Distinct Forms Research Articles

Testing for marginal covariate effect when the subgroup size induced by the covariate is informative.

In many cluster-correlated data analyses, informative cluster size poses a challenge that can potentially introduce bias in statistical analyses. Different methodologies have been introduced in statistical literature to address this bias. In this study, we consider a complex form of informativeness where the number of observations corresponding to latent levels of a unit-level continuous covariate within a cluster is associated with the response variable. This type of informativeness has not been explored in prior research. We present a novel test statistic designed to evaluate the effect of the continuous covariate while accounting for the presence of informativeness. The covariate induces a continuum of latent subgroups within the clusters, and our test statistic is formulated by aggregating values from an established statistic that accounts for informative subgroup sizes when comparing group-specific marginal distributions. Through carefully designed simulations, we compare our test with four traditional methods commonly employed in the analysis of cluster-correlated data. Only our test maintains the size across all data-generating scenarios with informativeness. We illustrate the proposed method to test for marginal associations in periodontal data with this distinctive form of informativeness.

Widespread form of Majocchi's granuloma in a kidney transplant recipient.

Kidney transplantation is the encouraged kidney replacement therapy due to providing more prolonged survival with a better quality of life. Unfortunately, kidney transplant recipients are susceptible to infections because of long-term utilization of immunosuppression. Despite dermatophyte infections are generally not life-threatening, the clinical significance has been recently enhanced by an increasing number of immunocompromised patients. We have presented a rare dermatophytosis course, Majocchi's granuloma, that spreads to all extremities during the early post-transplant period. A young kidney transplant recipient was exposed to intensive immunosuppression therapy due to acute rejection in the early period of post-transplantation. After four months, numerous nodular skin lesions were raised on various body parts. An invasive fungal infection was identified in the skin biopsy. Also, Trichophyton rubrum was isolated in the tissue cultures. Consequently, the patient was diagnosed with Majocchi's granuloma. An effectual treatment was attained with an oral terbinafine tablet. Majocchi's granuloma is a distinct form of dermatophytosis characterized by the spreading of infection into the dermis. In this unexpected case, we alerted physicians to opportunistic infections in the kidney transplant recipient.

Quasi-normal modes, Emission rate and Shadow of the charged AdS black hole with perfect fluid dark matter

Quasi-normal modes, Emission rate and Shadow of the charged AdS black hole with perfect fluid dark matter

Vagueness, Conditionals and Context Sensitivity

AbstractI argue that practically all vague language is context sensitive in a covert and unfamiliar way. I first outline a novel puzzle concerning the interaction of conditionals and vagueness. I then argue that the best way of resolving the puzzle is by positing context‐sensitive penumbral connections between sundry parts of language. I argue that these penumbral connections shift through a distinct form of Lewisian accommodation. The upshot is that meaning is a far shiftier thing than has typically been thought.

Molecular Detection of Anaplasma phagocytophilum in Small Mammals and Infesting Ticks in Laikipia County, Kenya.

Anaplasmosis is a set of disease conditions of various mammals caused by bacteria species of the genus Anaplasma. These are sub-microscopic, Gram-negative, obligate intracellular pathogens that infect both vertebrate and invertebrate hosts. Significant species that infect domestic and wildlife animals include Anaplasma marginale, Anaplasma ovis, Anaplasma mesaeterum, Anaplasma platys, and Anaplasma phagocytophilum. Although A. phagocytophilum has a widespread distribution, there are only a few epidemiological reports from sub-Saharan Africa. This study focused on molecular detection and characterization of A. phagocytophilum in small mammals and their infesting ticks in Laikipia County, Kenya. A total of 385 blood and 84 tick archival samples from small mammals (155 females and 230 males) were analyzed. The blood samples were subjected to a nested PCR-HRM melt analysis using species-specific primers to amplify the 16S ribosomal RNA genes. The ticks were also subjected to nested PCR-HRM involving 16S rRNA gene primers. Anaplasma phagocytophilum DNA was detected in 19 out of 385 samples using species-specific 16S rRNA gene primers giving a prevalence of 4.9% for A. phagocytophilum. Analysis of the tick's samples using 16S rRNA gene species-specific primers also detected A. phagocytophilum in 3 samples from Haemaphysalis leachi ticks (3/84) equivalent to prevalence of 3.6%. Sequencing of 16S rRNA PCR products confirmed A. phagocytophilum in small mammals and ticks' samples. Phylogenetic analysis of the haplotype from this study demonstrated a close ancestral link with strains from Canis lupus familiaris, Alces alces, Apodemus agrarius, and ticks (Haemaphysalis longicornis) reported in Europe, China, and Africa. Comparison was also made with a known pathogenic A. phagocytophilum variant HA and a nonpathogenic variant 1 that were clustered into a distinctive clade different form haplotypes detected in this study. All the haplotype sequences for A. phagocytophilum from this study were submitted and registered in GenBank under the accession numbers OQ308965-OQ308976. Our study shows that small mammals and their associated ticks harbor A. phagocytophilum. The vector competence for H. leachi in A. phagocytophilum transmission should further be investigated.

