Flower Basket Research Articles

Amphibious Architecture: A Biomimetic Design Approach to Flood Resilience

Amphibious buildings use the buoyancy principle in the design of their foundation systems to mitigate flood impact. In some cases, amphibious buildings are fitted with mechanical systems that further aid the buoyancy element to temporarily raise the building and guide its descent to natural ground level. These mechanical systems require external operation, preventing the amphibious building from passively responding during flood events as is one of the requirements of a robust flood mitigation measure. Additionally, buildings in flood environments are often left with stains on the exterior facade from floodwater contamination from sewage and chemicals, among others. This paper distinguishes three main components of an amphibious foundation: the buoyancy element, vertical guidance post, and structural sub-frame, and discusses their functionality. The natural world provides solutions to tackling environmental issues such as flooding. When systematically studied and transferred, nature can inspire innovative ideas for functional and sustainable designs for the built environments. Although there are many existing designs and a small number of constructed amphibious buildings, there are very few studies that discuss how the designs are derived, and even fewer on a framework emulating natural systems for transfer into amphibious building design. In that context, this research uses the biomimetic transfer process to abstract relevant biological systems, illustrating their potential for transfer into amphibious foundation design. The aim is to understand how these biological systems passively and continuously respond and adapt to their environment. Organisms such as the Venus flower basket, giant kelp, and red mangrove, among others, are discussed, to understand how they perform the identified functions. The steps of the biomimetic transfer process are used to integrate functions of amphibious buildings and processes of the studied biological systems. The final output of this paper is a discussion of the ways in which these derived relationships can be adopted in amphibious building design.

Comparison of the mechanical properties of retrieval basket catheters for bile duct stones: An experimental study.

Although numerous retrieval baskets are currently available for the extraction of bile duct stones, their mechanical properties have not been evaluated. This study aimed to ascertain the characteristics of retrieval baskets for bile duct stones by examining their mechanical properties. This experimental study tested the mechanical properties of seven retrieval baskets for bile duct stones. The radial force (RF) was measured using a dedicated measurement device and the axial force (AF) was measured using the conventional manual method. The mean RF differed significantly among the baskets (p < 0.001) and was the strongest for VorticCatch (1.62 N ± 0.02) and COAXIS (1.62 N ± 0.04), followed by RASEN (1.27 N ± 0.02), Memory Basket (0.95 N ± 0.01), 8-wire Nitinol Basket (0.93 N ± 0.01), StoneHunter (0.78 N ± 0.01) and Flower Basket (0.37 N ± 0.01), respectively. The mean AF differed significantly among the baskets (p < 0.001) and was the highest for VorticCatch (0.668 N ± 0.032), followed by COAXIS (0.629 N ± 0.041), StoneHunter (0.574 N ± 0.037), 8-wire Nitinol Basket (0.546 N ± 0.010), Memory Basket (0.542 N ± 0.024), RASEN (0.435 N ± 0.008) and Flower Basket (0.297 N ± 0.011), respectively. The baskets were categorized into four groups with comparable mechanical properties based on the RF and AF: group 1, low RF and low AF; group 2, moderate RF and moderate AF; group 3, high RF and moderate AF; and group 4, high RF and high AF. This study revealed distinct mechanical properties of various retrieval baskets used for extracting bile duct stones, which may enhance the understanding of their action. Our results could also aid the development of retrieval baskets in future.

Bio-inspired selective nodal decoupling for ultra-compliant interwoven lattices

Architected materials such as lattices are capable of demonstrating extraordinary mechanical performance. Lattices are often used for their stretch-dominated behavior, which gives them a high degree of stiffness at low-volume fractions. At the other end of the stiffness spectrum, bending-dominated lattices tend to be more compliant and are of interest for their energy absorption performance. Here, we report a class of ultra-compliant interwoven lattices that demonstrate up to an order of magnitude improvement in compliance over their traditional counterparts at similar volume fractions. This is achieved by selectively decoupling nodes and interweaving struts in bending-dominated lattices, inspired by observations of this structural principle in the lattice-like arrangement of the Venus flower basket sea sponge. By decoupling nodes in this manner, we demonstrate a simple and near-universal design strategy for modulating stiffness in lattice structures and achieve among the most compliant lattices reported in the literature.

In situ investigations of failure mechanisms of silica fibers from the venus flower basket (Euplectella Aspergillum).

