Force Profiles Research Articles

Effect of a variable electrode force on the LME crack formation during resistance spot welding of 3G AHSS

AbstractIn the pursuit of lightweight vehicles, third-generation advanced high-strength steels (3G AHSS) with increased mechanical properties are desired to be used for critical components. However, the exposure of these zinc-coated AHSS to the manufacturing conditions during resistance spot welding can trigger liquid metal embrittlement (LME), possibly compromising the mechanical properties. As the reproducibility of LME cracks in resistance spot welding is a challenge, the effect on the static and dynamic mechanical properties of the welds is not yet fully clarified and therefore a distinction between critical and non-critical cracks is not implemented in current standards. To achieve this, it is necessary to provoke LME cracks of a given size, for example by increasing the welding current, reducing the electrode force and hold time, or using manufacturing discontinuities. Due to its significant effect on the heat input and the tensile stresses during the resistance spot welding process, which impacts the LME crack propagation, the focus of this paper is on the electrode force. An expulsion-free decreasing force profile, which consists of a force run-in, force decrease, and force run-out time, has been derived in a two-stage Face-Centered-Central-Composite design of experiment for an electrogalvanized third-generation advanced high-strength steel (3G AHSS) DP1200 HD. The crack location, length, depth, and nugget geometries were investigated for each weld. With the decreasing force profile, it was possible to generate type A, B, and C cracks by parameter adaption, with type B and C cracks being the most dominant. The type C crack formation was investigated by aborting the welding process in defined time steps and the LME cracking mechanism was confirmed by welding dezincified samples. Based on the investigations carried out, the force profile was found suitable for generating different LME crack sizes to further investigate the mechanical joint properties as it was able to reproducibly generate defined cracks without expulsion and excessive electrode indentation while maintaining a minimum nugget diameter.

VARIABLE FRICTION MODEL DEVELOPMENT AND IMPLEMENTATION TO THE PULLING FORCE PREDICTION OF THE SPLIT-SLEEVE COLD EXPANSION PROCESS FOR ALUMINUM 2024-T3

Abstract This study aims to improve the accuracy of the pulling force estimation by establishing the variable friction model of the dry-lubricated split sleeve when cold working an aluminum 2024-T3 hole. The variable friction model was empirically obtained from the friction experimental setup simplified from the split-sleeve cold expansion process. The contact-pressure-dependent variable friction model was derived through a systematic design of experiments approach with three different normal stress conditions, namely low normal stress (220 MPa), medium normal stress (440 MPa), and high normal stress (660 MPa), to cover the range of normal stresses occurred in the cold expansion process. A full quadratic response surface model was drawn for the friction coefficient's nonlinear relationship between the mandrel and the lubricated sleeve, depending on the normal stresses. The variable friction model was verified with 3-dimensional friction test finite-element (FE) simulations. This FE modeling validates the variable friction model to predict the pulling forces with a sound agreement between the estimated and experimentally obtained values. We conducted split-sleeve cold expansion experiments to obtain the pulling force profile. Two 3-dimensional (3D) FE numerical analyses of the same split-sleeve cold expansion process were conducted using the variable friction model and a constant frictional coefficient of 0.05. The pulling force profiles from the FE modeling with the variable friction model closely align with those from the experiments to show the four distinct regions.

Limb Underloading in Walking Transmits Less Dynamic Knee Joint Contact Forces after Anterior Cruciate Ligament Reconstruction

ABSTRACT Introduction Individuals with anterior cruciate ligament reconstruction (ACLR) often walk with a less dynamic vertical ground reaction force (vGRF), exemplified by a reduced first peak vGRF and elevated midstance vGRF compared to uninjured controls. However, the mechanism by which altered limb loading affects actual tibial plateau contact forces during walking remains unclear. Methods Our purpose was to use musculoskeletal simulation to evaluate the effects of first peak vertical ground reaction force (vGRF) biofeedback on bilateral tibiofemoral contact forces relevant to the development of post-traumatic osteoarthritis (OA) in 20 individuals with ACLR. We hypothesized that reduced first peak vGRF would produce less dynamic tibial plateau contact forces during walking in individuals with ACLR. Results As the pivotal outcome from this study, and in support of our hypothesis, we found that less dynamic vGRF profiles in individuals with ACLR – observations that have associated in prior studies with more cartilage breakdown serum biomarkers and reduced proteoglycan density – are accompanied by less dynamic tibiofemoral joint contact forces during walking. Conclusion We conclude that more sustained limb-level loading, a phenotype that associates with worse knee joint health outcomes following ACLR and was prescribed herein using biofeedback, alters the loading profile and magnitude of force applied to tibiofemoral cartilage.