Mechanism analysis of the vortex ring and its effects on an axial descending rotor

A vortex ring is a flow phenomenon involving a complex toroidal vortex system. When a rotor is in descending flight, it may enter the vortex ring state (VRS), which will affect the rotor’s aerodynamic characteristics and even endanger it. In this paper, to clarify the aerodynamic mechanism by which the vortex ring exerts its effects on an axial descending rotor, an unsteady numerical simulation method for the rotor integrated with structured moving overset grids is proposed and validated using experimental data. This numerical simulation method is then applied to analyze the aerodynamic characteristics of the rotor in descending flight. The variations of the aerodynamic forces and the flow characteristics in the slipstream are analyzed to elucidate the physical mechanisms responsible for the relationships between the aerodynamic loads, flow field, and vortices when the rotor is in the VRS. The effects of the VRS cause a sharp drop in the average aerodynamic forces, which directly affects the safety and reliability of a rotor aircraft. In the slipstream of the descending rotor, a distinct vortex ring forms and moves upward as the velocity of descent increases. The most severe VRS occurs at a nondimensional velocity of descent of 1.13 when the center of the highly unsteady vortex ring is right at the blade tip, and this can be used as an indicator of the VRS. The physical mechanism by which the VRS exerts its effects can be attributed to the low pressure induced by strong vortices. The VRS decreases the pressure on the lower surface of the blade and increases the pressure on the upper surface, resulting in a reduction in the aerodynamic loads. In comparison with the hovering state, the VRS results in a much larger vortex strength and possesses a different vortex structure.

Nano-ZnO modified hydroxyapatite whiskers with enhanced osteoinductivity for bone defect repair

Abstract Hydroxyapatite (HA) whisker (HAw) represents a distinct form of HA characterized by its high aspect ratio, offering significant potential for enhancing the mechanical properties of bone tissue engineering scaffolds. However, the limited osteoinductivity of HAw hampers its widespread application. In this investigation, we observed HAw punctured osteoblast membranes and infiltrated the cell body, resulting in mechanical damage to cells that adversely impacted osteoblast proliferation and differentiation. To address this challenge, we developed nano-zinc oxide particle-modified HAw (nano-ZnO/HAw). Acting as a reinforcing and toughening agent, nano-ZnO/HAw augmented the compressive strength and ductility of the matrix materials. At the same time, the surface modification with nano-ZnO particles improved osteoblast differentiation by reducing the mechanical damage from HAw to cells and releasing zinc ion, the two aspects collectively promoted the osteoinductivity of HAw. Encouragingly, the osteoinductive potential of 5%nano-ZnO/HAw and 10%nano-ZnO/HAw was validated in relevant rat models, demonstrating the efficacy of this approach in promoting new bone formation in vivo. Our findings underscore the role of nano-ZnO particle surface modification in enhancing the osteoinductivity of HAw from a physical standpoint, offering valuable insights into the development of bone substitutes with favorable osteoinductive properties while simultaneously bolstering matrix material strength and toughness.

Day-to-Night Street View Image Generation for 24-Hour Urban Scene Auditing Using Generative AI

