Relative Frequency Research Articles

Detecting stochasticity in population time series using a non‐parametric test of intrinsic predictability

Abstract Many ecological systems dominated by stochastic dynamics can produce complex time series that inherently limit forecast accuracy. The ‘intrinsic predictability’ of these systems can be approximated by a time series complexity metric called weighted permutation entropy (WPE). While WPE is a useful metric to gauge forecast performance prior to model building, it is sensitive to noise and may be biased depending on the length of the time series. Here, we introduce a simple randomized permutation test (rWPE) to assess whether a time series is intrinsically more predictable than white noise. We apply rWPE to both simulated and empirical data to assess its performance and usefulness. To do this, we simulate population dynamics under various scenarios, including a linear trend, chaotic, periodic and equilibrium dynamics. We further test this approach with observed abundance time series for 932 species across four orders of animals from the Global Population Dynamics Database. Finally, using Adélie (Pygoscelis adeliae) and emperor penguin (Aptenodytes forsteri) time series as case studies, we demonstrate the application of rWPE to multiple populations for a single species. We show that rWPE can determine whether a system is significantly more predictable than white noise, even with time series as short as 10 years that show an apparent trend under biologically realistic stochasticity levels. Additionally, rWPE has statistical power close to 100% when time series are at least 30 time steps long and show chaotic or periodic dynamics. Power decreases to ~10% under equilibrium dynamics, irrespective of time series length. Among four classes of animal taxa, mammals have the highest relative frequency (28%) of time series that are both longer than 30 time steps and indistinguishable from white noise in terms of complexity, followed by insects (16%), birds (16%) and bony fishes (11%). rWPE is a straightforward and useful method widely applicable to any time series, including short ones. By informing forecasters of the inherent limitations to a system's predictability, it can guide a modeller's expectations for forecast performance.

Etiology and characteristics of non-aneurysmal thunderclap headache presenting to an acute setting

ObjectivesTo describe the characteristics and causes of non-aneurysmal thunderclap headache (TCH) and compare serious from benign underlying causes. MethodsRetrospective cohort study of consecutive adult patients with TCH presenting to a tertiary care academic medical center between 2010 and 2020. Aneurysmal subarachnoid hemorrhage cases were excluded. Cases were categorized into serious or benign; serious TCH was defined as any condition in which delayed diagnosis and treatment could result in neurological disability or death. Risk factors for serious TCH were analyzed. We adhere to standardized guidelines for reporting observational studies. ResultsA total of 932 patients presented with TCH. After exclusion of 393 patients with aneurysmal-type subarachnoid hemorrhage, 539 were included in the analysis. One-half (n = 275, 51.0 %) had a serious cause. Median age was 51 years, 69.0 % were female. Most frequent diagnoses were intracranial hemorrhage (n = 102, 18.9 %), reversible cerebral vasoconstriction syndrome (n = 97, 18.0 %), and idiopathic TCH (n = 102, 38.6 %). A multivariable logistic regression model for prediction of serious TCH included age, hypertension, migraines, recurrent TCH, level of consciousness and other clinical exam findings, and achieved an AUROC of 0.732. This score had a sensitivity of 79.9 % (95 % CI 73.5–83.5 %) for the identification of serious TCH. A 0.5-point increase in the risk score was associated with a 73 % increase in the odds of serious TCH (odds ratio 1.73, 95 % CI 1.53–1.95, p < 0.001). ConclusionOur study describes the relative frequency of presentation and etiologies among patients with TCH This score can aide clinicians in recognising patients with potentially serious cause of TCH, for whom additional imaging and neurological consultation is necessary.

Data collection methods for patient-reported outcome measures in cancer randomised controlled trials: a protocol for a rapid scoping review

BackgroundThere are different modes and ways to assess patient-reported outcomes (PROs) in clinical trials. However, there is little systematic information on how often different modes of assessment (MOA) are used...

