French-Canadian Research Articles

Clinical Expression of Familial Hypercholesterolemia in Patients from France and French Canada Carrying Identical-by-Descent Pathogenic LDLR Gene Variants: A Proof-of-Concept Study.

Background: Studying patients carrying identical-by-descent (IBD) pathogenic gene variants allows us to control for the disease-causing genetic background and to more accurately document the impact of modifiers. Familial hypercholesterolemia (FH) is characterized by elevated low-density lipoprotein cholesterol (LDL-c) levels and premature atherosclerosis and is often caused by defects in the LDLR gene. There is a high prevalence of FH in French Canada as a result of a founder effect from France in the 17th century. Several FH patients currently living in French Canada (founder population) and in France (colonizing population) carry IBD FH-causing variants. The expression of FH is affected by environmental and genetic modifiers, and patients with IBD variants may present different characteristics. Methods: In this study, we compared FH clinical expression patients carrying IBD LDLR pathogenic variants living in France or Canada. Four IBD variants, namely c.259T>G p.(Trp87Gly), c.2000G>A p.(Cys667Tyr), c.682G>A p.(Glu228Lys), and c.1048C>T p.(Arg350*), were selected. Untreated plasma lipid profiles, the apolipoprotein E (APOE) genotype, cardiovascular risk factors, and the occurrence of symptomatic ASCVD were compared in 105 adult carriers (30 from France and 75 from French Canada). Results: All parameters were similar between the two populations, except for untreated total cholesterol (10.14 ± 1.89 mmol/L vs. 8.65 ± 1.84 mmol/L, p = 0.0006) and LDL-c concentrations (7.94 ± 1.86 mmol/L vs. 6.93 ± 1.78 mmol/L, p = 0.016), which were significantly higher in FH patients living in France, an observation that was revealed across all studied LDLR variants. Conclusions: This study illustrates that FH patients sharing IBD pathogenic LDLR variants that have evolved in different geographic, cultural, and socio-economic environments for hundreds of years differ in terms of cholesterol levels, highlighting the importance of better understanding the interplay between genetic and environmental modulators of FH expression.

Étienne Parent, the Demise of the Mixed Constitution, and the Rise of Liberalism of Government in French Canada

Abstract Between the adoption of the Act of Union in 1840 and the British North America Act in 1867, French-Canadian elites had to reconceptualize the nature and virtues of the British constitutional system. Étienne Parent, an early defender of the ‘mixed constitution’ and one of the most influential thinkers among French-Canadian reformists, turned to the civil service to give the new constitutional regime a stable foundation. His theory of the ‘sovereignty of intelligence’ borrowed French liberal ideas to build a distinct model of constitutionalism out of British constitutional institutions. Parent’s thought also exemplifies how the idea that the constitution is the principal integrative force of the polity continued to shape French-Canadian constitutional imaginary in the mid-nineteenth century. Recovering this dynamic and historical approach to constitutionalism sheds light on this distinct constitutional model, obscured by the later influence of AV Dicey and his retrospective interpretation of nineteenth-century constitutionalism. Putting the emphasis on the administration, Parent’s theory of the ‘sovereignty of intelligence’ offered a form of government liberalism which differed from the liberalism associated with parliamentary sovereignty, and republicanism and popular sovereignty. In many respects, Parent participated directly in the consolidation of the constitutional model he defended, and his thought allows us to recapture the synergy and generative tension between the cabinet and the civil service that endures in the contemporary constitutional practices of Westminster parliamentary systems.

25-year comparison of coronary lesions anatomy and burden in two cohorts of French Canadians with familial hypercholesterolemia

25-year comparison of coronary lesions anatomy and burden in two cohorts of French Canadians with familial hypercholesterolemia

W8banaki Subsistence Patterns During the 18th and 19th Centuries at the Fort Odanak Site, Québec, Canada

