The isothermal compression of hydrogenated Ti–5.6Al–4.8Sn–2.0Zr–1.0Mo alloy has been carried out. The experimental result shows that the additional hydrogen significantly decreases the flow stress of Ti–5.6Al–4.8Sn–2.0Zr–1.0Mo alloy. The minimum peak stress at deformation temperature of 830–900 °C corresponds to the hydrogen content of 0.4 wt.%, alternatively the appropriate hydrogen content raises the true strain rate up to one order of magnitude in comparison with the received Ti–5.6Al–4.8Sn–2.0Zr–1.0Mo alloy. X-ray diffraction examination shows the appropriate hydrogen content accelerates the $${\upbeta}$$ phase transformation so as to improve the workability of this alloy. However, the hydride phase appears when the hydrogen content is about 0.734 wt.%, which increases of the flow stress in comparison to the flow stress of this alloy with hydrogen content of 0.4 wt.%.