Ethnobotanical survey of medicinal and ritual plants utilized by the indigenous communities of Benguet province, Philippines

BackgroundThe Sto. Niño site in Benguet province, Philippines was once a mining area that has now been transformed into an agricultural land. In this area, there has been significant integration of the three indigenous people (IPs) Ibaloi, Kankanaeys and Kalanguyas with the Ilocano community. These IPs safeguard biodiversity and traditional knowledge, including medicinal plant use. However, the documentation of these plant species and their medicinal applications has not been systematic, with the resultant loss of knowledge across generations. This study aims to document the medicinal and ritual plants used by the indigenous communities at the site, in order to preserve and disseminate traditional medicinal knowledge that would otherwise be lost.MethodsEthnobotanical data were collected in Sto. Niño, Brgy. Ambassador, Municipality of Tublay, Benguet, Philippines, and collected through semi-structured interviews, together with focus group discussions (FGD). A total of 100 residents (39 male and 61 female) were interviewed. Among them, 12 were key interviewees, including community elders and farmers, while the rest were selected through the convenience and snowball technique. Demographic information collected from the interviewees included age, gender, and occupation. Ethnobotanical information collected focused on medicinal plants, including the specific parts of plants used, methods of preparation, modes of treatment, and the types of ailments treated. Ethnobotanical quantitative indices of the relative frequency of citations (RFC) and informant consensus factor (ICF) were calculated to evaluate the plant species that were utilized by the community.ResultsA total of 28 medicinal plants from 20 different families and 6 ritual plants from 5 different families were documented. Asteraceae, Poaceae, and Lamiaceae (10.71%) family are the most mentioned medicinal plant species, followed by Myrtaceae and Euphorbiaceae (7.14%). The most widely used growth form were herbs (46.4%), while leaves (61.5%) were the most utilized plant part, and the preparation of a decoction (62.2%) was the most preferred method of processing and application. The medicinal plants were most commonly utilized for wound-healing, cough and colds, stomachache and kidney trouble, whereas ritual plants were largely used for healing, protection, and funeral ceremonies.ConclusionThis study marks the first report on the medicinal and ritual plants used by a group of indigenous communities in Sto. Niño, Brgy. Ambassador, Tublay, Benguet Province. The data collected show that plant species belonging to the Asteraceae, Poaceae, and Lamiaceae family were the most mentioned and should be further evaluated by pharmacological analysis to assess their wider use for medicinal treatment.

Legendary fermented herbs: an ethnobotanical study of the traditional fermentation starter of the Chuanqing people in Northwestern Guizhou, China

BackgroundPlants that contain brewing microorganisms are used in traditional fermentation starters, which are an essential part of local diet, nutrition, life, and health. Regionally, the plant species used and the microorganisms included in traditional fermentation starters are diverse, endowing local fermented drinks with different flavors and health benefits. However, related traditional knowledge has been scarcely documented or revealed.MethodsAn ethnobotanical survey was conducted in five towns of Nayong County in northwestern Guizhou, China. Snowball sampling, semi-structured interviews, free lists, and participatory observation were used to collect information on Jiuqu Plants (JPs) and jiuqu-making techniques. The PacBio platform was used to study the microbial community structure and diversity in the Chuanqing people’s jiuqu.ResultsIn total, 225 informants were interviewed, including 116 who provided plants and technological processes for making Chinese baijiu jiuqu (CBJ) and 139 who provided information about making fermented glutinous rice jiuqu (FGRJ). This study found that older people have more abundant knowledge about CBJ plants. Poaceae was found to be the dominant family used in making CBJ and FGRJ (7 species each). Compared to individual plant parts, the whole plant is most commonly used in two kinds of jiuqu (19.5% in CBJ and 22.6% in FGRJ). The Chuanqing people’s jiuqu is used to treat dietary stagnation and indigestion. The highest relative frequency of citation of the CBJ plant was Ficus tikoua Bureau, and the counterpart of the FGRJ plant was Buddleja macrostachya Benth. The dominant bacterial species in jiuqu were Gluconobacter japonicus (YQ1, YQ4) and Pediococcus pentosaceus (YQ2, YQ3), and the dominant fungal species was Rhizopus oryzae.ConclusionFor the first time, this study documents the unique traditional jiuqu knowledge and reveals the microbial mystery behind the FGRJ of the Chuanqing people.Therefore, this study encourages the use of online social media platforms in order to spread Jiuqu culture, the use of the new media wave in order to create multimedia databases, and also suggests that local communities should develop preservation intervention programs, in addition to nurturing the inheritors in order to prevent the disappearance of traditional Jiuqu knowledge. This research contributes to the conservation and demystification of the traditional jiuqu knowledge of the Chuanqing people and lays the foundation for further research on its microbiology, nutrition, and metabolomics.