ABSTRACT Built in the early eighteenth century on the banks of the Saint-François River (Québec, QC, Canada), the fortified Jesuit mission of Saint-François-de-Sales was an important W8banaki centre during the colonial period. Between 2010 and 2021, archaeological excavations conducted by the W8banaki Nation led to the discovery of the mission’s remains at the Fort Odanak site (CaFe-7) in the historical centre of the village of Odanak. They revealed numerous pit features (used for food storage or refuse disposal), post moulds and hearths, along with diverse artifact assemblages. The analysis of plant macro-remains found in six pits and two hearths at the site was undertaken to document the evolution of culinary practices at the mission and to reconstruct the local environment and its exploitation by the mission’s inhabitants. Results suggest the persistence of traditional Indigenous subsistence patterns during the eighteenth and nineteenth centuries as well as the integration of European foods into the Abenaki diet via trade and close contact with Canadien (i.e. French Canadian) farmers in the region.

Tracking uncertainty in germline genetic testing for hereditary cancer syndromes: Sources, attributes, and resolution of variants of uncertain significance in over 1 million individuals.

10513 Background: Genetic testing for hereditary cancer syndromes has diagnostic, prognostic and therapeutic implications; however, variant(s) of uncertain significance (VUS) are not clinically actionable. As such, VUS are a challenge to the entire medical community. Additionally, individuals from underrepresented race, ethnicity, and ancestry (REA) groups are disproportionately impacted by VUS. This study reports on the prevalence of VUS in patients referred for genetic testing for hereditary cancer syndromes and the results of reclassification. Methods: Patients were referred for diagnostic multigene panel testing for hereditary cancer from September 2014 to September 2022. Variants were classified as benign (B), likely benign (LB), VUS, likely pathogenic (LP), or pathogenic (P) using Sherloc, a validated system based on guidelines from ACMG/AMP. Both the number of unique VUS (uVUS) and the number of times they were observed in individuals (oVUS) were counted. All-time uVUS were separated as being reclassified and non-reclassified, and the relative contribution of evidence types used for reclassification was analyzed. Results: During this 8-year period, 1,122,444 unrelated individuals were tested for hereditary cancer with a mean number of 53 genes tested per individual. Results showed a mean of 0.45 oVUS per individual; 30.6% of individuals without a P/LP variant had at least 1 oVUS. The rate of oVUS normalized to the number of genes tested was highest in French Canadian and lowest in Ashkenazi Jewish individuals, as the mean number of genes sequenced to observe one VUS was 39.8 and 59.4, respectively. White individuals had a lower oVUS rate of 31.4% than Sephardic Jewish (53.8%), Asian (48.3%), Black (40.5%), Hispanic (37.6%), and additional underrepresented REA groups. In total, 7,542 (7.3%) of 103,767 uVUS were reclassified, affecting 88,877 individuals (7.9%); 5,864 (77.8%) of the reclassified uVUS were downgraded to B/LB, and 1,678 (22.2%) were upgraded to LP/P. Evidence from clinical observation contributed the most for upgrading uVUS (16.0-fold compared to non-reclassified uVUS), while evidence from experimental studies contributed the most to downgrading uVUS (23.9-fold). Conclusions: Experimental studies and clinical evidence were the most impactful types of evidence for reclassifications. This highlights the partnership among researchers, clinicians, and laboratories to resolve VUS. Further representation of diverse REA groups in genomic databases is needed to address the disparities in VUS rates, and additional research is needed into methods that could expedite the resolution of VUS so that patients can make more informed decisions.

La téléconsultation, une modalité prometteuse pour les programmes psychoéducatifs destinés aux parents d’enfants ayant un trouble du spectre de l’autisme

