Forward Masking Experiments Research Articles

Psychoacoustic measurements of ipsilateral cochlear gain reduction as a function of signal frequency.

Forward masking experiments at 4 kHz have demonstrated that preceding sound can elicit changes in masking patterns consistent with a change in cochlear gain. However, the acoustic environment is filled with complex sounds, often dominated by lower frequencies, and ipsilateral cochlear gain reduction at frequencies below 4 kHz is largely unstudied in the forward masking literature. In this experiment, the magnitude of ipsilateral cochlear gain reduction was explored at 1, 2, and 4 kHz using forward masking techniques in an effort to evaluate a range of frequencies in listeners with normal hearing. Gain reduction estimates were not significantly different at 2 and 4 kHz using two forward masking measurements. Although the frequency was a significant factor in the analysis, post hoc testing supported the interpretation that gain reduction estimates measured without a masker were not significantly different at 1, 2, and 4 kHz. A second experiment provided evidence that forward masking in this paradigm at 1 kHz cannot be explained by excitation alone. This study provides evidence of ipsilateral cochlear gain reduction in humans at frequencies below the 4 kHz region.

Electric-acoustic forward masking in cochlear implant users with ipsilateral residual hearing

In order to investigate the temporal mechanisms of the auditory system, psychophysical forward masking experiments were conducted in cochlear implant users who had preserved acoustic hearing in the ipsilateral ear. This unique electric-acoustic stimulation (EAS) population allowed the measurement of threshold recovery functions for acoustic or electric probes in the presence of electric or acoustic maskers, respectively. In the electric masking experiment, the forward masked threshold elevation of acoustic probes was measured as a function of the time interval after the offset of the electric masker, i.e. the masker-to-probe interval (MPI). In the acoustic masking experiment, the forward masked threshold elevation of electric probe stimuli was investigated under the influence of a preceding acoustic masker. Since electric pulse trains directly stimulate the auditory nerve, this novel experimental setup allowed the acoustic adaptation properties (attributed to the physiology of the hair cells) to be differentiated from the subsequent processing by more central mechanisms along the auditory pathway. For instance, forward electric masking patterns should result more from the auditory-nerve response to electrical stimulation, while forward acoustic masking patterns should primarily be the result of the recovery from adaptation at the hair-cell neuron interface.Electric masking showed prolonged threshold elevation of acoustic probes, which depended significantly on the masker-to-probe interval. Additionally, threshold elevation was significantly dependent on the similarity between acoustic stimulus frequency and electric place frequency, the electric-acoustic frequency difference (EAFD). Acoustic masking showed a reduced, but statistically significant effect of electric threshold elevation, which did not significantly depend on MPI. Lastly, acoustic masking showed longer decay times than electric masking and a reduced dependency on EAFD.In conclusion, the forward masking patterns observed for combined electric-acoustic stimulation provide further insights into the temporal mechanisms of the auditory system. For instance, the asymmetry in the amount of threshold elevation, the dependency on EAFD and the time constants for the recovery functions of acoustic and electric masking all indicate that there must be several processes with different latencies (e.g. neural adaptation, depression of spontaneous activity, efferent systems) that are involved in forward masking recovery functions.

Auditory enhancement and other context effects in normal, impaired, and electric hearing

Neal Viemeister’s contributions to our understanding of auditory enhancement stood out because they combined novel and intriguing empirical data with a testable theoretical framework to explain the results. Thirty-five years later, the resultant “adaptation of inhibition” hypothesis remains the default explanation for auditory enhancement effects, and it can be used to account for both basic auditory context effects as well as speech context effects. Recent work in our lab has focused on comparing speech and non-speech context effects in people with normal and impaired hearing, as well as cochlear implants, in an attempt to elucidate the underlying neural mechanisms and to work towards compensating for any loss of context effects in clinical populations via signal processing. This presentation will provide a survey of recent progress in this area with examples from simultaneous masking, forward masking, and speech discrimination experiments. [Work supported by NIH grant R01DC012262.]

Investigating time-efficiency of forward masking paradigms for estimating basilar membrane input-output characteristics.