Investigating the Reasons behind Companion Animal Relinquishment: A Systematic Content Analysis of Shelter Records for Cats and Dogs, 2018-2023.

The relinquishment of companion animals to shelters presents significant challenges for animal welfare organizations and has substantial implications for the well-being of both the animals and their owners. This study aims to investigate the reasons for voluntarily relinquishing animals to shelters, to examine species-specific differences (cats and dogs), to compare initial relinquishments to returns (re-relinquishments or readmissions), and to identify potential changes over a 6-year period framing the onset of the COVID-19 pandemic. A retrospective analysis of owner relinquishment records from an open admission shelter in the US was conducted using content analysis, a novel approach in this area of research. A total of 13 relinquishment reason categories were identified, as well as 9 separate categories for specific behavioral issues. Among 2836 randomly selected records, the most frequent reasons cited were Behavior Issues (28%), Housing/Moving (18%), Unable to Care (16%), Too Many Pets (10%), Financial (6%), and Owner Allergies (5%). The most common behavioral reasons reported were Aggression (32% of behavioral surrenders), Social Conflict (28%), and Soiling (13%). However, differences were observed in the pattern of relinquishment reasons based on statistical analyses of species, type of relinquishment, and year. Regarding temporal trends, Housing/Moving and Financial reasons were not found to have changed significantly since the pandemic, but the relative frequency of the category Unable to Care increased significantly in 2022 and 2023. Collectively, these findings partially replicate those from research spanning the past several decades in this area that has employed less systematic methodology and can further be used to help identify and understand the primary drivers of owner relinquishments.

Impaired Periodontitis-Induced Cytokine Production by Peripheral Blood Monocytes and Myeloid Dendritic Cells in Patients with Rheumatoid Arthritis: A Case-Control Study.

Background: Immune cells from rheumatoid arthritis (RA) patients display a reduced in vitro response to Porphyromonas gingivalis (P. gingivalis), which may have functional immune consequences. The aim of this study was to characterize, by flow cytometry, the frequency/activity of monocytes and naturally occurring myeloid dendritic cells (mDCs) in peripheral blood samples from patients with periodontitis and patients with periodontitis and RA. Methods: The relative frequency of monocytes and mDCs in the whole blood, the frequency of these cells producing TNFα or IL-6 and the protein expression levels for each cytokine, before and after stimulation with lipopolysaccharide (LPS) from Escherichia coli plus interferon-γ (IFN-γ), were assessed by flow cytometry, in peripheral blood samples from 10 healthy individuals (HEALTHY), 10 patients with periodontitis (PERIO) and 17 patients with periodontitis and RA (PERIO+RA). Results: The frequency of monocytes and mDCs producing IL-6 or TNF-α and the expression of IL-6 and TNF-α in the PERIO group were generally higher. Within the PERIO+RA group, P. gingivalis and related antibodies were negatively correlated with the monocyte and mDC expression of IL-6. A subgroup of the PERIO+RA patients that displayed statistically significantly lower frequencies of monocytes producing IL-6 after activation presented statistically significantly higher peptidylarginine deiminase (PAD)2/4 activity, anti-arg-gingipain (RgpB) IgG levels, mean probing depth (PD), periodontal inflamed surface area (PISA) and bleeding on probing (BoP). Conclusions: In the patients with PERIO+RA, innate immune cells seemed to produce lower amounts of pro-inflammatory cytokines, which are correlated with worse periodontitis-related clinical and microbiological parameters.