A smarter city should be a safer city. Nighttime safety in metropolitan areas has long been a global concern, particularly for large cities with diverse demographics and intricate urban forms, whose citizens are often threatened by higher street-level crime rates. However, due to the lack of night-time urban appearance data, prior studies based on street view imagery (SVI) rarely addressed the perceived night-time safety issue, which can generate important implications for crime prevention. This study hypothesizes that night-time SVI can be effectively generated from widely existing daytime SVIs using generative AI (GenAI). To test the hypothesis, this study first collects pairwise day-and-night SVIs across four cities diverged in urban landscapes to construct a comprehensive day-and-night SVI dataset. It then trains and validates a day-to-night (D2N) model with fine-tuned brightness adjustment, effectively transforming daytime SVIs to nighttime ones for distinct urban forms tailored for urban scene perception studies. Our findings indicate that: (1) the performance of D2N transformation varies significantly by urban-scape variations related to urban density; (2) the proportion of building and sky views are important determinants of transformation accuracy; (3) within prevailed models, CycleGAN maintains the consistency of D2N scene conversion, but requires abundant data. Pix2Pix achieves considerable accuracy when pairwise day–and–night-night SVIs are available and are sensitive to data quality. StableDiffusion yields high-quality images with expensive training costs. Therefore, CycleGAN is most effective in balancing the accuracy, data requirement, and cost. This study contributes to urban scene studies by constructing a first-of-its-kind D2N dataset consisting of pairwise day-and-night SVIs across various urban forms. The D2N generator will provide a cornerstone for future urban studies that heavily utilize SVIs to audit urban environments.

The comparative political economy of sustainability transitions: Varying obstacles, accelerants and power in national capitalisms

Sustainability Transition Research (STR) has increasingly recognised the importance of capitalism and the capitalist state in constraining and accelerating the adoption of low-carbon innovations, but has engaged far less with the distinctive forms of national capitalisms. This article highlights the relevant insights of comparative political economy (CPE) that provide a fuller comprehension of the capitalist diversity shaping contemporary sustainability transitions. Specifically, it calls for greater attention to be awarded to the idiosyncratic supply and demand dynamics relating to national growth models, interest coalitions and institutional coordination, and historically-constituted political tendencies of governance. Through these insights, it is argued, the complexities of instigating industrial decarbonisation though the effective application of low-carbon technologies and the geographic asymmetries of transition can be better understood. The importance of these insights is outlined theoretically and demonstrated empirically through an examination of the varying strategic and institutional dynamics characterising sustainability transitions in the contemporary global economy.

APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease.

This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer's disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. Data from the National Alzheimer's Coordinating Center and five large cohorts with AD biomarkers were analyzed. The analysis included 3,297 individuals for the pathological study and 10,039 for the clinical study. Findings revealed that almost all APOE4 homozygotes exhibited AD pathology and had significantly higher levels of AD biomarkers from age 55 compared to APOE3 homozygotes. By age 65, nearly all had abnormal amyloid levels in cerebrospinal fluid, and 75% had positive amyloid scans, with the prevalence of these markers increasing with age, indicating near-full penetrance of AD biology in APOE4 homozygotes. The age of symptom onset was earlier in APOE4 homozygotes at 65.1, with a narrower 95% prediction interval than APOE3 homozygotes. The predictability of symptom onset and the sequence of biomarker changes in APOE4 homozygotes mirrored those in autosomal dominant AD and Down syndrome. However, in the dementia stage, there were no differences in amyloid or tau positron emission tomography across haplotypes, despite earlier clinical and biomarker changes. The study concludes that APOE4 homozygotes represent a genetic form of AD, suggesting the need for individualized prevention strategies, clinical trials and treatments.

Alpha-Gal syndrome as a novel food allergy: a case report study

Introduction and importance: Alpha-Gal syndrome (AGS), a distinct form of mammalian meat allergy, presents unique characteristics that set it apart from typical IgE-mediated food hypersensitivities. AGS induces an allergic response typically 3–6 h post-ingestion of mammalian meat, such as beef, pork, or lamb. This prolonged reaction time differentiates AGS from other food allergies, which usually provoke a more immediate response. Case presentation: The authors present a case of a 35-year-old male patient who, unbeknownst to him, had been experiencing symptoms consistent with Alpha-Gal allergy for several years. His symptoms only subsided upon the complete elimination of mammalian meat from his diet. It was only then that the possibility of AGS was considered. Complete abstinence from mammalian meat, meat by-products, and other α-Gal containing foods is the most effective preventative strategy for AGS. No definitive cure for AGS has been established as of now. Treatment protocols for hypersensitivity reactions are contingent upon the severity of the reaction, with therapies ranging from antihistamine medications to the administration of epinephrine. Conclusion: There is considerable variability among AGS patients concerning the consumption of dairy products. Some individuals with AGS can safely consume dairy products without any adverse reactions, while others are advised to abstain due to potential allergenic responses. This variability in dairy tolerance among AGS patients warrants further investigation.