It is well known that pure-tone audiometry does not sufficiently describe individual hearing loss (HL) and that additional measures beyond pure-tone sensitivity might improve the diagnostics of hearing deficits. Specifically, forward masking experiments to estimate basilar-membrane (BM) input-output (I/O) function have been proposed. However, such measures are very time consuming. The present study investigated possible modifications of the temporal masking curve (TMC) paradigm to improve time and measurement efficiency. In experiment 1, estimates of knee point (KP) and compression ratio (CR) of individual BM I/Os were derived without considering the corresponding individual “off-frequency” TMC. While accurate estimation of KPs was possible, it is difficult to ensure that the tested dynamic range is sufficient. Therefore, in experiment 2, a TMC-based paradigm, referred to as the “gap method”, was tested. In contrast to the standard TMC paradigm, the maker level was kept fixed and the “gap threshold” was obtained, such that the masker just masks a low-level (12 dB sensation level) signal. It is argued that this modification allows for better control of the tested stimulus level range, which appears to be the main drawback of the conventional TMC method. The results from the present study were consistent with the literature when estimating KP levels, but showed some limitations regarding the estimation of the CR values. Perspectives and limitations of both approaches are discussed.

Effects of passive and active movement on vibrotactile detection thresholds of the Pacinian channel and forward masking

We investigated the gating effect of passive and active movement on the vibrotactile detection thresholds of the Pacinian (P) psychophysical channel and forward masking. Previous work on gating mostly used electrocutaneous stimulation and did not allow focusing on tactile submodalities. Ten healthy adults participated in our study. Passive movement was achieved by swinging a platform, on which the participant’s stimulated hand was attached, manually by a trained operator. The root-mean-square value of the movement speed was kept in a narrow range (slow: 10–20 cm/s, fast: 50–60 cm/s). Active movement was performed by the participant him-/herself using the same apparatus. The tactile stimuli consisted of 250-Hz sinusoidal mechanical vibrations, which were generated by a shaker mounted on the movement platform and applied to the middle fingertip. In the forward-masking experiments, a high-level masking stimulus preceded the test stimulus. Each movement condition was tested separately in a two-interval forced-choice detection task. Both passive and active movement caused a robust gating effect, that is, elevation of thresholds, in the fast speed range. Statistically significant change of thresholds was not found in slow movement conditions. Passive movement yielded higher thresholds than those measured during active movement, but this could not be confirmed statistically. On the other hand, the effect of forward masking was approximately constant as the movement condition varied. These results imply that gating depends on both peripheral and central factors in the P channel. Active movement may have some facilitatory role and produce less gating. Additionally, the results support the hypothesis regarding a critical speed for gating, which may be relevant for daily situations involving vibrations transmitted through grasped objects and for manual exploration.

Forward masking in the medial nucleus of the trapezoid body of the rat.

Perception of acoustic stimuli is modulated by the temporal and spectral relationship between sound components. Forward masking experiments show that the perception threshold for a probe tone is significantly impaired by a preceding masker stimulus. Forward masking has been systematically studied at the level of the auditory nerve, cochlear nucleus, inferior colliculus and auditory cortex, but not yet in the superior olivary complex. The medial nucleus of the trapezoid body (MNTB), a principal cell group of the superior olive, plays an essential role in sound localization. The MNTB receives excitatory input from the contralateral cochlear nucleus via the calyces of Held and innervates the ipsilateral lateral and medial superior olives, as well as the superior paraolivary nucleus. Here, we performed single-unit extracellular recordings in the MNTB of rats. Using a forward masking paradigm previously employed in studies of the inferior colliculus and auditory nerve, we determined response thresholds for a 20-ms characteristic frequency pure tone (the probe), and then presented it in conjunction with another tone (the masker) that was varied in intensity, duration, and frequency; we also systematically varied the masker-to-probe delay. Probe response thresholds increased and response magnitudes decreased when a masker was presented. The forward suppression effects were greater when masker level and masker duration were increased, when the masker frequency approached the MNTB unit's characteristic frequency, and as the masker-to-probe delay was shortened. Probe threshold shifts showed an exponential decay as the masker-to-probe delay increased.

