Artificial Intelligence Framework Research Articles

AI tool for predicting MGMT methylation in glioblastoma for clinical decision support in resource limited settings.

Glioblastoma is an aggressive brain cancer with a poor prognosis. The O6-methylguanine-DNA methyltransferase (MGMT) gene methylation status is crucial for treatment stratification, yet economic constraints often limit access. This study aims to develop an artificial intelligence (AI) framework for predicting MGMT methylation. Diagnostic magnetic resonance (MR) images in public repositories were used for training. The algorithm created was validated in data from a single institution. All images were segmented according to widely used guidelines for radiotherapy planning and combined with clinical evaluations from neuroradiology experts. Radiomic features and clinical impressions were extracted, tabulated, and used for modeling. Feature selection methods were used to identify relevant phenotypes. A total of 100 patients were used for training and 46 for validation. A total of 343 features were extracted. Eight feature selection methods produced seven independent predictive frameworks. The top-performing ML model was a model post-Least Absolute Shrinkage and Selection Operator (LASSO) feature selection reaching accuracy (ACC) of 0.82, an area under the curve (AUC) of 0.81, a recall of 0.75, and a precision of 0.75. This study demonstrates that integrating clinical and radiotherapy-derived AI-driven phenotypes can predict MGMT methylation. The framework addresses constraints that limit molecular diagnosis access.

Pharma in The Digital Era: The Role of Artificial Intelligence in Drug Development

The integration of Artificial Intelligence (AI) in the pharmaceutical sector marks a transformative era, where technology reshapes traditional drug development processes. This paper delves into the pivotal role AI plays in enhancing efficiency and precision in drug discovery, testing, and approval. Existing methods in drug development often suffer from high costs, extended timelines, and high attrition rates in clinical trials, posing significant barriers to timely patient care. To address these issues, we propose the Drug Development based on Artificial Intelligence (DD-AI) framework, leveraging AI-driven algorithms and machine learning models. The DD-AI framework enhances the identification and optimization of drug candidates, predicts clinical trial outcomes, and personalizes patient treatment plans. AI algorithms analyze vast datasets to discover potential drug molecules, simulate their interactions, and streamline the clinical trial process by identifying the most promising candidates. Implementing the DD-AI framework has demonstrated substantial improvements in reducing drug development costs and timelines while increasing the accuracy of trial outcomes. AI's predictive capabilities also personalize treatments, optimizing efficacy and minimizing adverse effects for patients. The DD-AI framework offers a robust solution to existing challenges in drug development, fostering a more efficient, cost-effective, and patient-centered approach. The findings underscore AI's transformative potential in revolutionizing pharmaceutical practices, ultimately benefiting patients with faster and more precise medical solutions.

Model Organoids: Integrated Frameworks for the Next Frontier of Healthcare Advancements.

The morphogenetic events leading to tissue formation can be recapitulated using organoids, which allows studying new diseases and modelling personalized medicines. In this review, culture systems comparable to human organs are presented, these organoids are created from pluripotent stem cells or adult stem cells. The efficient and reproducible models of human tissues are discussed for biobanking, precision medicine and basic research. Mechanisms used by these model systems with an overview of models from human cells are also covered. As human physiology is different from animals, culture conditions and tissue limits often become challenging. Organoids offer novel approaches for such cases with rapid screening, transplantation studies and in immunotherapy. Discrepancies with large datasets can be handled with an integrated framework of artificial intelligence or AI and machine learning. An attempt has been made to show the improved effectiveness, simplified iterations, along with image analysis that are possible from this synergy. AI-assisted organoids have the potential to transform healthcare by improving disease understanding and accelerating clinical decision-making through personalized and precision medicine.

