In this research article, the bioconvection of oxytactic microorganisms with magneto-hydrodynamic (MHD) 3D steady flow of Sisko nanomaterial over a stretching sheet through convective conditions is deliberated and analyzed. Possessions of thermophoresis, Brownian motion as well as mixed convection in the Sisko fluid are also deliberated. Sisko fluid is supposed to be electrically conducted over and done with a constant pragmatic magnetic field. The flow problem is communicated using governing relations and problem is transmuted into dimensionless form among non-similar procedure. To obtain convergent solutions we must solve nonlinear differential systems. The consequences of several physical parameters have been deliberate and discussed. Our results displayed that the higher microorganism difference parameter condensed the microorganism profile, while an opposite influence is established for magnetic parameter. Concentration proises of the Sisko fluid flow are improved by growing Biot number whereas contracted beside the Lewis number. In recent years, the scientists have shown great attention in the field of bioconvection owing to its countless applications such as amassing the cells, bioreactors, gas-bearing sedimentary, modeling oil, exclusion of living, and nonliving cells, and lots of additional.