Adesão ao uso da estratégia NutriSUS para fortificação alimentar infantil em municípios de Goiás

Introduction: The high demand for nutrients in children under five years of age, added to low nutritious diets, makes them vulnerable to micronutrient deficiencies. The NutriSUS Strategy, launched as part of the School Health Program (PSE) in 2014, aims to combat these deficiencies through the distribution of micronutrient sachets. The effectiveness of this strategy in Goiás, considering the weaknesses in the municipalities, needs to be evaluated. The objective of this study was to verify adherence to the NutriSUS Strategy in municipalities in the state of Goiás and the list of sachets used by agreed and added day care centers. Methods: A retrospective observational study analyzed data on micronutrient supplementation provided by the NutriSUS Strategy in the state of Goiás, between 2017 and 2019. The database available on the Ministry of Health website was used to identify adherence and coverage of the program in 10 regional health departments. The inclusion criteria were municipalities that implemented the strategy during the period studied, while those that did not adhere or did not show interest were excluded. The analysis was performed using absolute and relative frequencies in the EPI Info 7.2.6.0 program. Results: The NutriSUS Strategy was implemented in 35 (14.23%) of the total municipalities (n=246). Micronutrient supplementation targets were constant throughout the period from 2017 to 2019, with some cities, such as Araguapaz, Britânia, and Santa Helena de Goiás, exceeding their supplementation targets in some of the periods, while others, such as Aragarças, Hidrolândia, Piracanjuba, São Luís de Montes Belos, and Buriti Alegre, did not reach the expected targets. The analysis, by semester of supplementation coverage in daycare centers, showed significant fluctuations: a drop in 2017 from 45.44% to 32.60% from the first to the second semester. In 2018, the percentage was 34.43% in the first half of the year, but there was a significant increase to 52.37% in the second half of the year. In 2019, coverage rose to an average of 61.63% in the first half, followed by a drop to 35.74% in the second half. The data also revealed variations in standard deviation, reflecting fluctuations in program adherence. Conclusion: The NutriSUS Strategy showed a variable implementation in the municipalities of Goiás in the period studied, with fluctuations in supplementation coverage over time. The analysis highlighted both success in some locations and difficulties in others, highlighting the importance of continuously monitoring and adjusting supplementation strategies to ensure that all counties adequately benefit children from micronutrient supplementation.

[Artículo traducido] Características clínicas y sociodemográficas de la alopecia areata en 5 ciudades colombianas: un análisis del RENAAC

BackgroundAlopecia areata (AA) is an autoimmune disease characterized by non-scaring hair loss and preservation of hair follicles. The information available on disease course, and clinical features of AA is scarce worldwide, and almost nonexistent in Colombia. ObjectiveTo determine the clinical and sociodemographic characteristics of patients diagnosed with AA who presented to a dermatology consultation in five Colombian cities. Material and methodsThis was a retrospective and multicenter study on data from an ongoing National Registry of Alopecia Areata in Colombia (RENAAC) collected in Bogota, Cali, Cartagena, Barranquilla, and Medellin, Colombia from March 2022 through April 2023. Data was recorded in a standardized form by trained physicians. The variables were expressed as measures of central tendency and dispersion, and absolute and relative frequencies. ResultsA total of 562 patients were included, 59.4% of whom were women, aged between 15 and 49 years (63.9%) with a mean disease course of 1.7 years. The most common finding was multiple plaque (53.2%), the predominant AA subtype was patchy (71.4%), and 29.5% of the patients had a past dermatological history, 18.3% had a past endocrinological history, and 8.9% had a past psychiatric history. The treatments most widely used were steroid injections (76.4%), 5% topical minoxidil (46.4%), followed by high-potency corticosteroids (42.5%). Study limitations and conclusionsAA was slightly predominant in women. As seen in other populations, this disease had an earlier onset in men vs women. Presentation in pediatric age was uncommon. The previous history of other dermatological diseases was checked in almost one third of the patients. Analysis of the co-presentation of AA with other autoimmune diseases is biased due to excluding patients with systemic erythematous lupus from the study.

