Foremost Part Research Articles

Decentralization of Identity using Ethereum and IPFS

Introduction: The Identity of a user in digital world is an important factor for an individual. Identity management has been handled by various models which, over the period of time have been prone various security breaches. The foremost integral part of any identity model is the centralized storage, access of data. Considering this, in recent years, there has been evolution from centralization to de-centralization of Identity management. With respect to this new aspect, this paper proposes a solution to the centralized management problems, as a decentralized Identity Management System. The said approach utilizes Ethereum blockchain, IPFS, both supporting distributed data accessibility and data storage respectively. This paper also sheds light on the W3C specification of DID (De-centralized Identifier) which supports the Self-Sovereign Identity principles of Identity Management and are vital for de-centralization of Identity Management

Ethnomedical uses of Cananga odorata (Lam.) Hook. f. and Thomson in indigenous traditional medicine among Indonesia ethnic groups

Cananga odorata, commonly known as ylang-ylang, is an evergreen perennial tropical tree belonging to the Annonaceae family, which is traditionally and scientifically reported to have various pharmacological activities. This indigenous medicine study was carried out to document the traditional usage of C. odorata for medicinal reasons by Indonesian ethnic groups. This is one of numerous initiatives aimed at preserving indigenous knowledge and medical practices maintained by the community. Data were acquired during 2015 and 2017 through in-depth interviews with selected traditional healers from each ethnic group throughout 34 Indonesian provinces, who were chosen using a purposive sampling approach based on inclusion criteria. The information gathered includes the demographic data of healers, medicinal plants used, potions, and their applications for health purposes. Following the completion of the interview with the informant, specimens of medicinal plants were collected. Data quantification was accomplished by examining the value of plant parts and doing a simple ranking analysis for multihealth purposes. This study revealed 42 traditional applications of C. odorata by 36 traditional healers from 28 ethnic groups in 16 provinces to overcome 18 diseases. Cananga odorata was primarily obtained from the woodland instead of the house garden and other environments. Skin disease was identified as the most prevalent indication of C. odorata, in agreement with the most commonly employed administration method, the external route. Leaves became the foremost prominent plant part utilized by healers. This study emphasized the significant role of traditional healers in healing various illnesses with C. odorata and the variations in C. odorata ethnomedical usage as a traditional remedy in Indonesia. Nonetheless, cultivating initiatives should be started as more than 60% of identified C. odorata has yet to be grown. The study’s findings are likely to benefit various stakeholders, serve as baseline data for further studies on the efficacy and safety of C. odorata, and contribute to efforts for developing health products that employ C. odorata.

A Review on Food Wastes for Manufacturing New Food Products

Food waste utilisation is the very current global concern at today’s world. Fruits and vegetables are the foremost part of balanced diet. The cycle of healthy diet is not fulfilled without fruits. Furthermore, fruit peels possess also great benefits for people health. Researcher are trying to make new food products from different food wastes. From recent research study it was found that pomegranate peels, mango peels, orange peels, banana peels which contribute enormous good efficacy to provide good health status. These waste constituent help to develop different new fortified food products, which contain lots of bioactive compounds that helps to mitigate acute to chronic ailments. This review article will be discussed an up-to-date information about uses of food wastes for manufacturing new fortified food products.

A Review on Food Wastes for Manufacturing New Food Products

Food waste utilisation is the very current global concern at today’s world. Fruits and vegetables are the foremost part of balanced diet. The cycle of healthy diet is not fulfilled without fruits. Furthermore, fruit peels possess also great benefits for people health. Researcher are trying to make new food products from different food wastes. From recent research study it was found that pomegranate peels, mango peels, orange peels, banana peels which contribute enormous good efficacy to provide good health status. These waste constituent help to develop different new fortified food products, which contain lots of bioactive compounds that helps to mitigate acute to chronic ailments. This review article will be discussed an up-to-date information about uses of food wastes for manufacturing new fortified food products.

