Fluorescent Mesoporous Silica Research Articles

Fabrication of Rhenium Disulfide/Mesoporous Silica Core-Shell Nanoparticles for a pH-Responsive Drug Release and Combined Chemo-Photothermal Therapy.

A stimuli-responsive drug delivery nanocarrier with a core-shell structure combining photothermal therapy and chemotherapy for killing cancer cells was constructed in this study. The multifunctional nanocarrier ReS2@mSiO2-RhB entails an ReS2 hierarchical nanosphere coated with a fluorescent mesoporous silica shell. The three-dimensional hierarchical ReS2 nanostructure is capable of effectively absorbing near-infrared (NIR) light and converting it into heat. These ReS2 nanospheres were generated by a hydrothermal synthesis process leading to the self-assembly of few-layered ReS2 nanosheets. The mesoporous silica shell was further coated on the surface of the ReS2 nanospheres through a surfactant-templating sol-gel approach to provide accessible mesopores for drug uploading. A fluorescent dye (Rhodamine B) was covalently attached to silica precursors and incorporated during synthesis in the mesoporous silica walls toward conferring imaging capability to the nanocarrier. Doxorubicin (DOX), a known cancer drug, was used in a proof-of-concept study to assess the material's ability to function as a drug delivery carrier. While the silica pores are not capped, the drug molecule loading and release take advantage of the pH-governed electrostatic interactions between the drug and silica wall. The ReS2@mSiO2-RhB enabled a drug loading content as high as 19.83 mg/g doxorubicin. The ReS2@mSiO2-RhB-DOX nanocarrier's cumulative drug release rate at pH values that simulate physiological conditions showed significant pH responsiveness, reaching 59.8% at pH 6.8 and 98.5% and pH 5.5. The in vitro testing using HeLa cervical cancer cells proved that ReS2@mSiO2-RhB-DOX has a strong cancer eradication ability upon irradiation with an NIR laser owing to the combined drug delivery and photothermal effect. The results highlight the potential of ReS2@mSiO2-RhB nanoparticles for combined cancer therapy in the future.

Ultrabright fluorescent particles via physical encapsulation of fluorescent dyes in mesoporous silica: a mini-review.

Harnessing the power of mesoporous silica to encapsulate organic fluorescent dyes has led to the creation of an extraordinary class of nanocomposite photonic materials. These materials stand out for their ability to produce the brightest fluorescent particles known today, surpassing even the luminosity of quantum dots of similar spectrum and size. The synthesis of these materials offers precise control over the shape and size of the particles, ranging from the nano to the multi-micron scale. Just physical encapsulation of the dyes opens new possibilities for mixing different dyes within individual particles, paving the way for nearly limitless multiplexing capabilities. Moreover, this approach lays the groundwork for the development of highly sensitive sensors capable of detecting subtle changes in temperature and acidity at the nanoscale, among other parameters. This mini-review highlights the mechanism of synthesis, explains the nature of ultrabrightness, and describes the recent advancements and future prospects in the field of ultrabright fluorescent mesoporous silica particles, showcasing their potential for various applications.

Fluorogen-Functionalized Mesoporous Silica Hybrid Sensing Materials: Applications in Cu2+ Detection.

Since Cu2+ ions play a pivotal role in both ecosystems and human health, the development of a rapid and sensitive method for Cu2+ detection holds significant importance. Fluorescent mesoporous silica materials (FMSMs) have garnered considerable attention in the realm of chemical sensing, biosensing, and bioimaging due to their distinctive structure and easily functionalized surfaces. As a result, numerous Cu2+ sensors based on FMSMs have been devised and extensively applied in environmental and biological Cu2+ detection over the past few decades. This review centers on the recent advancements in the methodologies for preparing FMSMs, the mechanisms underlying sensing, and the applications of FMSMs-based sensors for Cu2+ detection. Lastly, we present and elucidate pertinent perspectives concerning FMSMs-based Cu2+ sensors.