Competencies displayed by multinational corporation senior managers in critical business situations

PurposeThis research investigates the types of critical business situations worked on by multinational corporations' senior managers and the competencies they employ to achieve desired outcomes.Design/methodology/approachThe research is based on a database of N = 440 critical success incidents obtained from semi-structured interviews with a sample of 143 senior managers during competency-based consulting projects over a 25-year period from 1995 to 2019. Content analysis was used to categorise critical success incidents, by similarity of business intent, into groups labelled as critical business situations. Behavioural coding was used to identify competencies.FindingsNine critical business situations were found, and 10 competencies identified, accounting for 79% of behaviours displayed by the senior managers. Five competencies were found to be used more universally and five were more dependent on the specific critical business situation.Research limitations/implicationsThis research provides an overview of the initial stage of this topic. Further empirical validation including applicability in contemporary business contexts, testing of competency relationships with critical business situation criterion-referenced outcomes, and temporal and geographic usage will be presented in an accompanying study.Practical implicationsKnowledge of the specific competencies and their relative frequencies when displayed in different critical business situations provide the potential to give more targeted development suggestions to senior managers facing similar situations.Originality/valueThis study examines concurrently, both the business situations and associated competencies of senior managers, a group for whom extant research is significantly limited.

How Do Off-Season Cover Crops Affect Soybean Weed Communities?

Weeds compete for environmental resources, leading to reduced soybean yield. In this context, integrated weed management strategies related to cultural control with the use of cover crops are necessary. Our aim was to evaluate weed occurrence in soybean systems with different cover crops. Field studies were conducted at Júlio de Castilhos, Santa Maria, Capão do Leão, Barra do Ribeiro, and Santo Ângelo, Rio Grande do Sul, Brazil. A randomized complete block design with four replications was used. Treatments consisted of black oats (Avena strigosa Schreb.), white oats (Avena sativa L.), rye (Secale cereale L.), hairy vetch (Vicia sativa L.), forage turnip (Raphanus sativus L.), and white clover (Trifolium repens L.) in pure stands or in mixtures. The analyzed variables were relative frequency, density, abundance, and importance value index, similarity index of weeds, dry shoot mass of cover crop, and soybean yield. Cover crops containing white or black oats reduced the relative importance value index of weeds, such as Lollium multiforum, Conyza spp., and Bidens pilosa. Forage turnip, hairy vetch, and white clover showed distinct responses. Black oats and forage turnip did not differ from cover crop mixtures in terms of dry shoot mass and grain yield, being superior to fallow, white clover, and hairy vetch.

Coexistence of 21 Hydroxylase Deficiency and Autoimmune Adrenalitis: A Case Report

Abstract21-Hydroxylase deficiency (21 OHD) is the most common cause of congenital adrenal hyperplasia (CAH). Despite its relative frequency, many aspects of this disease are understudied. The aim of our case report was to highlight the association between nonclassic CAH (NCCAH) and autoimmunity, and to encourage future research to explore the possible cause-and-effect relationship between CAH and tumorigenesis. Here, we report the case of a 41-year-old woman with a history of nonclassic 21 OHD, who demonstrated typical signs of acute adrenal insufficiency. As it is well known, this is an unusual presentation of NCCAH and therefore a panel of laboratory and radiological exams were conducted in order to determine the associated etiology of the adrenal insufficiency, which revealed to be autoimmune adrenalitis. Another striking particularity of our case is the coexistence of NCCAH and cutaneous T lymphoma in our patient, which to our knowledge has never been reported in literature. This case illustrates the need to scrutiny for the etiology of adrenocortical crisis in the setting of NCCAH. It also emphasizes the possible associations between NCCAH and autoimmunity in one hand and neoplasms on the other hand.