Efficient estimates of cochlear hearing loss parameters in individual listeners

It has been suggested that the level corresponding to the knee-point of the basilar membrane (BM) input/output (I/O) function can be used to estimate the amount of inner- and outer hair-cell loss in listeners with a moderate cochlear hearing impairment [e.g., Plack et al., (2004)]. In the present study, results from forward masking experiments based on temporal masking curves [TMC; Nelson et al. (2001)] are presented and used to estimate the knee-point level and the compression ratio of the I/O function. A time-efficient paradigm based on the single-interval-up-down method [SIUD; Lecluyse and Meddis (2009)] was used instead of an alternative forced-choice paradigm. In contrast with previous studies, the present study used only on-frequency TMCs to derive estimates of the knee-point level. Further, it is explored whether it is possible to estimate the compression ratio using only on-frequency TMCs. Ten normal-hearing and 10 hearing-impaired listeners (with mild-to-moderate sensorineural hearing loss) were tested at 1, 2, and 4 kHz. The results showed a reasonable reliability and an increased time-efficiency compared to AFC-based results and may be suitable for individualized hearing-aid fitting.

Abnormal auditory forward masking pattern in the brainstem response of individuals with Asperger syndrome

Abnormal auditory information processing has been reported in individuals with autism spectrum disorders (ASD). In the present study auditory processing was investigated by recording auditory brainstem responses (ABRs) elicited by forward masking in adults diagnosed with Asperger syndrome (AS). Sixteen AS subjects were included in the forward masking experiment and compared to three control groups consisting of healthy individuals (n = 16), schizophrenic patients (n = 16) and attention deficit hyperactivity disorder patients (n = 16), respectively, of matching age and gender. The results showed that the AS subjects exhibited abnormally low activity in the early part of their ABRs that distinctly separated them from the three control groups. Specifically, wave III amplitudes were significantly lower in the AS group than for all the control groups in the forward masking condition (P < 0.005), which was not the case in the baseline condition. Thus, electrophysiological measurements of ABRs to complex sound stimuli (eg, forward masking) may lead to a better understanding of the underlying neurophysiology of AS. Future studies may further point to specific ABR characteristics in AS individuals that separate them from individuals diagnosed with other neurodevelopmental diseases.

Forward-masking patterns produced by symmetric and asymmetric pulse shapes in electric hearing

Two forward-masking experiments were conducted with six cochlear implant listeners to test whether asymmetric pulse shapes would improve the place-specificity of stimulation compared to symmetric ones. The maskers were either cathodic-first symmetric biphasic, pseudomonophasic (i.e., with a second anodic phase longer and lower in amplitude than the first phase), or "delayed pseudomonophasic" (identical to pseudomonophasic but with an inter-phase gap) stimuli. In experiment 1, forward-masking patterns for monopolar maskers were obtained by keeping each masker fixed on a middle electrode of the array and measuring the masked thresholds of a monopolar signal presented on several other electrodes. The results were very variable, and no difference between pulse shapes was found. In experiment 2, six maskers were used in a wide bipolar (bipolar+9) configuration: the same three pulse shapes as in experiment 1, either cathodic-first relative to the most apical or relative to the most basal electrode of the bipolar channel. The pseudomonophasic masker showed a stronger excitation proximal to the electrode of the bipolar pair for which the short, high-amplitude phase was anodic. However, no difference was obtained with the symmetric and, more surprisingly, with the delayed pseudomonophasic maskers. Implications for cochlear implant design are discussed.

Psychophysical estimates of cochlear tuning using simultaneous and nonsimultaneous masking

This study attempts to estimate the tuning of an auditory filter, through both simultaneous and forward masking experiments with a notched‐noise masker or a sinusoidal masker, to investigate how the effects of suppression affect estimates of frequency selectivity. In these experiments, masked thresholds of the short probe signal (5‐ms ramps, no steady state) centered in the masker or delayed from the masker were measured for normal‐hearing subjects as a function of the signal frequency (0.5, 1.0, 2.0, and 4.0 kHz), signal level (10, 20, and 30 dB SL), signal delay, and notch‐width conditions in the notched‐noise masker, or the masker frequency in the sinusoidal masker. ERBs were calculated from derived auditory filters to compare the cochlear tuning. The estimated tunings became much sharper as the center frequency was increased. Moreover, the difference between the tunings of the filter at lower frequencies with either form of masking tended to be smaller than that at higher frequencies. The tuning may be affected by residual effects of suppression due to lower masker components below the signal frequency. [Work supported by special coordination funds for promoting science and technology of young researchers from the Japanese Ministry of Education.]

