Research Framework Research Articles

Benefits, Challenges, and Opportunities in Addressing Medicaid Beneficiaries' Non-Medical Risks to Health: A Qualitative Analysis.

North Carolina's Healthy Opportunities Pilots (HOP) is a Medicaid 1115 Waiver program that seeks to address nonmedical risks to health for Medicaid beneficiaries through multisector collaboration. Among other stakeholders, HOP involves collaboration between human services organizations that deliver interventions, network leads, which establish and oversee the human services organizations within a region of the state. To understand how employees at human services organizations and network leads prepared to deliver HOP services. Qualitative analysis of semistructured interviews. Interviews were conducted between April and June 2022. Interviews were recorded, transcribed verbatim, coded thematically, and analyzed using a conceptual model derived from the consolidated framework for implementation research. Organizations within North Carolina counties participating in HOP. Employees of human services and network lead organizations across all 3 HOP regions of North Carolina. The researchers interviewed 37 participants. Overall, organizations experienced benefits from HOP participation, including capacity-building resources, flexibility in allocating resources, and creating community-wide enthusiasm for addressing nonmedical risks to health. There were also key challenges. These included the time needed to build capacity, adjustments to the work processes and regulations inherent to multisector collaboration, geographic variation in availability of services to offer, and the difficulty of addressing different needs. Finally, participants recognized substantial opportunities that HOP presented, including membership in a more extensive network, exposure to a learning community, and a more sustainable funding source. The perspectives of individuals preparing to deliver HOP services offer important lessons for those developing and implementing large-scale programs that can address nonmedical threats to health.

Ethics for tourism: integrating Confucian harmony and ethical beliefs into animal tourism

ABSTRACT This study aims to explain Asian traveler behaviors concerning ethical animal tourism, using the value-attitude-behavior model as the research framework. Through structural equation modeling analysis, critical factors for developing ethical behavior in animal tourism were verified. This research enhances the tourism literature by 1) incorporating Confucian harmony as an influencing cultural value and confirmed its essential role in the animal tourism context, and 2) verifying the significance of ethical beliefs as an important predictor for awareness and attitude, which subsequently induce responsible behaviors. Furthermore, the findings suggest how industry professionals could influence travelers’ behavior in an ethical manner.

A proposed guide to reducing bias and improving assessments of decolonization in global health research

IntroductionThe movement to decolonize global health encompasses efforts to dismantle historically inequitable structures and processes in global health research, education, and practice. However, despite increasing literature on the decolonization of global health, gaps between action and knowledge exist in assessments of knowledge production. In this Perspective, we will outline potential biases in current approaches to assessing knowledge production and propose a systems-focused guide to improve the interrogation of knowledge production in this field.MethodsWe leverage the “Inner Setting” and “Outer Setting” domains of the Consolidated Framework for Implementation Research (CFIR), a well-established, commonly-used implementation science framework to critically assess the status quo of decolonization and to develop criteria to help guide decolonization efforts in academic contexts. We defined the Inner Setting as academic and research institutions leading and participating in global health research collaborations, and the Outer Setting as the funding, editorial, and peer review policies and practices that influence knowledge production in global health. Research institutions in the Inner organizational domain continually interact with the Outer policy domains. We categorize the levels at which decolonization may occur and where action should be focused as follows: (1) North–South, (2) South–South, (3) Local South, and (4) Local North. Using CFIR domains and the levels of action for decolonization, we propose a multi-level guide to improve on the standardization, granularity, and accuracy of decolonization assessments in global health research.Conclusion and expected impactThe proposed guide is informed by our global health research expertise and experiences as African scientists with extensive exposure in both global North and global South research contexts. We expect that the proposed guide will help to identify and address the biases identified and will lead to better knowledge-driven action in the process of decolonizing global health research.

Challenges and opportunities for Mi’kmaq Aboriginal and treaty rights to fish in Nova Scotia, Canada

Despite the recognition of the Aboriginal and treaty right to fish in Canada, there has been little movement towards enhancing governance that respects the authority of either the Mi’kmaq, the Indigenous peoples in Nova Scotia, or the federal Department of Fisheries and Oceans. Using a Two-Eyed Seeing research framework, three perspectives were derived from interviews exploring governance challenges and opportunities with key governmental and Indigenous actors. Based on the similarities and nuances among perspectives, key considerations to resolving challenges and incorporating identified opportunities from the research include: i) address injustice and lack of solidarity among First Nations arising from the Indian Act, ii) enhance the legitimacy of current governance by integrating Mi’kmaw and western Knowledge Systems iii) improve governance to address conflict and organization of Mi’kmaw fishers, and iv) build on the shared value of improved relationship where all governing authorities, including Mi’kmaq rights holders and the Mi’kmaq Grand Council, are recognized.