Ethnobotanical diversity, phytochemical screening and biological evaluation of selected medicinal mushrooms species

The current study was aimed to investigate the ethno-pharmacology, diversity, biological potentials of different mushrooms species from District Swabi, Pakistan. Ethno-pharmacological data was collected from 73 respondents based on interview, group discussion and field visits. Quantitative analysis such as informant consent factor (ICF), Use value (UV), Relative Frequency of Citation (RFC) were done. Morphological identification of mushrooms, extract preparation, phytochemical screening and statistical analysis of data was conducted. Phytochemical analysis of six mushroom species revealed that saponins, alkaloids, glycosides, flavonoids and phenols were present in six selected mushrooms, while tannin and steroids (−) present in Agaricus arvensis. In Morchella conica only steroids (−) was absent, Qunion (−) in Polyporus tuberaster, Pleurotus ostreatus and Omphalotus olearius were found absent. Moisture contents (10.17 ± 1.27) and crude fats (5.26 ± 1.50) present in Omphalotus olearius. Highest content of crude fibers (26.57 ± 0.86) and carbohydrates (62.18 ± 0.73) were found in Pleurotus ostreatus. Highest ash contents (12.62 ± 0.46) were reported in Polyporus tuberaster. The respondents’ consensus factor values ranged from 1.66 to 61.74 in which highest ICF value was 61.74 while the lowest was 1.66. The high RFC was recorded forAgaricus (0.67) while lowest RFC was observed in Clitocybe frondasa (0.05). The results of analgesic activity were compared to the diclofenac (Standard drug). The extracts of aqueous and methanolic extract were most active at the level of (400 mg/kg). As antipyretic agents, methanolic and aqueous extracts of Agaricus species were analyzed for anti-inflammatory activity compare to diclofenac (Standard drug) where the aqueous (200 mg/kg) and methanolic (400 mg/kg) were found to be very active. Finally, mushrooms with high (ICF and UV) were further investigated for phytochemicals and pharmacological analysis which revealed significant biological potentials. This provides basic ground information which can be used to explore novel mushroom-based medicines for the treatment of various diseases. The commercial cultivation of mushrooms represents a promising opportunity to leverage their diverse health benefits and nutritional properties. By prioritizing research and cultivation methods while educating the public, the potential of mushrooms as vital components of both nutrition and medicine can be significantly realized, impacting health outcomes and contributing to sustainable agricultural practices.

Item-validity analysis of the SED-S in a multicentre study of adults with intellectual disabilities.

Valid and reliable instruments for measuring emotional development are critical for a proper diagnostic assignment in individuals with intellectual disabilities. This exploratory study examined the psychometric properties of the items on the Scale of Emotional Development-Short (SED-S). The sample included 612 adults with intellectual disabilities (Mage = 37.35, SDage = 13.27; 59.8% males). Item validity analysis comprising sensitivity and specificity rates and discriminatory power were determined. The relative mean frequency of 'yes' answers to all 200 items was 29.5%. The mean sensitivity rate was 67.5% and the mean specificity rate was 79.3%. Most items (85.0%) showed good discriminatory power with the adjacent stage(s), especially between SED-1, SED-2, SED-3 and SED-4. Particularly in SED-4 some items showed weaknesses in the differentiation between these stages. This study adds to previous validation studies by showing that most SED-S items have psychometrically sound properties.

