Vortex electromagnetic (EM) waves carrying orbital angular momentum (OAM) wave, whose infinitely helical wavefront and orthogonal eigenvalues of unique physical properties introduce additional rotational degrees of freedom, which has demonstrated superior performance in target detection and azimuthal imaging. In order to enhance the imaging performance for maneuvering targets, this paper offers a solution to develop the vortex inverse synthetic aperture radar (ISAR) technique based on OAM beams design. Firstly, by the space geometry of radar and maneuvering targets, the vortex echo signal model is derived, and the characteristics are analyzed as well. Secondly, pre-processing approach is developed for initial phase compensation by the design of the transmitted OAM beams. Thirdly, the imaging method, based on fractional Fourier transform (FrFT) and Doppler centroid tracking (DCT), is proposed to achieve high-precision range compression and motion compensation to accomplish the range alignment while removing the phases caused by residual azimuth displacements. Finally, after the slow-time pulse compression, the time-invariant Doppler shift is generated, and the well-focused ISAR image can be obtained. The simulation results demonstrate that the proposed vortex ISAR imaging can achieve a higher azimuth resolution than the conventional planar EM ISAR paradigm with the same synthetic aperture length. This discovery provides an approach for OAM-based microwave imaging in a rather efficient manner, which has no harsh requirements for complicated and heavily computational post-processing.