Center of mass kinematic reconstruction during steady-state walking using optimized template models.

Template models, such as the Bipedal Spring-Loaded Inverted Pendulum and the Virtual Pivot Point, have been widely used as low-dimensional representations of the complex dynamics in legged locomotion. Despite their ability to qualitatively match human walking characteristics like M-shaped ground reaction force (GRF) profiles, they often exhibit discrepancies when compared to experimental data, notably in overestimating vertical center of mass (CoM) displacement and underestimating gait event timings (touchdown/ liftoff). This paper hypothesizes that the constant leg stiffness of these models explains the majority of these discrepancies. The study systematically investigates the impact of stiffness variations on the fidelity of model fittings to human data, where an optimization framework is employed to identify optimal leg stiffness trajectories. The study also quantifies the effects of stiffness variations on salient characteristics of human walking (GRF profiles and gait event timing). The optimization framework was applied to 24 subjects walking at 40% to 145% preferred walking speed (PWS). The findings reveal that despite only modifying ground forces in one direction, variable leg stiffness models exhibited a >80% reduction in CoM error across both the B-SLIP and VPP models, while also improving prediction of human GRF profiles. However, the accuracy of gait event timing did not consistently show improvement across all conditions. The resulting stiffness profiles mimic walking characteristics of ankle push-off during double support and reduced CoM vaulting during single support.

Anion Selectivities in Zwitterion Grafted Nanopores: Effect of Zwitterion Architecture.

The separation of ions of similar charge is a crucial challenge in many applications, from water treatment to precious metal recovery. Membranes with cross-linked zwitterionic amphiphilic copolymer (ZAC-X) selective layers, which feature self-assembled, zwitterion-lined nanodomains for permeation, offer unique permselectivity between monovalent anions (e.g., Cl-/F-). This has motivated studies on the mechanisms of transport and selectivity in this family of materials. In this study, we conducted molecular dynamics simulations of aqueous salt solutions within zwitterion-functionalized nanopores to elucidate the influence of dipole orientation of the ZI ligands on anion diffusivities, partitioning, and permeabilities. Our model compares systems with contrasting ZI organization: surface-cation-anion (S-ZI+-ZI-, Motif A) and surface-anion-cation (S-ZI--ZI+, Motif B). Our results reveal that Motif A exhibits less pronounced ion pairing due to a spatial separation in the radial profiles of cations and anions. Motif B demonstrates prominent ion pairing for smaller anions owing to their overlap with cation distributions. Further, our potential of mean force profiles reveals that anion partitioning increases with anion size in both ligand motifs, whereas Motif B exhibits significantly higher partitioning selectivity toward larger anions compared to Motif A. Our results for ion diffusivities show that the self-diffusivities of both anions and cations are lower for Motif B compared to Motif A. Such trends in anion partitioning and diffusivities can be explained by differences in the interactions and steric hindrance experienced by the anionic species in Motifs A and B. Finally, our results for anion permselectivity, obtained by combining partitioning and diffusivity, indicate that partitioning trends dominate over diffusivity trends. Consequently, anion permeability increases with anion size, and ligand Motif B yields much higher permselectivity toward larger anions compared to ligand Motif A.