Raspberry Pi-based design of intelligent household classified garbage bin

Until now, waste pollution is a global problem. The first and foremost part of the solution is waste classification, as it can effectively reduce the output of waste, so it is particularly important to classify household garbage in the household. However, classification of household garbage is a difficult task for people, and there are not enough designs and researches on automatic garbage classification bins at home. In this study, we designed and built a light and convenient intelligent garbage bin using devices such as motors, turn plates and a camera for classifying household garbage. Compared with the traditional garbage classification methods, two improvements in the algorithm are made, including the combination of the EfficientNetB2 model with the parallel mixed-attention mechanism and the design of the background noise removal algorithm. Finally, the algorithm is disposed to the Raspberry Pi to compose the complete classification system. The accuracy of this classification system in the test set was 93.38% and the results show that this bin can effectively distinguish recyclable waste, kitchen waste, hazardous waste and other waste, and is suitable for daily life garbage identification at home.

Rare Association of Congenital Atrichia with Central Nervous System: A Report of Three Cases

ABSTRACT Congenital atrichia a rare form of alopecia in children, presents with complete absence or sparse hair over the scalp and body, while the teeth, nails, and sweat glands are normal. Uncommonly, this hair abnormality can be associated with any systemic or cutaneous abnormalities. We report three cases of congenital atrichia with parental nonconsanguinity and central nervous associations such as developmental delay,spastic quadriparesis, failure to thrive, myoclonic seizures, and attention deficit hyperactivity disorder. The presence of papular lesions in two among the three children further supplemented our case report. Genetic analysis and counseling regarding the constancy of the condition will be the foremost important part of management.

Enhancing student engagement and learning outcomes through education technologies in medical education

Medical education is hastily evolving as motivated by shifting medical and health care settings with a diverse role of physician/instructor, changing medical science in varied pedagogical backgrounds. Educational technologies have been gradually introduced in medical education to facilitate effective learning with student engagement and improved learning outcomes. It has become an indispensable measure of communication, data storage and transformation, audio-visual media usage, production and sharing of medical knowledge. The role of educational technologies has evolved from a mere study tool to an integrated learning approach. The shift in medical care from habitual clinical scenarios to ambulatory settings has obliged the skill to afford care in a short while and necessitates modification in patient documents with added materials on well-being particulars and medical records being modernized. Educational technologies portray a foremost part in student engagement and without which the learning outcomes cannot be expected. A meaningful student engagement involves engaging students in every facet of the educational technology and knowledge acquisition for the purpose of strengthening their commitment to their self-education and community. The right choice of the educational technology for specific educational purposes of interactive learning is challenging and requires studies and reviews. Computer based learning, flipped classroom, mobile devices, smart phones, digital games, simulations, virtual reality, wearable technologies, social media, podcasts, YouTube etc. are of the techniques detailed in this review with regard to the engagement and learning outcomes of students, that addresses the encounters of the fluctuating educational settings in medical profession.

Semantic road segmentation based on adapted Poly-YOLO

With artificial intelligence continuing to change people’s everyday life in profound ways, the desire to endow vehicles with the ability to drive autonomously has emerged for years. Thus, autonomous driving has become a popular field. The autonomous driving task can be divided into three general procedures: perception, planning, and locomotion. The first and foremost part of these general procedures is the perception task. Among those perception methods, the most prevailing one is semantic segmentation, which is annotating and predicting the object located at the pixel level, meaning nearly all pixels should be classified into certain categories. However, this method provides enough accuracy while bringing a considerable computational burden. Thus, implementing real-time road semantic segmentation on autonomous driving vehicles is still a costly task. In this paper, an adapted model improved upon the Poly-YOLO baseline model is proposed, which is a well-developed object detection algorithm providing bounding polygons to enclose the target object, forming a polygon mask similar to that of semantic segmentation. This paper endeavors to enhance the model’s accuracy in detecting variously sized targets greatly and to fine-tune the model to generate more proximate enclosing polygons. The adapted model has experienced a leap in performance compared to the baseline Poly-YOLO model.

Prevalence of Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Mellitus & its Association with HbA1c

