Frankfurt Experience Research Articles

(936) Outcome after ECMO with Axillary Cannulation: The Frankfurt Experience

(936) Outcome after ECMO with Axillary Cannulation: The Frankfurt Experience

On demand treatment and home therapy of hereditary angioedema in Germany - the Frankfurt experience

BackgroundManifestation of acute edema in hereditary angioedema (HAE) is characterized by interindividual and intraindividual variability in symptom expression over time. Flexible therapy options are needed.MethodsWe describe and report on the outcomes of the highly individualized approach to HAE therapy practiced at our HAE center in Frankfurt (Germany).ResultsThe HAE center at the Frankfurt University Hospital currently treats 450 adults with HAE or AAE and 107 pediatric HAE patients with highly individualized therapeutic approaches. 73.9% of the adult patients treat HAE attacks by on-demand therapy with pasteurized pd C1-INH concentrate, 9.8% use additional prophylaxis with attenuated androgens, 1% of the total patient population in Frankfurt has been treated with Icatibant up to now. In addition adult and selected pediatric patients with a high frequency of severe attacks are instructed to apply individual replacement therapy (IRT) with pasteurized pd C1-INH concentrate. Improvement on Quality of Life items was shown for these patients compared to previous long-term danazol prophylaxis. Home treatment of HAE patients was developed in the Frankfurt HAE center in line with experiences in hemophilia therapy and has so far been implemented over a period of 28 years. At present 248 (55%) of the adult patients and 26 (24%) of the pediatric patients are practicing home treatment either as on demand or IRT treatment.ConclusionsIn conclusion, the individualized home therapies provided by our HAE center, aim to limit the disruption to normal daily activities that occurs for many HAE patients. Furthermore, we seek to optimize the economic burden of the disease while offering a maximum quality of life to our patients.

Minimally Invasive Radical Prostatectomy

Minimally Invasive Radical Prostatectomy

Quantitative analysis of chimerism after allogeneic stem cell transplantation by PCR amplification of microsatellite markers and capillary electrophoresis with fluorescence detection: the Frankfurt experience.

Quantitative analysis of chimerism after allogeneic stem cell transplantation by PCR amplification of microsatellite markers and capillary electrophoresis with fluorescence detection: the Frankfurt experience

Conundrums of Urban Planning in a Global Context: The Case of the Frankfurt Airport

The article reviews the complexity of urban policy formulation in Frankfurt, Germany, where officials are trying to enlarge the international airport to stay competitive in international air transportation and meet the challenges of global business operations. This case study analyzes an elaborate mediation process that helped the formal decision-makers avert the violence threatened by anti-globalization and environmentalist protesters. Although some legal challenges loom ahead, a majority of Frankfurt residents support the new airport expansion. The Frankfurt experience will help other communities minimize the confrontation between urban policy makers, corporate business elites, and citizen groups that are concerned with issues of public health and clean environment.

Urban Policy Responses to Foreign In-Migration: The Case of Frankfurt-am-Main

The impacts of immigration are primarily local; yet, local policy responses to immigration from abroad are still a rarity in the United States, and for that matter, in other countries. An exception is Frankfurt-on-the-Main, a major whose population is of foreign brith. The city's response to the presence of an immigrant population is recounted, to offer insights for American cities with similar proportions of immigrants although in a different cultural and legal context. In Frankfurt, the 1989 municipal election victory by a Social Democrat-Green coalition led to the creation of a Department of Multicultural Affairs (AMKA). This paper tells the story of the Department and its major achievements through 1993. The concluding analysis examines elements in Frankfurt's experience with immigration policy that may have relevance for American planners.

The Frankfurt experience in restenosis after coronary angioplasty

Three hundred and thirty-three of 356 patients underwent angiographic follow-up from 1 to 18 months (mean 5.6 months) after percutaneous transluminal coronary angioplasty (PICA). This is a reangiography rate of 94%. Recurrence rate after the first PTCA was 15% (n = 289). Restenosis rate was defined as an increase from immediate post-PTCA stenosis of more than 30%, or the loss of at least half of the initial gain in luminal diameter. Patients who needed a second angioplasty due to restenosis (n = 30) had a restenosis rate of 33%. Patients with angioplasty in the aortocoronary bypass (n = 14) had a restenosis rate of 45%. All patients were treated before, during and at least 4 to 6 months after the procedure with 60 to 100 mg of isosorbide dinitrate daily plus 160 to 360 mg of verapamil or 100 to 150 mg of gallopamil and 1.5 g of acetylsalicylic acid. In a second retrospective study 111 of 399 patients had the acetylsalicylic acid therapy discontinued or decreased. Forty-two of them developed restenosis (38%), whereas only 49 of 288 patients who continued to receive 1.5 g aspirin developed restenosis (17%). The restenosis rate was 32% in those who received the reduced dose of aspirin. Thus, a large dose of acetylsalicylic acid given before, during and 4 to 6 months after the procedure seems to be necessary to achieve a low rate of restenosis after PTCA.