The fibers of the deep-sea sponge Euplectella aspergillum exhibit exceptional mechanical properties due to their unique layered structure at a micrometer length scale. In the present study, we utilize a correlative approach comprising of in situ tensile testing inside a scanning electron microscope (SEM) and post-failure fractography to precisely understand mechanisms through which layered architecture of fibers fracture and improves damage tolerance in tensile loading condition. The real-time observation of fibers in the present study confirms for the first time that the failure starts from the surface of fibers and proceeds to the center through successive layers. The concentric layers surrounding the central core sacrifice themselves and protect the central core through various toughening mechanisms like crack deflection, crack arrest, interface debonding, and fiber pullout. STATEMENT OF SIGNIFICANCE: Biological materials often exhibit multiscale hierarchical structures that can be incorporated into the design of next generation of engineering materials. The fibers of deep-sea sponge E. aspergillum possess core-shell like layered architecture. Our in situ study reveals astounding strategies by which this architecture delays the fracture of the fiber. The core-shell architecture of these fibers behaves like fiber-reinforced ceramic matrix composite, where the outer shells act as a matrix and the central core acts as a fiber. The outer shells take the environmental brunt and scarify themselves to protect the central core. The precise understanding of damage evolution presented here will help to design architected materials for load-bearing applications.

Фармакогностическое исследование сырья Tripleurospermum inodorum (L.) Sch. Bip.

Введение новых видов растений в медицинскую практику требует проведения фармакогностического исследования, в том числе определение макро- и микроскопических показателей растительного сырья.В статье изложены результаты анатомо-морфологического исследования надземных органов трехре-берника непахучего (Tripleurospermum inodorum (L.) Sch. Bip.), собранного в природных условиях в фазе цветения. Растение проявляет антикоагулянтные свойства, обладает мягчительными, спазмоли-тическими и анальгезирующими свойствами, а также проявляет антибактериальную активность. По итогам анализа морфологических и анатомических показателей трехреберника непахучего определе-ны диагностические признаки сырья на макро- и микроскопическом уровнях. Так, на макроскопиче-ском уровне определены следующие признаки: форма, цвет стебля с поверхности и цвет на изломе;форма и степень рассечения листовой пластины, форма конечных долек листочков; форма цветочной корзинки, особенности строения листочков обвертки, цветоложа; строение и форма трубчатых и колокольчатых цветков. На микроскопическом уровне признаки сырья Tripleurospermum inodorum следующие: форма и структура стебля, размещение основных тканей; форма и строение клеток эпидермиса венчика цветка и листочков обвертки, расположение вместилищ и эфирно-масличных железок. Полученные результаты могут войти в проект нормативных документов на растительное сырье данного вида.

Fasad Sculpture of Provincial Eclectics on the Example of Rostov-on-Don: Iconography, Symbols, Stylistics

The article is devoted to the study of eclectic facade sculpture in the historical center of Rostov-on-Don, considered in accordance with specific neo-styles. Sculpture plays an important compositional role in the design of the facades of Neo-Baroque monuments, emphasizing the rhythmic organization of facades, emphasizing the central and corner parts of buildings. Sculptural decor in the design of facades, designed within the neo-Greek and Neo-Renaissance, obeys the compositional rhythm set by architectural forms, is most often placed in architecturally limited fields, highlights the compositional axes of facades and more actively uses motifs of ancient origin. In general, the iconography of the sculptural decor includes plant motifs (laurel, flower, fruit garlands, flower baskets, acanthus, wreaths, rosettes), images of objects, including symbolic ones (shells, cartouches, caduceus, flowerpots, a cornucopia, a fountain, attributes of industry, trade, sciences and arts, armorial shields), zoomorphic images (mainly lion mascarons, griffins), mixanthropic and anthropomorphic images. Among the latest figurines are putti, mascarons of satyrs, Aphrodite, Hermes; belt herms of Hercules, Omphale, Deianira; sculptures of nymphs, Apollo, Ceres, goddesses of Glory; scenes from the history of Cupid and Psyche. The symbolism of the sculptural decor corresponds to the purpose of the building, expresses the ideas of prosperity and progress: Ceres, Apollo, the goddess of Glory — on the building of the City Duma; musical instruments and theatrical masks — on the theater building; plots symbolizing various types of activities — on the building of the Property Pledge Society; attributes of trade, industry, sciences, arts, mascarons of Hermes and his caduceus, cornucopia — on tenement houses; Hercules, Dejanira, Omphala, Aphrodite’s mascarons are on the mansions. There is a “universalization” of the mascarons of Hermes and his caduceus, which are used everywhere, regional motifs appear (bees, salting fish), the use of neo-style decor on the building, reproducing the type of kuren, is noted. Stylistically, the sculpture is focused mainly on classicism and the Renaissance, using the techniques of mannerism, baroque, rococo. The prototypes are the motifs of the sculptural decoration of famous buildings in St Petersburg, Vienna, Berlin, Brussels, chronologically close to the monuments under consideration.

