As the global demand for food increases, the efficiency and environmental sustainability of refrigeration systems have become increasingly critical issues. Cascaded refrigeration systems (CRSs) are widely used in the Chinese food cold chain due to their capacity to meet a wide range of temperature requirements. However, energy consumption of these systems is always high. If phase change materials (PCMs) are combined with the refrigeration systems, the energy-saving effect is remarkable. The paper reviews the integration of PCMs within CRS, focusing on their potential to reduce energy consumption, thereby improving food safety and reducing reliance on conventional, electricity-intensive refrigeration methods. The study categorizes and explores the low-temperature applications of PCMs in CRS, providing novel insights into enhancing energy efficiency in food cold chain logistics. Despite most PCM research focusing on single-stage systems, this review innovates by introducing PCM integration in multistage cascade systems, which is particularly relevant for low-temperature requirements. The discussion encompasses the structure, working fluids, and applications of CRSs in the cold chain, emphasizing the role of PCMs in sustainable cold chain management. The review concludes by highlighting the need for further research on PCMs in CRS, especially regarding their economic viability and large-scale implementation potential.