Unwinding DNA strands by single-walled carbon nanotubes: Molecular docking and MD simulation approach

Despite the growing research into the use of carbon nano-tubes (CNTs) in science and medicine, concerns about their potential toxicity remain insufficiently studied. This study utilizes molecular docking calculations combined by molecular dynamics simulations to investigate the dynamic intricacies of the interaction between single-walled carbon nanotubes (swCNTs) and double-stranded DNA (dsDNA). By examining the influence of swCNT characteristics such as length, radius, and chirality, our findings shed light on the complex interplay that shapes the binding affinity and stability of the dsDNA-swCNT complex. Molecular docking results identify a zigzag swCNT, with a radius of 0.16 Å and a length of 38 Å, as exhibiting the highest binding affinity with dsDNA (−23.9 kcal/mol). Comprehensive analyses, spanning docking results, binding energies, RMSD, radius of gyration, and potential of mean force (PMF) profiles, provide a detailed understanding of the denaturation dynamics. The PMF profiles reveal the thermodynamic feasibility of the DNA-CNT interaction, outlining distinct energy landscapes and barriers: when the selected swCNT binds within the dsDNA groove, the system becomes trapped at the first and second local energy minima, occurring at 1.48 nm and 1.00 nm, respectively. Intramolecular hydrogen bond calculations show a significant reduction, affirming the denaturing effect of swCNTs on DNA. Furthermore, the study reveals a significant reduction in the binding affinity of Ethidium Bromide (EB) to dsDNA following its interaction with swCNT, with a decrease in EB binding to dsDNA of approximately 13.2 %. This research offers valuable insights into the toxic effects of swCNTs on dsDNA, contributing to a rationalization of the cancerous potential of swCNTs.

Optimization of Load-transfer Functions for a Large-diameter Pile in Multi-layered Geological Conditions via a Stochastic Search Algorithm

The paper presents the combination of the load transfer method (computational model) and the genetic algorithm (optimization model) for the automated inverse analysis of instrumented pile load tests. The output of this process are the input parameters governing the shape of the load-transfer functions and thus the prediction accuracy when the load-transfer method is used as a design tool for deep foundations. The optimization problem is converted into an unconstrained task by applying the static penalty approach. Two types of measurements are considered in a newly proposed objective function: the load-displacement curve monitored in a pile head and the axial force profiles along a pile derived from strain gauges. Firstly, the local sensitivity analysis via the Design of Experiments is carried out to identify the parameters of the genetic algorithm which significantly influences the rate of convergence during the optimization process. Subsequently, a fully automated inverse analysis of the loading test of the large-diameter bored pile in multilayered geological conditions is presented. The simultaneous combination of two instrumentation sources leads to a stable unique solution with a sufficient match between the prediction and measurements despite a larger number of unknown – optimized variables.

Characterization of plugging and unplugging process for electric vehicle charging connectors based on Force/Torque measurements

Understanding the magnitude and profile of forces and torques (F/T) to properly execute the plugging and unplugging for electric vehicles (EVs) charging is crucial for designing reliable robots in automated charging stations (ACS). Previous research focuses on F/T measurement for controlling force during robotic tasks. In contrast, this study aims to refine automation workflows for smoother operation. By utilizing the comprehensive F/T measurements, it becomes possible to extract precise information during the plugging and unplugging process. This data provides insight into interaction dynamics, improving the robot’s ability to perform tasks more accurately and efficiently. Through experiments involving 40 participants, anthropometric and F/T data were analysed using statistics, uncovering key relationships between height, weight, and forces. The F/T profiles were predicted using polynomial, Fourier series, and Gaussian models, with the Gaussian proving the most accurate. Peak force and impulse are significantly higher during plugging (74.15 Ns) than unplugging(57.92Ns).