Objective: Diabetes mellitus progressively augmented over the previous years in India and through the world, with India subsidizing a foremost part of the global encumbrance. The current study has been aimed to assess left ventricular diastolic dysfunction in diabetic person and to evaluate the correlation of diastolic dysfunction also its HbA1c range.
 Material and methods: This prospective, cross-sectional, observational study has been performed for one year from September 2018 to August 2019 in the Bhima bhoi medical college & Hospital, Balangir, Odisha. 70 patients of Type 2 DM have been enrolled in the present study. The primary objective of the present study is to evaluate the incidence of LVDD in cases with Type 2 DM without any prior cardiac complications. Glycosylated haemoglobin has been estimated by ion exchange resin method. 2D Doppler Echocardiography was used to diagnose LVDD.
 Results: A large proportion or 48.6% of the diabetics in the study were diagnosed with LVDD of grade I severity. Data revealed that increased levels of glycated haemoglobin caused the severity of LVDD to worsen. With HbA1c levels between 0-8.9 per cent, 67.4% had grade I LVDD, with HbA1c levels between 9-10.9%, majority or 76.9% had grade II dysfunction and similarly with HbA1c between 11-18%, 90.9% of patients had grade III LVDD. This correlation found to be statistically significant (p<0.00001).
 Conclusion: Higher values of FPG, PPPG and HbA1c were associated with higher incidence of LVDD. Thus, optimal glycaemic control may lower the risk of having early diastolic dysfunction and its progression. This has been perceived with cases with Type 2 diabetes mellitus may remain asymptomatic despite having significant left ventricular diastolic dysfunction

Design, synthesis, and molecular docking studies of novel quinoxaline derivatives as anticancer agents.

As lung cancer was placed foremost part among other types of cancer in terms of mortality. Recent researches are widely focused on developing multi-targeted and site-specific targeted drug designs. In the present study, we designed and developed a series of quinoxaline pharmacophore derivatives as active EGFR inhibitors for the treatment of non-small cell lung cancer. The compounds were synthesized through a condensation reaction between hexane-3,4-dione and methyl 3,4-diaminobenzoate as a first step. Their structures were confirmed by 1 H-NMR, 13 C-NMR, and HRMS spectroscopic methods. Cytotoxicity (MTT) were applied to determine anticancer activity of the compounds against breast (MCF7), fibroblast (NIH3 T3), and lung (A549) cell lines as EGFR inhibitors. Doxorubicin was used as a reference agent, compound 4i exhibited a significant effect among other derivatives with IC50 = 3.902 ± 0.098 μM value against A549 cell line. The docking study showed that the best position on EGFR receptor could be observed with 4i. From the obtained evaluations of the designed series, compound 4i was a promising agent as EGFR inhibitor for further investigation and evaluation studies in the future.

Carnival and the Theme of Migration

Carnival and the Theme of Migration

UGAVs-MDVR: A Cluster-Based Multicast Routing Protocol for Unmanned Ground and Aerial Vehicles Communication in VANET

Unmanned ground vehicles (UGVs) are becoming the foremost part of rescue teams for protecting human lives from severe disasters and reducing human casualties by informing them about the risks ahead, such as mine detection and clearance. In mine detection, a centralized system is required so that the UGVs can communicate with each other efficiently to disseminate the mine detection messages (MDMs) to incoming vehicles of military and civilians. Therefore, in this piece of research, a novel unmanned ground and aerial vehicle (UGAV)-based mine-detection-vehicle routing (MDVR) protocol has been proposed, mainly for the mine detection and clearance teams using a vehicular ad hoc network (VANET). The protocol disseminates the MDMs using UGVs and unmanned aerial vehicles (UAVs) in combination to overcome the limitations of only inter-UGV communication. The proposed protocol performs cluster-based multicast communication in real time using UAVs so that the dynamic mobility of UGVs cannot affect the performance of MDM dissemination. Hence, the proposed scheme is adaptable because any failure in message delivery can cause a high level of destruction. The proposed cluster-based scheme can adapt to any real-time scenario by introducing the level-based cluster-head election scheme (LBCHE), which works concerning its assigned priority for reducing the delay incurred in MDMs dissemination. The simulation of the proposed protocol in the network simulator (NS) shows that the overhead and delay are reduced in MDMs dissemination. At the same time, the throughput, packet delivery ratio, and stability increased compared to the other competing protocols.

Study on single-group dynamics in evacuation considering pre-defined and undeclared leadership

Grouping is a common phenomenon that occurs everywhere. The leader-follower relationship inside groups has often been qualitatively characterized in previous models using simple heuristics. However, a general method is lacking to quantitatively explain leadership in an evacuating group. To understand the evolution of single-group dynamics throughout an evacuation, we developed an extended social force model integrated with a group force. A series of single-group evacuations from a room were simulated. An information-theoretic method, transfer entropy (TE), was applied to detect predefined and undeclared leadership among evacuees. The results showed that the predefined leader was correctly detected by TE, suggesting its capability in measuring leadership based on time series of evacuees’ movement information (e.g., velocity and acceleration). When evacuees were grouped together, TE was higher than when they were alone. Leaders presented a monotonically increasing cumulative influence curve over the investigated period, whereas followers showed a diminishing tendency. We found that leadership emergence correlated with evacuees’ spatial positions. The individual located in the foremost part of the group was most likely to become a leader of those in the rear, which concurred with the experimental observations. We observed how a large group split into smaller ones with undeclared leadership during evacuation. These observations were quantitatively verified by TE results. This study provides novel insights into quantifying leadership and understanding single-group dynamics during evacuations.