Plant-based fish analogues vs. fish: Assessment of consumer perception, acceptance, and attitudes

Plant-based fish is developed to mimic the taste, texture, and appearance of fish. Despite being the fastest-growing segment in plant-based analogues sales, it remains a niche product due to several hindrances, including sensory and nutritional issues. This study assessed consumer perception, attitudes and acceptance drivers of plant-based canned tuna involving 165 consumers who evaluated for liking and described through the Check-All-That-Apply method five plant-based and three animal-based samples. Consumers’ food neophobia level, food related lifestyles and food frequency consumption of a series of plant-based and animal-based products were investigated as potential explanatory variables in drivers of acceptance. Generalised linear models showed that plant-based samples scored very low (<40 VAS score), while animal-based products were well accepted (63.6 – 75.2). Principal Coordinate Analysis revealed that pink colour, tuna/fish flavour, and dryness characterised tuna samples and contributed positively to liking, while unappealing appearance, off-flavour, legume/vegetable flavour, bitterness, gelatinous and gumminess, characterised plant-based samples and contributed negatively to liking. Agglomerative hierarchical analysis identified two consumer clusters differing in liking for plant-based fish analogues. One cluster (27 % of consumers) showed significantly higher liking scores for all plant-based samples, a higher consumption of plant-based analogues and seemed more careful when buying food, both regarding its nutritional composition and its naturalness than the other cluster. This study suggests that the exploitation of plant-based ingredients (textured soy, pea and wheat proteins) affect all sensory dimensions of plant-based canned tuna and highlights the importance of sensory optimisation in the development of plant-based alternatives to meet consumer preferences.

Orbital Lesions: A bird's eye view of series of 2068 cases in 27 years in a tertiary care hospital in Pakistan.

To determine the relative frequency of orbital lesions based on the site of origin and histopathology at a Tertiary care hospital (Mayo Hospital, Lahore Pakistan) from 1996 till 2022 (27 years). This descriptive case series included 2651 patients of all age groups presenting with orbital lesions who initially got enrolled at Institute of Ophthalmology Mayo Hospital, Lahore from 1996 till 2022. Of these, 583 patients left against medical advice. So, clinical data of 2068 patients were completely analyzed. Lesions were managed medically and/ or surgically. Final clinical diagnosis, with the help of histopathology, was used to classify the lesions. There were 1258 (60.9%) adults and 810 (39.1%) children, 1358 (65.66%) were neoplastic while 710 (34.33%) non-neoplastic lesions. Amongst the neoplastic lesions, 405 (29.8 %) were benign and 953 (70.2%) malignant. Primary orbital lesions were 1676 (81.04%), Secondary orbital lesions were 300 (14.51%), Endocrine/ hematopoietic reticulo-endothelial system lesions were 84 (4.06%) and Metastatic lesions from distant organs were 08 (0.39%). Retinoblastoma, rhabdomyosarcoma, optic nerve gliomata were common in children. Pleomorphic adenoma & adenocystic carcinoma of lacrimal gland, cavernous hemangioma, optic nerve meningioma, neurofibroma, schwannoma, squamous cell carcinoma of eyelid, carcinoma of maxillary antrum and lymphomas were more common in adults.

Systematic scoping review of cluster randomised trials conducted exclusively in low-income and middle-income countries between 2017 and 2022

ObjectiveCluster randomised trials (CRTs) are used for evaluating health-related interventions in low-income and middle-income countries (LMICs) but raise complex ethical issues. To inform the development of future ethics guidance, we...

Clausal Postpositioning in German Regional Language

This article presents the results of a corpus study of clausal postpositioning, that is, the occurrence of a sentential constituent in the postfield of the matrix clause to which it is syntactically linked, in German regional language. Analysis of 11,027 clauses from 60 spoken regiolect and dialect texts reveals that clausal postpositionings occur most frequently as non-relative finite clauses, followed by relative clauses, and lastly, infinitival constructions. Notably, while non-relative finite clauses comprise a smaller proportion of postpositionings in regiolect compared to dialect, relative clauses and infinitival constructions show the opposite trend. Adjunct clauses occur most frequently, followed by complement clauses, in both regiolect and dialect. Furthermore, in both varieties, postpositioning is more prevalent in verb-first and verb-second clauses than in verb-final clauses. This finding is attributed to restrictions on syntactic subordination. Finally, non-relative finite clause and relative clause types that may be embedded in both the postfield and inner field are center-embedded at mean relative frequencies of 13.42% and 28.17%, respectively. These findings shed light on contradictory claims in the literature regarding the possibility and frequency of clausal embedding in the inner field.