Provider Perceptions toward Extended-Release Buprenorphine for Treatment of Opioid Use Disorder.

The persistence of the opioid crisis and the proliferation of synthetic fentanyl have heightened the demand for the implementation of novel delivery mechanisms of pharmacotherapy for the treatment of opioid use disorder, including injectable extended-release buprenorphine (buprenorphine-ER). The purpose of this study was to understand provider-level barriers to prescribing buprenorphine in order to facilitate targeted strategies to improve implementation for patients who would benefit from this novel formulation. Using an interview template adapted from the Consolidated Framework for Implementation Research (CFIR), we conducted structured focus group interviews with 20 providers in an outpatient addiction clinic across 4 sessions to assess providers' perceptions of buprenorphine-ER. Ninety-four unique comments were identified and deductively coded using standardized CFIR constructs. Providers expressed mixed receptivity and confidence in using buprenorphine-ER. Although providers could identify a number of theoretical advantages to the injectable formulation over sublingual buprenorphine, many expressed reservations about using it due to inexperience, negative patient experiences, uncertainties about patient candidacy, cost, and logistical constraints. Provider concerns about buprenorphine-ER may limit utilization. Some concerns may be mitigated through improved education, research, and logistical support. Given the putative benefits of buprenorphine-ER, future research should target barriers to implementation, in part based on hypotheses generated by these findings.

Offering extended use of the contraceptive implant via an implementation science framework: a qualitative study of clinicians' perceived barriers and facilitators.

The etonogestrel contraceptive implant is currently approved by the United States Food and Drug Administration (FDA) for the prevention of pregnancy up to 3 years. However, studies that suggest efficacy up to 5 years. There is little information on the prevalence of extended use and the factors that influence clinicians in offering extended use. We investigated clinician perspectives on the barriers and facilitators to offering extended use of the contraceptive implant. Using the Consolidated Framework for Implementation Research (CFIR), we conducted semi-structured qualitative interviews. Participants were recruited from a nationwide survey study of reproductive health clinicians on their knowledge and perspective of extended use of the contraceptive implant. To optimize the diversity of perspectives, we purposefully sampled participants from this study. We used content analysis and consensual qualitative research methods to inform our coding and data analysis. Themes arose deductively and inductively. We interviewed 20 clinicians including advance practice clinicians, family medicine physicians, obstetrician/gynecologist and complex family planning sub-specialists. Themes regarding barriers and facilitators to extended use of the contraceptive implant emerged. Barriers included the FDA approval for 3 years and clinician concern about liability in the context of off-label use of the contraceptive implant. Educational materials and a champion of extended use were facilitators. There is opportunity to expand access to extended use of the contraceptive implant by developing educational materials for clinicians and patients, identifying a champion of extended use, and providing information on extended use prior to replacement appointments at 3 years.

Clinician Views of Proactive Tobacco Treatment Programs: A Qualitative Evaluation.

Proactive tobacco treatment programs are an evidence-based strategy to recruit patients who smoke to make supported quit attempts. However, such programs are rarely implemented. We performed a qualitative assessment of clinicians to inform the creation of a proactive outreach program for patients with chronic obstructive pulmonary disease (COPD) who smoke. Informed by the Consolidated Framework for Implementation Research, we conducted semi-structured interviews to assess clinician views of proactive outreach, including barriers, program structure, and the use of technology. Clinicians included primary and specialty care physicians, nurses and advanced practice providers, pharmacists, respiratory therapists, a psychologist, and relevant members of leadership. Interviews were transcribed and analyzed using directed content analysis. Clinicians in all roles identified that proactive outreach could be an effective use of resources to help patients with COPD who smoke quit with several advantages over the current state. Clinicians disagreed on the priority population (e.g., younger patients, sicker patients), and to some extent on whether proactive outreach is a clinical priority. Though they supported that technology could be part of the outreach program, most advocated for multiple avenues (phone calls, drop-in clinic, texting), as these patients were perceived to be low technology utilizers. The primary implementation barriers were competing priorities and cost, as well as unclear billing and staffing models. Clinicians support proactive outreach for patients with COPD, but the optimal way to structure, staff, and fund such programs remains unclear. Health systems should leverage implementation strategies to speed uptake of these potentially life-saving programs.