The disclosure to parents of a diagnosis of Autism Spectrum Disorder (ASD) for a child has an impact on their mental health and well-being. Programs have been established to support them. One of these programs, “Beyond ASD, parenting skills within my reach!”, created in Quebec, has been tested and validated on Quebec and French populations. So far, the evaluation of the effects of the program on a Canadian population showed interesting results regarding knowledge about ASD, parents’ use of strategies, locus of control, and parental stress, but these variations and positive changes were also observed in a control group with access to another form of intervention. The preliminary results for a French population indicated that parents appeared to be significantly less stressed, and they improved certain areas of their quality of life. These results showed the need to offer support to parents after they were given a diagnosis of autism for their child as a post-diagnosis proposal. Nevertheless, parents are often overwhelmed after their child's diagnosis, because of the accumulation of work, school and specific interventions for their child. French parents also experience difficulties due to transportation problems in the Île-de-France region. The COVID-19 sanitary restrictions only served to heighten these difficulties. Therefore, professional mental healthcare providers aimed to pursue offering a program to parents following the diagnosis of their child in spite of these constraints. Moreover, recent studies have demonstrated the efficacy of teleconsultation for healthcare treatments. The objectives of the present study were to quantitatively assess parental satisfaction and their perception of change in their parenting skills after they participated in the program delivered through teleconsultation, and how they qualitatively expressed themselves about the advantages and limits of the teleconsultation modality. We also sought to be able to determine to which type of parents this program could be recommended, the expected benefits for parents in terms of shared experience, learning and exchanges, and finally to evaluate the program itself as a post-diagnosis proposal. The study involved fourteen parents of children with ASD: eleven French and three French Canadians. The quantitative results showed an average satisfaction of 95.36% and an acceptability of 89.46% of the total score; the qualitative results indicated the satisfaction of parents who participated in the teleconsultation program in France and Quebec. They are consistent with the results obtained in face-to-face sessions. The results show the benefits for parents who used the teleconsultation program, while allowing a greater number of people to participate. This preliminary study of the feasibility and acceptability of the teleconsultation modality for parents of children with ASD makes it possible to consider a validation of this new modality. The quantitative and qualitative data demonstrated that parents reported acquiring new skills at a crucial period for them when they felt the increased needs and challenges in their perceived competencies to deal with self-efficacy and stress compared to other parents. The results confirmed parental interest in psychoeducational programs after their child had been given an ASD diagnosis. They were satisfied with the relationship they had with the professionals and other parents in the teleconsultation program. The results also indicated they felt respected and understood. The use of teleconsultation didn’t seem to interfere with these feelings and helped them during a difficult personal time. The limits of the present study include a possible social bias, a limited number of subjects, and a possible inequality in the participants’ ability to use digital media. Whereas diagnosis and parental intervention represent a societal stake, we need to adapt programs involving new modalities in order to reach the largest number of parents possible, and we need to remain mindful to follow recommendations and parental feedback regarding the necessity of maintaining informal time to encourage exchanges between parents. New challenges seem to be raised and considered for future implementation.

Human induced pluripotent stem cells (hiPSCs) derived cells reflect tissue specificity found in patients with Leigh syndrome French Canadian variant (LSFC).

Leigh syndrome French Canadian type (LSFC) is a recessive neurodegenerative disease characterized by tissue-specific deficiency in cytochrome c oxidase (COX), the fourth complex in the oxidative phosphorylation system. LSFC is caused by mutations in the leucine rich pentatricopeptide repeat containing gene (LRPPRC). Most LSFC patients in Quebec are homozygous for an A354V substitution that causes a decrease in the expression of the LRPPRC protein. While LRPPRC is ubiquitously expressed and is involved in multiple cellular functions, tissue-specific expression of LRPPRC and COX activity is correlated with clinical features. In this proof-of-principle study, we developed human induced pluripotent stem cell (hiPSC)-based models from fibroblasts taken from a patient with LSFC, homozygous for the LRPPRC*354V allele, and from a control, homozygous for the LRPPRC*A354 allele. Specifically, for both of these fibroblast lines we generated hiPSC, hiPSC-derived cardiomyocytes (hiPSC-CMs) and hepatocyte-like cell (hiPSC-HLCs) lines, as well as the three germ layers. We observed that LRPPRC protein expression is reduced in all cell lines/layers derived from LSFC patient compared to control cells, with a reduction ranging from ∼70% in hiPSC-CMs to undetectable levels in hiPSC-HLC, reflecting tissue heterogeneity observed in patient tissues. We next performed exploratory analyses of these cell lines and observed that COX protein expression was reduced in all cell lines derived from LSFC patient compared to control cells. We also observed that mutant LRPPRC was associated with altered expression of key markers of endoplasmic reticulum stress response in hiPSC-HLCs but not in other cell types that were tested. While this demonstrates feasibility of the approach to experimentally study genotype-based differences that have tissue-specific impacts, this study will need to be extended to a larger number of patients and controls to not only validate the current observations but also to delve more deeply in the pathogenic mechanisms of LSFC.