S2857 Post-ERCP Greater Curvature Hematoma Complicated by Polymicrobial Infection: Case Report and Literature Review

Introduction: ERCP has become critical in diagnosing and treating biliary and pancreatic diseases. ERCP-related complications occur in 2.5 - 8% of procedures and include pancreatitis, biliary hemorrhage, and cholangitis. Rarely, subcapsular hepatic, splenic, and duodenal hematomas have been reported in case reports. Here we present a rare case of an intramural post-ERCP hematoma at the greater curvature of the stomach, complicated by polymicrobial infection. Case Description/Methods: A 67-year-old male with a past medical history of choledocholithiasis status-post ERCP with plastic stent placement three months prior presented as a transfer from an outside hospital in septic shock on vasopressors. Upon arrival ultrasound revealed a 13mm common bile duct (CBD) and gallstones measuring up to 1 cm. Emergent ERCP was performed and showed a proximally migrated CBD plastic stent with distal flap not visible and pus extruding from the major papilla (Image A). Multiple maneuvers were required to extract the stent including balloon, rat-tooth forceps, and flower basket. The patient was too unstable for further maneuvers such as Spyglass. The CBD was swept with a balloon and a fully-covered metal stent was placed. Liver function tests after the ERCP improved; however, the patient had a hemoglobin drop of 2 g/dL and continued to require pressors so a computed tomography of abdomen and pelvis was performed. It demonstrated an 11.3 cm fluid collection centered around the greater curvature of the stomach with hyperattenuating foci concerning for blood of varying chronicity (Image 1B). The collection was drained by radiology the next day and appeared grossly bloody. Upon culture the fluid grew Pseudomonas aeruginosa, Enterococcus faecalis, and Candida albicans. Patient was subsequently given multiple different antibiotic regimens due to resistance and the hematoma has nearly resolved since. (Figure) Discussion: ERCP-related complications can occur even when done by skilled endoscopists. Complex interventions are more likely to cause such complications. In particular, scope placement in the "long scope position" could have sheared the short gastric veins and resulted in our patient’s hematoma. While it is a rare complication, hematoma formation can cause ischemia and infection and lead to significant morbidity or mortality. Our case highlights a rare complication of ERCP that requires early recognition and response.Figure 1.: Image 1A: Pus near major papilla concerning for cholangitis Image 1B: 11.3 cm collection/hematoma in the left upper abdomen, centered at the greater curvature of the stomach. Scattered hyperattenuating foci within the stomach and within this collection, which likely represent blood products of varying ages.

The morphologic analysis of a not well-known anatomical structure's calcifications (Bochdalek's flower basket calcifications).

The aim of the study was to define the morphology of calcifications belonging to a not very well-known anatomical structure (calcification of foramen of Luschka/Bochdalek's flower basket calcification [Boc FBC]). Two hundred sixty-four computed tomography (CT) scans obtained from healthy patients were included in the study (50.0038 ± 24.78309 [0-92 years old] [mean age ± standard deviation; range]). The morphology of the calcifications in the fourth ventricle (CFV) and Boc FBC was evaluated and compared with other common intracranial calcifications in each patient. Boc FBC was detected in 22.35% (59/264) of the patients. Out of 101 patients aged above 60 years, 59 presented Boc FBC (the rate increased to 55.45%), thus in our sample 94.91% of the detected Boc FBCs (56/59) were seen after 60 years of age. No Boc FBC was found under the age of 50. Statistically, there was a highly significant correlation between Boc FBC and pineal/habenular (p < 0.01) as well as choroid plexus calcifications (p < 0.01). The correlation between CFV and Boc FBC was significant (p < 0.05). It was found that 37.3% of Boc FBCs had a conical form. This form was not accompanied by any vascular calcifications, either basilar or vertebral. Therefore, seeing the conical form was valuable in the differential diagnosis. In our study, Boc FBCs were seen in advanced age and were not encountered under the age of 50. The conical form was seen in one-third of the cases, but it was a very beneficial finding for distinguishing Boc FBC from other calcifications if any. In the advanced age group, calcifications, especially choroid plexus calcifications and pineal/habenular calcifications, are highly associated with Boc FBC. In the presence of CFV, the probability of encountering Boc FBC is very high.