Ethical review of preclinical research

The main goal of medicine has been and remains the desire to preserve the health of the population, increase human life expectancy and its quality. For those purposes, it is necessary to constantly improve treatment measures, create and introduce into medical practice new methods of therapy, innovative medicines, guided by strict rules of evidence of their high effectiveness and safety, study the mechanisms of physiological processes of a living organism in normal conditions and in pathology, the possibilities of correction and prevention of disease processes, and this means the need to conduct research, including those involving animals. The modern ethical and legal framework for research involving animals contains a requirement for mandatory examination of a research project by an ethical committee, monitoring its implementation, and analysis of the results. An ethics committee is a structure implemented into the research process to help researchers navigate the complex network of guidelines, rules and best practices, as well as the existing legal framework for conducting scientific research that guarantees quality results of work that do not violate these principles and restrictions. The local ethics committee is responsible for ensuring that research conducted in the territory under its supervision complies with modern ethical standards. This article presents the experience of the local ethics committee of the Kazan State Medical University in the ethical review of research projects involving animals, and substantiates the list and content of the requirements for documents submitted by the researcher for ethical review. The shortcomings identified in the preclinical research protocols submitted for examination were separately analyzed, and references were provided to the ethical and legal framework existing in the Russian Federation.

Co-production of a systematic review on decision coaching: a mixed methods case study within a review

BackgroundCo-production is a collaborative approach to prepare, plan, conduct, and apply research with those who will use or be impacted by research (knowledge users). Our team of knowledge users and researchers sought to conduct and evaluate co-production of a systematic review on decision coaching.MethodsWe conducted a mixed-methods case study within a review to describe team co-production of a systematic review. We used the Collaborative Research Framework to support an integrated knowledge translation approach to guide a team through the steps in co-production of a systematic review. The team agreed to conduct self-study as a study within a review to learn from belonging to a co-production research team. A core group that includes a patient partner developed and conducted the study within a review. Data sources were surveys and documents. The study coordinator administered surveys to determine participant preferred and actual levels of engagement, experiences, and perceptions. We included frequency counts, content, and document analysis.ResultsWe describe co-production of a systematic review. Of 17 team members, 14 (82%) agreed to study participation and of those 12 (86%) provided data pre- and post-systematic review. Most participants identified as women (n = 9, 75.0%), researchers (n = 7, 58%), trainees (n = 4, 33%), and/or clinicians (n = 2, 17%) with two patient/caregiver partners (17%). The team self-organized study governance with an executive and Steering Committee and agreed on research co-production actions and strategies. Satisfaction for engagement in the 11 systematic review steps ranged from 75 to 92%, with one participant who did not respond to any of the questions (8%) for all. Participants reported positive experiences with team communication processes (n = 12, 100%), collaboration (n = 12, 100%), and negotiation (n = 10–12, 83–100%). Participants perceived the systematic review as co-produced (n = 12, 100%) with collaborative (n = 8, 67%) and engagement activities to characterize co-production (n = 8, 67%). Participants indicated that they would not change the co-production approach (n = 8, 66%). Five participants (42%) reported team logistics challenges and four (33%) were unaware of challenges.ConclusionsOur results indicate that it is feasible to use an integrated knowledge translation approach to conduct a systematic review. We demonstrate the importance of a relational approach to research co-production, and that it is essential to plan and actively support team engagement in the research lifecycle.

A qualitative study examining the experiences of people who use drugs in supportive housing in London, Ontario

Background Since 2016, London, Ontario has experienced increasing numbers of opioid overdoses and overdose related deaths. Supportive housing agencies have been especially impacted, experiencing an 890% increase in opioid overdose from 2018-2021. A coalition was formed between London housing agencies and our research team to better understand the perspective of precariously housed participants who use drugs on existing substance use and overdose related policies within housing agencies. We aimed to center participant voices in policy development efforts. Methods Using a community-based participatory research framework, 17 participants were interviewed at three housing agencies. Drawing on qualitative descriptive methods, transcripts were subject to content analysis and three themes were identified. Results Themes included (1) conflicts between agency rules and resident realities, (2) safe use accessibility, (3) trust and understanding key to facilitating harm reduction. Conclusion Trust and understanding were weaved across all themes and mediated participants’ opioid overdose experience and risk of overdose related deaths. We recommend interventions to rebuild trust and foster understanding alongside harm reduction-based policies to reduce overdose related deaths.