How appreciation preferences compare across employees who speak different languages

PurposeResearch has demonstrated that employees desire to be shown appreciation in various ways. The five languages of appreciation provide a model for exploring these differences. This study aims to explore whether individuals who speak different languages (and are from various cultures) differ in how they prefer to be shown appreciation.Design/methodology/approachThe Motivating By Appreciation Inventory (MBAI) is an online tool that assesses each person’s preferences in how they desire to be shown appreciation at work. Initially developed in English, the MBAI has been translated into seven additional languages. Over 2,200 employees took the MBAI in their preferred spoken language: Mandarin (Chinese), Danish, French (Canadian), Portuguese (Brazilian), Spanish (Latin American), Thai and Turkish. The frequency of each group’s preferred appreciation languages was analyzed to determine similarities and differences across the languages spoken.FindingsGiven the non-normal distribution of the data, the Kruskal–Wallis test found that there was a significant difference in preferences for participants’ primary appreciation language across the seven groups of various spoken languages. One key theme was that words of affirmation were most frequently chosen by five of the seven language groups, whereas employees from Thailand and Turkey chose acts of service most frequently. Additionally, tangible gifts were the least frequently chosen appreciation language by all groups, and at rates below their US counterparts. In three of the languages, quality time was preferred significantly less compared with the other languages.Research limitations/implicationsSome of the groups’ findings (Portuguese, Thai) may be impacted by a confounding variable of the type of work setting (manufacturing) in which the employees worked – in comparison to office-based work settings.Practical implicationsOne theme was, in comparison to other ways of receiving appreciation, tangible gifts are not highly valued by most employees across all language groups. Therefore, organizations using gifts as the primary way to communicate appreciation to employees may be wasting a lot of money. Similar to English-speaking employees, five of the seven language groups chose words as their preferred appreciation language. A wide range exists, however, across language groups with regards to the proportion who desire words, quality time or acts of service. Multicultural organizations should pay attention to employee preferences, lest they waste time and energy on undesired actions.Originality/valueTo the best of the author’s knowledge, this is the first study that has examined the preferences of how employees like to be shown appreciation across seven different language groups.

Association between the GLP1R A316T Mutation and Adolescent Idiopathic Scoliosis in French Canadian and Italian Cohorts.

Studies have revealed anthropometric discrepancies in girls with adolescent idiopathic scoliosis (AIS) compared to non-scoliotic subjects, such as a higher stature, lower weight, and lower body mass index. While the causes are still unknown, it was proposed that metabolic hormones could play a role in AIS pathophysiology. Our objectives were to evaluate the association of GLP1R A316T polymorphism in AIS susceptibility and to study its relationship with disease severity and progression. We performed a retrospective case-control association study with controls and AIS patients from an Italian and French Canadian cohort. The GLP1R rs10305492 polymorphism was genotyped in 1025 subjects (313 non-scoliotic controls and 712 AIS patients) using a validated TaqMan allelic discrimination assay. Associations were evaluated by odds ratio and 95% confidence intervals. In the AIS group, there was a higher frequency of the variant genotype A/G (4.2% vs. 1.3%, OR = 3.40, p = 0.016) and allele A (2.1% vs. 0.6%, OR = 3.35, p = 0.017) than controls. When the AIS group was stratified for severity (≤40° vs. >40°), progression of the disease (progressor vs. non-progressor), curve type, or body mass index, there was no statistically significant difference in the distribution of the polymorphism. Our results support that the GLP1R A316T polymorphism is associated with a higher risk of developing AIS, but without being associated with disease severity and progression.

Validation of the French–Canadian version of the COVID-19 Peritraumatic Distress Index with parents of an infant.

Validation of the French–Canadian version of the COVID-19 Peritraumatic Distress Index with parents of an infant.

