Formation Mechanism Research Articles

Interannual Variation of Global Surface Potential Vorticity Forcing in Boreal January and Its Link with Long-Persisting Droughts in Southwest China

Abstract An increasing number of studies have recognized the essential influence of surface potential vorticity (PV) forcing on atmospheric circulation. In this study, we investigated the temporal characteristics of global surface PV forcing in January and its associated climate anomalies. The global surface PV forcing exhibited a pronounced decreasing trend, implying reduced forcing on atmospheric PV. Its interannual component was accompanied by cold winters on the Eurasian and North American continents and long-persisting droughts in southwest China (SWC), consistent with the coexistence of these extreme events. Based on the global surface PV forcing index, the mechanism underlying long-persisting droughts, which lasted from October to January, was investigated. The formation mechanisms of persistent drought varied monthly. Specifically, the occurrence of drought in October was closely related to Rossby wave activity over Eurasia, which enhanced the anomalous anticyclone over the Tibetan Plateau and subsequently induced air descent over SWC. In contrast, drought in November and December could be ascribed to La Niña events in the central Pacific, which facilitated subsidence over SWC through local meridional circulation anomalies. Distinct from other months, the combined effects of La Niña events and circulation anomalies over northern Eurasia caused the drought in January. The former reduced precipitation over southern SWC, whereas the latter influenced precipitation over central SWC. The present study provides novel insights into simultaneous extreme events in the Northern Hemisphere. Significance Statement Long-persisting droughts in southwest China (SWC) usually coexist with cold winters in the Eurasian and North American continents. Here, we suggested that the coexistence of these extremes was closely linked to interannual variability in global surface potential vorticity forcing. Based on this relationship, the mechanism underlying long-persisting droughts in SWC, lasting from October to January, was investigated. The formation of these droughts could be ascribed to Rossby wave activity over Eurasia in October and to La Niña events in the central Pacific in November and December. The drought in January was ascribed to the combined effects of La Niña and circulation anomalies over northern Eurasia. This study provides a broader view for understanding extremes that occurred simultaneously in the Northern Hemisphere.

Direct In Situ Fabrication of Strong Bonding ZIF-8 Film on Zinc Substrate and Its Formation Mechanism

There is much promise for creating metal organic framework (MOF) films on metal substrates in fields including sensing and electrical conduction. For these applications, direct production of MOF films with strong bonding on metal substrates is extremely desirable. In this study, a simple one-step method without the need for additives or pre-modification is used to directly create zeolitic imidazolate framework-8 (ZIF-8) films with strong bonding on zinc substrate. The formation mechanisms of ZIF-8 film are analyzed. The strong bonding ZIF-8 film can be attributed to an in-situ grown ZnO interlayer between the ZIF-8 and substrate. The growth process shows the formation time of zinc oxide on the substrate, which is subsequently covered by ZIF-8 crystals. The ZnO interlayer results from a combination of decomposition products of the solvent and the zinc ions. Furthermore, the ZnO interlayer serves as a sacrificial precursor for the in-situ nucleation and continuous growth of ZIF-8 film. It serves as an anchoring site between ZIF-8 film and substrate, resulting in strong adhesion. This paper describes a simple and straightforward production process that is expected to provide a theoretical basis for the laboratory preparation of ZIF films.

A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding

The SARS-CoV-2 nucleocapsid protein is indispensable for viral RNA genome processing. Although the N-terminal domain (NTD) is suggested to mediate specific RNA-interactions, high-resolution structures with viral RNA are still lacking. Available hybrid structures of the NTD with ssRNA and dsRNA provide valuable insights; however, the precise mechanism of complex formation remains elusive. Similarly, the molecular impact of nucleocapsid NTD mutations that have emerged since 2019 has not yet been fully explored. Using crystallography and solution NMR, we investigate how NTD mutations influence structural integrity and RNA-binding. We find that both features rely on a core network of residues conserved in Betacoronaviruses, crucial for protein stability and communication among flexible loop-regions that facilitate RNA-recognition. Our comprehensive structural analysis demonstrates that contacts within this network guide selective RNA-interactions. We propose that the core network renders the NTD evolutionarily robust in stability and plasticity for its versatile RNA processing roles.