A Machine Learning Approach for Predicting Pedaling Force Profile in Cycling

Accurate measurement of pedaling kinetics and kinematics is vital for optimizing rehabilitation, exercise training, and understanding musculoskeletal biomechanics. Pedal reaction force, the main external force in cycling, is essential for musculoskeletal modeling and closely correlates with lower-limb muscle activity and joint reaction forces. However, sensor instrumentation like 3-axis pedal force sensors is costly and requires extensive postprocessing. Recent advancements in machine learning (ML), particularly neural network (NN) models, provide promising solutions for kinetic analyses. In this study, an NN model was developed to predict radial and mediolateral forces, providing a low-cost solution to study pedaling biomechanics with stationary cycling ergometers. Fifteen healthy individuals performed a 2 min pedaling task at two different self-selected (58 ± 5 RPM) and higher (72 ± 7 RPM) cadences. Pedal forces were recorded using a 3-axis force system. The dataset included pedal force, crank angle, cadence, power, and participants’ weight and height. The NN model achieved an inter-subject normalized root mean square error (nRMSE) of 0.15 ± 0.02 and 0.26 ± 0.05 for radial and mediolateral forces at high cadence, respectively, and 0.20 ± 0.04 and 0.22 ± 0.04 at self-selected cadence. The NN model’s low computational time suits real-time pedal force predictions, matching the accuracy of previous ML algorithms for estimating ground reaction forces in gait.

Cooperativity and halonium transfer in the ternary NCI···CH3I···-CN halogen-bonded complex: An ab initio gas phase study.

The strength and nature of the two halogen bonds in the NCI···CH3I···-CN halogen-bonded ternary complex are studied in the gas phase via ab initio calculations. Different indicators of halogen bond strength were employed to examine the interactions including geometries, complexation energies, Natural Bond Order (NBO) Wiberg bond indices, and Atoms in Molecules (AIM)-based charge density topological properties. The results show that the halogen bond is strong and partly covalent in nature when CH3I donates the halogen bond, but weak and noncovalent in nature when CH3I accepts the halogen bond. Significant halogen bond cooperativity emerges in the ternary complex relative to the corresponding heterodimer complexes, NCI···CH3I and CH3I···-CN, respectively. For example, the CCSD(T) complexation energy of the ternary complex (-18.27kcal/mol) is about twice the sum of the complexation energies of the component dimers (-9.54kcal/mol). The halonium transfer reaction that converts the ternary complex into an equivalent one was also investigated. The electronic barrier for the halonium transfer was calculated to be 6.70kcal/mol at the CCSD(T) level. Although the MP2 level underestimates and the MP3 overestimates the barrier, their calculated MP2.5 average barrier (6.44kcal/mol) is close to that of the more robust CCSD(T) level. Insights on the halonium ion transfer reaction was obtained by examining the reaction energy and force profiles along the intrinsic reaction coordinate, IRC. The corresponding evolution of other properties such as bond lengths, Wiberg bond indices, and Mulliken charges provides specific insight on the extent of structural rearrangements and electronic redistribution throughout the entire IRC space. The MP2 method was used for geometry optimizations. Energy calculations were performed using the CCSD(T) method. The aug-cc-pVTZ basis set was employed for all atoms other than iodine for which the aug-cc-pVTZ-PP basis set was used instead.

In-situ monitoring of multi-physical dynamics in ceramic additive manufacturing

Ceramic additive manufacturing is an innovative technology for developing complex ceramic structures, while a direct understanding of the physical phenomena occurring in sequential layers remains challenging, affected by the material design such as the presence of inorganic particles and their contents. This study provides a direct analysis of how the ceramic particles influence fabrication behavior utilizing an in-situ monitoring system. The force profile provides immediate feedback on fractures and geometric design, with the fluctuation in force directly corresponding to specific structural characteristics and stability during the fabrication. Furthermore, the multi-physical dynamics was investigated with a unit signal based on the effect of ceramic on the rheological-curing-mechanical behavior. For example, the mechanical behavior was characterized in real-time, as shown through an intensified peak of 6.6 kPa during the manufacturing of a ceramic composite, a 5.6 times increase compared to pure resin. The monitored data quantified the geometric dynamics and the multi-physical mechanism in real-time, achieved from the data on the overall fabrication status and the unit signal analysis of continuous manufacturing. This method can improve the reliability of ceramic additive manufacturing by providing insight into how ceramics impact fabrication behavior on sequential layers in real-time.

Physical effort precrastination determines preference in an isometric task.

