The magnetic parameters within lacustrine sediments serve as invaluable proxies for deciphering the paleoenvironmental and paleoclimatic conditions. However, the dissolution of magnetic minerals can significantly alter detrital magnetic mineral assemblages, thereby complicating their interpretation in paleoenvironmental reconstructions. In an effort to clarify the impact of this dissolution on the grain size of magnetic minerals in lacustrine sediments, we undertook a thorough analysis of the rock magnetic properties on samples from the interval characterized by low ARM (anhysteretic remanent magnetization)/SIRM (saturation isothermal remanent magnetization) values between 140 and 320 ka in the Heqing (HQ) lacustrine drill core, located in Southwest China. Temperature-dependent magnetic susceptibility and FORC diagrams revealed a predominance of single-vortex and pseudo-single domain (PSD) magnetite and maghemite within the sample. When compared to samples from both the glacial and interglacial periods, the high SIRM, elevated magnetic susceptibility, and low ARM/SIRM ratio intervals from 140 to 320 ka suggested a high concentration of magnetic minerals coupled with a relatively low concentration of fine-grained particles in the sediments. The reductive dissolution of the fine-grained magnetic oxides is responsible for the reduction in the fine-grained magnetic particles in this interval. Our findings indicate that pedogenic fine-grained magnetite and maghemite are the first to dissolve, followed by the dissolution of coarser-grained iron oxides into finer particles. This process underscores the complex interplay between magnetic mineral dissolution and grain size distribution in lacustrine sediments, with significant implications for the reliability of paleoenvironmental interpretations derived from magnetic parameters.