Flux trajectory analysis of Airy-type beams.

Airy beams are solutions to the paraxial Helmholtz equation known for exhibiting shape invariance along their self-accelerated propagation in free space. These two properties are associated with the fact that they are not square integrable, that is, they carry infinite energy. To circumvent this drawback, families of so-called finite-energy Airy-type beams have been proposed in the literature and, in some cases, also implemented in the laboratory. Here an analysis of the propagation of this type of structured light beam is presented from a flux trajectory perspective with the purpose of better understanding the mechanisms that make infinite and finite energy beams exhibit different behaviors. As is shown, while the foremost part of the beam can be clearly and unambiguously associated with the well-known accelerating term, the rear part of the beam corresponds to a nearly homogeneous distribution of flow trajectories, particularly for long propagation distances. This is shown to be related to an effective transfer of trajectories between adjacent lobes (gradually, from the fore part of the beam to its rear part), which leads to smearing out the transverse flow along the rear part of the beam. This is in sharp contrast to the situation found in ideal Airy beams, where trajectories belonging to a given lobe of the intensity distribution remain the same all along the propagation. The analysis is supplemented with an also trajectory-based description of Young's experiment performed with finite-energy Airy beams to provide a dynamical understanding of the autofocusing phenomenon observed with circular Airy beams.

The Challenge of Nietzsche: How to Approach His Thought

The Challenge of Nietzsche: How to Approach His Thought

디미뜨리에 깐떼미르(Dimitrie Cantemir)의 『몰도바 기술(記述)(Descriptio Moldaviae)』 (1714-1716) 해체하기

Even though Cantemir failed at politics in rumanian history, this failure turned into rumanian humanities. His life-long wish came true when he be came a Moldovan ruler, he attempted to be free from Ottoman Turks but failed at it and exiled to Russia. He started to write about his fatherlatiesnd, where he could not return alive .At the year of 1711 his attention and acts changed from linguistics and philosophy when in Constantinople to the annals when in Russia. 『Description on Moldova』 was written at early 18 century, but it is very valuable material in rumanian history of documents. Any scholar who studies rumanian humanities needs this document to know about ancient Dachian myths and customs. Cantemir verified this book’s value by the metaphor that history is like an clear mirror which reflects the glorious moments of history and the images of the people. The contents of this book which was written about his love for his homeland is very accurate and detailed considering his long hostaged and exiled periods. He explained the location and presence of his fatherland, Moldova by putting the geography of Moldova at the foremost part of the book to let the ignorant Europeans to know his country. He mentioned Dacian kingdom, Trajan, Dragosh repeatedly so that as a first monarch of Moldovan republic, he emphasized the identity of Moldova as a roman descendants, who were formed from the union of dacian and roman people. As he was a monarch from royal family, he stressed on the ruler’s role in monarch’s election and resignation. He also wrote about his country’s formation of the people and the important annual events and marital’ burial ceremony. He dreamt of his country’s independence by being a monarch and stabilizing it even though he was a hopeless hostage. He made a detailed description about Moldova’s state affairs and it’s people as if he had been a monarch of it for a long time. Records about Sanziene which is a main material of rumanian oral literature and Zburator which is one of the 4 major myths is essential for those scholars who study Romanian humanities. He verified his book by founding out that Moldovan(Romanian) language originated from Latin and these two languages were very similar.(Hankuk University of Foreign Studies)

Emphasizing Pulmonary Function With Respiratory Therapy in an Infant With Congenital Adrenal Hyperplasia, Bronchopneumonia and Leptomeningitis