Franco-Americans and Racial Discourse in Historical Perspective

French Canadian immigrants to the United States and their Franco-American descendants faced discrimination and marginalization due to their religious faith, their language, and their customs. From the late nineteenth century to the Second World War, they occupied an ambiguous place in the country’s ethnic and racial landscape. Their uncertain status resulted from their dual identity as a people of Western European descent and as North American settlers whose racial belonging was contested. Steering through that ambiguity and seeking a full-fledged whiteness, Franco-Americans at times accepted the racial litmus tests established by the dominant Anglo-Saxon group, not least by distancing themselves from East Asian migrants, African Americans, and Indigenous peoples.

Endometrial Cancer in a Family With RAD51D Gene Mutation.

RAD51 complex plays an important role in homologous recombination deficiency and germline mutations have a well-documented association with breast and tubo-ovarian carcinoma, as well as serous-type endometrial carcinoma. We report a family of French Canadian ancestry with a germline mutation in RAD51D and two sisters presenting with endometrial carcinoma, endometrioid-type. The risk factors for endometrial adenocarcinoma, endometrioid-type are discussed in the context of the RAD51-associated carcinomas described to date.

The Phraseology of Legal French and Legal Popularisation in France and Canada: A Corpus-Assisted Analysis

The popularisation of legal knowledge is a critical issue for equal access to law and justice. Legal discourse has been justly criticised for its obscure terminology and convoluted phrasing, which notably led to the Plain Language Movement in English-speaking countries. In Canada, the concept of Plain Language has been applied to French since the 1980s due to the official policy of bilingualism, while the concept has only been recently discussed in France. In this paper, we examine the impact of Plain Language rewriting on legal phraseology in French popularisation contexts. The first aim of our study is to see if plain texts published in France contain more traces of legal phraseology than French Canadian texts. Our second objective is to determine if a ‘phraseology of plain language’ can be identified across genres and languages. To do this, we compare two corpora of expert-to-expert legal texts written in French—made up, respectively, of legislative texts published in France and judicial texts published by the Supreme Court of Canada—with two corpora of texts that are claimed to have been written in Plain French Language for a non-expert readership—texts that guide laypersons through legal and administrative processes in France and summaries of decisions by the Supreme Court of Canada. Using n-grams, we extract and discuss the patterns that emerge from the corpora. In particular, our analyses rely on the concept of ‘lexico–grammatical patterns’, defined as the minimal unit of meaningful text made up of recurrent sequences of lexical and grammatical items. We then identify a sample of recurring lexico–grammatical patterns and their discursive functions.

Late Onset of Severe Demyelinating Peripheral Neuropathy in a 62-Year-Old African American Woman.

Hereditary neuropathies are typically associated with an early onset of symptoms, but same types of neuropathies may also manifest late, after the age 50 years. A 62-year-old African American woman presented with a 6-year history of gait unsteadiness and has been using a walker since the age 57 years after an unwitnessed fall. Gradual worsening of walking difficulties was later followed by decreased dexterity. The family history was negative for neuromuscular disorders, including neuropathy. On examination, the patient had both distal and proximal weakness with distal sensory loss to all modalities and hyporeflexia. Charcot Marie Tooth Examination Score was 12. Previous electrodiagnostic testing at the age 60 years showed severe sensorimotor demyelinating polyneuropathy with bilateral severe carpal tunnel syndrome. Genetic testing showed a homozygous pathogenic mutation in SH3TC2 gene (c.2860C>T; p.Arg954*), associated with CMT4C. CMT4C is the most common recessive demyelinating sensorimotor polyneuropathy and overall comprises 0.4%-1.7% of all patients with Charcot-Marie-Tooth disease. It is more common in French Canadians and Spanish Roma and in recent natural history study; only 1 of 56 patients was African American. This report demonstrates sporadic occurrence of CMT4C in other ethnic groups as well.

Adaptation of a psycho-educational group programme to improve coping in dementia caregiving: a feasibility study with mixed-methods.