Uncovering Disease Mechanisms through AI and Visual Computing: A Multi-Scale Approach to Biological Data Interpretation

This research focuses on uncovering complex disease mechanisms by employing artificial intelligence (AI) and visual computing to interpret multi-scale biological data. By analyzing data from molecular to organ-level systems, this study aims to bridge the gap between cellular insights and clinical applications, offering new perspectives on diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases. Through a comprehensive approach to data integration, the project compiles omics and imaging data to enable holistic analysis across biological scales. The use of hierarchical neural networks, graph neural networks (GNNs), and convolutional neural networks (CNNs) allows for multi-dimensional modeling and the extraction of disease-related patterns. The findings are validated with clinical data to support actionable insights, laying the groundwork for personalized disease models and precision therapeutic strategies. Expected outcomes include breakthroughs in disease understanding, advancements in precision medicine, and the establishment of a robust AI framework that will contribute to future biomedical applications. This multidisciplinary approach promises to transform diagnostics, prognosis, and treatment, facilitating a deeper understanding of disease mechanisms and their translation into clinical practice. The integration of multi-scale data enables a nuanced view of disease, capturing interactions that may be obscured in single-level analyses. By employing advanced visual computing techniques, the project highlights structural abnormalities within tissue samples, linking cellular changes to systemic disease pathways. This approach not only aids in identifying novel biomarkers but also supports the development of individualized treatment models that predict patient-specific responses. With validation from clinical datasets, the AI framework is poised to enhance clinical decision-making, offering insights tailored to the unique biological profiles of patients. The project’s multi-scale methodology serves as a foundation for future biomedical research, setting a new standard for AI-driven disease analysis.

Leveraging explainable artificial intelligence for early prediction of bloodstream infections using historical electronic health records.

Bloodstream infections (BSIs) are a severe public health threat due to their rapid progression into critical conditions like sepsis. This study presents a novel eXplainable Artificial Intelligence (XAI) framework to predict BSIs using historical electronic health records (EHRs). Leveraging a dataset from St. Olavs Hospital in Trondheim, Norway, encompassing 35,591 patients, the framework integrates demographic, laboratory, and comprehensive medical history data to classify patients into high-risk and low-risk BSI groups. By avoiding reliance on real-time clinical data, our model allows for enhanced scalability across various healthcare settings, including resource-limited environments. The XAI framework significantly outperformed traditional models, particularly with tree-based algorithms, demonstrating superior specificity and sensitivity in BSI prediction. This approach promises to optimize resource allocation and potentially reduce healthcare costs while providing interpretability for clinical decision-making, making it a valuable tool in hospital systems for early intervention and improved patient outcomes.

A Novel Hybrid XAI Solution for Autonomous Vehicles: Real-Time Interpretability Through LIME-SHAP Integration.

The rapid advancement in self-driving and autonomous vehicles (AVs) integrated with artificial intelligence (AI) technology demands not only precision but also output transparency. In this paper, we propose a novel hybrid explainable AI (XAI) framework that combines local interpretable model-agnostic explanations (LIME) and Shapley additive explanations (SHAP). Our framework combines the precision and globality of SHAP and low computational requirements of LIME, creating a balanced approach for onboard deployment with enhanced transparency. We evaluate the proposed framework on three different state-of-the-art models: ResNet-18, ResNet-50, and SegNet-50 on the KITTI dataset. The results demonstrate that our hybrid approach consistently outperforms traditional approaches by achieving a fidelity rate of more than 85%, interpretability factor of more than 80%, and consistency of more than 70%, surpassing the conventional methods. Furthermore, the inference time of our proposed framework with ResNet-18 was 0.28 s; for ResNet-50, it was 0.571 s; and that for SegNet was 3.889 s with XAI layers. This is optimal for onboard computations and deployment. This research establishes a strong foundation for the deployment of XAI in safety-critical AV with balanced tradeoffs for real-time decision-making.

