Frequency Of Hypertensive Disorders Research Articles

COVID-19 infection and hypertension disorders during pregnancy

The objective: to determine the impact of COVID-19, which occurred before or during pregnancy, on the frequency of development and features of the course of gestational hypertension and preeclampsia.Materials and methods. An observational retrospective study with parallel control one was conducted. The pregnancy course and its outcomes in 178 women during the period of the COVID-19 pandemic – from March 2020 to January 2022 – who were observed in the women’s consultation of a private medical center, were analyzed. It is important to note that the medical documentation was taken one after the other, without being specially selected according to any principle, that is, the analysis carried out had the character of continuous screening.Out of 178 pregnant women, 125 (70.2%) persons were sick with COVID-19, they were included in the main group; 53 (29.8%) women who were part of the comparison group did not get sick. The groups are comparable by age and body mass index. The age of the women was 19–51 years; in the main group – 30.5±4.9 years, in the comparison group – 30.9±5.6 years. Body mass index (kg/m2) at the beginning of pregnancy in women of the main group was 21.6±4.3; comparison group – 22.9±4.8. There were 104 (58.4%) primigravida, 74 (41.6%) – multigravida. 117 (65.7%) women were primipara, 61 (34.3%) – multipara.All pregnant women were performed with a standard examination in accordance with the Order No. 417 of the Ministry of Health of Ukraine dated 15.07.2011. Clinical and anamnestic risk factors for the development of preeclampsia were assessed in all women without exception, on the basis of which 3 women were assigned to the risk group. In addition, 158 (88.8%) pregnant women as part of the first combined screening had an additional examination to determine the risk of developing preeclampsia, as a result of which additional 23 women were included in the risk group. As a result, 26 (14.6%) pregnant women from 12 weeks of gestation were prescribed prophylaxis using acetylsalicylic acid.Results. In women who have had COVID-19, hypertensive disorders of pregnancy develop statistically significantly less often than in those who have not had the disease. After mildly symptomatic COVID-19 the risks of hypertensive disorders in pregnant women are statistically significantly reduced: gestational hypertension – RR=1.15, 95% CI: 1.0–1.3; preeclampsia – RR=1.1, 95% CI: 1.0–1.2, all hypertensive disorders – BP=1.3, 95% CI: 1.1–1.6.The groups did not differ among themselves in the prevalence of generally accepted risk factors. The frequency of hypertensive disorders depending on the vaccination was analyzed. The risk of gestational hypertension in vaccinees who did not suffer from COVID-19 is reduced by 1.4 times (RR=1.4, 95% CI: 1.0–1.9), the risk of all hypertensive disorders in pregnant women in this same group is reduced 2 times (RR=2.0, 95% CI: 1.2–3.5).The development of preeclampsia also probably depends on the vaccination status (χ2=4.0; p=0.04; φ=-0.17). In non-vaccinated persons it increases by 1.1 times (RR=1.1, 95%CI: 1.2–1.8). The risk of all hypertensive disorders is also higher in the group with a negative vaccine status (RR=1.3, 95%CI: 1.0–1.7) only at the level of significance p=0.06, that is, it appears as a certain tendency.Conclusions. Hypertensive disorders associated with pregnancy are less likely to develop in women who have experienced COVID-19 in the preconception period or during pregnancy. Vaccination against COVID-19 reduces the frequency of hypertensive disorders in pregnant women, regardless of the disease presence.Since immune mechanisms, along with placental-vascular mechanisms play a significant role in the pathogenesis of preeclampsia, let’s assume that the experienced coronavirus infection or vaccination against it disrupts certain links of immunity, which results in a decrease in the frequency of hypertensive disorders in pregnant women.

The role of monoamines in the development of complicated pregnancy in chronic arterial hypertension

In the Russian Federation, the frequency of hypertensive disorders during gestation is 7-29%, while 80% of cases are chronic arterial hypertension. The mechanism of the complicated course of pregnancy in hypertensive disorders is not clear and is debatable. The article presents the features of the monoamine status in pre-pregnant women with chronic arterial hypertension.

Endometrial preparation does not affect the risk of hypertensive disorders of pregnancy in low-risk women undergoing frozen embryo transfer

Objective Frozen embryo transfer (FET) is associated with a higher risk of hypertensive disorders in pregnancy. The objective of the present study is to evaluate the effect of different protocols of endometrial preparation on the risk of these disorders. Methods We conducted a retrospective cohort study on 594 singleton pregnancies achieved by embryo transfer of single frozen-thawed blastocysts. Women with preexisting risk factors for hypertensive disorders were excluded. Women were divided into two groups according to the endometrial preparation protocol: either natural cycle (n = 495) or programming cycle with hormonal replacement therapy (n = 97). The primary outcome was the frequency of hypertensive disorders in pregnancy: specifically, gestational hypertension and preeclampsia. Results No differences emerged between women following the natural cycle and those following the programming cycle in the frequency of gestational hypertension (5 vs. 4%) and preeclampsia (1.1 vs. 1.2%). No impact emerged also after multivariate analyses. Conclusions Women receiving hormonal replacement therapy have the same risk of gestational hypertension and preeclampsia as women following natural cycles when considering low-risk singleton pregnancies.

