Nanomaterials are quite significant in the physiological and engineering processes. Such materials have motivated the recent scientists in view of their enhanced thermophysical characteristics than conventional liquids. With this in mind, the intention here is to address the peristaltic activity of Sisko nano-liquid subject to Hall and Ohmic heating effects. Fluid-saturated porous space is modeled using the modified Darcy’s law. Thermal radiation is also accounted. In addition, the analysis carried out is subject to thermal jump, velocity slip and zero mass flux condition. Numerical solution to the resulting nonlinear problem through the lubrication approach is developed. Solution analysis is made by pointing out the impacts of sundry variables. The temperature profile increases by increasing the Hartman number due to the Joule heating effect. However, temperature decreases by increasing the Hall parameter.