A Systematic Review and Conceptual Framework for Natural Resource Performance Management

The topic of "Performance management of natural resources" has drawn more attention in the last few decades. Investigating how to manage natural resource performance more optimally is crucial for the long-term social and economic advancement of a nation. This study reviews the research progress of performance management of natural resources (including water resources) based on the pertinent literature of "Performance management of natural resources" and "performance management and evaluation of nature resources" in Web of Science. Through a review of the literature and inductive analysis, the authors found that the pursuit of sustainable resource consumption and management has emerged as the frontier direction of study. However, there is still room for development in the natural resource performance management evaluation system and methods, as well as the requirement for a comprehensive conceptual interpretation and analytical framework. As the literature on the factors impacting the success of natural resource management is currently lacking in depth, future research should concentrate on bolstering the usage of quantitative models. Enhancing the combination of research and quantitative models is also essential. This study builds research framework for natural resource performance management based on the body of current literature and the real-world experience of nations worldwide. In order to support decision-making for the sustainable use of natural resources, the authors describe the process and mechanism of performance management of natural resources and provide some workable evaluation methods based on a variety of evaluation objectives, subjects, and means.

A systematic review on research trends, datasets, algorithms, and frameworks of children’s nutritional status prediction

<a name="_Hlk138773759"></a><span lang="EN-US">The monitoring of children's nutritional status serves as a crucial tool for assessing the health of both children and society as a whole. In this regard, machine learning has been employed to predict nutritional status for monitoring purposes. This topic has been extensively discussed; however, the question remains as to which algorithm or machine learning framework can yield the highest accuracy in predicting the nutritional status of children within a specific region. Furthermore, determining the appropriate dataset for predictions is also crucial. Therefore, this review aims to identify and analyze the research trends, dataset characteristics, algorithms, and frameworks utilized in studies pertaining to the nutritional status of children under the age of five from 2017 to early 2022. The selected papers focus on the application of machine learning techniques in predicting nutritional status. The findings of this research reveal that the Bangladesh DHS 2014 dataset is among the popular choices for machine learning applications in this field. The most commonly employed algorithms include Neural Networks, Random Forests, Logistic Regression, and Decision Trees which demonstrated promising performance. Lastly, the data preprocessing stage within a framework plays a significant role in models aimed at predicting nutritional status.</span>

The scientific knowledge of three large language models in cardiology: multiple-choice questions examination-based performance

Background: The integration of artificial intelligence (AI) chatbots like Google’s Bard, OpenAI’s ChatGPT, and Microsoft’s Bing Chatbot into academic and professional domains, including cardiology, has been rapidly evolving. Their application in educational and research frameworks, however, raises questions about their efficacy, particularly in specialized fields like cardiology. This study aims to evaluate the knowledge depth and accuracy of these AI chatbots in cardiology using a multiple-choice question (MCQ) format. Methods: The study was conducted as an exploratory, cross-sectional study in November 2023 on a bank of 100 MCQs covering various cardiology topics that was created from authoritative textbooks and question banks. These MCQs were then used to assess the knowledge level of Google’s Bard, Microsoft Bing, and ChatGPT 4.0. Each question was entered manually into the chatbots, ensuring no memory retention bias. Results: The study found that ChatGPT 4.0 demonstrated the highest knowledge score in cardiology, with 87% accuracy, followed by Bing at 60% and Bard at 46%. The performance varied across different cardiology subtopics, with ChatGPT consistently outperforming the others. Notably, the study revealed significant differences in the proficiency of these chatbots in specific cardiology domains. Conclusion: This study highlights a spectrum of efficacy among AI chatbots in disseminating cardiology knowledge. ChatGPT 4.0 emerged as a potential auxiliary educational resource in cardiology, surpassing traditional learning methods in some aspects. However, the variability in performance among these AI systems underscores the need for cautious evaluation and continuous improvement, especially for chatbots like Bard, to ensure reliability and accuracy in medical knowledge dissemination.