Factors Associated with Pregnancy Outcomes in Hypertensive Pregnant Women in a District Hospital in Benin

Introduction: Hypertension is a major cause of maternal and perinatal morbidity and mortality. This study aims at exploring the outcomes of pregnancy and associated factors in hypertensive pregnant women in Come district hospital from 2014 to 2016. Methods: This is a retrospective, analytical study carried out in June 2016, involving a total of 345 hypertensive patients. Socio-demographic and medical features, including pregnancy and foetal outcomes parameters, were recorded in the case files. Top-down stepwise logistic regression was performed at the 5% threshold. Results: The frequency of hypertensive disorders during pregnancy was estimated at 7.32% and unfavourable outcomes at 35.65%. The adverse maternal outcomes recorded were postpartum death and haemorrhage whereas adverse foetal issues were prematurity, low birth weight, low Apgar scores, stillbirth and death. Factors statistically associated with pregnancy outcome were paucigravida (OR = 2.01 ([1.05 - 3.88]), p = 0.035), history of stillbirth (OR = 4.75 ([1.01 - 22.1]), p = 0.048) and anticonvulsant therapy (OR = 0.32 ([0.19 - 0.54]), p < 0.001). Conclusion: Adequate monitoring via Antenatal Care (ANC) check-ups, timely recourse to care and an effective communication strategy should reduce hypertensive disorders incidence and adverse outcomes in pregnant women.

HYPERTENSIVE DISORDERS IN PREGNANT WOMEN SUBJECT TO THE CLIMATE CHANGE

Based on the analysis of the world literature, it turned out that climate change in the direction of warming worsens pregnancy and perinatal outcomes. However, the results of numerous studies conducted in different parts of the world to study the correlation between ambient temperature, relative humidity and intensity of sunlight, as well as the frequency of hypertensive disorders during pregnancy, are contradictory. Despite differences in results, a tendency to a higher incidence of preeclampsia is observed during the cold months. An explanation in support of this theory would be that more low temperatures affect the incidence of preeclampsia and eclampsia, increasing the vasospasm inherent in the disease. Recognizing the exact relationship with different weather conditions can help you understand what factors may be involved in the launch of these processes. These studies are particularly relevant in the conditions of Tajikistan, where the mass of extragenital diseases present in pregnant women in the region is also joined by the climate warming factor. Keywords: Hypertensive disorders, pregnancy, climate, seasonality.

The frequency of hypertensive disorders during pregnancy in maternal deaths in Isfahan Province, Iran

BACKGROUND: The findings of incidence or prevalence studies can help managers and policy makers evaluate the degree of changes and its relation with the performed interventions. This study aimed to determine the frequency of hypertensive disorders during pregnancy in maternal deaths that occurred during 2006-10 in Isfahan Province, Iran. METHODS: This descriptive, cross-sectional study assessed all maternal deaths that occurred during 2006-10 in Isfahan. Data was collected by reviewing available documents using a checklist whose validity has been approved by experts. Data was analyzed by descriptive statistics and chi-square and Fisher's exact tests in SPSS 12 . RESULTS: In total, 58 women who had died due to complications of pregnancy and childbirth were studied. The mean age of the subjects was 30.2 ± 6.5 years (range: 17-45 years). From 22.4% of maternal deaths which were due to gestational hypertension, 92.3% were preeclampsia and eclampsia. One case of chronic hypertension (7.7%) was also observed. Other types of hypertension in pregnancy were not detected. The first direct cause of maternal death was hypertension disorders. Underlying diseases (36.2%) and bleeding (18.9%) were the other major causes of death. CONCLUSION: The number of deaths caused by blood pressure disorders, as a direct and important factor in maternal deaths, reduced during the 5-year course of study. In order to improve pregnancy outcomes, measures should be taken for early detection and diagnosis of these disorders. Keywords: Hypertension, Pregnancy, Maternal Mortality Rate, Preeclampsia, Eclampsia

O605 The effect of mean monthly relative air humidity and temperature on the frequency of hypertensive disorders of pregnancy in Recife, northeastern Brazil

O605 The effect of mean monthly relative air humidity and temperature on the frequency of hypertensive disorders of pregnancy in Recife, northeastern Brazil