How the brain decides when to invest effort is a central question in neuroscience. When asked to walk a mile to a destination, would you choose a path with a hill at the beginning or the end? The traditional view of effort suggests we should be indifferent-all joules are equal so long as it does not interfere with accomplishing the goal. Yet, when total joules are equal across movement decisions, the brain's sensitivity to the temporal profile of effort investment remains poorly understood. Here, we sought to parse the interaction of time and physical effort by comparing subjective preferences in an isometric arm-pushing task that varied the duration and timing of high and low effort. Subjects were presented with a series of two-alternative forced choices, where they chose the force profile they would rather complete. Subjects preferred earlier physical effort (i.e., to precrastinate) but were idiosyncratic about preference for task timing. A model of subjective utility that includes physical effort costs, task costs, and independent temporal sensitivity factors described subject preferences best. Interestingly, deliberation time and response vigor covary with the same subjective utility model for preference, suggesting a utility that underlies both decision making and motor control. These results suggest physical effort costs are temporally sensitive, with earlier investment of effort preferred to later investment, and that the representation of effort is based on not only the total energy required but also when it is required to invest that energy.NEW & NOTEWORTHY We use a novel paradigm that differentiates physical effort costs, task costs, and time, where subjects choose between isometric arm-pushing tasks. Subjects prefer high physical effort earlier than later. They also decide faster and respond more vigorously the greater their preference. We find a generalizable subjective utility model that includes independent time-sensitivity of physical effort and task costs. Together, we demonstrate that subjective effort includes not only the total effort invested but also its timing.

A transcrestal sinus floor elevation strategy based on a haptic robot system: An in vitro study.

To reveal the force profiles recorded by haptic autonomous robotic force feedback during the transcrestal sinus floor elevation (TSFE) process, providing a reference for the surgery strategy during TSFE. A total of 42 maxillary sinus models with different angles of the sinus floor (30°, 40°, 50°, 60°, 70°, 80°, and 90°, compared to vertical plane) were 3D printed. Implant site preparation was performed using a robotic system, and the total force (Ft) and axial force along the drill (Fz) during the surgery were recorded by the haptic robotic arm. The actual initial breakthrough point (drill contacting sinus floor) and complete breakthrough point (drill penetrating the sinus floor) were defined visually (the actual IBP and the actual CBP). The theoretical initial breakthrough point (the theoretical IBP) and the theoretical complete breakthrough point (the theoretical CBP) defined by the robot-guided system and the CBCT were determined by real-time force feedback and imaging distance measurement, respectively. The distance from the bottom of the resin model to the actual IBP and the actual CBP was defined as Di and Dt, respectively. The difference in Fz began to increase significantly at 70°, while the difference in Ft became significant at 60°. When the angle was greater than 70°, there was no significant difference in the discrepancy between the actual and theoretical perforation points. Compared to judging the breakthrough point by CBCT, real-time force feedback TSFE under robotic surgery achieved more accurate initial breakthrough point detection. The smaller the angle, the larger the breakthrough force for the drill. The real-time force feedback of haptic robotic system during TSFE could provide reliable reference for dentists. More clinical studies are needed to further validate the application of robotic surgery assisted TSFE.

Effects of protein grass hay as alternative feed resource on lamb's fattening performance and meat quality

Protein grass hay (PGH) was used as a new feed source for lambs to study its effect on fattening performance and meat quality. Fifty-six male lambs were allotted to four experimental groups and fed for eight weeks either alfalfa hay (AH)-based diet (control) or diets in which AH was replaced with 33 %, 66 %, or 99 % PGH. The inclusion of PGH did not affect final body weight, dry matter intake, average daily gain, feed conversion ratio, or carcass weight. Moreover, substituting AH with PGH at any level did not influence the ruminal fermentation or serum biochemical parameters, meat color, water holding capacity, shear force, or amino acid profile. However, relative liver weight was increased with 66 % substitutions. Furthermore, replacing 99 % AH with PGH decreased the meat's pH at 24 h. Higher levels of C18:3n-3, C20:5n-3, and total n-3 PUFA and a lower ratio of n-6: n-3 PUFA were also observed in meat from lambs fed PGH at 99 %. These findings suggest that PGH could be incorporated into the lamb's diet up to 99 % without compromising fattening performance and body health while improving their meat n-3 PUFA deposition.

Evaluation of a Slim Modiolar Electrode Array: A Temporal Bone Study.

