Treatment-resistant depression (TRD), defined as inadequate results after treatment with at least two antidepressants for 8 weeks, may be attributed to multiple factors, including the patient’s personality. In this research, we explored personality profiles based on egograms among 28 outpatients (22 men, 6 women) with TRD. Participants completed two self-questionnaires: the Tokyo University Egogram (TEG) and the Self Grow-up Egogram (SGE). Personality profiles showed the mean energy distribution among five ego states: Controlling Parent (CP), Nurturing Parent (NP), Adult (A), Free Child (FC), and Adapted Child (AC). In all 28 patients, the TEG and the SGE revealed a trough of FC and a peak of AC. SGE results showed a negative correlation between the Hamilton Rating Scale for depression score and FC energy. When patients were separated according to CP, egograms revealed low Adult energy in the low CP group and high Adult energy in the high CP group. Overall, this study indicated low FC energy and high AC energy in TRD and revealed two types of personalities with either low CP/low Adult energy or high CP/high Adult energy. These results should be considered in TRD therapy.