Biochemical risk factors and outcomes of acute promyelocytic leukemia patients with thrombotic events: a matched pair analysis.

Acute promyelocytic leukemia (APL) stands out as a distinctive form of acute leukemia, exhibiting a higher occurrence of thrombotic events when contrasted with other leukemia subtypes. Since thrombosis is a relatively rare but unfavorable condition with poor prognostic implications, it is crucial to determine the risk factors for thrombotic events in APL(thrombosis in large venous or arterial from onset to differentiation therapy in 30d). We performed a retrospective study involving 950 APL patients between January 2000 and October 2022, from which 123 were excluded by younger than 16years of age, 95 were excluded by incomplete data, and 6 were excluded by thrombosis related to CVC or PICC. A total of 23 APL patients with thrombosis for inclusion in our analysis were performed a 1:5 ratio matching based on sex (perfect match) and age (within 5years) to patients without thrombosis. These patients were continuously monitored in the outpatient department over a period of 5years. We meticulously examined clinical and laboratory data to pinpoint the risk factors related to thrombotic events in APL. Our primary clinical endpoints were all-cause mortality and achieving complete remission, while secondary clinical outcomes included APL relapse. Thrombotic events were observed in 2.4% (23/950) of APL patients. Compared to patients without thrombosis, patients with thrombosis had higher lactate dehydrogenase (LDH) [313 (223, 486) vs. 233 (188, 367) U/L, p = 0.020], higher indirect bilirubin [11.2 (7.4, 18.6) vs.8.3 (6.0, 10.7) umol/L, p = 0.004], higher creatinine [72 (62, 85) vs. 63 (54, 74) umol/L, p = 0.026], higher CD2 expression (65.2 vs. 15.2%, p < 0.001), higher CD15 expression (60.9 vs. 24.3%, p = 0.001), and PML/RARαisoforms (p < 0.001). Multivariate-logistic-regression analysis revealed several factors that were markedly related to thrombosis, including LDH (OR≈1.003, CIs≈1.000-1.006, p = 0.021), indirect bilirubin (OR≈1.084, CIs≈1.000-1.188, p = 0.043), CD2 expression positive (OR≈16.629, CIs≈4.001-62.832, p < 0.001), and CD15 expression positive (OR≈7.747, CIs≈2.005-29.941, p = 0.003). The S-type (OR≈0.012, CIs≈0.000-0.310, p = 0.008) and L-type (OR≈0.033, CIs≈0.002-0.609, p = 0.022) PML/RARα isoforms were negatively associated with thrombosis. Kaplan-Meier curves indicated that the survival rates were remarkably varied between APL patients with and without thrombosis (HR:21.34, p < 0.001). LDH and indirect bilirubin are variables significantly associated with thrombosis in APL, S-type and L-type PML/RARαisoforms exhibit a negative association with thrombotic events. The thrombotic events of APL can predict the subsequent survival of thrombosis. The findings of our study have the potential to facilitate early detection of thrombosis and enhance the prognosis for individuals with APL who develop thrombosis. Further validation of our findings will be essential through future prospective or multicenter studies.

Exploring Submesoscale Eddies in the Southern Caspian Sea: A Focus on Rudsar and Sefidrud Regions

Understanding the circulation patterns, identifying locations for eddy generation, and monitoring eddy behaviors are all areas of interests for different water bodies. This study focused on submesoscale eddies in the southern Caspian Sea, specifically close to Rudsar and Sefidrud, due to their distinct form and high turbidity. The high-resolution FVCOM model was utilized to identify high turbidity locations for a period from 2010 to 2014. The results of the two selected locations were explored individually using various techniques. Also, the obtained MODIS satellite images were compared to the daily averaged current results. The findings showed distinct turbid current patterns, and most of the eddies were classified as submesoscale. The alterations in shoreline orientation and wind direction were identified as the two most significant factors affecting this highly turbid area, with river discharge having a significant effect on eddy development close to the Sefidrud delta. The detected eddies at Rudsar in 2013 were found to be more diverse than those at the Sefidrud delta. The circulation and eddy patterns of these locations were prepared. The findings really emphasize how crucial it is to look into the small-scale circulations and eddies along the coastal areas of the southern Caspian Sea. These results offer valuable insights into the generation and behavior of these eddies, particularly when influenced by morphological changes, local currents, and various other factors.

