The timeline of formation and development of the Khabarovsk Research Institute of Epidemiology and Microbiology of Rospotrebnadzor, one of the earliest research institutes of epidemiological specialty in Russian Federation, are presented. The institute was found in 1925. In more than 90-year history of the research institute activity were formed main priority research areas relevant for the territory and country such as research on epidemiology, etiology, immunology of anthroponosis and zoonosis concerning Russian Far East – HIV-infection and viral hepatitis, insectborne and zoonotic infectious diseases, gelminthoses and parasitic diseases, intestinal bacterial and viral infections, respiratory diseases. Research institute has made a considerable contribution in development of vaccines and serum-based preparations, improvement of epidemiological analysis approach and methods, diagnosis and prophylaxis of infectious diseases.