Facile synthesis of fluorescent mesoporous nanocarriers with pH-sensitive controlled release of naturally derived dieckol

Dieckol is a marine polyphenol found in the brown algae Ecklonia cava and has been actively studied because it has various biological activities such as antioxidant, anti-inflammatory, and antibacterial. Herein, fluorescent mesoporous silica nanoparticles (FMSNs) were synthesized for the efficient delivery of naturally derived Die molecules. The Die-loaded FMSNs (FMSNs-Die) were further coated with polyethylene glycol (PEG) and graphene oxide (GO) nanosheets, termed as FMSNs-Die@PEG and FMSNs-Die@PEG@GO, respectively. The release kinetics was investigated using Fickian-type exponential and Kosmeyer-Peppas relaxation models. Overall, the FMSN-based nanocarriers exhibited a faster release at pH 4.5 than at pH 7.4. The release rate at pH 7.4 decreased in the following order: FMSNs-Die > FMSNs-Die@PEG > FMSNs-Die@PEG@GO. In contrast, the release rate at pH 4.5 exhibited a somewhat different order of FMSNs-Die@PEG ≥ FMSNs-Die > FMSNs-Die@PEG@GO. Notably, the difference of the release rates at these pH values was most pronounced for the PEG-coated FMSNs, signifying the strong pH-responsive release behavior of Die molecules. Within the pH ranges (pH 4.5 – 7.4), double-layer-coated FMSNs exhibited the significantly delayed release rates as compared to coating-free and single-layer-coated analogs. Our nanocarriers demonstrated pH-sensitive controlled release of Die, suggesting as a smart drug delivery system for natural product-derived drugs.

Chitosan coated fluorescent mesoporous silica for the sensitive and selective detection of H2O2

A novel turn-on fluorescent sensor for hydrogen peroxide (H2O2) was prepared from chitosan (CS) coating mesoporous silica nanoparticles (MSNs) loaded with 1-(4-Aminophenyl)-1,2,2-triphenylethene (TPE-NH2) and silver nanoparticles (AgNCs). The surface of MSNs was coated by CS as the gatekeeper and the template for loading of AgNCs. Because of the surface plasmon-enhanced energy transfer (SPEET), AgNCs effectively quenched the fluorescence emission of nanoparticles. In the presence of H2O2, AgNCs can be oxidized to Ag+, resulting in the recovery of fluorescence. This fluorescent sensor was characterized with respect to its chemical composition, morphological features and optical properties by means of FTIR, XRD, TGA, SEM, TEM, XPS, UV–Vis and fluorescence spectroscopy. The MSN/TPE-CS@Ag nanoparticles showed good sensitivity and selectivity for H2O2 even with various interfering ions and agents. Under optimized conditions, the detection limit for H2O2 was 0.64 μM in the rage of 1–300 μM. The feasibility of the practical application of this probe was confirmed by accurate quantitative of H2O2 in practical samples.

Effects of Methoxyfenozide-Loaded Fluorescent Mesoporous Silica Nanoparticles on Plutella xylostella (L.) (Lepidoptera: Plutellidae) Mortality and Detoxification Enzyme Levels Activities.

The diamond back moth, Plutella xylostella, causes severe damage at all crop stages, beside its rising resistance to all insecticides. The objective of this study was to look for a new control strategy such as application of insecticide-loaded carbon dot-embedded fluorescent mesoporous silica nanoparticles (FL-SiO2 NPs). Two different-sized methoxyfenozide-loaded nanoparticles (Me@FL-SiO2 NPs-70 nm, Me@FL-SiO2 NPs-150 nm) were prepared, with loading content 15% and 16%. Methoxyfenozide was released constantly from Me@FL-SiO2 NPs only at specific optimum pH 7.5. The release of methoxyfenozide from Me@FL-SiO2 NPs was not observed other than this optimum pH, and therefore, we checked and controlled a single release condition to look out for the different particle sizes of insecticide-loaded NPs. This pH-responsive release pattern can find potential application in sustainable plant protection. Moreover, the lethal concentration of the LC50 value was 24 mg/L for methoxyfenozide (TC), 14 mg/L for Me@FL-SiO2 NPs-70 nm, and 15 mg/L for Me@FL-SiO2 NPs-150 nm after 72 h exposure, respectively. After calculating the LC50, the results predicted that Me@FL-SiO2 NPs-70 nm and Me@FL-SiO2 NPs-150 nm exhibited better insecticidal activity against P. xylostella than methoxyfenozide under the same concentrations of active ingredient applied. Moreover, the activities of detoxification enzymes of P. xylostella were suppressed by treatment with insecticide-loaded NPs, which showed that NPs could also be involved in reduction of enzymes. Furthermore, the entering of FL-SiO2 NPs into the midgut of P. xylostella was confirmed by confocal laser scanning microscope (CLSM). For comparison, P. xylostella under treatment with water as control was also observed under CLSM. The control exhibited no fluorescent signal, while the larvae treated with FL-SiO2 NPs showed strong fluorescence under a laser excitation wavelength of 448 nm. The reduced enzyme activities as well as higher cuticular penetration in insects indicate that the nano-based delivery system of insecticide could be potentially applied in insecticide resistance management.