DORIVOR TIRNOQGULDAGI TUNLAMLAR VA ULAR SONINI BOSHQARISHDA ENTOMOFAGLARNING AHAMIYATI

This article provides information about the role of entomophages in the fight against Noctuidae and their numbers. As a result of research, calendula officinalis is harmed by Heliothis armigera Hb, Phytometra gamma L, Agrotis segetum Den. et Schiff, Agrotis exclamationis L and Leucania vibellina Hb. Among them, the cotton bollworm is the most common and harmful species. It is known in the pharmaceutical industry as the main raw material used inflorescence of calendula – basket. These pests severely damage not only the roots or stems of plants, but also the most valuable organ – the flower basket. The article discusses the effectiveness of the biological application of the entomophage bracon against the cotton bollworm. When using the entomophage bracon in pest control in the ratio of 1 : 5, the entomophage showed the best efficiency of 78.5-88.2%.

Extraordinarily early Venus' flower basket sponges (Hexactinellida, Euplectellidae) from the uppermost Ordovician Anji Biota, China

AbstractThe deep‐sea hexactinellid sponge Euplectella is an iconic living genus with no known fossil record. The family Euplectellidae (which includes a subset of genera that share the common name ‘Venus' flower basket’) has a very sparse record from the Middle Cretaceous onwards, and an estimated crown‐group origin at around 300 Ma based on molecular clocks. New material of Venus' flower baskets from the latest Ordovician Anji Biota of China (444 Ma) dramatically extends the known and predicted range of the group, with implications for the diversification of the class Hexactinellida and the timing of development of deep‐sea ecosystems. The new material is described as Anjiplectella davidipharus gen. et sp. nov., with an additional taxon remaining in open nomenclature but demonstrating diversification within the group by this time.

Dimensional quality assessment of cable-stayed bridge by combining terrestrial and drone laser scanner

Xinglinpu Bridge was built on the S3801 freeway in 2019 in preparation for the winter Olympics in Beijing, China. It is a cable-stayed steel bridge with pylons in the shape of flower baskets. Using Xinglinpu Bridge as a case study, a systematic approach to the dimensional quality assessment of complex bridges using a combination of three-dimensional (3D) point clouds obtained by terrestrial laser scanning (TLS) and unmanned aerial vehicle (UAV) surveys is proposed in this paper. The currently available methods for dimensional quality assessment of complex bridges rely largely on manual inspection and contact-type measurement devices, which are time consuming and costly. To overcome these limitations, this paper presents a framework for dimensional quality assessment composed of three parts: scanning schemes for TLS and UAV, scanning implementation and measurement of geometric dimensions. The results of configuration detection verified the high-quality construction of Xinglinpu Bridge, although millimetre-scale differences were obtained between the point clouds and the design value. The potential and limitations of 3D laser scanning for assessing the quality of complex bridges are discussed.

Psychological and Physiological Relaxation Induced by Nature-Working with Ornamental Plants

Objective. Nature has a significant impact on general well-being. However, till date, little psychophysiological evidence is available on the benefits of nature-based activities in adults. The primary goal of this study was to determine the physiological and psychological benefits of horticultural activity in adults. The participants were instructed to perform the making of a flower basket (horticultural activity) and a computer task (i.e., control activity) was compared.Methods. A total of 40 Chinese females (mean age 22.2 ± 0.9 years) participated in this experiment. The Blood pressure, the State-Trait Anxiety Inventory (STAI), and the electroencephalograms (EEGs) were used to measure the participants’ psychophysiological responses.Results. Analysis of the STAI data showed a lower anxiety score after performing the horticultural activity than after performing the control activity. Furthermore, in the EEG evaluation, variations in the brainwaves were observed after both activities.Conclusions. The study results suggest that horticultural activity induced physiological and psychological relaxation in adults.

