It is widely known that flow in fractured sedimentary rock is dominated by the interconnected fractures in the rock mass, but it is difficult to determine which fractures observed in boreholes are active, meaning they transmit water under natural gradient conditions A methodology is presented that uses optical televiewer (OTV) and continuous core logs synergistically with FLUTe™ Transmissivity (T) profiling, straddle packer testing, rock core permeability testing, active line source temperature logs, and rock core VOC concentration profiles to determine the number and position of active fractures in a 196-meter borehole in sandstone. The application of this methodology indicates that 40% of the identified fractures are active in this borehole with a frequency of 0.61 active fractures per meter, which compares well with the number of fractures identified with the straddle packer Rec method used in the largest transmissive zones, while the low transmissivity zones tested are consistent with laboratory-measured rock matrix hydraulic conductivity. High-resolution, hydraulically based methods provide the necessary evidence to improve estimates of active fractures that control solute transport. This paper demonstrates how multiple, spatially resolved data sets can be used synergistically to inform fracture network parameters thereby constraining hydraulic aperture and surface area calculations that control flow and diffusion, with the aim of improving the estimation of plume migration rates and mass discharge to receptors in fractured sedimentary rocks.