Facile purification of glass fiber powder by sedimentation for enhanced epoxy resin composites

Glass fiber powder contains two distinct forms: crumb-shaped and rod-shaped glass fiber powder particles. The shape and size of the particles in glass fiber powder have a great influence on its application. In order to separate rod-shaped glass fiber, the effects of different dispersants, such as SHMP, NaOL, and Na2SiO3 on them were investigated by settling experiments. Zeta potential, X-ray photoelectron spectroscopy (XPS), optical microscope, and other methods were used to analyze the adsorption behavior and settling mechanism. Three-point bending experiment and dynamic mechanical analysis (DMA) were used to evaluate the performance of epoxy resin composites reinforced with the raw glass fiber powder and the rod-shaped glass fiber powder. The results show that SHMP can effectively separate crumb-shaped glass fiber powder and rod-shaped glass fiber powder, leading to a notable increase in sedimentation recovery difference, up to Δ=51.08%. A preferential sedimentation separation mechanism is proposed to elucidate the settling mechanism. When the content of glass fiber powder and rod-shaped glass fiber is 5%, the glass transition temperature shifts significantly towards higher values, leading to the optimum comprehensive mechanical properties of the composites. Compared with the original epoxy resin, the flexural strength increased by 10.38% to 95.18MPa and by 20.11% to 103.57MPa. Similarly, the storage modulus increased by 14.14% to 2083MPa and by 21.64% to 2220MPa.

An Overview of Diabetic Cardiomyopathy.

Diabetic cardiomyopathy (DCM) is a myocardial disorder that is characterised by structural and functional abnormalities of the heart muscle in the absence of hypertension, valvular heart disease, congenital heart defects, or coronary artery disease (CAD). After witnessing a particular form of cardiomyopathy in diabetic individuals, Rubler et al. came up with the moniker diabetic cardiomyopathy in 1972. Four stages of DCM are documented, and the American College of Cardiology/American Heart Association Stage and New York Heart Association Class for HF have some overlap. Diabetes is linked to several distinct forms of heart failure. Around 40% of people with heart failure with preserved ejection fraction (HFpEF) have diabetes, which is thought to be closely associated with the pathophysiology of HFpEF. Diabetes and HF are uniquely associated in a bidirectional manner. When compared to the general population without diabetes, those with diabetes have a risk of heart failure that is up to four times higher. A biomarker is a trait that is reliably measured and assessed as a predictor of healthy biological activities, pathological processes, or pharmacologic responses to a clinical treatment. Several biomarker values have been discovered to be greater in patients with diabetes than in control subjects among those who have recently developed heart failure. Myocardial fibrosis and hypertrophy are the primary characteristics of DCM, and structural alterations in the diabetic myocardium are often examined by non-invasive, reliable, and reproducible procedures. An invasive method called endomyocardial biopsy (EMB) is most often used to diagnose many cardiac illnesses.

Exploring Binding Pockets in the Conformational States of the SARS-CoV-2 Spike Trimers for the Screening of Allosteric Inhibitors Using Molecular Simulations and Ensemble-Based Ligand Docking.

Understanding mechanisms of allosteric regulation remains elusive for the SARS-CoV-2 spike protein, despite the increasing interest and effort in discovering allosteric inhibitors of the viral activity and interactions with the host receptor ACE2. The challenges of discovering allosteric modulators of the SARS-CoV-2 spike proteins are associated with the diversity of cryptic allosteric sites and complex molecular mechanisms that can be employed by allosteric ligands, including the alteration of the conformational equilibrium of spike protein and preferential stabilization of specific functional states. In the current study, we combine conformational dynamics analysis of distinct forms of the full-length spike protein trimers and machine-learning-based binding pocket detection with the ensemble-based ligand docking and binding free energy analysis to characterize the potential allosteric binding sites and determine structural and energetic determinants of allosteric inhibition for a series of experimentally validated allosteric molecules. The results demonstrate a good agreement between computational and experimental binding affinities, providing support to the predicted binding modes and suggesting key interactions formed by the allosteric ligands to elicit the experimentally observed inhibition. We establish structural and energetic determinants of allosteric binding for the experimentally known allosteric molecules, indicating a potential mechanism of allosteric modulation by targeting the hinges of the inter-protomer movements and blocking conformational changes between the closed and open spike trimer forms. The results of this study demonstrate that combining ensemble-based ligand docking with conformational states of spike protein and rigorous binding energy analysis enables robust characterization of the ligand binding modes, the identification of allosteric binding hotspots, and the prediction of binding affinities for validated allosteric modulators, which is consistent with the experimental data. This study suggested that the conformational adaptability of the protein allosteric sites and the diversity of ligand bound conformations are both in play to enable efficient targeting of allosteric binding sites and interfere with the conformational changes.