Mechanisms of Secondary Spreading and Micro Droplet Formation on Steel

Abstract A new theory for secondary spreading based on the wetting theory of thin films is presented. It explains how micro droplets within the spreading zone and the primary droplet retain their shape, although connected by a thin electrolyte film and how humidity and salt concentration affect the growth rate of micro droplets. The trigger for secondary spreading, polarization or alkalization, is identified by using droplets of sodium hydroxide solution. Secondary spreading thus occurs on steel from pH 13.5 without corrosion or external polarization. The limiting pH value found explains why secondary spreading on steel only occurs when certain salts are used. 
The effect of the substrate is investigated by changing the microstructure of the steel. By comparing the sizes of micro droplets and micro structural phases and by scanning electron microscopy/energy-dispersive X-ray analysis measurements of the spreading zone, the existence of an electrolyte film connecting the micro droplets is supported. Ecorr potential profiles of secondary spreading droplets of sodium chloride solution on steel acquired by means of SKP are used to assess the contribution of secondary spreading to the total corrosion current, which is estimated to be low compared to that of the cathodic zone at the edge of the droplet

Evaluation of Microwave Heating Uniformity for Ready-to-Eat Rice in Metalized Packaging Structure

Microwave energy utilization undergoes two stages via absorption and conversion inside ready-to-eat rice (RER) under microwave reheating. The reasonable utilization of microwave energy inside the processed material may enhance the uniformity of the temperature distribution. To analyze the uniformity changes inside RER, the effects of microwave reflection, refraction, and absorption by a metal aluminum film were studied through the thermodynamic properties. A simulation model was developed using the co-simulation method of COMSOL Multiphysics with MATLAB programming to analyze the mechanism of material properties and electromagnetic distribution on temperature distribution uniformity, as well as the formation mechanism of the temperature distribution uniformity of microwave-reheated RER. Based on models of the designed package boxes covering the metal film, the optimal structure was developed to include a metal aluminum film with a width of 5 mm and a thickness of 0.30 mm, which was sprayed on the edges and corners of a rectangular packaging box. The packaging boxes covering the metal films may reduce the average temperature of the upper and lower layers in RER by 8.03 °C and 7.42 °C, respectively, while the temperature distribution uniformity increased by 35.71% and 72.22%. The introduction of a metalized package significantly enhances the temperature uniformity inside RER under microwave reheating.

Probing the Nanostructure and Reactivity of Epoxy-Amine Interphases.

Understanding and controlling the structure of interphase regions in epoxy resins have been a long-standing goal in high-performance composite and coating development, since these are widely considered to be weak points in the microstructure of these materials, determining key properties such as fracture strength and barrier performance. These buried nanoscale regions are, however, inaccessible to conventional analytical techniques, and little is understood about their underlying formation mechanism. Here, we combine molecular dynamics (MD) simulation with nanoscale infrared chemical mapping to develop new understanding of the interphase using model epoxy-amine binders composed of diglycidyl ether of bisphenol A (DGEBA) cross-linked using m-xylylenediamine (MXDA). Iron oxide powders are used as exemplary surfaces, where we demonstrate that the electrostatic binding energies between the amine cross-linker and particles range from repulsive (magnetite, Fe3O4) to weakly attractive (hematite, Fe2O3) to strong immobilization (goethite, FeOOH). We find that interfacial binding occurs upon mixing and determines the overall level of residual amine content in the bulk matrix but does not correlate with a detectable amine depletion in the vicinity of particles. In all cases, an excess of both epoxy and amine functionality is detected close to particles, and the extent of matrix undercuring is found to be dependent on the entropic segregation of the unreacted material during the ambient cure. Detailed MD simulations demonstrate that spatial segregation of the unreacted precursors is expected in the interphase, leading to the experimental observation that, even after extensive postcure heating, individual particles remain embedded in a nanoscale underdeveloped environment.

A physically modelled selection function for compact binary mergers in the LIGO-Virgo O3 run and beyond

Abstract Despite the observation of nearly 100 compact binary coalescence (CBC) events up to the end of the Advanced gravitational-wave (GW) detectors' third observing run (O3), there remain fundamental open questions regarding their astrophysical formation mechanisms and environments. Population analysis should yield insights into these questions, but requires careful control of uncertainties and biases. GW observations have a strong selection bias: this is due first to the dependence of the signal amplitude on the source's (intrinsic and extrinsic) parameters, and second to the complicated nature of detector noise and of current detection methods. In this work, we introduce a new physically-motivated model of the sensitivity of GW searches for CBC events, aimed at enhancing the accuracy and efficiency of population reconstructions. In contrast to current methods which rely on re-weighting simulated signals (injections) via importance sampling, we model the probability of detection of binary black hole (BBH) mergers as a smooth, analytic function of source masses, orbit-aligned spins, and distance, fitted to accurately match injection results. The estimate can thus be used for population models whose signal distribution over parameter space differs significantly from the injection distribution. Our method has already been used in population studies such as reconstructing the BBH merger rate dependence on redshift.