Imaging Intracellular Drug/siRNA Co-Delivery by Self-Assembly Cross-Linked Polyethylenimine with Fluorescent Core-Shell Silica Nanoparticles.

Multifunctional theranostic nanomaterial represents one type of emerging agent with the potential to offer both sensitive diagnosis and effective therapy. Herein, we report a novel drug/siRNA co-delivery nanocarrier, which is based on fluorescent mesoporous core-shell silica nanoparticles coated by cross-linked polyethylenimine. The fluorescent mesoporous core-shell silica nanoparticles can provide numerous pores for drug loading and negative charged surface to assemble cross-linked polyethylenimine via electrostatic interaction. Disulfide cross-linked polyethylenimine can be absorbed on the surface of silica nanoparticles which provide the feasibility to bind with negatively charged siRNA and release drug “on-demand”. In addition, the hybrid nanoparticles can be easily internalized into cells to realize drug/siRNA co-delivery and therapeutic effect imaging. This work would stimulate interest in the use of self-assembled cross-linked polyethylenimine with fluorescent mesoporous core-shell silica nanoparticles to construct multifunctional nanocomposites for tumor therapy.

Nanotechnology and Conventional Techniques to Detect Latent Fingerprints on Surfaces

Abstract: This review paper centers around the use of legal science in dormant unique mark identification by the utilization of particular nanomaterials and their advantages concerning the nature of finger impression pictures. The use of measurable science in the discovery of the idle unique finger impression The benefits and significant aftereffects of studies directed on inert finger impression recognition with different nanomaterials which incorporate metal nano-particles, metallic oxide nanoparticles, semiconductor quantum specks, carbon dabs, polymer dabs, fluorescent silica nanoparticles, fluorescent mesoporous silica nanoparticles, fluorescent silica nanoparticles, formed polyelectrolyte spots, accumulation prompted outflow brilliant atom joined nanomaterials and phenomenal earth fluorescence nanoparticles are basically talked about. A portion of the nanomaterials utilized for idle finger impression discovery didn't bring about great quality finger impression pictures and these detriments are featured. Keywords: Nanotechnology, Nanomaterials, latent fingerprint, fluorescence

Polyethylenimine Functionalized Ultrasmall Mesoporous Silica Nanoparticles for siRNA Delivery

AbstractSmall interfering RNA (siRNA) for gene therapy has attracted great attention. However, due to easy degradation and inaccessibility to the cells, the gene silencing efficiency is not always satisfactory. To overcome this hurdle, developing an excellent nanocarrier to deliver siRNA into cancer cells is crucial. Fluorescent mesoporous silica nanoparticles are considered to be a superb nanocarrier for siRNA delivery systems because of its negligible toxicity and good biocompatibility. Herein, we developed an efficient fluorescent ultrasmall mesoporous silica nanocarrier for siRNA loading and delivery. The ultrasmall nanocarriers with polyethylenimine coating have a uniform size of about 10 nm. We find that the amino groups on polyethylenimine can protect siRNA from being degraded. Based on the fluorescence observation, we show that polyethylenimine‐coated mesoporous silica nanocarrier loaded with siRNA can be uptake by 293T cells. Importantly, we also prove that siRNA can be delivered into 293T cells by our nanocarrier and subsequently inhibit the expression of related genes. The study provides insights into the development of nonviral fluorescence nanocarriers for siRNA delivery, which have important implications for targeted cancer therapy.

Fluorescent mesoporous silica nanomaterials for targeted tumor chemotherapy

Mesoporous silica nanoparticles are considered as ideal carriers for the development of drug delivery systems (DDS) because of their specific features such as low biological toxicity, easy surface modification, high loading efficiency, sustainable release of anti-cancer drugs and easy fabrication. In this work, novel mesoporous silica nanoparticles with fluorescent and tumor targeting functions (YMSN-FA) were successfully synthesized by grafting perylene imide derivatives (Y580) and folic acid (FA) onto the surface of the silica nanoparticles. Subsequently, the nanoparticles were loaded with paclitaxel (PTX) to fabricate smart composite materials (PTX-YMSN) with targeted chemotherapy and tumor imaging functionalities. Imaging and therapeutic results of PTX-YMSN towards Hela cells demonstrate potential applicability of PTX-YMSN. This study combines the unique advantages of drug delivery nanosystem and organic fluorophore to provide a new and effective strategy for the treatment of tumor.