As the number of people living with dementia rapidly increases worldwide, the support provided by their informal caregivers remains key to the sustainability of most healthcare systems, this voluntary contribution representing 40% of the costs of dementia worldwide. Informal caregiving in dementia, however, is linked to long periods of chronic stress with frequent and serious negative consequences on the health and quality of life of the caregiver. A psycho-educational group intervention focusing on coping with the daily stress of dementia caregiving ("Learning to feel better… to help better"), developed in French-speaking Canada and showing broad effects on quality of life, was selected with the aim of 1) adapting it to a new cultural context (French-speaking Switzerland) based on identified facilitators and barriers, using a participative approach; and 2) conducting a feasibility study to evaluate whether the adapted programme showed similar or improved feasibility and effects compared to the original Canadian programme. A mixed-methods concurrent nested design was used to evaluate the feasibility and the effects on five quantitative core outcomes. Additional qualitative data helped document in depth the acceptability and impact of the intervention. We shortened the programme from 30 to 21h in total, which resulted in increased accessibility, in terms of facilitated recruitment of participants and inclusion of a broader range of informal caregivers. There were significant reductions in subjective burden (effect size: d = -0.32) and psychological distress (d = -0.48), as well as decreases in the stress reactions of informal caregivers related to the behaviour problems of the persons with dementia (d = -0.57). The qualitative results emphasized the usefulness of providing informal caregivers with structured procedures for efficiently tackling everyday challenges, and of enabling learning through a variety of channels and activities. Substantial improvements are associated with this 21-h group intervention, organised in 7 sessions of 3h each, focused on learning more efficient strategies to cope with the daily stress of dementia caregiving. This intervention empowered informal caregivers to master their daily challenges with more confidence, satisfaction and calm. ISRCTN13512408 (registration date 17.05.2021, retrospectively registered).

ChemRAP uncovers specific mRNA translation regulation via RNA 5′ phospho-methylation

5′-end modifications play key roles in determining RNA fates. Phospho-methylation is a noncanonical cap occurring on either 5′-PPP or 5′-P ends. We used ChemRAP, in which affinity purification of cellular proteins with chemically synthesized modified RNAs is coupled to quantitative proteomics, to identify 5′-Pme “readers”. We show that 5′-Pme is directly recognized by EPRS, the central subunit of the multisynthetase complex (MSC), through its linker domain, which has previously been involved in key noncanonical EPRS and MSC functions. We further determine that the 5′-Pme writer BCDIN3D regulates the binding of EPRS to specific mRNAs, either at coding regions rich in MSC codons, or around start codons. In the case of LRPPRC (leucine-rich pentatricopeptide repeat containing), a nuclear-encoded mitochondrial protein associated with the French Canadian Leigh syndrome, BCDIN3D deficiency abolishes binding of EPRS around its mRNA start codon, increases its translation but ultimately results in LRPPRC mislocalization. Overall, our results suggest that BCDIN3D may regulate the translation of specific mRNA via RNA-5′-Pme.

Intercultural transfer over the Atlantic in early 20th century – How the European cooperative banking system travelled to Quebec: the case of Desjardins Group

PurposeThis paper aims to study historical intercultural transfer by examining the case of the Mouvement Desjardins, a Quebec, Canada-based cooperative bank founded in 1900 by Alphonse Desjardins. The aim of the cooperative was to support the hitherto marginalized French–Canadian population and to initiate their economic and entrepreneurial activities.Design/methodology/approachThe authors focus on a historical single-case analysis. This conducts them to analyse primary data from letters exchanged between Alphonse Desjardins and European actors, as well as company documents of the Groupe Desjardins.FindingsThe intercultural transfer of the cooperative bank model and its implementation in North America as a successful, self-sustaining model is owing to recontextualization and strategic decisions of the social entrepreneur Alphonse Desjardins based on intensive written correspondence with European bank directors who promoted the cooperative system.Research limitations/implicationsThis research instigates an impulse to extend our knowledge of intercultural transfer by looking into other historical cases to provide validation or add subtleties to our understanding of intercultural transfer dynamics.Originality/valueThis paper expands the current understanding of intercultural transfer and its powerful influence, namely, how an implemented cooperative bank system can contribute through successful recontextualization to institutional change and societal improvements. It also provides new insights into the creation and growth of social enterprises based on shared values within communities and coordinated strategic intentions across communities.