A Study on the Influence of Natural Fractures in Tight Sandstone Reservoirs on Hydraulic Fracture Propagation Behavior and Post-Fracture Productivity

Tight sandstone gas reservoirs are rich in reserves and are an important part of unconventional oil and gas resources. However, natural fractures’ impact on hydraulic fracture propagation behavior and network formation mechanisms remain unclear. Exploring how to optimize fracturing parameters to maximize post-fracturing productivity requires further investigation. Therefore, this study focused on the characteristics of tight sandstone gas reservoirs and established a three-dimensional numerical simulation model for hydraulic fracture propagation and post-fracturing productivity using production history matching to validate the reliability of the model. Based on this model, this study investigated the influence mechanisms of natural fracture angles, density, and lengths on hydraulic fracture propagation behavior and network formation. The spatial distribution of hydraulic fracture widths in three dimensions is also explored. When natural fracture angles are lower, a greater number of natural fractures are activated, leading to more developed secondary hydraulic fractures and the formation of complex fracture networks. Hydraulic fractures tend to penetrate directly through high-angle natural fractures. Single-well cumulative gas production increases initially with increasing natural fracture angles, then decreases, but increases with higher natural fracture density and length. Optimal fracturing in areas with longer natural fractures, lower angles, and higher density distribution enhances single-well productivity effectively.

The Influence of Social Networks on Tourism Support Behaviors Among Ethnic Village Residents

In the realm of tourism intervention and the reconfiguration of social networks among residents in ethnic villages, research on tourism support behavior is pivotal for comprehending the motivations behind resident participation and fostering sustainable tourism development. This study carried out a survey of 440 residents from Huangluo Yao Village and Jinkeng Dazhai Village in Longsheng County, Guilin City, Guangxi Zhuang Autonomous Region, China, using a questionnaire and explored the influencing mechanism of social networks on tourism support behavior based on the cognitive–affective processing system (CAPS) theory using structural equation modeling (SEM). The findings reveal that both strong and weak ties exert direct impacts on tourism support behavior while also indirectly influencing it via cultural identity. Furthermore, government governance capacity serves as a positive moderating factor in the relationships between ethnic village residents’ social networks—both strong and weak—and cultural identity, as well as between weak ties and tourism support behavior. The conclusions drawn from this study not only enhance the understanding of the formation mechanisms underlying tourism support behavior but also offer valuable insights for local governments aiming to implement effective strategies to promote tourism development.

Insight into the Structure and Formation Mechanism of Esmolol Hydrochloride Polymorphs Based on Experiments and Molecular Simulations

Insight into the Structure and Formation Mechanism of Esmolol Hydrochloride Polymorphs Based on Experiments and Molecular Simulations

The effect of temperature on the activity of microorganisms in the area of the Bureiskiy Landslide

The manuscript presents the results of experimental studies of the adaptive potential of microorganisms that are part of the bacterioplankton of the surface and bottom water layers of the Bureiskoe Reservoir in the zone of the landslide that descended in the winter of 2018. In the summer of 2022, the structure and activity of microbial complexes from area near the landslide were studied. More than 60 strains of microorganisms of different physiological groups were isolated. On the example of 4 strains isolated from different habitats (above and below the landslide body, surface and bottom layers of water) after 30 days of freezing at a temperature of –18°C, their viability and activity in the utilization of easily available nitrogen-containing organic substances were shown. In experimental cyclic freezing-thawing, two variants of thawing were used: slow thawing in a refrigerator from –18°C to +4°C; fast defrosting over a wide temperature range from –18°C to +23°C (at room temperature). Regardless of location, all strains grew vigorously in vitro with use of a readily available peptone carbon source before and after freezing. The maximum activity on peptone was shown by strain 40 BB (below the landslide body, bottom water) in the absence of substrate change. Utilization of peptone as a source of amino acids and peptides could be accompanied by activation of the protective function against cold stress. The selected strains of microorganisms differed in their ability to transform sodium humate molecules depending on the conditions of the freeze/thaw cycles. According to the spectral characteristics, significant changes in the aliphatic and aromatic components of the humate molecule occurred with the participation of strains 45 AB and 40 BB isolated from the bottom water. These strains were more active at low thawing temperatures, which actually corresponded to the in situ temperature of the bottom water layers, which is 4–6°C. Strain 13 BS from surface water sampled below the landslide body is characterized by active transformation of the aromatic component of humic substances in a wide range of thawing temperatures (from –18 to +23°C). The results indicate that in different regions during the thawing of permafrost and the influx of specific organic substances the specific mechanisms of formation of the quality of natural waters may manifest.

