça Holandesa.

Squamous cell carcinoma: morphological & topographical spectrum: a two year analysis.

Squamous cell carcinoma, which is a malignant tumor of the squamous epithelium, has been a major cause of morbidity and mortality worldwide. It is a major health problem across the world and among the most common cancers seen in both Indian men and women as can be gauged from the records of the National Cancer Registry Programme. This study was undertaken to analyze the spectrum of squamous cell carcinoma cases presenting at M.Y. Hospital, Indore, during 2years between 2007 and 2008, to understand the morphological patterns of squamous cell carcinoma lesions and classify them into morphological categories given by International Classification of Diseases for Oncology (ICD-O, third edition), to analyze the anatomical site distribution pattern of squamous cell carcinoma lesions and categorize them in topographical classes given by ICD-O. Over a 2-year period, 959 cases were retrieved from the files of histopathology laboratory, department of pathology, M.G.M. Medical College, Indore. Out of total 959 cases, the maximum cases-290 (30.24%)-of squamous cell carcinoma were found between the fourth and fifth decades of life. The frequency of squamous cell carcinoma in patients older than 30years was 96.35%, while in cases of less than 30years, it was 03.65%. Most of the reported cases of squamous cell carcinoma included invasive types (i.e., 94.3%). Cases with distant metastasis constituted 4.7%, while only 1% were noninvasive or in situ. The frequency of squamous cell carcinoma presenting at our institution was highest among those involving the lip, oral cavity, and pharynx (56.50%), followed by those involving female genital organs (30.24%). The respective involvement of skin, digestive organs, and respiratory systems was 4.70, 3.86, and 2.40% in decreasing order of frequency. Frequency was least (1.05%) among the cases reported to show metastatic deposits of squamous cell carcinoma in lymph nodes. Regarding the topographical spectrum, the maximum number of cases (26.07%) of squamous cell carcinoma encountered belonged to ICD-O category C-53 (i.e., cervix). Among the morphological categories, the most frequently encountered was that of squamous cell carcinoma, keratinizing (35.2%).

Changing Patterns (Age, Incidence, and Pathologic Types) of Schistosoma-associated Bladder Cancer in Egypt in the Past Decade

To assess the patterns of schistosomiasis-associated bladder cancer in Egypt from 2001 to 2010 in a retrospective study. Bilharzial bladder carcinoma is the most common cancer, particularly in Egyptian men. Classically, carcinoma in a bilharzial bladder is most commonly of the squamous cell type. During the past decade, certain changes have occurred in the features in Schistosomiasis-associated carcinoma in Egypt with a decline in the frequency of squamous cell carcinoma and increase in the frequency of transitional cell carcinoma. This was a retrospective study of 1932 patients treated at Kasr Al Aini Hospital, Cairo University, from 2001 to 2010. Two groups were selected: group 1 included 1002 patients from 2001 to 2005 and group 2 included 930 patients from 2006 to 2010. The mean patient age increased from 41±11.2 years to 52±8.6 years, and the male/female ratio changed from 5.6:1 to 4.2:1. The incidence of associated bilharziasis decreased from 80% to 50%. A significant increased occurred in transitional cell carcinoma from 20% to 66%, with a significant decrease in squamous cell carcinoma from 73% to 25%. No difference was observed in the tumor stage or grade or incidence of lymph node metastases between the 2 groups. The pattern of incidence of the various histologic types of bladder cancer have changed, with most cases now transitional cell carcinoma, in contrast to the findings in the earlier Egyptian series. Additional studies are encouraged to explain the factors explaining these changes.

The incidence of non-melanoma skin cancer after a single field treatment with aminolevulinic acid and blue light photodynamic therapy

e14646 Background: Non-melanoma skin cancer (NMSC) is the most common form of human cancer. Aminolevulinic acid photodynamic therapy (ALA PDT) is a safe and effective treatment for NMSC precursors. It is unknown if ALA PDT treatment will affect incidence of NMSC in high risk patients (pts). Methods: A retrospective study was undertaken using a Veteran Affairs Boston Health Care System Medical Record Database. Study population included immunocompetent pts with history of NMSC, multiple actinic keratosis (AKs), and moderate to severe dermatoheliosis (DH). Study pts received a single application of 20 % ALA to the face or scalp following by exposure to blue light at 10 J/cm2. Differences in incidence of NMSC two years prior and two years after ALA PDT were tested using the Wilcoxon rank sum test. Data were analyzed by the median and interquartile range (IQR). Results: 43 Caucasian males (range 59- 87 yrs), 37 (87%) had history of NMSC on the face or scalp, 32 (78%) had basal cell carcinoma (BCC), 11 (22%) squamous cell carcinoma (SCC), 100% of patients had multiple (&gt;4) AKs prior to treatment and 23 (75% ) had moderate to severe DH determined by Griffiths scale. Prior to ALA-PDT 74 NMSC's were documented: 40 (54%) BCC and 34 (46%) SCC. 46 NMSC's were documented following ALA-PDT: 22 (48%) BCC and 24 (52%) SCC. Prior to ALA-PDT, the frequency of BCC averaged 2 [IQR 1 to 3, max=4], and the frequency of SCC averaged 1 [IQR 1 to 1, max=3]. Following ALA-PDT, the occurrence of BCC averaged 1 [IQR 0 to 1, max=5], and that of SCC averaged 1 [IQR 0 to 2, max= 4]. The difference between BCC frequency before and after ALA-PDT treatment shown a significant reduction in BCC incidence (P = 0.0018). No such differences were observed between the frequency of SCC before and after ALA-PDT (P=0.6230) Conclusions: A single ALA-PDT treatment to the face or scalp in high risk patients significantly reduces the incidence of BCC, the incidence of SCC was not reduced. The potential role of ALA PDT as a NMSC chemopreventive modality warrants further investigation in larger samples with an alternative treatment protocols. No significant financial relationships to disclose.

Treatment of advanced non-small cell lung cancer in the elderly: Spanish Lung Cancer Group (SLCG) experience

18012 Background: The number of elderly patients (p) with cancer continues to increase. Approximately two-thirds of p diagnosed with non-small cel lung cancer are &gt; 65 years (y), and nearly 50% are &gt; 70 y. The aim of our study was to discern whether clinical characteristics, toxicity, response rate, treatment and survival are different in p &lt; 70 y vs p = 70 y. Methods: We reviewed the database of 6 SLCG clinical trials with different doublet combinations from 2000 to 2005 Results: Of 1653 p included, only 280 p (17% ) were = 70 y. No significant differences were found between the two groups with respect to gender, stage, response rate or histology. However, a higher frequency of squamous cell carcinoma was found in p = 70y. No differences were found in median number of cycles administered. The only significant difference was found in the higher frequency of grade 3–4 neutropenia among p = 70 y. (Table) Conclusions: p = 70 y were a small percentage of all p included in these clinical trials. However, outcome and toxicities were similar in p = 70y vs &lt;70 y, and “fit” elderly p can be treated with standard doublets. Further research is warranted on genetic differences for customizing treatment in this population. [Table: see text] No significant financial relationships to disclose.