Evaluation of the Slim Modiolar (SM) electrode in temporal bones (TB) will elucidate the electrode's insertion outcomes. The SM electrode was designed for atraumatic insertion into the scala tympani, for ideal perimodiolar positioning and with a smaller caliber to minimize interference with cochlear biological processes. The SM electrode was inserted into TBs via a cochleostomy. First, the axial force of insertion was measured. Next, TBs were inserted under fluoroscopy to study insertion dynamics, followed by histologic evaluation of electrode placement and cochlear trauma. A subset of TBs were inserted with the Contour Advance (CA) electrode for comparison. Sixteen of 22 insertions performed to measure the axial force of insertion had flat or near zero insertion force profiles. Six insertions had increased insertion forces, which were attributed to improper sheath depth before electrode insertion. Under real-time fluoroscopy, 23 of 25 TBs had uneventful insertion and good perimodiolar placement. There was 1 scala vestibuli insertion due to suboptimal cochleostomy position and 1 tip roll over related to premature electrode deployment. When compared with the CA electrode, 14 of 15 insertions with the SM electrode resulted in a more perimodiolar electrode position. No evidence of trauma was found in histologic evaluation of the 24 TBs with scala tympani insertions. TB evaluation revealed that the SM electrode exerts minimal insertion forces on cochlear structures, produces no histologic evidence of trauma, and reliably assumes the perimodiolar position. Nonstandard cochleostomy location, improper sheath insertion depth, or premature deployment of the electrode may lead to suboptimal outcomes.

Crucial textural properties of braised pork to evaluate the oral mastication behavior and its water distribution to influence tenderness.

The complex composition of braised pork, including lean meat, pigskin, and fat, makes it difficult for sensory evaluation of its texture properties. This study investigated the correlation between sensory texture attributes and physicochemical properties to achieve an objective and comprehensive evaluation of the texture of braised pork. Sensory analysis demonstrated that the overall texture acceptability of braised pork was significantly and negatively influenced by sensory texture attributes (including sensory hardness, chewiness, and toughness), while it was positively impacted by sensory adhesiveness, softness, and juiciness. Shear force and texture profile analysis (TPA) variables, reflecting mastication behavior, were used to characterize the textural properties of braised pork. They were closely related to water distribution, with a higher proportion of immobilized water (P21), indicating a higher water holding capacity and a more tender texture. Correlation analysis between sensory texture attributes and physicochemical properties through partial least squares regression further revealed significant associations between shear force, TPA variables, and sensory texture attributes. Moreover, the proportion of immobilized water (P21) significantly and negatively affected sensory hardness and chewiness, whereas the proportion of free water (P22) significantly influenced sensory toughness. Sensory texture attributes could be well predicted by the physicochemical properties by projecting test samples onto calibration models established by known samples. Therefore, a combination of sensory and instrumental measures can reliably reflect the texture properties of braised pork. PRACTICAL APPLICATION: The combination of sensory and instrumental methods is an effective strategy to accurately and objectively evaluate the texture properties of braised pork, which overcomes the limitations caused by the complexity of the composition and texture traits of braised pork. The accurate evaluation and standardization of texture properties is an important premise for the repeatable and stable cooking of traditional braised pork. Furthermore, this research method and findings can also be applied to guide the procedural optimization of smart appliances (e.g., induction cookers) for cooking braised pork.

The role of time-varying external factors in the intensification of tropical cyclones

Abstract. The role of time-varying external parameters in tropical cyclone (TC) dynamics is explored through a low-order conceptual box model. Specifically, we look at stable-to-stable state transitions which may be linked to tropical cyclone intensification, dissipation, or eyewall replacement cycles (ERCs). To this end, we identify two parameters of interest: the exponent of radial decline and sea-surface temperature. We examine how variations in these parameters affect the stable states of the model and consider the behaviour of the system under different time-dependent forcing profiles for the parameters. By externally forcing the exponent of radial decline and sea-surface temperature, we show the existence of rate-dependent behaviour in the model. These findings are brought together in a case study of Hurricane Irma (2017). The results highlight the role of the radial vorticity gradient in behaviour such as rate-induced tipping and overshoot recovery. They also show that a simple model can be used to explore relatively complex tropical cyclone dynamics.