Nano-size Joule-Heating to Achieve Low-Ohmic Ag-Si Contact on Boron Emitters of n-TOPCon Solar Cells.

Over the past decade, Tunnel Oxide Passivated Contact (TOPCon) solar cells have emerged as a leading technology for high-efficiency silicon solar cells. Conventional metallization processes using silver/aluminum (Ag/Al) pastes encounter significant hurdles due to reliability risks and insufficient contact quality. Recent advancements in laser-induced metallization technologies, particularly laser-enhanced contact optimization (LECO), offer promising solutions. However, the mechanism of silver-silicon (Ag-Si) contact formation on the P+ emitter of TOPCon cells via LECO processing remains incompletely understood. This study designs and prepares two types of glass frits (GF-A and GF-B) for TOPCon cells and investigates the electrical properties of corresponding devices. Advanced techniques are employed to examine the Ag-Siinterfaces. The results demonstrate that GF-A-based TOPCon cells (Cell-A) outperformed GF-B-based cells (Cell-B) due to the construction of a current-confined Ag-Si interface. A composite conductive model for the Ag-Si interfaces by LECO treatment is introduced, revealing the nano-size Joule-heating to achieve the Ag-Si eutectic structure as the underlying formation mechanism. This work contributes to the understanding of metal-silicon contact optimization in solar cells and introduces novel methodologies for laser-induced synthesis and micro-nano interface engineering.

A Prenucleation-Stage Sample of ZnSe Assisting Lower-Temperature Shell Growth on CdSe Magic-Size Clusters via Monomer Addition.

Surface passivation of colloidal semiconductor nanocrystals is usually performed at elevated temperatures with undefined changes to core nanocrystals. Using a prenucleation-stage sample of ZnSe-containing clusters (prepared at 160°C), the first surface passivation is reported at 25°C, which transforms photoluminescent (PL)-inactive CdSe magic-size clusters (MSCs) to PL-active ones. The PL-inactive CdSe MSCs display an absorption doublet peaking at 421/450 nm. With a similar absorption doublet, the resulting PL-active CdSe/ZnSe MSCs exhibit a sharp PL signal at 460 nm. It is argued that the Zn-Se bond formation is decoupled from the growth of the ZnSe shell, which proceeds via the addition of ZnSe monomers. The chemical transformation at room temperature implements the principle of isodesmic reactions where M-Se bonds cleaved in the reactant are similar to those formed in the product. The present study paves an avenue for surface passivation under mild conditions, providing an in-depth understanding of the shell formation mechanism.

Distribution Characteristics and Formation Mechanism of Main Hydrochemical Ions in Qingshui River

Qingshui River is a vital source for human life and industrial production in Zhangjiakou City. Determination of the formation mechanism of the main hydrochemical ions is important for the sustainable development and utilization of surface water resources in the Qingshui River. In view of this, 20 surface water samples were collected from the agricultural and urban reaches of the Qingshui River in July 2022. Based on the detection of hydrochemical ions and stable isotopes （δ2H-H2O and δ18O-H2O）, the hydrogeochemical methods, multivariate statistical analysis, and positive matrix factorization model （PMF） were used to comprehensively understand the chemical formation mechanism of surface water from qualitative to quantitative perspectives. The results showed that the average pH value in the Qingshui River was 8.66, indicating weakly alkaline water. The average concentrations of cations and anions decreased in the orders of Ca2+ > Na+ > Mg2+ > K+ > NH4+ and HCO3- > SO42- > NO3- > Cl- > F- > NO2- in the river water, respectively. The main hydrochemical type was identified as HCO3-Ca·Mg water. For the natural background, surface water was mainly controlled by rock weathering and evaporation crystallization and rock weathering was identified as the primary driving factor. The main hydrochemical compositions in the Qingshui River were derived from the dissolution of carbonate rocks and silicate rocks. Regarding anthropogenic activities, the portions of river water in the agricultural reaches were mainly affected by the excessive application of chemical fertilizers. Furthermore, the concentration of NO3- （1.88-47.4 mg·L-1） exceeded the standard for drinking purposes （10 mg·L-1）. The concentration of F- （0.38-1.92 mg·L-1） was above the acceptable limit for drinking purposes （1.0 mg·L-1） in the southern urban reaches portion of the river water, which could have been attributed to the industrial sewage discharge. The obtained results from the PMF model showed that the hydrochemical compositions in the river water of agricultural reaches were mainly controlled by four factors, namely synthetic fertilizers （29.6%）, livestock manure （16.4%）, rock weathering （17.4%）, and natural geology （13.7%）, while hydrochemical compositions in the river water of urban reaches were mainly affected by the domestic pollutants （30.5%）, industrial discharges （20.1%）, natural geology （18.4%）, and rock weathering （16.7%）.