Deep learning-powered efficient characterization and quantification of microplastics

Characterizing and quantifying microplastics (MPs) are time-consuming and labor-intensive tasks traditionally. This paper presents an artificial intelligence (AI) framework aiming to automate these tasks by integrating computer vision and deep learning techniques. The approach leverages Fourier Transform Infrared (FTIR) spectra and visual images. Primary novelties of this research involve the development of: (1) an AI framework integrating efforts of data processing, analytics, visualization, and human-computer interaction; (2) a method for transforming FTIR data into contour images; (3) data augmentation strategies for resolving data scarcity and imbalance issues; (4) deep learning models for identifying MPs; (5) computer vision algorithms for quantifying MPs; and (6) an engineer-friendly graphic user interface (GUI) for enhancing data accessibility. The AI framework has been applied to polyethylene, polypropylene, polystyrene, polyamide, ethylene-vinyl acetate, and cellulose acetate. Results confirmed the efficacy of the framework, exhibiting high accuracy scores in classification (98 %), segmentation (99 %), and quantification (96 %) tasks. This research advances the capability of automatic assessment of MPs.

The Impact and Future of Generative Pre-trained Transformers: A Study of GPT in Enhancing Business and Technology

With the development of artificial intelligence (AI), natural language processing (NIP) has clearly become the key to enhancing AI capabilities, especially through the deployment of GPT. This paper explores the major advances and related commercial applications of GPT, as it is at the cutting edge of AI technology with far-reaching capabilities in terms of text generation, language understanding, and human-machine interaction. Developed by OpenAI, GPT uses innovative transformer architecture to make breakthroughs in a variety of language tasks, marking a major evolution in the potential applications of AI in various industries. This research explores the integration of GPT in sectors, highlighting how its complex text processing capabilities can be utilized to improve efficiency and innovative service delivery. The study highlights the transformative impact of GPT on business efficiency, strategic decision-making, and customer engagement, thanks to its scalable and adaptable AI framework. Finally, the document reflects the need for a strong ethical framework and regulatory supervision to guide the deployment of GPT technologies. As the Global Trade Agreement evolves, it is committed to shaping the future of global industry by promoting innovation while calling for a balanced approach to ethical considerations and social impacts.

Does Artificial Intelligence Bring to Renewable Energy Innovation？Yes, Empirical Investigation for 51 Countries?

ABSTRACT The development of high-tech industries, represented by artificial intelligence (AI), plays an important role in driving renewable energy innovation (REI). This paper analyzes the effects and mechanisms of AI on REI, using data from 51 countries from 1993 to 2019. The results show that AI can promote REI by increasing research and development (R&D) investment, improving labor productivity and institutional quality. The impact varies depending on the level and type of REI, the type of AI, the level of national income, and the extent of digital infrastructure. In addition, by constructing a spatial Durbin model, this paper also shows that AI inhibits the innovation level of neighboring countries while promoting REI at home. In view of this, countries should make full use of the advantages of AI, increase investment in R&D of AI in the field of RE, improve the efficiency of RE production and use, and establish an international cooperation framework of AI for energy innovation among countries in an effort to promote REI.

Development trends and knowledge framework of artificial intelligence (AI) applications in oncology by years: a bibliometric analysis from 1992 to 2022

PurposeOncology is the primary field in medicine with a high rate of artificial intelligence (AI) use. Thus, this study aimed to investigate the trends of AI in oncology, evaluating the bibliographic characteristics of articles. We evaluated the related research on the knowledge framework of Artificial Intelligence (AI) applications in Oncology through bibliometrics analysis and explored the research hotspots and current status from 1992 to 2022.MethodsThe research employed a scientometric methodology and leveraged scientific visualization tools such as Bibliometrix R Package Software, VOSviewer, and Litmaps for comprehensive data analysis. Scientific AI-related publications in oncology were retrieved from the Web of Science (WoS) and InCites from 1992 to 2022.ResultsA total of 7,815 articles authored by 35,098 authors and published in 1,492 journals were included in the final analysis. The most prolific authors were Esteva A (citaition = 5,821) and Gillies RJ (citaition = 4288). The most active institutions were the Chinese Academy of Science and Harward University. The leading journals were Frontiers ın Oncology and Scientific Reports. The most Frequent Author Keywords are "machine learning", "deep learning," "radiomics", "breast cancer", “melanoma” and "artificial intelligence," which are the research hotspots in this field. A total of 10,866 Authors' keywords were investigated. The average number of citations per document is 23. After 2015, the number of publications proliferated.ConclusionThe investigation of Artificial Intelligence (AI) applications in the field of Oncology is still in its early phases especially for genomics, proteomics, and clinicomics, with extensive studies focused on biology, diagnosis, treatment, and cancer risk assessment. This bibliometric analysis offered valuable perspectives into AI's role in Oncology research, shedding light on emerging research paths. Notably, a significant portion of these publications originated from developed nations. These findings could prove beneficial for both researchers and policymakers seeking to navigate this field.

