Abstract Spring runoff is critical to agricultural, industrial, and municipal water supply as well as environmental uses in the western United States. Although spring runoff in this region has long been predicted based on late winter and early spring montane snow water storage, the role of soil moisture carryover from the previous winter is less understood and utilized in forecasts. We quantify the relationship between antecedent winter soil moisture and spring runoff for 85 unmanaged catchments in the western United States. Using a regression-based approach, we estimate the proportional reduction in error in seasonal runoff forecasts associated with soil moisture. We classify the catchments into two regimes: interior (cold and relatively dry) and maritime (warmer and wetter), based on seasonal variations in soil moisture. Soil moisture generally is relatively unchanged through the winter period in interior catchments, whereas it increases (mostly gradually, but occasionally rapidly) in maritime catchments. We find that winter temperature dominates soil moisture variability in both types of catchments. We find two patterns in the predictability of spring runoff. First, including antecedent winter soil moisture as a predictor enhances forecast accuracy and variance explanation in spring runoff for both interior and maritime catchments, particularly and with greater significance in interior catchments. Second, spring runoff prediction skill from antecedent winter soil moisture increases with elevation. Overall, we find strong evidence that the use of antecedent soil moisture can improve spring runoff forecast skill for catchments in the western United States. Significance Statement Spring runoff forecasts are crucial for water supply in the western United States, but typically exclude information about soil moisture despite its key role in the water balance. Our study explores how and why incorporating information about winter’s soil moisture levels affects spring runoff forecasts across 85 catchments in the western United States. We find that doing so can produce modest improvements in the prediction skill of spring runoff for both interior and maritime catchments but is particularly noticeable in interior catchments and at higher elevations where temperatures are lower. Overall, our research strongly supports the idea that using information about soil moisture from the previous winter can improve accuracy in spring runoff forecasts for the western United States.