Privacy-Preserving and Secure Industrial Big Data Analytics: A Survey and the Research Framework

Privacy-Preserving and Secure Industrial Big Data Analytics: A Survey and the Research Framework

Against Artificial Education: Towards an Ethical Framework for Generative Artificial Intelligence (AI) Use in Education

The arrival of Generative Artificial Intelligence (AI) is fundamentally different from prior technologies used in educational settings. Educators and researchers of online, blended, and in-person learning are still coming to grips with possible applications of AI in the learning experience with existing technologies; let alone understanding the potential consequences that future developments in AI will produce. Despite potential risks, AI may revolutionize previous models of teaching and learning and perhaps create opportunities to realize progressive educational goals. Given the longstanding tradition of philosophy to examine questions surrounding ethics, ontology, technology, and education, the purpose of this critical reflection paper is to draw from prominent philosophers across these disciplines to address the question: how can AI be employed in future educational contexts in a humanizing and ethical manner? Drawing from the work of Gunther Anders, Michel Foucault, Paolo Freire, Benjamin Bloom, and Hannah Arendt, we propose a framework for assessing the use and ethics of AI in modern education contexts regarding human versus AI generated textual and multimodal content, and the broader political, social, and cultural implications. We conclude with applied examples of the framework and implications for future research and practice.

Deciphering the difference puzzle of risk-sharing: A comparative analysis of infrastructure PPP development within China and US

Appropriate risk sharing is crucial for the successful implementation of Public-Private Partnership projects. However, under different social systems, the international community lacks a clear risk-sharing framework in Public-Private Partnership research. This study employs a multi-case study method to examine the practice of risk sharing in infrastructure Public-Private Partnership projects within China and the US, aiming to provide a clear risk management framework for Public-Private Partnership projects. The research findings reveal common elements and similar characteristics in risk-sharing practices. Contrary to the goal of transferring all risks to the private sector, both countries actually allocate risks to the party with stronger risk control capabilities or share risks between the government and the private sector. The US benefits from more mature policies and has a comprehensive Public-Private Partnership model implementation framework; in contrast, as an emerging market for Public-Private Partnership models, China's current laws and regulations need further improvement. The results of this study not only contribute to optimizing risk-sharing arrangements and improving investment efficiency of the project, but also promote the development of cross-border infrastructure projects, and provide valuable experience and insights for the sustainable development of global infrastructure.

Integrating Theology into Migration Studies for Ethical Perspectives and Collaborative Solutions

This study explores the intersection of theology and migration studies and provides a comprehensive framework for theologians and researchers to engage with the ethical dimensions of global migration. It addresses the need for an integrated perspective that goes beyond socio-political and economic analyses. The study identifies a gap in the literature in the integration of theology into migration studies and proposes specific tasks for theologians and researchers. Theologians should integrate theology into migration studies, engage in critical theological reflection, understand ethical imperatives, and reinterpret religious texts. Researchers should develop frameworks that challenge conventional discourses and translate theological principles into actionable guidelines. Key tasks for researchers include interdisciplinary collaboration, analysing language and perceptions, political advocacy and social engagement. The study's unique contribution is a roadmap that integrates theology into migration studies and provides scholars with a guide to navigate the complex challenges of migration.

Engaging student volunteers in non-clinical navigation: ACS community access to resources, education, and support (ACS CARES).

e13577 Background: Despite known benefits of oncology patient navigation in improving patient outcomes, implementation is variable and many programs are understaffed. The American Cancer Society (ACS) developed the ACS CARES (Community Access to Resources, Education, and Support) program to expand navigation capacity through the standardized training of students from local universities as volunteers providing non-clinical navigation support. Methods: This pragmatic, real-world hybrid type 2 study utilizes the Consolidated Framework for Implementation Research (CFIR) to evaluate the implementation of student volunteer navigation for patients receiving cancer care at 3 pilot sites. Volunteers meet with patients in clinic, administer a modified NCCN distress thermometer health-related social needs (HRSNs) screen, and administer non-clinical navigation support. Initial process measures from the first 3 months of the pilot data include number and demographics of patients served, distress scores and HRSNs, and time spent by volunteers. Results: Pilot sites spanned diverse geographic regions (rural mid-West, rural-suburban Southeast, urban West) and included clinics with multiple cancer types. From 10/23/23-12/23/23, 22 volunteers navigated 73 patients who were 53% female, 22% Black, and an average age of 57. Of all patients, 46% had a moderate (score 3-6) and 37% had a severe (score 7-10) distress score. ACS CARES volunteers identified 116 HRSNs (56% practical, 18% physical, 17% emotional, 7% social, 2% spiritual). The most common practical HRSNs were finances and transportation. Volunteers spent an average of 78.6 min per patient per in-person meeting, 14 min per patient per follow-up call, 25 min per patient coordinating care and sending encrypted messages, and 90 min per patient identifying and providing resources to address barriers to care. Total time providing non-clinical navigation was over 250 hours. Conclusions: Student volunteers embedded in oncology clinics provided non-clinical navigation support to 73 patients in the first 3 months of the ACS CARES program, further extending the reach and depth of support provided by pilot site care teams. Future analyses will include survey and EMR data to examine program impact on clinical and patient reported outcomes and healthcare utilization. Clinical trial information: 2013209-1.

