Constructing multifaceted bio-inspired environmentally friendly films combining the synergistic advantages of multiple bionics can improve the static antifouling effect of antifouling-releasing silicones and mitigate the toxicity to marine ecology. In this work, based on the multiple anti-fouling mechanisms of fluorescent corals, designed Cs3Bi2Br9/ZnS/PDMS (CZP) flexible fluorescent films with surface microstructures and interpenetrating network Moreover, the blue fluorescence in the CZP films can be maintained for a long time in seawater environment (attributed to bismuth-based chalcogenides), and the formation of the heterostructure of Cs3Bi2Br9/ZnS (CBB/ZS) improves the ability of releasing reactive oxygen species (hydroxyl radical, superoxide radical, and singlet-linear oxygen).The CZP films obtained excellent antifouling effect under static conditions with antimicrobial rate up to 90.51% and anti-algae adhesion to diatoms up to 96.60%, which was attributed to the synergistic effect of the fluorescence functionality, micronized structure, and free radical release. Consequently, this work provides a promising avenue for the development of marine antifouling silicon-based films for efficient and environmentally friendly applications.