A set of hereditary diseases affecting the adrenal glands, a couple of walnut-sized structures above the kidneys, is known as congenital adrenal hyperplasia (CAH). The adrenal glands generate essential hormones like cortisol, mineralocorticoids, and androgens. It is usually diagnosed in the early neonatal period. The documentation of this case study is aimed to provide a case of an infant with CAH associated with bronchopneumonia and leptomeningitis. Brought with complaints of poor feeding, moderate fever associated with chills, and loose stools, was an 11-months-old patient with a known diagnosis of CAH. Symptoms have shown that the baby was in a possible adrenal crisis. He was intubated with an endotracheal tube after repeated episodes of seizures. Investigations revealed signs of bronchopneumonia and leptomeningitis. A thorough assessment, once completed, helped in analyzing relevant problems to be treated with respiratory therapy. Respiratory therapy, in this case, was aimed at improving the blood oxygen levels and assisting breathing by clearing out secretions and opening up the airways. Parent education was the foremost part of the treatment regime, followed by bronchodilator administration, conventional chest physiotherapy, postural drainage positions in the mother’s lap, lung squeezing technique, and perioral pressure. A holistic and multidisciplinary approach is beneficial in patients with CAH undergoing an adrenal crisis. It needs to be offered to the patients who would be benefited, considering the effect, which needs to be reassessed on specific outcomes with changes in the management with the improving condition.

Awareness and Practice Regarding Cross Infection Control Among Dental House Officers in a Tertiary Care Setting

Background: Dental care workers including dental assistant & doctors are at joint risk of receiving infection. Cross infection can be defined as “the spread of infection between staff members & patients in clinical setting.” Precautions should be adopted while treating or checking the patients. Methods: This cross-sectional study of 3 months duration was carried on dental house officers of Multan Medical and dental college Multan. 60 dental house officers willingly participated in our study. Universal sampling technique was utilized in order to collect the data. Informed consent was sign up from the partakers. Results: Out of sixty dental house officers, males were twenty seven while females were thirty three . 85% participants consider that dental clinics/hospitals are more predisposed to the infection/contamination than other medical fields. 73.3% partakers wash the hands regularly after providing the treatment to every patient. All the partakers reported that usage of PPE has a foremost part in the prevention of cross contamination. Majority of the partakers use gloves as well as facemask but goggles or protective eyewear, head caps & aprons were not in use by most of participants. Conclusion: Adequate awareness/knowledge but less satisfactory practice about infection control was reported. Knowledge acquired must also be transferred into everyday practice. Continuous infection control education through lectures/ tutorials or seminars must be organized. Cross-contamination control guidelines should also be established by dental colleges.

AN OVERVIEW OF FAIR AND FESTIVALS OF THE BODOS AND PARTICIPATION OF WOMENFOLK

The Bodos are the early settler of North-east India basically Assam and also inhabitants of neighboring countries of India like Nepal, Bhutan, and Bangladesh. Racially the Bodo belongs to the Mongoloid stock of the Indo-Mongoloids or Indo-Tibetans. The Bodos are most adventurous in their cultural activities. The Bodos are most close to nature. Hence, the maximum activities are closed to nature and their livelihood also depends on nature. The observation of the socio-cultural activities and their economy depends on nature. The Bodos observe diverse fairs and festivals at different times or seasons before cultivation, during the cultivation, and after the end of the cultivation. During the observation of the fair and festivals, all the people come to enjoy willingly together. The Bodos are very rich in their culture and tradition which are reflected quite in their fairs and festivals. The fair and festivals of the Bodos mostly related to agriculture and allied activities. These fairs and festivals are classified into three types of Seasonal festivals, Agricultural festivals, and religious festivals. In all the fairs and festivals womenfolk have a big contribution or role in Bodo society. The womenfolk are foremost part of the celebration of the fair and festivals of the Bodos.

General Aspects, Applications, and Recent Advancements of 1, 2-Disubstituted Benzimidazole Mannich Bases: A Privileged Scaffold

Chemistry of heterocyclic compounds performs foremost part in synthesis of various pharmacological active compounds. Existence of benzimidazole core in innumerable group of medicinal agents, such as anti-inflammatory, anticancer, antiviral, antimicrobial, antihypertensive, and immune-modulators, contributed them to be essential announcer for growth of new pharmacological active agents. Mannich synthesis is significantly used in organic chemistry. This reaction is useful for synthesizing many bioactive drug molecules. The survey of literature notifies the fact about these bases that are extremely energetic and acknowledge to constitute dominant actions like anti-tumor, antibacterial, anthelmintic, anti-psychotic, anti-malarial, anti-tubercular, anti-viral activities, and many more.