Abstract Aim Research is key to the development of any nation, with health research being of high value to society. Research provides data that is useful for the generation and provision of knowledge needed for policy making, planning and strategic management to develop nations. Despite the African population accounting for nearly 14% of the world’s population, little published research originates from African scholars. Purpose The purpose of this article is to highlight the reasons for the lack of robust research by scientists from African low-and-middle-income countries and to emphasize the inequity experienced by African scientists in global health research. Possible solutions to the dearth in African global health research are equally explored. Findings Insufficient research has led to poor growth, development and advancements in health in Africa. A significant gap in African-led and published research, lack of mentorship, inequitable access to research funding and grant eligibility, and increased dependency on foreign organizations have contributed to the lack of sustainability and failure of African research. Conclusion Research is crucial for national development, especially in health. However, African researchers are underrepresented in global publications. To optimize research, local needs and African researchers must be prioritized, and research systems in African institutions must be strengthened. Additionally, the international community must respect, be transparent, and support research development in Africa. These efforts are essential for fostering a robust research environment, addressing global health challenges, and promoting sustainable development across Africa and LMICs.
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