to assess and compare the effect of mid-root perforation repair using Biodentine and Portland cement in single-rooted endodontically treated mandibular premolars in terms of stress distribution using finite element analysis (FEA) and fracture resistance test. In the FEA, an extracted human mandibular premolar tooth was scanned using cone beam computed tomography, and a 3-dimensional (3D) solid model was created. A sound tooth model (ST), an endodontically treated model (ET), an instrumented and mid-root perforated and repaired by Biodentine model (BM), and perforated and repaired by Portland cement model (PCM) were the 4 models simulated. A vertical force of 300N on the occlusal plane was applied. Evaluation of von Mises stress distribution and maximum displacement were investigated. In the fracture resistance in vitro study, 28 extracted premolars were selected and randomized into 4 groups, (n = 7), (A) is the negative control intact group, (B) is the positive control of endodontically treated group, (C) is mid-root perforated and repaired by Biodentine group and (D) is mid-root perforated and repaired by Portland cement. All Teeth were instrumented except for group A, group B was obturated while groups C and D were instrumented, perforated, repaired, and obturated. All groups were restored coronally except group A. Fracture force was measured; subsequently, the fracture repairability was evaluated. Finally, the data were statistically evaluated using one-way analysis of variance (ANOVA); the significance level was set at P ≤ 0.05 and the repairability of teeth after fracture was correlated to the maximum loading using Pearson's coefficient tests. In FEA, Maximum von Mises stress was descending assorted as 121.1MPa for ET, 115.6MPa for BM and PCM, and 109MPa for ST, and in the mid-root area or perforation site were 20MPa for PCM, 16.17MPa for BM, 10.16MPa for ET and 8.1MPa for ST while the Maximum Displacement was descending assorted as 0.0179mm for ET, 0.0169mm for BM and PCM and 0.0151mm for ST. In the fracture resistance test, Group A showed higher fracture resistance than other groups significantly. There was a non-significant difference between Groups B, C, and D. There was also an insignificant correlation between the maximum loading and the repairability of the tooth after fracture. FEA and fracture resistance test showed that the 2 repair materials are acceptable and recommended in iatrogenic mid-root perforation.
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