One of the key issues in current international relations studies is the structure of knowledge. The epistemological foundations of political and economic theories of international development are losing their relevance as the influence of theory on the practice of international relations wanes. The declining ability of international analysis to predict the future of world politics and economics emphasizes the need for a broader, interdisciplinary approach to the study of international relations. This study aims to explore the possibility of creating a new, practical and interdisciplinary model of analysis to address the problems of the modern international system. This approach to the systemic analysis of international relations involves broadening the scope of the study by integrating international political and economic (IPE) analysis and including three analytical levels: explanatory, normative and critical. The article defines the terminology, structure, principles and criteria of such an analysis based on the problems of modern political science. The author also points out the main difficulties in the formation of theoretical and methodological basis of the three-level analysis. Examples of analyzing problems, namely the impact of trade barriers on the instability of global supply chains and the international dimension of the energy crisis of the Federal Republic of Germany (2022 – present) are given, demonstrating the quality and consistency of the results of such analysis.