This study characterized in-situ stress-fields and multi-scale fractures in the low porosity and low permeability Mississippian-aged “Meramec and Osage” intervals in the Anadarko Basin of central Oklahoma. As the two reservoirs' productivity is influenced by fractures, understanding fracture nature, frequency and distribution is important for the development of these reservoirs. The study implemented an integrated approach to characterize in-situ stress-fields and related fractures utilizing 3D seismic data, cores, petrophysics, and formation micro-imaging logs. Density of fractures was interpreted from integrated analyses of seismic, petrophysical, core, and FMI log data. Fracture orientations were determined from the seismic and FMI log data. Detected fractures in the “Meramec” interval preferentially occur in pervasively calcite-cemented rock with low porosity. Because of the adverse effect of calcite cementation, fractures did not significantly improve reservoir quality within the “Meramec” interval. In contrast, detected fractures in the “Osage” interval added sufficient porosity and permeability to overcome negative cementation effects and improved the overall reservoir quality. This study revealed a rotation of the horizontal stress orientations from ancient stress regimes to the present-day in-situ stress regimes. The study demonstrated the application of integrated seismic and non-seismic data in fracture and stress-field characterization, improved our understanding of the effects of fractures on reservoir quality to reduce risks associated with exploring low-porosity/low-permeability mixed carbonate and siliciclastic reservoirs.