Single-residue effects on the behavior of a nascent polypeptide chain inside the ribosome exit tunnel.

Nascent polypeptide chains (NCs) are extruded from the ribosome through an exit tunnel (ET) traversing the large ribosomal subunit. The ET's irregular and chemically complex wall allows for various NC-ET interactions. Translational arrest peptides (APs) bind in the ET to induce translational arrest, a property that can be exploited to study NC-ET interactions by Force Profile Analysis (FPA). We employed FPA and molecular dynamics (MD) simulations to investigate how individual residues placed in a glycine-serine repeat segment within an AP-stalled NC interact with the ET to exert a pulling force on the AP and release stalling. Our results indicate that large and hydrophobic residues generate a pulling force on the NC when placed ≳10 residues away from the peptidyl transfer center (PTC). Moreover, an asparagine placed 12 residues from the PTC makes a specific stabilizing interaction with the tip of ribosomal protein uL22 that reduces the pulling force on the NC, while a lysine or leucine residue in the same position increases the pulling force. Finally, the MD simulations suggest how the Mannheimia succiniproducens SecM AP interacts with the ET to promote translational stalling.

GAIT CHANGES FOLLOWING CERAMIC-ON-CERAMIC HIP RESURFACING ARTHROPLASTY: A PROSPECTIVE STUDY

A ceramic-on-ceramic hip resurfacing implant (cHRA) was developed and introduced in an MHRA-approved clinical investigation to provide a non metallic alternative hip resurfacing product. This study aimed to examine function and physical activity levels of patients with a cHRA implant using subjective and objective measures both before and 12 months following surgery in comparison with age and gender matched healthy controls.Eighty-two unilateral cHRA patients consented to this study as part of a larger prospective, non-randomised, clinical investigation. In addition to their patient reported outcome measures (PROMs), self- reported measures of physical activity levels and gait analysis were undertaken both pre- operatively (1.5 weeks) and post operatively (52 weeks). This data was then compared to data from a group of 43 age gender and BMI matched group of healthy controls. Kinetics and kinematics were recorded using an instrumented treadmill and 3D Motion Capture. Statistical parametric mapping was used for analysis.cHRA improved the median Harris Hip Score from 63 to 100, Oxford Hip score from 27 to 48 and the MET from 5.7 to 10.3. cHRA improved top walking speed (5.75km vs 7.27km/hr), achieved a more symmetrical ground reaction force profile, (Symmetry Index value: 10.6% vs 0.9%) and increased hip range of motion (ROM) (31.7° vs 45.9°). Postoperative data was not statistically distinguishable from the healthy controls in any domain.This gait study sought to document the function of a novel ceramic hip resurfacing, using those features of gait commonly used to describe the shortcomings of hip arthroplasty. These features were captured before and 12 months following surgery. Preoperatively the gait patterns were typical for OA patients, while at 1 year postoperatively, this selected group of patients had gait patterns that were hard to distinguish from healthy controls despite an extended posterior approach. Applications for regulatory approval have been submitted.

Ion Correlation-Driven Hysteretic Adhesion and Repulsion between Opposing Polyelectrolyte Brushes.

Polyelectrolyte (PE) brushes are widely used in biomaterials and nanotechnology to regulate the surface properties and interactions. Here, we apply the electrostatic correlation augmented self-consistent field theory to investigate the interactions between opposing PE brushes in a mixture of 1:1 and 3:1 salt solutions. Our theory predicts a hysteretic feature of the normal stress induced by strong ion correlations. In the presence of trivalent ions, the force profile is discontinuous: repulsive in the compression branch and adhesive in the separation branch. The molecular origin of the hysteretic force is the coexistence of two collapsed modes: two separated condensed layers on each surface in the compression and a single bundled condensed layer in the separation. With the systematic inclusion of ion correlations, our theory captures well the hysteretic force, adhesive separation, "jump-in" and "jump-out" features, and the "specific ion effect", all in good agreement with the reported experimental results.