Adipocyte-derived fatty acid uptake induces obesity-related breast cancer progression: a review.

Obesity is a metabolic disorder that occurs when excess energy taken into the body is stored as fat. It is known that this metabolic imbalance affects the development of other diseases such as cancer, cardiovascular diseases, insulin resistance, and diabetes. The main cellular component of adipose tissue is adipocytes, and the environmental interactions of adipocytes are important to study the mechanism of disorder formation. Breast tissue is rich in adipose tissue and obesity is known to be an important risk factor in the development of breast cancer. Altered adipogenesis and lipogenesis processes in adipocytes in breast tissue support tumor development through the transfer of fatty acids released from adipocytes. We believe that blending adipocyte biology with breast cancer development is important for investigating the mechanisms that regulate breast tumor malignant behavior and providing new targets for treatment. Fatty acids, which are an energy source for breast cancer cells, are discussed from molecular perspectives in this review.

Hexagonal Boron Nitride as a Two-Dimensional Surfactant: Low-Density Flame-Resistant Composites Based on Boron Nitride Exfoliated by an Interface Trapping Technique.

Hexagonal boron nitride (hBN) is a two-dimensional material isoelectric to graphene. It has a hexagonal structure with alternating boron and nitrogen atoms and is electrically insulating, thermally conductive, and chemically inert. However, like graphene, its use as a functional nanofiller requires exfoliation. Here, we present a method for exfoliating and dispersing hexagonal boron nitride (hBN) sheets within a polymer matrix. This is achieved by a solvent interface trapping method (SITM), where hBN exfoliates and spreads at a high-energy oil/water interface, separating the two phases and lowering the system's free energy. hBN thus acts as a surfactant, allowing us to form stable water-in-oil emulsions stabilized by films of overlapping hBN sheets. Polymerizing the continuous oil phase results in polymerized high internal phase emulsions (polyHIPE), with the foam cells lined with hBN. In the investigation presented here, we use acoustic spectroscopy, optical and electron microscopy, and image analysis to study the emulsion and polyHIPE formation mechanisms. We find that the amount of hBN used, the flake size of the hBN, the mixing time, the type of initiator used, and the oil-to-water ratio all play a role in the morphology of the final polyHIPE. Lastly, we demonstrate the flame-retardant properties of the hBN polyHIPEs and show that, at 1% loadings, the presence of hBN prevents dripping and relighting of the composites, even when the material is heated to a red glow.

Observed Climatology and Formation Mechanisms of Sea Fog Along the Trans‐Arctic Shipping Routes

AbstractAs Arctic sea ice rapidly melts, trans‐Arctic shipping routes are emerging with significant economic value and potentially reshaping global shipping patterns. The safety of ships navigating along these routes will be severely threatened by low visibility caused by Arctic sea fog. Here, we utilize ship and coastal site observations spanning 1979–2023 to investigate the climatological features and mechanisms of Arctic sea fog from June to September. We find that the Northern Sea Route (NSR, along the Russian coast) experiences a mean fog frequency of 20.0%, significantly higher than the 11.5% fog frequency observed along the Northwest Passage (NWP, along the Canadian coast). Fog frequency shows null correlation with sea ice but a strong negative correlation (−0.80) with surface air temperature. The lower mean surface air temperature in the NSR region enhances relative humidity and atmospheric stability, which are conducive to fog formation and maintenance. We further reveal that fog formation mechanisms differ between the NSR and NWP. Along the NSR, fog is usually advection fog, associated with upper boundary layer warming and moistening; in contrast, along the NWP, fog is typically radiation fog linked to near‐surface cooling. Our study highlights the distinct fog frequency and dominant mechanisms along the different trans‐Arctic shipping routes, thereby establishing observed reference for the model validation of simulating Arctic sea fog.

