In this work, we investigate the mode of interaction of a family of fluorescent zinc complexes with HSâ and H2S. Different experiments, performed by diverse spectroscopic techniques, provide evidence that HSâ binds the zinc center of all the complexes under investigation. Treatment with neutral H2S exhibits a markedly different reactivity which indicates selectivity for HSâ over H2S of the systems under investigation. Striking color changes, visible to the naked eye, occur when treating the systems with HSâ or by an H2S flow. Accordingly, also the fluorescence is modulated by the presence of HSâ, with the possible formation of multiple adducts. The results highlight the potential of the devised systems to be implemented as HSâ/H2S colorimetric and fluorescent sensors. Bioimaging experiments indicate the potential of using this class of compounds as probes for the detection of H2S in living cells.