Flower Basket Retrieval: Utilization of a Device with a Unique Design for Endoscopic Rescue in Cases Involving Proximal Migration of Pancreatic Duct Stents

Flower Basket Retrieval: Utilization of a Device with a Unique Design for Endoscopic Rescue in Cases Involving Proximal Migration of Pancreatic Duct Stents

Bio-Inspired Design for Additive Manufacturing - Case Study: Microtiter Plate

AbstractBio-inspired design is an innovative methodology for transferring biological solutions into technical solutions, for example for the design of weight- and load-optimized components. Bio-inspired design therefore offers great potential for meeting the challenges of designing additively manufactured components, such as avoiding warpage, supporting structures and material minimisation. Nevertheless, apart from bio-inspired topology optimization tools, bio-inspired design is rarely used in industrial practice because for many companies the practical applicability up to the prototype is not obvious. The aim of this work is therefore a practical approach to the search for biological systems, analysis, abstraction and transfer of analogies. We apply bio-inspired design on the design of a microtiter plate manufactured by stereolithography, whose dimensional accuracy is impaired by warpage. Here, the venus’ flower basket, a deep-sea sponge, can serve as a model. It has a hierarchical structure of silicate needles whose elements are abstracted for bio-inspired transfer. We show and evaluate the transfer of different analogies using a prototype.

Morphometry and microsurgical anatomy of Bochdalek's flower basket and the related structures of the cerebellopontine angle.

Bochdalek's flower basket (Bfb) is the distal part of the horizontal segment of the fourth ventricle's choroid plexus protruding through the lateral aperture (foramen of Luschka). The microsurgical anatomy of the cerebellopontine angle, fourth ventricle and its inner choroid plexus is well described in the literature, but only one radiological study has investigated the Bfb so far. The goal of the present study was to give an extensive morphometric analysis of the Bfb for the first time and discuss the surgically relevant anatomical aspects. Forty-two formalin-fixed human brains (84 cerebellopontine angles) were involved in this study. Photomicrographs with scale bars were taken in every step of dissection to perform further measurements with Fiji software. The lengths and widths of the Bfb, rhomboid lip and lateral aperture of the fourth ventricle as well as the related neurovascular and arachnoid structures were measured. The areas of two sides were compared with paired t-tests using R software. Significance level was set at p<0.05. Protruding choroid plexus was present in 77 cases (91.66%). In 6 cases (7.14%), the Bfb was totally covered by the rhomboid lip, and in one case (1.19%), it was absent. The mean width of the Bfb was 6.618mm (2-14mm), the mean height 5.658mm (1.5-14mm) and mean area 25.80mm2 (3.07-109.83mm2). There was no statistically significant difference between the two sides (p=0.1744). The Bfb was in contact with 20 AICAs (23.80%), 6 PICAs (7.14%) and 39 vestibulocochlear nerves (46.42%). Arachnoid trabecules, connecting the lower cranial nerves to the Bfb or rhomboid lip, were found in 57 cases (67.85%). The Bfb is an important landmark during various surgical procedures. Detailed morphology, dimensions and relations to the surrounding neurovascular structures are described in this study. These data are essential for surgeons operating in this region.

Internal structure of sponge glass fiber revealed by ptychographic nanotomography.

Sponge glass spicules have solicited great interest due to their mechanical and optical properties. Herein we use ptychographic nanotomography to obtain detailed insights into the internal structure of an anchor spicule from the Venus flower basket. The obtained dataset has 90nm resolution in 3D and provides quantitative determination of the electron density. The data reveal significant variations in electron density across the spicule. The central organic filament is found to be slightly but significantly displaced from the spicule central axis. Analysis of the electron density affords an estimate of a protein volume fraction in the organic filament of about 70%. In the highly mineralized part of the spicule, the electron density is seen to display circular symmetry and be neigh independent of position along the spicule long axis. Variations in the electron density beyond those included in current models of spicule mechanics are observed.

Estimation of consumers demand functions of cut-flowers products: A case study of Pakistani, Punjab