How can geostatistics help us understand deep learning? An exploratory study in SAR-based aircraft detection

Deep Neural Networks (DNNs) have garnered significant attention across various research domains due to their impressive performance, particularly Convolutional Neural Networks (CNNs), known for their exceptional accuracy in image processing tasks. However, the opaque nature of DNNs has raised concerns about their trustworthiness, as users often cannot understand how the model arrives at its predictions or decisions. This lack of transparency is particularly problematic in critical fields such as healthcare, finance, and law, where the stakes are high. Consequently, there has been a surge in the development of explanation methods for DNNs. Typically, the effectiveness of these methods is assessed subjectively via human observation on the heatmaps or attribution maps generated by eXplanation AI (XAI) methods. In this paper, a novel GeoStatistics Explainable Artificial Intelligence (GSEAI) framework is proposed, which integrates spatial pattern analysis from Geostatistics with XAI algorithms to assess and compare XAI understandability. Global and local Moran’s I indices, commonly used to assess the spatial autocorrelation of geographic data, assist in comprehending the spatial distribution patterns of attribution maps produced by the XAI method, through measuring the levels of aggregation or dispersion. Interpreting and analyzing attribution maps by Moran’s I scattergram and LISA clustering maps provide an accurate global objective quantitative assessment of the spatial distribution of feature attribution and achieves a more understandable local interpretation. In this paper, we conduct experiments on aircraft detection in SAR images based on the widely used YOLOv5 network, and evaluate four mainstream XAI methods quantitatively and qualitatively. By using GSEAI to perform explanation analysis of the given DNN, we could gain more insights about the behavior of the network, to enhance the trustworthiness of DNN applications. To the best of our knowledge, this is the first time XAI has been integrated with geostatistical algorithms in SAR domain knowledge, which expands the analytical approaches of XAI and also promotes the development of XAI within SAR image analytics.

Advanced artificial intelligence framework for T classification of TNM lung cancer in 18FDG-PET/CT imaging

The integration of artificial intelligence (AI) into lung cancer management offers immense potential to revolutionize diagnostic and treatment strategies. The aim is to develop a resilient AI framework capable of two critical tasks: firstly, achieving accurate and automated segmentation of lung tumors and secondly, facilitating the T classification of lung cancer according to the ninth edition of TNM staging 2024 based on PET/CT imaging. This study presents a robust AI framework for the automated segmentation of lung tumors and T classification of lung cancer using PET/CT imaging. The database includes axial DICOM CT and18FDG-PET/CT images. A modified ResNet-50 model was employed for segmentation, achieving high precision and specificity. Reconstructed 3D models of segmented slices enhance tumor boundary visualization, which is essential for treatment planning. The Pulmonary Toolkit facilitated lobe segmentation, providing critical diagnostic insights. Additionally, the segmented images were used as input for the T classification using a CNN ResNet-50 model. Our classification model demonstrated excellent performance, particularly for T1a, T2a, T2b, T3 and T4 tumors, with high precision, F1 scores, and specificity. The T stage is particularly relevant in lung cancer as it determines treatment approaches (surgery, chemotherapy and radiation therapy or supportive care) and prognosis assessment. In fact, for Tis-T2, each increase of one centimeter in tumor size results in a worse prognosis. For locally advanced tumors (T3-T4) and regardless of size, the prognosis is poorer. This AI framework marks a significant advancement in the automation of lung cancer diagnosis and staging, promising improved patient outcomes.