Effect of electrode configuration on psychophysical forward masking in cochlear implant listeners

Bipolar stimulation has been thought to be more beneficial than monopolar stimulation for speech coding in cochlear implants, on the basis of its more restricted current flow. The present study examined whether bipolar stimulation would indeed lead to reduced channel interaction in a behavioral forward masking experiment tested in four Nucleus 24 users. The masker was fixed on one channel and three masker levels that were balanced for loudness between the configurations were chosen. As expected, masking was maximal when the masker and probe channels were spatially close and decreased as they were separated. However, overall masking patterns did not consistently demonstrate sharper tuning with bipolar stimulation than monopolar. This implies that the spatial extent of a bipolar current field is not consistently narrower than that of an equally loud monopolar stimulus; therefore, it should not be assumed that bipolar stimulation leads to reduced channel interaction. Notably, bipolar masking patterns appeared to display more variations across channels, possibly influenced more by anatomical and neural irregularities near electrode contacts than monopolar masking patterns. The present psychophysical results provide a theoretical basis regarding the widespread use (and success) of monopolar configurations by implant users.

Explaining two-tone suppression and forward masking data using a compressive gammachirp auditory filterbank

The gammatone filter was imported from auditory physiology to provide a time-domain version of the roex auditory filter and enable the development of a realistic auditory filterbank for models of auditory perception. The gammachirp auditory filter was developed to extend the domain of the gammatone auditory filter and simulate the changes in filter shape that occur with changes in stimulus level. Recently, the gammachirp was extended to explain the level-independent frequency glide of the impulse response and a large volume of simultaneous masking data quantitatively. Although this could be implemented with a static filter, we used a time-varying filter whose active component is an IIR asymmetric compensation filter. In this case, it is necessary to estimate the signal level that controls the level dependency, and explain how the level measurement produces the time course of threshold observed in forward masking experiments. In this talk, we propose a new implementation of the time-varying, compressive gammachirp auditory filterbank to explain two-tone suppression and forward masking data qualitatively. We will also show that the system can resynthesize compressed speech sounds and so provide the basis for a gammachirp analysis/synthesis filterbank. [Work supported by GASR(B)(2) No. 15300061, JSPS.]

A masking level difference due to harmonicity.

The role of harmonicity in masking was studied by comparing the effect of harmonic and inharmonic maskers on the masked thresholds of noise probes using a three-alternative, forced-choice method. Harmonic maskers were created by selecting sets of partials from a harmonic series with an 88-Hz fundamental and 45 consecutive partials. Inharmonic maskers differed in that the partial frequencies were perturbed to nearby values that were not integer multiples of the fundamental frequency. Average simultaneous-masked thresholds were as much as 10 dB lower with the harmonic masker than with the inharmonic masker, and this difference was unaffected by masker level. It was reduced or eliminated when the harmonic partials were separated by more than 176 Hz, suggesting that the effect is related to the extent to which the harmonics are resolved by auditory filters. The threshold difference was not observed in a forward-masking experiment. Finally, an across-channel mechanism was implicated when the threshold difference was found between a harmonic masker flanked by harmonic bands and a harmonic masker flanked by inharmonic bands. A model developed to explain the observed difference recognizes that an auditory filter output envelope is modulated when the filter passes two or more sinusoids, and that the modulation rate depends on the differences among the input frequencies. For a harmonic masker, the frequency differences of adjacent partials are identical, and all auditory filters have the same dominant modulation rate. For an inharmonic masker, however, the frequency differences are not constant and the envelope modulation rate varies across filters. The model proposes that a lower variability facilitates detection of a probe-induced change in the variability, thus accounting for the masked threshold difference. The model was supported by significantly improved predictions of observed thresholds when the predictor variables included envelope modulation rate variance measured using simulated auditory filters.

Electrically evoked compound action potential (ECAP) of the cochlear nerve in response to pulsatile electrical stimulation of the cochlea in the rat: effects of stimulation at high rates.