Hydrogeochemical Characteristics and Genesis of Hot Springs in Da Qaidam Area, Northern Qaidam Margin of the Qaidam Basin

Hydrogeochemical research on fluids is an effective method to understand the formation mechanism, occurrence environment, and circulation process of groundwater. The groundwater sampling sites are located in the town of Dachaidan on the northeastern edge of the Tibetan Plateau, which was selected as the study object. Samples were collected from hot and cold springs and surface water in the area. This study is based on the analysis of water chemistry and isotopes, and aims (1) to discuss the chemical characteristics of groundwater in Da Qaidam, (2) to estimate the deep reservoir temperatures, recharge elevation and circulation depth of geothermal waters, and (3) to figure out the heat source beneath the geothermal area and its genetic mechanism. The result showed the following: The hydrochemical type of the hot spring is Cl·SO4-Na and Cl-Na, and the hydrochemical type of cold spring is SO4·HCO3-Na·Ca and Cl·HCO3·SO4-Ca·Na. The main source of groundwater recharge is snow and ice melt water. The recharge elevation ranges from 4666.8 m to 5755.9 m. The geothermal reservoir temperature is about 119.15–126.6 °C. Ice and snow melt water infiltrate into the high mountainous areas on the north side of Da Qaidam and circulate underground through the developed deep and large fractures. Part of the groundwater migrates upwards under the water conduction of the Da Qaidam fault fracture zone to form cold springs, while another part is heated by deep circulation and exposed to the surface in the form of medium to low temperature tectonic hot springs. The research results can provide a scientific basis for geothermal resource exploitation and utilization in Qinghai Province.

Advances in Flow Control Methods for Pump-Stall Suppression: Passive and Active Approaches

This article provides a comprehensive review of key approaches to suppressing stall flow in pumps, offering insights to enhance pump performance and reliability. It begins by outlining the formation mechanisms and characteristics of stalls, followed by an in-depth analysis of various stall types. The discussion highlights passive and active flow control methods, emphasizing their roles in suppressing stall phenomena. Passive flow-control strategies, including surface roughness, grooves, obstacles, fixed guide vanes, and vortex generators, are examined with a focus on their mechanisms and effectiveness in suppressing stall. Similarly, active flow-control techniques, such as jets and adjustable guide vanes, are explored for their capacity to regulate the flow field and suppress stall. The novelty of this review lies in its exploration of the effectiveness of passive and active flow-control methods in suppressing pump stall, with a focus on their mechanisms of action and the underlying principles of stall formation. The findings reveal that appropriate flow-control measures can mitigate laminar flow separation and reduce performance losses associated with stall. However, careful attention must be given to the optimal arrangement of control devices. Finally, the article highlights the limitations of current implementations of combined active and passive flow-control methods while offering insights into the future potential of advanced flow-control technologies in regard to suppressing stall.

A Novel Self-Assembled Paclitaxel Nanodispersion Facilitates Rapid In-Vitro/In-Vivo Dissociation and Protein Binding.

The study aims to prepare and characterize a novel paclitaxel (PtX) preconcentrate formulation using polymer and lipid excipients that forms nanodispersion upon dilution. The goal was to understand the mechanism of nanodispersion formation and its properties. The water-insoluble PtX was dissolved in organic solvents containing ethanol, polyethylene glycol (PEG400), povidone (PVP), caprylic acid (CA), and sodium cholesterol sulfate (CS). This formulation was diluted in 5% w/v dextrose medium to form PtX nanodispersion, which was assessed for particle size, stability, in-vitro/in-vivo dissociation and protein binding. Transmission electron microscopy (TEM), Small Angle Neutron Scattering (SANS), and Molecular Dynamics (MD) simulations were used to analyse the structure of the nanoparticles. The formulation was a clear, slightly yellow solution. The PtX nanodispersion displays particle size of ~ 100nm with a zeta potential of -25, and the pH of 4.0. It displayed nearly spherical coacervate nanoparticles with a sponge-like structure, lacking internal structure order as revealed by TEM and SANS. MD simulations confirmed self-assembly of PtX and excipients forming nanoparticles. In vitro dissociation studies in simulated plasma demonstrated rapid dissociation of nanodispersion, releasing free PtX that immediately binds to plasma proteins. In vivo studies in rabbits corroborated these findings, showing rapid dissolution. The results present a novel formulation design that forms sponge-like coacervate nanoparticle due to complimentary interactions of the excipients that otherwise are unable to self-assemble under similar conditions of dilution. This alternative formulation solves the limitations of currently marketed PtX products and can provide its effective delivery in clinical settings.