Pathology Report Interpretation and Disease Diagnosis Using Fuzzy Logic Embedded in an Artificial Intelligence Framework: A New Paradigm for Digital Technologies.

Introduction Accurate diagnosis is essential for effective treatment in healthcare settings. Digital technologies have revolutionized medical diagnostics, particularly in pathology laboratory report analyses, by enhancing speed, quality, and precision. Diagnostic pathology has advanced significantly with digital imaging, AI algorithms, and computer-assisted techniques. Traditional machine learning methods require extensive training data, struggle with decision-making flexibility, and lack interpretability when handling new data. Methods This paper introduces a novel approach to address these challenges: a fuzzy logic-based system for interpreting pathology laboratory reports and diagnosing diseases, while considering the restrictions of engineered interpretations so that the degree of reliability of the output of the system is at par with human perception. Results The analysis highlights the impressive accuracy of the fuzzy logic-based diagnosis system, which is closely aligned with professional diagnoses. Notably, it correctly identified "normal" with an 83% probability, showcasing its potential for early disease detection. Performance evaluations indicated that the precision, recall, and F-measure significantly improved as the number of probable diagnoses considered increased. Furthermore, the system exhibited enhanced predictive accuracy for disease recurrence when incorporating multiple probable diagnoses, underscoring its robust clinical effectiveness. Conclusion A fuzzy logic-based system within an AI framework for interpreting pathology laboratory reports and diagnosing 17 diseases across various demographics is presented. The performance of the algorithm, assessed using specialized classification metrics, showed stable and satisfactory results. The analysis revealed a direct correlation between the number of probable diagnoses considered and improved diagnostic accuracy with enhancements in precision, recall, and F-measure. Broadening the diagnostic scope optimizes immediate patient care and long-term treatment planning, potentially enhancing patient outcomes and healthcare quality.

LuckyMera: a modular AI framework for building hybrid NetHack agents

In the last few decades we have witnessed a significant development in Artificial Intelligence (AI) thanks to the availability of a variety of testbeds, mostly based on simulated environments and video games. Among those, roguelike games offer a very good trade-off in terms of complexity of the environment and computational costs, which makes them perfectly suited to test AI agents generalization capabilities. In this work, we present LuckyMera, a flexible, modular, extensible and configurable AI framework built around NetHack, a popular terminal-based, single-player roguelike video game. This library is aimed at simplifying and speeding up the development of AI agents capable of successfully playing the game and offering a high-level interface for designing game strategies. LuckyMera comes with a set of off-the-shelf symbolic and neural modules (called "skills"): these modules can be either hard-coded behaviors, or neural Reinforcement Learning approaches, with the possibility of creating compositional hybrid solutions. Additionally, LuckyMera comes with a set of utility features to save its experiences in the form of trajectories for further analysis and to use them as datasets to train neural modules, with a direct interface to the NetHack Learning Environment and MiniHack. Through an empirical evaluation we validate our skills implementation and propose a strong baseline agent that can reach state-of-the-art performances in the complete NetHack game. LuckyMera is open-source and available at https://github.com/Pervasive-AI-Lab/LuckyMera.

Explainable AI for Transparent MRI Segmentation: Deep Learning and Visual Attribution in Clinical Decision Support

For medical diagnosis and therapy planning, the importance of accurate MRI segmentation cannot be overemphasized. Conversely, the inscrutability of deep learning models remains obstacles to their application in therapeutic contexts. In this article, an interpretability artificial intelligence framework is introduced. It combines an MRI segmentation model based on deep learning, visual attribution algorithms and natural language explanations. EXPERIMENT The dataset is consisting of plenty of different types of brain MRI scans, and used to test the architecture. The average of Dice score of our method is 88.7% and 92.3% for segmentation of tumor and categorization of tissues, respectively. Both are pretty epic scores. The insights extracted from both the visual attributions and textual explations improve our understanding of how the model arrives at its decisions, thereby increasing the transparency and interpretability of the model. believe this approach to explainable artificial intelligence can help to close the gap between state-of-the-art performance in MRI segmentation and clinical interpretability, by increasing the transparency of complex models and facilitating their implementation into a clinical workflow. Conclusion Our approach may have implications in the transparent and reliable development of AI-based decision support systems for medical imaging

