The present article discusses the condition of existence of the black and indigenous people imposed by slavery in Brazilian colonialism, which results in what we call the coloniality device, a device that becomes the rule within the colonies. This device is a death machinery that will be fundamental and fundamental in the economy and in the formation of colonial society, and that will consist of deliberate actions to make the black and indigenous body die. To reach our goal, we rely on the works of Achile Mbembe, Michel Foucault , Giorgio Agamben, Frantz Fanon, Jaques Derrida, Enrique Dussel, Suely Carneiro, among other authors. As a result, we found that the coloniality device operated as a technology of death for the black and indigenous population, being central to the production of the mechanisms of subjectification of society based on slavery. Within the colonies, a racist policy of violence prevailed, mobilized by the state apparatus, which imposed areas of exception on the black and indigenous population and the consequent annihilation of these bodies, transforming them into killable lives.