Advancing inclusive research (AIR) in Africa: Strengthening healthcare systems to enhance access on the continent through the Africa AIR site alliance model.

e13778 Background: While Africa makes up 17% of the total world population, it has 24% of the global disease burden. Furthermore, although Africa is rich in genomic diversity, Africans make up <4% of the patients in global pharma studies and 1% of the global genomic database. In 2020 there were only 63 African patients in Roche global clinical trials. The Africa AIR Site Alliance model was undertaken to address the growing importance of interventional clinical trials with advanced diagnostics and therapies in Africa, as well as the lack of representation of the African population in global datasets, which contribute to continued health disparities, poor outcomes and existing inequities. Methods: In countries with a legal research framework, no clinical trial holds and who have conducted at least 1 Roche clinical trial during the last 5 years potential Centers of Excellence for the Africa AIR Site Alliance were identified. For patients, sites had invoiceable services to ensure they were supported and could potentially include education about clinical trial participation, reasonable travel and accommodation, or covering the cost of missed work or childcare. Sites participated in training on how to conduct clinical trials, including opportunities to share best practices across sites. Results: Four pilot countries were selected and had Centers of Excellence identified to work as partners with Roche for global clinical trials: Morocco (Marrakech University Hospital Center), Nigeria (University College Hospital Ibadan), Kenya (University of Nairobi Institute of Tropical and Infectious Diseases) and South Africa (Limpopo Cancer Research Institute). After entering the Africa AIR Site Alliance, sites reported consistent application of standard operating procedures and manuals, trained and empowered staff, increased organization and appropriate patient support, plus knowledge and experience with industry trials. Sites are successfully participating in an increased number of global clinical trials in various therapeutic areas with 23 patients enrolled at the Africa AIR Site Alliance sites in oncology and ophthalmology studies. Conclusions: The Africa AIR Site Alliance model is a groundbreaking initiative that has the potential to revolutionize clinical research in Africa with a positive long-term impact on the African healthcare ecosystem and clinical care delivery. Limited diversity and representation in genomic, safety and efficacy data have hampered scientific and medical progress on the continent. The Africa AIR Site Alliance provides critical support, knowledge and skills for conducting clinical trials and assists in removing barriers for underrepresented patients to participate in these trials. Future work will focus on expanding to additional countries in Africa and creating a robust network of Centers of Excellence for innovative research.

The Influence of Opinion Leaders on Consumer Buying Behavior Among Millennials in Klang Valley

Opinion leaders have emerged as individuals with social influence who serve as the core of an interpersonal communication network. The social trends have made opinion leaders significantly influence buying behavior, especially among millennials. A deeper understanding of the characteristics of opinion leadership is still needed and based on the two-step flow theory, we developed a research framework to study opinion leaders’ influence (trust, credibility, and originality) on consumer buying behavior. A simple random sampling method was used, and the sample comprised 398 millennials in Klang Valley, Malaysia. Data were collected via a self-administered questionnaire. Regarding the relationships involving the opinion leaders’ elements, Pearson correlation analysis found that the trust (r=0.545; p=0.00), credibility (r=0.518; p=0.00), and originality (r=0.398; p=0.00) of opinion leaders are significantly related to consumer buying behavior. Multiple regression analysis was then applied to examine the most influential opinion leader factors on millennials’ buying behavior. The result showed that this model contributed a total of 30.7% and that trust (β = 0.368, p = 0.000) is the most influencing factor on millennials buying behavior. Marketers will have an updated perspective on the influence of opinion leaders on consumer buying behavior knowing the profiles of opinion leaders is extremely beneficial for consumers to make wise purchase decisions.