An empirical study of AI techniques in mobile applications

The integration of artificial intelligence (AI) into mobile applications has significantly transformed various domains, enhancing user experiences and providing personalized services through advanced machine learning (ML) and deep learning (DL) technologies. AI-driven mobile apps typically refer to applications that leverage ML/DL technologies to perform key tasks such as image recognition and natural language processing. Despite existing research exploring how mobile apps exploit AI techniques, they have the following main limitations: (1) Most existing studies focus on DL-based apps, with limited research on ML-based apps. (2) Existing research typically focuses on investigating the apps and the technologies utilized in the apps, lacking user-level analysis. (3) The number of apps studied is limited, with only 1,000 to 2,000 ML/DL apps identified after filtering. To fill the gap, in this paper, we conducted the most extensive empirical study on AI applications, exploring on-device ML apps, on-device DL apps, and AI service-supported (cloud-based) apps. Our study encompasses 56,682 real-world AI applications, focusing on three crucial perspectives: (1) Application analysis, where we analyze the popularity of AI apps and investigate the update states of AI apps; (2) Framework and model analysis, where we analyze AI framework usage and AI model protection; (3) User analysis, where we examine user privacy protection and user review attitudes. Our study has strong implications for AI app developers, users, and AI R&D. On one hand, our findings highlight the growing trend of AI integration in mobile applications, demonstrating the widespread adoption of various AI frameworks and models. On the other hand, our findings emphasize the need for robust model protection to enhance app security. Additionally, our study highlights the importance of user privacy and presents user attitudes towards the AI technologies utilized in current AI apps. We provide our AI app dataset (currently the most extensive AI app dataset) as an open-source resource for future research on AI technologies utilized in mobile applications.

Enhancing transparency in data-driven urban pluvial flood prediction using an explainable CNN model

Mitigating severe losses caused by pluvial floods in urban areas with dense population and property requires effective flood prediction for emergency measures. Physics-based models face issues with low computational efficiency for real‐time flood prediction. An alternative approach for rapid prediction instead of physics-based models is to predict from a data-driven perspective. However, data-driven approaches for urban flood prediction are often perceived as “black box” and might raise concerns. In this study, we propose an explainable deep learning (DL) approach for rapid urban pluvial flood prediction with enhanced transparency using a convolutional neural network (CNN) and the explainable artificial intelligence (AI) framework Shapley additive explanation (SHAP). We process a systematic stepwise feature selection process and establish a CNN model considering topography, drainage networks and rainfall to predict maximum inundation depths. Then, SHAP is applied to provide trustworthy explanations for the decision making in model results. The results show that: 1) Forward selection can offer insights into selecting effective input variables for improved predictions and promote understanding of DL modelling. The spatial pattern of inundation depths predicted by the proposed CNN model shows good agreement with those predicted by the physics-based model, demonstrated by average correlation coefficient (CC) and mean absolute error (MAE) values of 0.982 and 0.021 m, respectively. 2) The CNN model substantially outperforms the physics-based model in computational speed when using the same hardware, achieving speedups of 210 times on GPU and 51 times on CPU in the case study (575167 grid cells, 14.38 km2). Particularly, it can still achieve good performance on a CPU-only standard laptop without high-performance hardware, with only a modest increase in computational time. 3) The SHAP explainable analysis confirms that the CNN model correctly captures the relationships between input variables and water depth, revealing a reasonable decision-making process, enhancing its transparency. The explainable DL approach incorporating SHAP for rapid urban pluvial flood prediction is promising to build trust among stakeholders and provide a trustworthy reference for prompt measures aiming at saving lives and protecting assets during flood emergencies. Additionally, the proposed DL approach can potentially be further expanded to analyze the causes of urban flooding events and serve as a foundation for exploring the transferability of data-driven urban flood prediction, providing benefits for better urban flood risk management.