Europium (III)-doped mesoporous silica nanoparticles (SiO2-Eu NPs) prepared via the soaking method

Mesoporous silica nanoparticles (NPs) exhibiting magnetic, fluorescent, or magneto-fluorescent properties have attracted enormous attention because of the rapid development of theranostic nanoprobes. In this study, we report the simple yet efficient soaking method for the development of fluorescent mesoporous silica NPs within the size range of ~71–105 nm. Nitrogen adsorption-desorption experiments revealed that prepared SiO2-Eu NPs exhibit a large surface area of ~649 m2 g−1 that is suitable for potential drug delivery purposes. Photoluminescence study suggested that SiO2-Eu NPs emit a typical red emission with a maximum of ~615 nm and a quantum yield of ~7.94%. It is suggested that the proposed method can be extended to the fabrication of other metal-doped silica NPs.

Revealing the Phagosomal pH Regulation and Inflammation of Macrophages after Endocytosing Polyurethane Nanoparticles by A Ratiometric pH Nanosensor.

The effect of the intracellular pH of macrophages after taking up biodegradable polymer nanoparticles (NPs) on immunomodulating functions has not been explored so far. Previous studies have demonstrated that biodegradable polyurethane (PU) NPs exhibit immunosuppressive activity. Yet, the intracellular mechanism is not clearly understood. In this study, a uniquely designed pH nanosensor is employed for tracking the intracellular pH value of macrophages to reveal the intracellular journey of PU NPs and to clarify the intracellular pH effect on the corresponding inflammatory response. First, fluorescent mesoporous silica nanoparticles (FRMSNs) is used to detect the pH change in macrophages after endo/phagocytosis of PU NPs. Second, PU is coated on the external surface of FRMSNs to examine the intracellular trafficking process of PU in the macrophages. The results show that the majority of PU-coated FRMSNs remain to stay at the cytosol-early endosome/phagosome regions. The intracellular pH value and other supporting results show that the immune response of PU NPs may be correlated to their internalization journey. The retardation in the degradation process of the PU NPs may intervene with the lysosome activity and repress the immunostimulatory effect, which contributes to the low immune response of PU NPs.

STING Activator c-di-GMP-Loaded Mesoporous Silica Nanoparticles Enhance Immunotherapy Against Breast Cancer

Reversing the immunosuppressive tumor microenvironment (TME) is a strategic initiative to sensitize cancer immunotherapy. Emerging evidence shows that cyclic diguanylate monophosphate (c-di-GMP or cdG) can induce the stimulator of interferon genes (STING) pathway activation of antigen-presenting cells (APCs) and upregulate expression of type I interferons (IFNs) to enhance tumor immunogenicity. In vitro anionic cdG revealed fast plasma clearance, poor membrane permeability, and inadequate cytosolic bioavailability. Therefore, we explored a comprehensive "in situ vaccination" strategy on the basis of nanomedicine to trigger robust antitumor immunity. Rhodamine B isothiocyanate (RITC) fluorescent mesoporous silica nanoparticles (MSN) synthesized and modified with poly(ethylene glycol) (PEG) and an ammonium-based cationic molecule (TA) were loaded with negatively charged cdG via electrostatic interactions to form cdG@RMSN-PEG-TA. Treatment of RAW 264.7 cells with cdG@RMSN-PEG-TA markedly stimulated the secretion of IL-6, IL-1β, and IFN-β along with phospho-STING (Ser365) protein expression. In vivo cdG@RMSN-PEG-TA enhanced infiltration of leukocytes, including CD11c+ dendritic cells, F4/80+ macrophages, CD4+ T cells, and CD8+ T cells within the tumor microenvironment (TME), resulting in dramatic tumor growth inhibition in 4T1 breast tumor-bearing Balb/c mice. Our findings suggest that a nanobased platform can overcome the obstacles bare cdG can face in the TME. Our approach of an in situ vaccination using a STING agonist provides an attractive immunotherapy-based strategy for treating breast cancer.

Indoxacarb-loaded fluorescent mesoporous silica nanoparticles for effective control of Plutella xylostella L. with decreased detoxification enzymes activities.

