In this work, we establish a novel approach to the foundations of relativistic quantum theory, which is based on generalizing the quantum-mechanical Born rule for determining particle position probabilities to curved spacetime. A principal motivator for this research has been to overcome internal mathematical problems of relativistic quantum field theory (QFT) such as the ‘problem of infinities’ (renormalization), which axiomatic approaches to QFT have shown to be not only of mathematical but also of conceptual nature. The approach presented here is probabilistic by construction, can accommodate a wide array of dynamical models, does not rely on the symmetries of Minkowski spacetime, and respects the general principle of relativity. In the analytical part of this work, we consider the 1-body case under the assumption of smoothness of the mathematical quantities involved. This is identified as a special case of the theory of the general-relativistic continuity equation. While related approaches to the relativistic generalization of the Born rule assume the hypersurfaces of interest to be spacelike and the spacetime to be globally hyperbolic, we employ prior contributions by C. Eckart and J. Ehlers to show that the former condition is naturally replaced by a transversality condition and that the latter one is obsolete. We discuss two distinct formulations of the 1-body case, which, borrowing terminology from the non-relativistic analog, we term the Lagrangian and Eulerian pictures. We provide a comprehensive treatment of both. The main contribution of this work to the mathematical physics literature is the development of the Lagrangian picture. The Langrangian picture shows how one can address the ‘problem of time’ in this approach and, therefore, serves as a blueprint for the generalization to many bodies and the case that the number of bodies is not conserved. We also provide an example to illustrate how this approach can in principle be employed to model particle creation and annihilation.