In-hospital mortality, readmission, and prolonged length of stay risk prediction leveraging historical electronic patient records.

This study aimed to investigate the predictive capabilities of historical patient records to predict patient adverse outcomes such as mortality, readmission, and prolonged length of stay (PLOS). Leveraging a de-identified dataset from a tertiary care university hospital, we developed an eXplainable Artificial Intelligence (XAI) framework combining tree-based and traditional machine learning (ML) models with interpretations and statistical analysis of predictors of mortality, readmission, and PLOS. Our framework demonstrated exceptional predictive performance with a notable area under the receiver operating characteristic (AUROC) of 0.9625 and an area under the precision-recall curve (AUPRC) of 0.8575 for 30-day mortality at discharge and an AUROC of 0.9545 and AUPRC of 0.8419 at admission. For the readmission and PLOS risk, the highest AUROC achieved were 0.8198 and 0.9797, respectively. The tree-based models consistently outperformed the traditional ML models in all 4 prediction tasks. The key predictors were age, derived temporal features, routine laboratory tests, and diagnostic and procedural codes. The study underscores the potential of leveraging medical history for enhanced hospital predictive analytics. We present an accurate and intuitive framework for early warning models that can be easily implemented in the current and developing digital health platforms to predict adverse outcomes accurately.

Ethical Artificial Intelligence Framework Theory (EAIFT): A New Paradigm for Embedding Ethical Reasoning in AI Systems

The rapid development of artificial intelligence (AI) has created several ethical issues, including bias, a lack of transparency, and privacy concerns, demanding the incorporation of ethical governance directly into AI systems. This study introduces the Ethical Artificial Intelligence Framework Theory (EAIFT), a novel approach to incorporating ethical reasoning into AI. It emphasizes real-time oversight, open decision-making, bias detection, and the ability to change ethical and legal norms. EAIFT advocates for establishing "ethical AI watchdogs" that automatically monitor and ensure the ethical operation of AI systems, together with dynamic compliance algorithms that can adapt to regulatory changes. The paradigm also encourages transparency and explainability to build user trust and detect and correct biases to ensure fairness. This paper employs a qualitative methodology that combines stakeholder interviews, content analysis, and expert commentary to evaluate EAIFT's potential to increase ethical accountability in various areas, including healthcare, banking, and criminal justice. The findings suggest that EAIFT outperforms existing ethical frameworks by proactively reducing biases, increasing transparency, and ensuring adherence to ethical standards. While presenting a comprehensive and adaptable technique, the study also acknowledges limitations in empirical testing and the need for additional research to widen EAIFT's applicability to future ethical challenges in artificial intelligence. The paper suggests future research subjects, such as empirical testing in different scenarios, a more in-depth examination of ethical risks, and the inclusion of the framework into new AI technologies to promote responsible AI governance by societal norms and values.

Toward High-Quality Real-World Laboratory Data in the Era of Healthcare Big Data.

With Industry 4.0, big data and artificial intelligence have become paramount in the field of medicine. Electronic health records, the primary source of medical data, are not collected for research purposes but represent real-world data; therefore, they have various constraints. Although structured, laboratory data often contain unstandardized terminology or missing information. The major challenge lies in the lack of standardization of test results in terms of metrology, which complicates comparisons across laboratories. In this review, we delve into the essential components necessary for integrating real-world laboratory data into high-quality big data, including the standardization of terminology, data formats, equations, and the harmonization and standardization of results. Moreover, we address the transference and adjustment of laboratory results, along with the certification for quality of laboratory data. By discussing these critical aspects, we seek to shed light on the challenges and opportunities inherent to utilizing real-world laboratory data within the framework of healthcare big data and artificial intelligence.