Plutella xylostella L. is a cosmopolitan lepidopteron insect pest for numerous vegetables and crops. The extensive use of insecticides has resulted in the emergence of resistance in P. xylostella. Thus, development of innovative strategies to overcome the insecticide resistance and control P. xylostella effectively is highly desirable. Inspired by the concept and breakthrough of nanomedical strategies to treat multidrug resistance, nanotechnology may find potential application in overcoming or delaying insecticide resistance. Carbon dots-embedded fluorescent mesoporous silica nanoparticles (FL-SiO2 NPs) were successfully developed. Indoxacarb-loaded nanoparticles (IN@FL-SiO2 NPs) were facilely prepared with loading content of 24%. The release of indoxacarb from IN@FL-SiO2 NPs was pH sensitive. IN@FL-SiO2 NPs exhibited better insecticidal activity against P. xylostella than indoxacarb technical under the same doses of active ingredient applied. Moreover, the activities of detoxification enzymes including GST, CarE, and P450 of P. xylostella were suppressed by treatment with IN@FL-SiO2 NPs. Furthermore, the entry of FL-SiO2 NPs into the midgut of P. xylostella was confirmed by CLSM observation. Although there is no absolute correlation between the enzyme activity and resistance, the change in corresponding enzyme activity can afford valuable information on the resistance situation. IN@FL-SiO2 NPs treated P. xylostella displayed higher mortality, along with decreased enzymes activities, which indicates that nano-based delivery system of insecticide could be potentially applied in insecticide resistance management. © 2020 Society of Chemical Industry.

Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers

Treatment resistance, relapse and metastasis remain critical issues in some challenging cancers, such as chondrosarcomas. Boron-neutron capture therapy (BNCT) is a targeted radiation therapy modality that relies on the ability of boron atoms to capture low energy neutrons, yielding high linear energy transfer alpha particles. We have developed an innovative boron-delivery system for BNCT, composed of multifunctional fluorescent mesoporous silica nanoparticles (B-MSNs), grafted with an activatable cell penetrating peptide (ACPP) for improved penetration in tumors and with gadolinium for magnetic resonance imaging (MRI) in vivo. Chondrosarcoma cells were exposed in vitro to an epithermal neutron beam after B-MSNs administration. BNCT beam exposure successfully induced DNA damage and cell death, including in radio-resistant ALDH+ cancer stem cells (CSCs), suggesting that BNCT using this system might be a suitable treatment modality for chondrosarcoma or other hard-to-treat cancers.

Carbohydrate coated fluorescent mesoporous silica particles for bacterial imaging

This work investigated the synthesis of carbohydrate functionalized methylene blue doped amine grafted mesoporous silica nanoparticles (MB AMSN) and their application in bioimaging. A single-pot synthesis methodology was developed via a modified co-condensation sol-gel technique for simultaneous incorporation of the dye molecule in the nanoparticles, with amine grafting for subsequent functionalization. The obtained nanoparticles (∼ 450 nm) are mesoporous and have a high surface area (538 m2/g), pore-volume (0.3 cm3/g), showed excellent UV-vis absorbance, and dye encapsulation efficiency (> 75 %). These fluorescent nanoparticles were further functionalized with carbohydrate molecules before application as contrast agents in bacterial cells. In the present study, gram-positive (E. coli) and gram-negative (B. subtilis) bacteria were used as model organisms. Confocal laser microscopy results showed that the nanoparticles are highly fluorescent, and SEM of glucose conjugated MB doped nanoparticles indicated close interaction with E. coli with no toxicity observed towards either bacterial cells. The results demonstrate that by suitable surface functionalization, the methylene blue doped silica nanoparticles can be used as bioimaging agents.

Ratiometric Imaging of the in Situ pH Distribution of Biofilms by Use of Fluorescent Mesoporous Silica Nanosensors.

