Background:Several factors might affect the fracture resistance of all-ceramic crowns, including cement thickness.Aim:To evaluate the influence of cement thickness on the fracture resistance.Objective:To determine the effect of varying the adhesive gap thickness on the fracture loads of all-ceramic CEREC 3D molar crowns.Methods:Standardized prepared epoxy resin molar dies (Viade Inc.) were fabricated. A standard molar crown was designed using a CEREC 3D machine (Sirona Dental Systems). Twenty-four crowns were milled from Vita Mark II blocks (Vita Zahnfabrik), using adhesive gap settings of 30, 60 and 90 µm (n=8). A dual-cure resin cement (PanaviaF 2.0, Kuraray) was used to cement the crowns to their respective dies, following manufacturer's recommendation. After 1 week of storage in distilled water at 37°C, each crown was loaded in compression until complete failure in a universal testing machine (Instron 8501) and fracture loads (N) were recorded. Fractured specimens were sectioned to determine cement thickness. Sections were examined using a traveling light microscope to measure cement thickness. Data were statistically analyzed using one-way ANOVA test and Pearson's correlation at (α=0.05).Results:The mean fracture loads and standard deviation values in N were 1,267.57 (122.82), 1,225.20 (179.46) and 1,180.76 (161.77) for the crowns with 30, 60 and 90µm, respectively. ANOVA indicated no significant differences among mean fracture strength values (p= 0.55). All crowns failed in a catastrophic mode and were not repairable.Conclusions:Adhesive cement gap as achieved with three CEREC 3D settings from 30 to 90µm had no significant effect on fracture strength of crowns made from Vita Mark II blocks.