The objective of this study was to estimate purchase frequency of the selected cut-flower items and demand functions in Punjab and Pakistan. Simple random sampling technique was employed to collect primary data from 120 consumers using a well-structured and field pretested questionnaire during the year 2012-13. The results of the findings revealed that the average price was the highest in case of flowers stage decoration (Rs. 9546), followed by jewelry set (Rs. 677), flower basket (Rs. 394), mala (Rs. 334,), bouquets (Rs. 259), garland (Rs. 41), and gajjra (Rs. 21). Most of the selected consumers (61%) occasionally purchased flowers. The reason of occasionally purchasing was that mostly the consumers purchased the flowers at the occasions of various ceremonial days, i.e., Valentines Day, birth of baby, and death of a relative, etc. About 45% of the selected consumers preferred rose flower. The reasons of high preference for rose flowers were that this is a common flower, mostly grown in all areas of Pakistan and everyone is familiar to it. After rose the jasmine flower (27%) is preferred due to its attractive smell and fragrance, it is also a common flower and mostly grown in Pakistan. It is the national flower of Pakistan. The results of the demand function revealed that the variable of age was significant for the selected cut-flower items, but the variable of education of the consumers was insignificant in case of flowers car decoration. The consumers are restrained to decide about the rational price of the item purchased. There is a limited number of cut-flower shops. Majority of the shops are located in the rich areas of the cities. Common consumers are to travel long distances to purchase flower items. More retail flower shops should be set up by the local bodies in all parts of the cities. The market committees should standardize prices for cut-flower items for the benefit of consumers. Policy need to be designed to increase the demand of flowers by electronic and press media.

Technique for Retrieving Basket and Lithotripter During Endoscopic Retrograde Cholangiopancreatography

A 27-year-old woman with a prior cholecystectomy underwent endoscopic retrograde cholangio pancreatography (ERCP) for abdominal pain and choledocholithiasis. After biliary sphincterotomy, a flower basket was used to grasp and retrieve a 15-mm mid–common bile duct (CBD) stone. However, the flower basket became impacted in the CBD (Figure A). Then, the distal CBD was dilated using a 15-mm CRE balloon dilator (Boston Scientific, Natick, MA). Despite this, the basket could not be pulled out. The outer plastic sheath of the basket was removed and a Soehendra mechanical lithotripter then was inserted alongside the basket wires into the CBD and mechanical lithotripsy (Cook Medical, Winston-Salem, NC) of the stone was attempted.

English

Nowadays, tourism plays pivotal role for economic and social development of many nations. It is considered as the world&rsquo;s first investment movement of the 21st century. Thus, developing countries are giving due attention to service delivery industries like tourism that contributes a lot to their economy. Ethiopia has its own long centuries of history and rich culture. For instance, Amhara national regional state has been endowed with rare and endemic cultural and natural heritages. In this regard, the island monasteries of Lake Tana which are the green flower baskets of the lake have potentials for the development of tourism in the area but yet it is fully unexploited. Currently, tourism sector is facing multifaceted challenges, and it is attracting the intellectual gaze of many scholars from various disciplines. This article is a step in that direction. The grand objective of this article is to examine the historical vicissitude of tourism developments in the island monastery of Kebran Gabriel. Towards this end, archival sources are consulted and interview is made with informants. &nbsp;So, it is needless to say that this article attests the challenges and prospects of the island monastery of Kebran Gabriel as a tourist site since 1950&rsquo;s. &nbsp; Key words: Kebran Gabriel, treasury, attraction, preservation, museum.

No miracles among friends

Sir, How often does the doctor who has taken care of you during a prolonged and difficult illness also lights your funeral pyre, then takes your ashes in a basket of flowers to the Ganges? I know of one such doctor. He cared for my sister. Years before he cared for my farther, his surgical mentor and friend. It is a very rare Hindu custom for a Brahmin daughter to light her father’s funeral pyre, but that was my father’s wish. Years later, the good doctor was a mentor to my son, then a novice intern and now a surgeon. All of this does matter. [1] What does not matter is that my sister had acute lymphocytic leukemia with an oncogene addicted BCR/ABL fusion protein where a tyrosine kinase inhibitor (TKI) of that protein is capable of producing complete remissions. [2] It does not matter because there are no acute leukemia treatment facilities in my sister’s hometown and the expense of such treatments is phenomenal, despite the directive from the Supreme Court of India that certain life-saving medicines (which includes imatanib, the first generation BCR/ABL TKI) be sold at a reduced price. Moreover, many basic unfulfilled needs in India, like malnutrition and malaria that claim the lives of millions still exsits. Making treatments available for adult acute leukemia to most Indians must take a place at the back of the line. An initial bone marrow flow cytometry and molecular screening confirmed the pre-B cell phenotype and the presence of the Philadelphia chromosome - the BCR/ABL fusion protein. Imatanib and a corticosteroid were started. There were many determinations for complete blood count (CBC) and assessment of electrolytes, renal function, and uric acid levels. There were admissions for transfusions and hydration. Pre-orbital and generalized edema initially required dose modifications and unilateral blindness [3] then