Biofilms are communities of microorganisms enclosed in a self-generated matrix of extracellular polymeric substances. While biofilm recalcitrance and persistence are caused by several factors, a reduction in antimicrobial susceptibility has been closely associated with the generation of pH gradients within the biofilm structure. Cells embedded within the biofilm create a localized acidic microenvironment, which is unaffected by the external pH. Therefore, pH monitoring is a promising approach for understanding the complexities of a three-dimensional heterogeneous biofilm. A fluorescent pH nanosensor was designed through the synthesis of mesoporous silica nanoparticles (47 ± 5 nm diameter) conjugated to a pH-sensitive dye (fluorescein) and a pH-insensitive dye (rhodamine B) as an internal standard (dye-MSNs). The fluorescence intensity of fluorescein (IF) reduced significantly as the pH was decreased from 8.5 to 3.5. In contrast, the fluorescence intensity of rhodamine B (IR) remained constant at any pH. The ratio of IF/IR produced a sigmoidal curve with respect to the pH, in a working pH range between 4.5 and 7.5. Dye-MSNs enabled the measurement of pH gradients within Pseudomonas fluorescens WCS 365 biofilm microcolonies. The biofilms showed spatially distinct low-pH regions that were enclosed into large clusters corresponding to high-cell-density areas. Also present were small low-pH areas that spread indistinctly throughout the microcolony caused by the mass transfer effect. The lowest detected pH within the inner core of the microcolonies was 5.1, gradually increasing to a neutral pH toward the exterior of the microcolonies. The dye-MSNs were able to fully penetrate the biofilm matrix and allowed a quantitative ratiometric analysis of pH gradients and distribution throughout the biofilm, which was independent of the nanoparticle concentration.

Preparation and Characterization of Carboxyl Functionalized Fluorescent Mesoporous Silica Nanoparticles Containing 8-Hydroxyquinolinate Zinc Complexes

Fluorescent mesoporous silica nanoparticles functionalized with carboxyl group (Znq-CMS-COOH) were successfully synthesized by in situ formation route of 8-hydroxyquinolinate zinc complexes in channels of mesoporous silica nanoparticles and post-grafting of carboxyl group on the surface. Moreover, the particle size and structural properties of Znq-CMS-COOH were characterized by transmission electron microscopy (TEM), field emission scanning electron microscopy (FE-SEM), dynamic light scattering (DLS). Fourier transform infrared spectroscopy (FT-IR), UV-vis spectrometer, fluorescence spectrometer and nitrogen adsorption-desorption measurements. The obtained results suggest that the Znq-CMS-COOH presents the uniform spherical shape with the mean diameter of about 85 nm and the obvious wormhole arrangement mesoporous. In addition, the Znq-CMS-COOH possesses green fluorescence with the emission peaks at 495 nm. So the Znq-CMS-COOH, which is beneficial to further modification and tracing, might be a great potential carrier for applying in drug delivery system in the future.

Fluorescent coumarin-modified mesoporous SBA-15 nanocomposite: Physico-chemical characterization and interaction with prokaryotic and eukaryotic cells

Abstract Three novel fluorescent mesoporous silica composites were obtained through the covalent immobilization of 7-amino-4-(trifluoromethyl)coumarin, 6-amino-chromen-2-one and 7-amino-4-methyl-3-coumarinylacetic acid, respectively, inside the channels of mesoporous silica SBA-15. Presence of fluorescent moieties was assessed by elemental analysis, thermal analysis, infrared, UV–Vis, 29Si- and 13C-CP/MAS NMR, and fluorescence spectroscopy. Reduction of specific surface area of the composites by 50–60% and also the average pore size diameter by 0.5–0.55 nm compared to unfunctionalized SBA-15 was evidenced by N2 adsorption desorption analysis. Their antioxidant, antimicrobial activity and cytotoxicity on HeLa-2 cells were evaluated in order to formulate some potential applications of the obtained compounds. The obtained results recommend the obtained fluorescent mesoporous nanocomposites as potential candidates for the development of novel probes for the in situ tracking of oxidative stress, as well as for antimicrobial applications.

Synthesis and Characterization of Fluorescent Mesoporous Silica(Znq-CMS)with a Zinc Complex of 8-Hydroxyquinoline

This experiment is to prepare fluorescent mesoporous silica and explore its characteristics of the zinc complex of 8-hydroxyquinoline, synthesize CMS-SH by base-catalyzed sol-gel method, and then complex the zinc complex of 8-hydroxyquinoline. Go in and successfully synthesize Znq-CMS. In addition, the particle size and potential of CMS-SH and Znq-CMS were characterized by dynamic scattering (DLS), and the fluorescence characteristics of Znq-CMS were characterized by a fluorescence spectrophotometer and an ultraviolet lamp. The results show that Znq-CMS has good dispersibility and fluorescence effect. The purpose of this study is to explore a new model of drug delivery system for stimulus response.