金文“叀”字考

The ancient character “叀” is very common, and the shapes are also diverse. This article conducts a detailed analysis of the ancient “叀” character by analyzing the shape of the characters “叀” in oracle bone inscriptions and “叀” in bronze inscriptions. This article presents a table format for statistical analysis and classification comparison of the font forms of the ancient “叀” character. The focus is on a detailed analysis of the character “叀” from the two distinct forms, the interpretation of inscriptions on bronze inscriptions and modern translations, and the words “specialized” and “beneficial” related to “叀”. In addition, a brief analysis of the grammatical meaning of the character “叀” in Jinwen is also conducted. Jinwen is an important language material for studying ancient Chinese. In the development and evolution of characters, the phenomenon of mixed use of characters and borrowing characters is very common. However, during the use and evolution of the character “芔”, due to the occurrence of confusion in its use, it has intricate connections with the ancient “芔” character in terms of pronunciation and form, and also has the pronunciation of “zhuān” and “huì”. However, there are also obvious differences in semantics and pragmatics.

Michel Serres’s Sensorial Philosophy and the Importance of Skin in Francis Bacon’s Nudes

Prompted by the exhibition Francis Bacon: Man and Beast (January–April 2022), this article takes a cultural studies and historical poetics approach to the significance of skin in Bacon’s nudes. Drawing upon Michel Serres’s philosophy and the work of prominent figures within skin studies, this article argues that Bacon’s paintings intuitively embody the significance of skin as a dynamic site/sight of sensory, lived, experience shaped by socio-historical context. Bacon’s nudes are considered in relation to the dermalogical turn; the topological body; Didier Anzieu’s skin ego and skin as our ‘deepest surface’; and the importance of movement in Bacon’s imagery, which correlates with Serres’s notion that learning occurs through bodily motion. Serres recognises that cultural works – including painting and other creative practices – can convey complex multiplicities of knowledge synthesised into new and distinct forms.

When Conventional Medicine Fails: Bori and Olokun Ritual Dance as Treatment for Post-Traumatic Stress Disorder (PTSD) for Nigerian Armed Forces

This article attempts a conceptualisation of African ritual dance therapy (ARDT) as a distinct form and practice of dance movement therapy (DMT). We argue that Bori and Olokun dances, two of Nigeria’s most potent ritual dances, possess therapeutic elements that bear on the treatment of combatants of the Nigerian armed forces currently engaged in a theatre of war against terrorism and banditry in Nigeria. Our argument is premised on the discovery that military hospitals in Nigeria is currently over-stretched with about 57% of the military and paramilitary personnel (participants) suffering from post-traumatic stress disorders (PTSD) resulting from their encounters with terrorists’ cells and bandits. We argue against the institutional frame that sanctions the normalization of conventional medical practice as well as medicine in the diagnosis and treatment of men of the armed forces faced with PTSD. We use ARDT dance ethnography as a theoretical premise to contend that African ritual dance therapy (ARDT) offers an alternative curation for the men of the Nigerian Armed Forces. We use the research instrumentations of focus group discussion and ARDT workshop sessions to get data from 12 para/military participants. We found out that the Bori and Olokun ARDT convey diverse spirit-restorative medicaments that can serve the Nigerian Armed Forces.

Two common and distinct forms of variation in human functional brain networks.

The cortex has a characteristic layout with specialized functional areas forming distributed large-scale networks. However, substantial work shows striking variation in this organization across people, which relates to differences in behavior. While most previous work treats individual differences as linked to boundary shifts between the borders of regions, here we show that cortical 'variants' also occur at a distance from their typical position, forming ectopic intrusions. Both 'border' and 'ectopic' variants are common across individuals, but differ in their location, network associations, properties of subgroups of individuals, activations during tasks, and prediction of behavioral phenotypes. Border variants also track significantly more with shared genetics than ectopic variants, suggesting a closer link between ectopic variants and environmental influences. This work argues that these two dissociable forms of variation-border shifts and ectopic intrusions-must be separately accounted for in the analysis of individual differences in cortical systems across people.