Some cochlear implant patients achieve better speech recognition with pulsatile electrical stimulation presented at high rates. The present study aimed to explore, in an animal model of cochlear implants, how the excitability of the cochlear nerve is affected by pulsatile electrical stimulation delivered at high rates, of up to 1,000-2,000 pulses per second (pps). Adult rats (n=23) were implanted with two or three stimulating electrodes in the left cochlea. In four of these rats, the left cochlea was deafened by local perfusion with 1 per cent or 4 per cent neomycin solutions prior to implantation. Pulsatile stimuli consisted of 20 micros electrical pulses, delivered in trains of 200 ms duration, separated by a pause of 200 ms. The pulse rates ranged from 100 to 2,000 pps (intra-train pulse rate). Electrically evoked compound action potentials (ECAPs) of the cochlear nerve were recorded either intracochlearly or from epidural electrodes (extra-cochlearly). With increasing pulse rates, the average ECAP amplitude decreased, whereas the average ECAP latency and its variability (SD) increased. For rates above 300 pps, the amplitude of the ECAP to the individual successive pulses delivered in the train progressively decreased during the initial part of the train, corresponding to a short-term adaptation of the cochlear nerve. This effect progressively increased for pulse rates ranging from 300 to 2,000 pps. In addition, there was a phenomenon of long-term adaptation, as indicated by a decrease in the amplitude of the ECAP to the first pulse of the train, indicating that the pause of 200 ms between each train was not long enough for full recovery of the cochlear nerve. This long-term adaptation was progressively more pronounced for increasing pulse rates. To characterize further the recovery in excitability of the cochlear nerve, forward masking experiments were conducted, showing a decrease of the ECAP amplitude when the interval between the first pulse (masker) and the second pulse (probe) was shorter than 2 ms. This ECAP decrease was slow for intervals between 2 and 1 ms and then abrupt for shorter intervals. The observations described above were similar for extra- and intra-cochlear recordings and were little, if at all, affected by treatment of the cochlea with neomycin.

A model of dynamic auditory perception and its application to robust word recognition

This paper describes two mechanisms that augment the common automatic speech recognition (ASR) front end and provide adaptation and isolation of local spectral peaks. A dynamic model consisting of a linear filterbank with a novel additive logarithmic adaptation stage after each filter output is proposed. An extensive series of perceptual forward masking experiments, together with previously reported forward masking data, determine the model's dynamic parameters. Once parameterized, the simple exponential dynamic mechanism predicts the nature of forward masking data from several studies across wide ranging frequencies, input levels, and probe delay times. An initial evaluation of the dynamic model together with a local peak isolation mechanism as a front end for dynamic time warp (DTW) and hidden Markov model (HMM) word recognition systems shows an improvement in robustness to background noise when compared to Mel-frequency cepstral coefficients (MFCC), linear prediction cepstral coefficients (LPCC), and relative spectra (RASTA) based front ends.

Injury-induced Reorganization of Frequency Maps in Adult Auditory Cortex: The Role of Unmasking of Normally-inhibited Inputs

Restricted cochlear lesions in adult animals, causing partial deafness, result in a reorganization of primary auditory cortex (AI) such that the region deprived of its normal input by the lesion is occupied by an expanded representation of peri-lesion cochlear regions, and hence of peri-lesion frequencies. One possible mechanism underlying the change in frequency responsiveness involved in such reorganization is that inputs to the cortical neurons at frequencies at and near their “new” post-lesion characteristic frequencies (CFs) are normally present but suppressed by inhibition, and are “unmasked” by the effects of the lesion. Evidence in support of this explanation is provided by two-tone forward-masking experiments which reveal that many Al neurons receive surround inhibitory input. When input to such neurons at their CF is reduced by an intense temporary-threshold-shift (TTS)-inducing stimulus, the response areas of some neurons expand into the region of their inhibitory surrounds, the effect that would be expected if unmasking were involved in cortical reorganization. In other neurons, however, response areas contracted after the TTS-inducing stimulation. Although unmasking of normally-inhibited inputs is likely to contribute to auditory cortical reorganization, the immediate unmasking that is seen in visual and somatosensory systems is unlikely to play a major role in auditory cortical reorganization, as no evidence of immediate unmasking was seen following acute cochlear lesions in guinea pigs.

