Context: With the release of an outcome-based quality measure from the Centers for Medicare and Medicaid Services that aimed to reduce emergency department (ED) and hospital admissions for patients receiving outpatient chemotherapy, new models of care needed to be implemented. Clinical Setting: This case study describes development and implementation of a cancer acute care clinic (CACC) within an extremely busy infusion center located in a National Cancer Institute-designated Comprehensive Cancer Center. Modifications that were necessary in the context of COVID-19 pandemic are described. Process: The development of the CACC involved a transdisciplinary team who determined CACC’s purpose; established patient admission criteria; created a nursing leadership and staffing plan; developed initial operating procedures; and made necessary adjustments to provide care during the COVID-19 pandemic. Clinical pathways were developed to guide care. Informal patient and staff surveys were done to evaluate satisfaction with CACC’s services. Outcomes: Of the initial 142 visits, 75.4% of patients were discharged home, and 12.6% and 12.0% were admitted to the ED or hospital, respectively. Both patients and staff reported high levels of satisfaction with CACC services. Conclusion: While COVID-19 disrupted plans for an evaluation of reductions in ED visits, because of high levels of staff and patient satisfaction, plans are underway to expand CACC services and conduct more formal outcome evaluations. Implications for Practice: Description of the processes involved in the development and implementation of the CACC may serve as a model for other organization on how to provide acute care to oncology patients.