Fournier's gangrene is a rare but deadly condition, with propensity for people with diabetes and long-term alcohol abuse, although it can also afflict patients with non-obvious immunological impairment. The nidus might be found in the genitourinary tract, lower gastrointestinal tract or the skin and is a mixed aerobic and anaerobic infection. The gangrene's development and spread is often fulminating resulting in multiple organ failure and death. Fournier’s gangrene in female patients has been reported to be associated with infection from episiotomy wounds and Bartholin’s abscess. But despite advanced management, mortality is still high and averages 20-30% .The current article discusses a case of Fournier’s gangrene in a female patient that was further complicated by a hyperglycemic hyperosmolar condition with approaching multi-organ dysfunction, as well as the successful medical and surgical therapy of the patient.