Comparison of suppression across frequencies

Although much research has focused on the temporal, spectral, and intensity relationships between a masker and a suppressor, there has been little attention directed towards relative amounts of suppression in different frequency regions. The purpose of this experiment was to compare the magnitude of suppression at 500 and 2000 Hz in two forward-masking experiments with seven normal-hearing persons. In the first experiment, the threshold for a 10-ms probe was determined as the bandwidth of a 400-ms masker increased from 0.05 to 1.6 times the probe frequency. Suppression was determined by observing a decrease in threshold when the masker bandwidth exceeded the estimated critical band. In the second experiment, the threshold for a 10-ms probe was obtained with a 400-ms tonal masker in two conditions: masker-alone and masker+suppressor. Suppressor frequencies ranged from 1.1 to 1.5 times the probe frequency. Suppression was indicated by a lower threshold in the masker+suppressor condition relative to that in the masker-alone condition. In both experiments, the magnitude of suppression was smaller for the 500-Hz probe relative to the 2000-Hz probe.

Exploration of Factors Beyond Audibility That May Influence Speech Recognition

The effects of reduced ability to differentiate acoustic information on speech reception are difficult to separate from the effects of reduced absolute sensitivity. One possible way is to explore abilities to differentiate acoustic information while holding absolute sensitivity constant. Two auditory phenomena known as enhancement and suppression, which are thought to be related to speech reception ability, were evaluated in persons with normal absolute sensitivity who had either normal or reduced speech recognition in noise. Results of forward masking experiments do not support the notion that enhancement or suppression is reduced in persons with reduced speech recognition in noise. However, their pattern of performance differed from that of listeners with normal speech recognition in noise when the duration of certain complex maskers was varied.

Offset AP masker tuning curve and the FFT of the stimulus

In previous experiments, it was noted that a cochlear compound action potential (CAP) can be produced by the offset of a tone, provided that the amplitude of the tone is modulated by a trapezoid with slopes that are typically much steeper than required to produce onset responses. Subsequently, such trapezoidal tone bursts with steep slopes were used as probe stimuli in simultaneous and forward masking experiments that were designed to evaluate the tuning characteristics of these offset CAPs. Masker tuning curves (MTCs) were generated by plotting the masker frequency necessary to reduce the amplitude of the offset CAP by 50%. Simultaneous masking of the offset CAP generated a W-shaped MTC, with two sharply tuned tips and one sharply tuned peak. Forward masking generated a sharply tuned V-shaped offset MTC. By contrast, for onset CAPs, both simultaneous and forward masking generated V-shaped MTCs. The very steep stimulus slopes required to produce an offset CAP are likely to generate much more acoustic splatter than the more gradual slopes required to produce an onset CAP, and this may be related to the different shapes of the onset and offset simultaneous MTCs. To explore this possibility, the relationship of the spectral characteristics (determined by fast Fourier transform, or FFT) to the shape of the MTC was studied.(ABSTRACT TRUNCATED AT 250 WORDS)

Temporal integration of forward masking in listeners having sensorineural hearing loss.

Findings are described from three experiments that were designed to contrast estimates of auditory time and frequency analysis in highly practiced, young adult subjects having sensorineural hearing loss of cochlear origin with subjects having normal hearing. In one experiment, pure-tone detection threshold was measured for two durations of tones. For the hearing-impaired subjects, smaller differences were found between thresholds for the two durations of tones than were found for the normally hearing subjects at test frequencies where the sensitivity loss was greatest. In a subsequent forward masking experiment, masked thresholds were obtained at 3 kHz as a function of masker level at several masker durations. The results indicated that, for the range of values tested, masked probe thresholds changed less as a function of masker duration for the hearing-impaired subjects than for normally hearing subjects. However, forward masking grew as a function of masker level more steeply for the hearing-impaired listeners than for the normally hearing listeners. We believe that this result indicates abnormal temporal processing of sequential sounds. In a third experiment, psychophysical tuning curves were measured in a forward masking procedure for two maskers that differed in duration by approximately an order of magnitude. Again, the hearing-impaired subjects demonstrated less change in forward masking as a function of masker duration than normally hearing subjects. Further, the sharpness of the tuning curves from the hearing-impaired listeners was markedly reduced as compared to normal. It is believed that the results reflect a disruption of the normal temporal and spectral representation of sounds in the hearing-impaired subjects.