Socio-Economic Impact of Ethnobotanical Appraisal of Traded Medicinal Plants on Local Communities of District Astore (Gilgit Baltistan)

Medicinal plants are the only possible solution to treat various complications of human beings. The local community of district Astore, Gilgit Baltistan are dependent on medicinal plants for their primary healthcare. The present study was conducted to identify and document the medicinal uses of traded medicinal plants and to assess their socio-economic impact and current status in the respective area. A total of 26 traded medicinal plants were explored from the various villages as informed by the experienced respondents. The collected plants were pasted on herbarium sheets for identification purpose. Ethno medicinal uses were also documented and the collected data was analyzed by using statistical indices i.e. Use value, Relative frequency citation, Fidelity level and Pearson correlation coefficient. Questionnaire survey was conducted and 80 respondents were interviewed to assess the socio-economic impact and current status of traded medicinal plants. The most frequent used part of medicinal plant was leaves followed by roots and seeds. The RFC (0.88) and UV (0.98) were recorded highest for Thymus linearis. The Pearson correlation coefficient value between RFC and UV was 0.944, indicating a strong relationship between RFC and UV. Survey results showed that the traded medicinal plants played a pivotal role by enhancing socio-economic condition of local communities. Findings also indicated that the traded medicinal plants are gradually decreasing due to anthropogenic activities like improper method of collection, illegal trade, unsustainable use and lack of protection and conservation measures.

Cross-cultural study on the uses of traditional herbal medicine to treat various women's health issues in Northeast India

BackgroundThis cross-cultural study conducted in the diverse regions of Assam, Meghalaya, and Manipur sheds light on the common utilization of five specific medicinal plants among indigenous communities residing in these areas. ObjectivesThe main focus of this study is to document and compare the traditional medicinal plant used and the knowledge and practices related to women's health issues in different cultures; to identify commonalities and differences in the use of medicinal plants across cultures and various medicinal plants used traditionally by the indigenous communities to treat women's health problems according to their indigenous name, scientific name. Materials and methodsThe study used a survey method and a pre-structured interview schedule through one-on-one interactive communication and field observation. The authors collected data from three different states, i.e., Assam (Karbi Anglong district & Udalguri district), Meghalaya (East Khasi Hills district), and Manipur (Senapati district) by personally meeting and interacting with traditional herbal medicinal practitioners. For this study, 10 practitioners from each area of study were interviewed. During the data collection process, the vernacular name of the medicinal plant, methods of preparation, mode of application, and probable dosage were compiled and documented involving practitioners belonging to four different communities, i.e, Bodo, Karbi, Khasi, and Poumai Naga of the selected states. ResultsA total of 39 plant species were meticulously collected and documented across the Karbi Anglong district and Udalguri district in Assam, East Khasi Hills district in Meghalaya, and Senapati district in Manipur. Turmeric (Curcuma longa), ginger (Zingiber officinale), gooseberry (Emblica officinalis), papaya (Carica papaya), and passion fruit (Passiflora edulis) have emerged as common medicinal resources within these communities. Poaceae, represented by 5 species, emerged as the dominant family among the collected plants, highlighting the diversity and significance of these botanical remedies. Zingiber officinale Roscoe " has the highest usage report of 18 with an RFC (Relative frequency citation) of 0.45. ConclusionThe study's findings reveal a rich repository of traditional herbal knowledge in the northeast regions of India. Notably, the indigenous communities of these regions use plant resources to cure a wide range of ailments. This study emphasizes the necessity of documenting, preserving, and transmitting traditional herbal medicinal knowledge for both cultural and practical reasons. It also provides vital insights into the importance of cross-cultural study in promoting different cultures, the richness of traditional medicinal knowledge by engaging with diverse cultures and demonstrates the possibilities for incorporating traditional medicine into modern healthcare systems, particularly in treating women's health issues across these culturally diverse regions.