“It is like the re-enactment show”: Narrative and historical culture among young French Canadian students

This study of historical consciousness illustrates the cultural processes by which French Canadian students narrate the history of their national past. Findings are based on data collected through a narrative inquiry with 635 francophone students from a variety of backgrounds. Although participants made explicit references to and use of formal learning from their school history courses, a majority of participants produced simplified narratives largely informed by mythistories of their historical culture. These findings suggest that the current curricular emphasis on historical thinking may fail to challenge students’ historical ideas in ways that take into consideration the forces of historical culture (mythistories, mnemonic infrastructure representations, conceptions of the past) and help them generate more complex narratives of the collective past that acknowledge the diversity of perspectives present in the society in which they life.

Healthcare Top Management’s Transformational Leadership Behaviors and Nurses’ Occupational and Organizational Turnover Intention

Aims: This study examines the contribution of top management’s transformational leadership behaviors on two targets of nurses’ turnover intention (organization and occupation) by focusing on the indirect (through vigor and dedication) and conditional indirect associations (involving autonomous motivation as a moderator).Background: Although the issue of nurse turnover has received growing scientific attention, the research is currently silent about the specific targets of turnover intention and more importantly, the potential pathways through which top management’s transformational leadership behaviors relate to each target.Method: Cross‐sectional data from a sample of 426 French–Canadian nurses and structural equation modeling were used to test the proposed model.Results: Top management’s transformational leadership behaviors distinctly predicted organizational and occupational turnover intention through specific nurses’ states of engagement. While perceived transformational leadership positively predicted vigor, its indirect associations (via dedication) with organizational and occupational turnover intention depend on nurses’ level of autonomous motivation at work.Conclusion: In times of nurse shortage, the present findings provide insights into how and when top management’s transformational leadership behaviors relate to nurses’ organizational and occupational turnover intention.Implications for Nursing Management: Healthcare organizations are advised to foster top management transformational leadership behaviors and autonomous motivation to sustain the nursing workforce.

Ne rien avoir ou ne rien être, au gré des variations : une analyse de l’œuvre Nous qui n’étions rien de Madeleine Thien (trad. Catherine Leroux) en tant que « nouveau » roman historique

Various Variations from Having Nothing to Being Nothing, an Analysis of Madeleine Thien’s Do Not Say We Have Nothing (and its French Version) as a “New” Historical Novel
 Traditionally, historical novels have been subjected to various negative preconceptions and have often been categorized as lowbrow. Despite their popular and commercial success, authors of such novels rarely win prestigious literary awards. However, 'Do Not Say We Have Nothing,' a historical novel by Madeleine Thien published in 2016, was critically acclaimed and received high praise, winning two major Canadian prizes— the Scotiabank Giller Prize and the Governor General’s Literary Award for Fiction. It was also shortlisted for the Man Booker Prize. Its French translation, 'Nous qui n’étions rien,' also gained significant recognition, as Catherine Leroux, Thien’s translator, was awarded a Governor General’s Literary Award for the French version in 2019. The novel has been translated into thirteen other languages, another significant sign of consecration. In this paper, two questions will be explored. Firstly: what characteristics of 'Do Not Say We Have Nothing' (and of its French translation 'Nous qui n’étions rien') explain its critical success? Secondly: do these characteristics match those of the 'new' historical novel? 'New' historical novels are here understood as well-documented, complex, and intertextual works that started to appear in the 1980s and tend to break away from the tradition of historical novels based on bewildering action and detailed descriptions, often written in plain language. A general finding is that the appreciations of the juries of two important English-language literary prizes in Canada, as well as many reviews published in different journals and magazines, mention that the book’s complexity and the reflections it prompts are two major positive aspects of the novel. As for the writing itself, whereas Thien’s style has been deemed 'simple,' consistent with traditional historical novels, Leroux’s version does not appear to be as accessible. Nevertheless, it was lauded by critics and the Governor General’s Literary Awards jury. It is worth asking if this more formal and literary style was not seen as an additional strength by the French institution and reviewers. A brief analysis of fiction works winning major prizes in Canada in the years prior to and following 'Do Not Say We Have Nothing' has also been conducted and seems to indicate that historical novels tend to win more prizes in English Canada than in French Canada.