The operation of marine vessels, especially large-tonnage ones, is accompanied by the occurrence of serious damage to hull structures within bow in stormy conditions. A new mechanism to explain the catastrophic destruction of the side grillages of large-tonnage ships in the area of the bow is proposed. Simulation of the process of flow around the fore end when it is digged in a wave using SPH technology showed that when the flow speeds around the fore end occur when the vessel moves in developed waves, there is a sharp drop in pressure in certain areas of the bow end. This circumstance can lead to the occurrence of cavitation that is confirmed by modeling the process of flow around the fore end using ANSYS FLUENT software. During stall cavitation, a cavitation cavern of considerable size may arise, the collapse of which is accompanied by the occurrence of hydrodynamic loads that can destroy hull structures. A calculation method is proposed that allows one to estimate the magnitude of hydrodynamic loads acting on the ship’s hull during the collapse of a cavitation cavern. To prevent damage to the bow in storm conditions, a number of constructive measures have been proposed. One of the options for solving the problem is to install a deck fairing in the bow that eliminates the negative influence of structural cavitators in the traditional design when the bow is digged in the wave. It is also possible to install a compressed air supply system to those areas of the bow where vacuum occurs when a liquid flows around when digged in a wave.